Sample analysis system and method for quality detection of magnetic bead reagent

Abstract

Embodiments of the present application provide a sample analysis system and a quality detection method of magnetic bead reagent. The sample analysis system comprises a reagent storage module, a magnetic bead processing device, an image acquisition module and a control module. The reagent storage module is used for placing a reagent container, and the reagent container at least comprises a reagent container containing magnetic bead reagent. The magnetic bead processing device is used for homogenizing the magnetic beads in the magnetic bead reagent. The image acquisition module is used for acquiring a reagent image of the homogenized magnetic bead reagent from the bottom of the reagent container containing the magnetic bead reagent. The control module is configured to acquire the reagent image, determine abnormal magnetic bead reagent according to the reagent image, and process the abnormal magnetic bead reagent. The abnormal magnetic bead reagent can be avoided from being used in subsequent sample testing to cause abnormal test results, or the test results of the abnormal magnetic bead reagent can be prompted to be ignored by patients and medical staff, so as to avoid the patients and medical staff from receiving incorrect detection results and misjudging the disease condition.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a sample analysis system and a method for quality testing of magnetic bead reagents. Background Technology

[0002] In chemiluminescence immunoassay, magnetic beads are a mature and widely used technique for heterogeneous phase separation.

[0003] Irreversible aggregation of magnetic beads can occur during transportation and storage due to factors such as inversion, lateral placement, or excessively high or low storage temperatures. This aggregation leads to precipitation or rapid settling of the magnetic beads even after mixing, resulting in abnormal effective concentrations. Ultimately, this causes incorrect test results after the reagent is applied to the instrument, leading to erroneous results for patients and potentially serious consequences. Magnetic bead aggregation is a widespread problem in the industry, but no solution has yet been provided. Summary of the Invention

[0004] The following is an overview of the subject matter described in detail in this application. This overview is not intended to limit the scope of the claims.

[0005] This application provides a sample analysis system and a method for quality testing of magnetic bead reagents, which can determine whether the magnetic bead reagents are abnormal by acquiring reagent images from the bottom of the reagent container.

[0006] On one hand, embodiments of this application provide a sample analysis system, including a reagent storage module, a magnetic bead processing device, an image acquisition module, and a control module, wherein:

[0007] The reagent storage module is used to place reagent containers, and the reagent containers include at least a reagent container containing magnetic bead reagents;

[0008] The magnetic bead processing device is used to homogenize the magnetic beads in the magnetic bead reagent.

[0009] The image acquisition module is used to acquire a reagent image of the homogenized magnetic bead reagent from the bottom of the reagent container containing the magnetic bead reagent;

[0010] The control module is configured to acquire the reagent image, identify abnormal magnetic bead reagents based on the reagent image, and process the abnormal magnetic bead reagents.

[0011] In one embodiment of this application, the magnetic bead processing device includes a mixing module for mixing the magnetic bead reagent in the reagent container containing the magnetic bead reagent. The homogenization process includes the mixing process, which is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container containing the magnetic bead reagent.

[0012] In one embodiment of this application, the magnetic bead processing device includes a mixing module for mixing the magnetic bead reagent in the reagent container containing the magnetic bead reagent. The homogenization process includes the mixing process, which drives the magnetic beads in the magnetic bead reagent to disperse.

[0013] In one embodiment of this application, a reagent transfer mechanism is further included. The magnetic bead processing device includes a mixing module for mixing the magnetic beads in the reagent container containing the magnetic bead reagent and a homogenizing module for homogenizing the magnetic beads in the reagent container containing the magnetic bead reagent. The homogenization process includes the mixing process and the homogenizing process. The mixing process is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container containing the magnetic bead reagent. The homogenizing process is used to drive the magnetic beads in the magnetic bead reagent to disperse. The control module is further configured to:

[0014] Before the image acquisition module acquires the reagent image of the bottom of the reagent container containing the magnetic bead reagent, the mixing module is controlled to perform the mixing process and the mixing module is controlled to perform the mixing process.

[0015] The reagent transfer mechanism is controlled to transfer the reagent container, which has undergone the mixing and homogenization processes, to the image acquisition module.

[0016] In one embodiment of this application, controlling the mixing module to perform the mixing process and controlling the mixing module to perform the mixing process includes:

[0017] The mixing module is controlled to perform the mixing process;

[0018] The reagent transfer mechanism is controlled to transfer the reagent container that has undergone the mixing treatment to the mixing module;

[0019] The mixing module is controlled to perform the mixing process.

[0020] In one embodiment of this application, the sample analysis system further includes a pre-opening mechanism, and the control module is further configured to:

[0021] After the initial mixing process and before the homogenization process, the reagent transfer mechanism is controlled to transfer the reagent container that has undergone the initial mixing process to the pre-opening mechanism, and the pre-opening mechanism is controlled to perform a pre-opening operation on the reagent container.

[0022] In one embodiment of this application, the image acquisition module is positioned at the location where the pre-opening operation is performed.

[0023] In one embodiment of this application, the sample analysis system further includes a reagent loading module and a reagent transfer mechanism, and the control module is further configured to: when it is detected that the reagent loading module has placed the reagent container containing magnetic bead reagents, control the reagent transfer mechanism to transfer the reagent container containing magnetic bead reagents to the magnetic bead processing device;

[0024] Alternatively, the sample analysis system may further include a reagent transfer mechanism, and the control module may be configured to control the reagent transfer mechanism to transfer the reagent container containing magnetic bead reagents placed in the reagent storage module to the magnetic bead processing device.

[0025] Alternatively, the magnetic bead processing device may include a mixing module disposed within the reagent storage module, the mixing module being used to homogenize the reagent container containing the magnetic bead reagent placed in the reagent storage module.

[0026] In one embodiment of this application, the treatment of the abnormal magnetic bead reagent includes:

[0027] The reagent transfer mechanism is controlled to transfer the reagent container to the reagent loading module.

[0028] In one embodiment of this application, a reagent anomaly alert module is further included, wherein processing the abnormal magnetic bead reagent includes:

[0029] The reagent abnormality alert module is controlled to issue an abnormality alert signal.

[0030] In one embodiment of this application, the mixing module is disposed within the reagent storage module.

[0031] In one embodiment of this application, the image acquisition module includes an absorbent for contacting the bottom of the reagent container containing magnetic beads, a camera located below the absorbent, and a light source located above the absorbent for illuminating the sidewall of the reagent container containing magnetic beads.

[0032] In one embodiment of this application, the image acquisition module further includes a housing for partially accommodating the camera, a lens barrel extending from the lens of the camera to below the water-absorbing member, a light-transmitting and water-blocking member disposed on the top of the lens barrel, a dustproof baffle movable between a first position and a second position, and a driving member for moving the dustproof baffle; wherein, in the first position, the dustproof baffle blocks the light-transmitting and water-blocking member; and in the second position, the light-transmitting and water-blocking member is exposed.

[0033] In one embodiment of this application, the image acquisition module further includes a position detection device for detecting the position of the dustproof baffle; the control module is configured to:

[0034] Before the image acquisition module acquires the reagent image of the bottom of the reagent container containing magnetic beads, the driving component moves the dustproof baffle from the first position to the second position; and after the image acquisition module acquires the reagent image of the bottom of the reagent container containing magnetic beads, the driving component moves the dustproof baffle from the second position to the first position.

[0035] In one embodiment of this application, the step of determining the abnormal magnetic bead reagent based on the reagent image includes:

[0036] The abnormal magnetic bead reagent is determined based on the pixel grayscale of each pixel in the reagent image.

[0037] In one embodiment of this application, determining the abnormal magnetic bead reagent based on the pixel grayscale of each pixel in the reagent image includes at least one of the following:

[0038] Based on the pixel grayscale of each pixel in the reagent image and the preset binarization threshold, the reagent image is segmented into magnetic bead agglomeration part and non-magnetic bead agglomeration part, and the abnormal magnetic bead reagent is determined based on the area of ​​the magnetic bead agglomeration part.

[0039] Multiple target regions are divided from the reagent image, and the abnormal magnetic bead reagent is determined based on the average pixel gray value of each pixel in the multiple target regions and a preset gray value threshold.

[0040] Based on the histogram of pixel grayscale values ​​of each pixel in the reagent image, the abnormal magnetic bead reagent is identified;

[0041] Based on the discrete distribution of pixel grayscale values ​​in the reagent image, the abnormal magnetic bead reagent is identified.

[0042] On the other hand, embodiments of this application provide a sample analysis system, including a reagent storage module, an image acquisition module, and a control module, wherein:

[0043] The reagent storage module is used to place reagent containers, and the reagent containers include at least a reagent container containing magnetic bead reagents;

[0044] The image acquisition module is used to acquire reagent images from the bottom of the reagent container containing magnetic bead reagent;

[0045] The control module is configured to acquire the reagent image and determine whether the magnetic bead reagent is abnormal based on the reagent image.

[0046] In one embodiment of this application, a magnetic bead processing device is further included, which is used to homogenize the reagent container containing magnetic bead reagent, and the homogenization process is used to improve the uniformity of the magnetic bead reagent.

[0047] On the other hand, embodiments of this application provide a method for quality testing of magnetic bead reagents, including:

[0048] The reagent container containing magnetic beads is subjected to a homogenization treatment, which is used to improve the uniformity of the magnetic beads.

[0049] Acquire reagent images from the bottom of the reagent container;

[0050] Determine whether the magnetic bead reagent is abnormal based on the reagent image.

[0051] In one embodiment of this application, when it is determined that the magnetic bead reagent is abnormal, an abnormality alert signal is issued, and / or the reagent container is withdrawn.

[0052] The embodiments of this application include at least the following beneficial effects:

[0053] On one hand, in one embodiment of the sample analysis system provided by this application, a reagent container containing magnetic beads is placed in a reagent storage module. The magnetic beads in the reagent are homogenized by a magnetic bead processing device, which can improve the uniformity of the magnetic beads. Then, an image acquisition module acquires a reagent image of the homogenized magnetic beads from the bottom of the reagent container. The control module then performs anomaly identification based on the reagent image of the magnetic beads. After identifying abnormal magnetic beads, the abnormal magnetic beads are processed to prevent them from being used in subsequent sample tests and causing abnormal test results. Alternatively, it can prompt patients and medical staff to ignore test results obtained using abnormal magnetic beads, thus avoiding patients and medical staff receiving incorrect test results and misjudging the condition.

[0054] On the one hand, in one embodiment of the sample analysis system provided by this application, a reagent container containing magnetic bead reagents is placed in a reagent storage module. An image acquisition module acquires a reagent image of the magnetic bead reagents from the bottom of the reagent container. Then, a control module performs anomaly identification based on the reagent image of the magnetic bead reagents. After identifying abnormal magnetic bead reagents, the abnormal magnetic bead reagents are processed to prevent them from being used in subsequent sample tests and causing abnormal test results. Alternatively, it can prompt patients and medical staff to ignore test results obtained using abnormal magnetic bead reagents, thus avoiding patients and medical staff receiving incorrect test results and misjudging the condition.

[0055] On the one hand, the quality detection method for magnetic bead reagent provided in one embodiment of this application acquires a reagent image of the bottom of a reagent container containing magnetic bead reagent after homogenization treatment and determines whether the magnetic bead reagent is abnormal based on the reagent image, so as to avoid misdiagnosis of the condition.

[0056] Other features and advantages of this application will be set forth in the following description and will be apparent in part from the description or may be learned by practicing the application. Attached Figure Description

[0057] The accompanying drawings are used to provide a further understanding of the technical solutions of this application and constitute a part of the specification. They are used together with the embodiments of this application to explain the technical solutions of this application and do not constitute a limitation on the technical solutions of this application.

[0058] Figure 1 A block diagram of a sample analysis system provided in Embodiment 1 of this application;

[0059] Figure 2 This is a block diagram of a sample analysis system provided in Embodiment 2 of this application;

[0060] Figure 3 This is a block diagram of a sample analysis system provided in Embodiment 3 of this application;

[0061] Figure 4 This is a block diagram of a sample analysis system provided in Embodiment 4 of this application;

[0062] Figure 5 A flowchart illustrating a method executed by a control module in a sample analysis system according to one embodiment of this application;

[0063] Figure 6 A flowchart illustrating a method executed by a control module in a sample analysis system, as provided in another embodiment of this application;

[0064] Figure 7 A block diagram of a sample analysis system provided for five embodiments of this application;

[0065] Figure 8 A three-dimensional structural diagram of an image acquisition module in a sample analysis system provided in this application embodiment;

[0066] Figure 9 A side view of an image acquisition module in a sample analysis system provided in an embodiment of this application;

[0067] Figure 10 An exploded view of a portion of the structure of an image acquisition module in a sample analysis system provided in this application embodiment;

[0068] Figure 11 A cross-sectional view of an image acquisition module in a sample analysis system provided in this application embodiment;

[0069] Figure 12 for Figure 11 Enlarged view of point A;

[0070] Figure 13 This is a block diagram of a sample analysis system provided in Embodiment Six of this application;

[0071] Figure 14 A flowchart illustrating a quality testing method for magnetic bead reagents provided in this application embodiment. Detailed Implementation

[0072] The present application will be further described below with reference to the accompanying drawings and specific embodiments. The described embodiments should not be considered as limitations on the present application, and all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of the present application.

[0073] In the following description, references are made to “some embodiments,” which describe a subset of all possible embodiments. However, it is understood that “some embodiments” may be the same subset or different subsets of all possible embodiments and may be combined with each other without conflict.

[0074] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing embodiments of this application only and is not intended to limit this application.

[0075] This application provides a sample analysis system capable of detecting and analyzing one or more samples from the human body. These samples may be (but are not limited to) blood, urine, semen, or sweat. For example, the sample analysis system may be a biochemical analyzer, an immunoassay analyzer, or other types of sample analyzers.

[0076] In the process of sample processing and testing, reagents are usually added to the sample to prepare it for subsequent testing. Magnetic bead reagents are a commonly used reagent in immunoassay analyzers. They generally need to be collected when the magnetic beads are evenly distributed to ensure the accuracy of the test results. However, during transportation and storage, conditions such as inversion, lateral placement, and excessively high or low storage temperatures can cause irreversible aggregation of the magnetic beads. Aggregation results in precipitation or rapid sedimentation of the magnetic beads even after mixing, leading to abnormal effective concentrations. This ultimately causes abnormal test results after the reagent is applied to the analyzer, resulting in patients receiving incorrect test results and potentially serious consequences.

[0077] This application provides a sample analysis system and a method for quality testing of magnetic bead reagents, which can determine whether the magnetic bead reagents are abnormal by acquiring reagent images from the bottom of the reagent container.

[0078] like Figure 1 The diagram shown is a block diagram of a sample analysis system according to an embodiment of this application. (Refer to...) Figure 1 The sample analysis system includes a reagent storage module 100, a magnetic bead processing device 200, an image acquisition module 300, and a control module 400. The control module 400 is connected to the reagent storage module 100, the magnetic bead processing device 200, and the image acquisition module 300, respectively. Each module is described in detail below.

[0079] The reagent storage module 100 is used to hold reagent containers, which include at least a reagent container containing magnetic bead reagents. In some embodiments, the reagent storage module 100 is arranged in a disk-shaped structure and has multiple positions for carrying reagent containers. The reagent storage module 100 is rotatable and drives the reagent containers it carries to rotate, thereby rotating the reagent containers to the reagent aspiration position so that other modules of the sample analysis system can aspirate the reagents for subsequent reaction with the sample and detection analysis.

[0080] The magnetic bead processing device 200 is used to homogenize magnetic beads in a magnetic bead reagent. It is understood that homogenization improves the uniformity of the magnetic bead reagent, dispersing reversible agglomerations and preventing these agglomerations from affecting the determination of whether the magnetic bead reagent is abnormal. In some embodiments, the homogenization process includes at least one of a mixing process and a blending process.

[0081] The image acquisition module 300 is used to acquire reagent images of the homogenized magnetic bead reagent from the bottom of the reagent container containing the magnetic bead reagent. It should be noted that since the aggregated magnetic beads in the reagent generally settle at the bottom of the reagent container, acquiring reagent images of the magnetic bead reagent from the bottom of the reagent container makes it easier and more accurate to identify the aggregation phenomenon of the magnetic bead reagent from the reagent image.

[0082] The control module 400 is configured to acquire reagent images, identify abnormal magnetic bead reagents based on the reagent images, and process the abnormal magnetic bead reagents.

[0083] In this embodiment, the reagent container containing magnetic beads is placed in the reagent storage module 100. The magnetic beads in the reagent are homogenized by the magnetic bead processing device 200, which can improve the uniformity of the magnetic bead reagent. Then, the image acquisition module 300 acquires the reagent image of the homogenized magnetic bead reagent from the bottom of the reagent container. The control module 400 then performs anomaly identification based on the reagent image of the magnetic bead reagent. After identifying abnormal magnetic bead reagents, the abnormal magnetic bead reagents are processed to prevent them from being used in subsequent sample tests and causing abnormal test results. Alternatively, patients and medical staff can be prompted to ignore test results obtained using abnormal magnetic bead reagents, thus avoiding patients and medical staff receiving incorrect test results and misjudging the condition.

[0084] Reference Figure 2 In one embodiment, the magnetic bead processing device 200 includes a mixing module 210 for mixing the magnetic bead reagent in a reagent container containing magnetic bead reagent. The homogenization process includes the mixing process, which is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container.

[0085] In this embodiment, the main function of the mixing module 210 is to detach the deposited magnetic beads from the reagent container. Therefore, various structures capable of achieving this purpose can be adopted, such as magnetic attraction structures, ultrasonic structures, and stirring structures. In some embodiments, the mixing module 210 is movably configured. When mixing is required, the mixing module 210 is driven to move to the position of the corresponding magnetic bead reagent to perform corresponding operations on the magnetic bead reagent. For example, the reagent storage module 100 has a mounting part for placing a reagent container containing magnetic bead reagent. The mixing module 210 can move relative to the mounting part to act on the magnetic bead reagent in the corresponding reagent container. In other embodiments, the mixing module 210 may remain stationary. When mixing is required, the reagent container containing magnetic bead reagent is driven to move to the position corresponding to the mixing module 210 to achieve mixing. For example, when the mixing module 210 is a permanent magnet, when mixing is required, the reagent container containing magnetic bead reagent can be moved into the magnetic field of the permanent magnet, and the permanent magnet adsorbs the deposited magnetic beads, causing them to detach from the deposition position. Once the mixing effect is achieved, move the magnetic bead reagent to a position outside the magnetic field of the permanent magnet.

[0086] Reference Figure 3 In one embodiment, the magnetic bead processing device 200 includes a mixing module 220 for mixing magnetic bead reagents in a reagent container. The homogenization process includes a mixing process, which drives the magnetic beads in the magnetic bead reagents to disperse.

[0087] Typically, in unequally mixed magnetic bead reagents, the magnetic beads tend to aggregate and deposit at the bottom of the reagent container. Therefore, in this embodiment, the mixing module 220 is mainly used to drive the magnetic beads detached from their deposition positions to disperse, so that the magnetic beads can be uniformly dispersed in the magnetic bead reagent. The mixing module 220 is primarily used to break up aggregated magnetic beads and disperse them. Various structures capable of breaking up and driving the magnetic beads can be used, such as ultrasonic structures, stirring structures, or the reagent container's own breaking up structure. In some embodiments, the mixing module 220 is movably configured. When mixing is required, the mixing module 220 is moved to the position of the corresponding magnetic bead reagent to perform the corresponding operation. For example, the reagent storage module 100 has a mounting section for placing the reagent container containing the magnetic bead reagent. The mixing module 220 can move relative to the mounting section to act on the magnetic bead reagent in the corresponding reagent container. In other embodiments, the mixing module 220 may remain stationary. When mixing is required, the reagent container containing the magnetic beads is driven to move to a position corresponding to the mixing module 220 to achieve mixing. The mixing module 220 may have a mounting part for placing the reagent container containing the magnetic beads and a related driving structure to drive the mounting part to move the reagent container containing the magnetic beads relative to the mixing module 220.

[0088] Reference Figure 4 In one embodiment, the magnetic bead processing device 200 includes a mixing module 210 for mixing the magnetic bead reagent in a reagent container containing magnetic bead reagent and a homogenizing module 220 for homogenizing the magnetic bead reagent in the reagent container. The homogenization process includes mixing and homogenizing. The mixing process is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container, and the homogenizing process is used to drive the magnetic beads in the magnetic bead reagent to disperse.

[0089] In this embodiment, the mixing module 220 can operate simultaneously with the mixing module 210 acting on the magnetic bead reagent, or it can act on the magnetic bead reagent after the mixing module 210 has finished acting on it. After the magnetic beads detach from their deposition positions, they are easier to mix. The mixing module 210 is mainly used to drive the magnetic beads deposited in the magnetic bead reagent to detach from their deposition positions in the magnetic bead liquid container. The mixing module 220 is mainly used to drive the magnetic beads detached from their deposition positions to disperse, so that the magnetic beads can be uniformly dispersed in the magnetic bead reagent. The combination of the mixing module 210 and the mixing module 220 not only eliminates the need for manual mixing by the user and improves mixing efficiency, but also achieves better mixing results. Furthermore, during the process of driving the deposited magnetic beads to detach from the cavity wall of the reagent container, the mixing module 210 will also disperse some magnetic beads to a certain extent, playing a certain role in mixing. This function, combined with the mixing function of the mixing module 220, can further mix the magnetic bead reagent more evenly, thereby avoiding the problem of misidentifying reversible agglomeration as irreversible agglomeration and thus judging qualified reagents as unqualified reagents.

[0090] Reference Figure 4 In one embodiment, the sample analysis system further includes a reagent transfer mechanism 500. (Refer to...) Figure 5 The control module 400 is also configured to execute steps S510 to S520.

[0091] In step S510, before the image acquisition module 300 acquires the reagent image of the bottom of the reagent container containing the magnetic bead reagent, the mixing module 210 is controlled to perform the mixing process and the mixing module 220 is controlled to perform the mixing process.

[0092] In step S520, the reagent transfer mechanism 500 is controlled to transfer the reagent container that has undergone mixing and homogenization to the image acquisition module 300.

[0093] In this embodiment, since the sample analysis system has multiple different modules such as the reagent storage module 100, the mixing module 210, the mixing module 220, and the image acquisition module 300, it is difficult to set up the reagent transfer mechanism 500 in the same location for the reagent container containing magnetic beads. This would allow the reagent container to be transferred to different stations so that different modules of the sample analysis system can perform corresponding processing operations on the magnetic beads in the reagent container.

[0094] Reference Figure 6 In one embodiment, the mixing control module 210 in step S510 performs the mixing process and the mixing control module 220 performs the mixing process, including steps S610 to S630.

[0095] Step S610: Control the mixing module 210 to perform mixing processing;

[0096] In step S620, the reagent transfer mechanism 500 is controlled to transfer the reagent container that has undergone the mixing treatment to the mixing module 220;

[0097] Step S630: Control the mixing module 220 to perform mixing processing.

[0098] It is understood that in this embodiment, the mixing module 210 and the mixing module 220 are located at different positions in the sample analysis system, so that the mixing station for mixing the reagent container containing magnetic beads is not in the same position as the mixing station for mixing. Therefore, the mixing process is completed at the mixing station first, and then the reagent transfer mechanism 500 transfers the reagent container containing magnetic beads to the mixing module 220, and then the mixing module 220 completes the mixing process at the mixing station.

[0099] Reference Figure 4 In one embodiment, the sample analysis system further includes a pre-opening mechanism 600, and the control module 400 is further configured to:

[0100] After the initial mixing process and before the homogenization process, the reagent transfer mechanism 500 is controlled to transfer the reagent container that has undergone the initial mixing process to the pre-opening mechanism 600, and the pre-opening mechanism 600 is controlled to perform a pre-opening operation on the reagent container.

[0101] In this embodiment, the pre-opening operation specifically involves opening the reagent container lid to a first opening degree. When the lid is opened to this first degree, the opening is small enough that the aspiration needle cannot be inserted into the reagent container for aspiration. For example, the first opening degree is a small slit, thereby balancing the pressure difference between the inside and outside of the reagent container and reducing the resistance when opening to the second opening degree. The second opening degree is the opening degree at which the aspiration needle can be inserted into the reagent container for aspiration. By pre-opening the lid to the first degree before opening to the second degree, a large burden is avoided on the opening module and the reagent container during a single opening, which could affect the lifespan of the opening module and damage the bottle cap structure.

[0102] In one embodiment, after the initial mixing process, a pre-opening operation is performed before the homogenization process, followed by the homogenization process, and then the cap is opened again. This ensures that the aspiration needle can draw up the homogenized magnetic bead reagent, which helps improve the accuracy of the detection.

[0103] In another embodiment, the mixing process, the homogenization process, the pre-opening of the lid, and the opening of the lid can also be performed sequentially.

[0104] In one embodiment, the image acquisition module 300 is positioned at the location where the pre-opening operation is performed.

[0105] It should be noted that, in addition to acquiring reagent images of the magnetic bead reagent from the bottom of the reagent container to determine whether the magnetic bead reagent is abnormal, the image acquisition module 300 can also be reused to detect the cap orientation of the reagent container. Therefore, the image acquisition module 300 is set at the position where the pre-capping operation is performed, and the cap orientation can be detected before the pre-capping operation is performed, which can reduce the number of times the reagent container is transferred between different workstations and improve the detection efficiency.

[0106] Reference Figure 7 In one embodiment, the sample analysis system further includes a reagent loading module 700 and a reagent transfer mechanism 500. The control module 400 is also configured to: when it is detected that the reagent loading module 700 has a reagent container, control the reagent transfer mechanism 500 to transfer the reagent container to the magnetic bead processing device 200.

[0107] The sample analysis system in this embodiment is a sample analysis system with automatic loading function, which is equipped with a reagent loading module 700. After the reagent container containing magnetic bead reagent is placed in the reagent loading module 700 and detected, the reagent transfer mechanism 500 transfers the reagent container to the magnetic bead processing device 200 for homogenization processing.

[0108] In one embodiment, the sample analysis system further includes a reagent transfer mechanism 500, and the control module 400 is further configured to control the reagent transfer mechanism 500 to transfer a reagent container placed in the reagent storage module 100 to the magnetic bead processing device 200.

[0109] In this embodiment, the sample analysis system is one without automatic loading function. The reagent containers need to be manually loaded, meaning medical personnel or other operators can directly place the reagent containers in the reagent storage module 100. Furthermore, the mixing module 210 or homogenizing module 220 in the magnetic bead processing device 200 is not located in the same position as the reagent storage module 100. Therefore, the reagent containers placed in the reagent storage module 100 need to be transferred to the magnetic bead processing device 200 via the reagent transfer mechanism 500 for subsequent homogenization processing.

[0110] In one embodiment, the magnetic bead processing device 200 includes a mixing module 220 disposed within the reagent storage module 100. The mixing module 220 is used to homogenize the reagent containers placed in the reagent storage module 100. The homogenization process includes a mixing process.

[0111] In this embodiment, the sample analysis system is a sample analysis system without automatic loading function. The sample analysis system requires manual loading of reagent containers. That is, medical staff or other operators can directly place the reagent containers in the reagent storage module 100. Furthermore, the mixing module 220 is set inside the reagent storage module 100. That is, the mixing station and the storage station are in the same location. The reagent containers placed in the reagent storage module 100 can be directly mixed without the need for transfer operations.

[0112] The control module 400 of the sample analysis system acquires the reagent image acquired by the image acquisition module 300 and determines whether the magnetic bead reagent is abnormal based on the reagent image. If the control module 400 determines that the magnetic bead reagent is normal based on the reagent image, the magnetic bead reagent can be used to perform other subsequent operations. For example, the reagent moving mechanism 500 moves the reagent container from the image acquisition module 300 to the reagent storage module 100. After opening the lid, the magnetic bead reagent is added to the reaction cup through the liquid aspiration mechanism to mix and react with the sample, thereby realizing the detection and analysis of the sample. If the control module 400 determines that the magnetic bead reagent is abnormal based on the reagent image, the abnormal magnetic bead reagent needs to be processed.

[0113] In one embodiment, handling abnormal magnetic bead reagents includes controlling the reagent transfer mechanism 500 to withdraw the reagent container, for example, controlling the reagent transfer mechanism 500 to transfer the reagent container from the image acquisition module 300 to the reagent loading module 700.

[0114] In this embodiment, the control reagent transfer mechanism 500 withdraws the reagent container, preventing the abnormal magnetic bead reagent from being used in subsequent sample testing and analysis, thus avoiding erroneous test results caused by the use of abnormal magnetic bead reagent. Specifically, the control reagent transfer mechanism 500 transfers the reagent from the image acquisition module 300 to the reagent loading module 700. Medical personnel or other operators can discard the magnetic bead reagent directly withdrawn to the reagent loading module 700, or they can observe the magnetic bead reagent withdrawn to the reagent loading module 700 to manually confirm whether there is obvious magnetic bead aggregation, and can discard the abnormal magnetic bead reagent, such as by discarding or destroying it.

[0115] Reference Figure 7 In one embodiment, the sample analysis system further includes a reagent anomaly alert module 800, which handles abnormal magnetic bead reagents by controlling the reagent anomaly alert module 800 to issue an anomaly alert signal.

[0116] In this embodiment, the sample analysis system, by configuring a reagent anomaly alert module 800, detects an anomaly in the magnetic bead reagent and controls the module 800 to issue an anomaly alert signal. This alerts medical staff or other operators to retrieve the abnormal magnetic bead reagent for direct disposal or manual observation to confirm the presence of obvious magnetic bead aggregation. The abnormal magnetic bead reagent can then be discarded or destroyed. The reagent anomaly alert module 800 can take various forms, such as an indicator light emitting a light signal, a speaker emitting a sound signal, displaying a warning sign on the sample analysis system's built-in display screen, or sending anomaly alert information to a server or mobile terminal.

[0117] In one embodiment, the mixing module 220 is disposed within the reagent storage module 100.

[0118] It is understandable that the reagent storage module 100 can hold reagent containers containing magnetic beads for extended periods, therefore, under normal circumstances, the reagent storage module 100 provides suitable environmental conditions for storing magnetic beads. Furthermore, the mixing process for magnetic beads is relatively long. If this mixing process is performed under environmental conditions unsuitable for the storage of magnetic beads, it will adversely affect the quality of the magnetic beads. In this embodiment, the mixing module 220 is located within the reagent storage module 100, meaning that the mixing process for the magnetic beads is also performed under suitable storage environmental conditions, thus avoiding the adverse effects on the quality of the magnetic beads caused by the long mixing time.

[0119] Reference Figure 8 and Figure 9In one embodiment, the image acquisition module 300 includes an absorbent 310 for contacting the bottom of the reagent container 110, a camera 320 located below the absorbent 310, and a light source 330 located above the absorbent 310 for illuminating the sidewalls of the reagent container 110.

[0120] In this embodiment, the absorbent 310 can be a ring-shaped foam that can directly contact the bottom of the reagent container 110 and absorb the condensate flowing down from the side wall of the reagent container 110; the light source 330 can be two strip light sources symmetrically arranged on both sides of the reagent container 110, so as to symmetrically illuminate the side wall of the reagent container 110 from both sides, ensuring the uniformity of illumination; the camera 320 adopts a CMOS camera or a CCD camera. CMOS stands for Complementary Metal-Oxide-Semiconductor, which is a large-scale integrated circuit chip with advantages such as fast signal reading speed and low power consumption. CMOS cameras use CMOS sensors to capture images and read pixel data by scanning line by line; CCD stands for Charge-Coupled Device, which is a semiconductor chip used to capture images. CCD cameras use CCD sensors to read pixel data by charge transfer, which has high sensitivity and signal-to-noise ratio.

[0121] Reference Figures 8 to 10 In one embodiment, the image acquisition module 300 further includes a housing 321 for partially accommodating the camera 320, a lens barrel 322 extending from the lens of the camera 320 to below the water-absorbing member 310, and a light-transmitting and water-proof member 323 disposed on the top of the lens barrel 322. Exemplarily, the housing 321 has a receiving cavity in which the camera 320 is partially housed, and the lens of the camera 320 extends out of the receiving cavity. The lens barrel 322 is open at both ends, one end is disposed on the housing 321 and fitted onto the lens of the camera 320, and the other end extends vertically. The light-transmitting and water-proof member 323 is disposed at the end of the lens barrel 322 away from the housing 321 (i.e., the top of the lens barrel 322) and seals one open end of the lens barrel 322, thereby placing the camera 320 in a relatively enclosed space.

[0122] Since the lens of camera 320 is exposed vertically upward to the air, and condensation will adhere to the outer wall of reagent container 110 after it is transferred from reagent storage module 100 or reagent loading module 700 to image acquisition module 300, the lens of camera 320 is very prone to dust and droplets. In this embodiment, the outer shell 321 enclosing the camera 320 and the lens barrel 322 extending from the lens of the camera 320 to below the water-absorbing component 310 can prevent dust in the air from accumulating inside the camera 320 from the side for a long time, causing irreversible damage to the camera 320 or adhering to the lens surface of the camera 320, affecting image quality, thus achieving all-round protection for the camera 320, especially the lens; the light-transmitting and water-proof component 323 can be made of flat glass or transparent resin plate, etc. The light-transmitting and water-proof component 323 can prevent condensation or dust from entering the lens barrel 322 and adhering to the lens of the camera 320. In addition, the bottom of the reagent container 110, the water-absorbing component 310 and the light-transmitting and water-proof component 323 form a relatively sealed space, which can prevent external air from entering the space below the bottom of the reagent container 110 and forming condensation.

[0123] Reference Figures 8 to 11 In one embodiment, the image acquisition module 300 further includes a dustproof baffle 340 movable between a first position and a second position, and a driving member 350 for moving the dustproof baffle 340; wherein, in the first position, the dustproof baffle 340 blocks the light-transmitting and water-proof member 323; in the second position, the light-transmitting and water-proof member 323 is exposed.

[0124] In this embodiment, the driving component 350 can be a stepper motor. The output shaft of the stepper motor is connected to the dustproof baffle 340 through a coupling, thereby driving the dustproof baffle 340 to move between the first position and the second position. When the camera 320 is not taking pictures, the driving component 350 drives the dustproof baffle 340 to move to the first position. At this time, the dustproof baffle 340 blocks the light-transmitting and water-proof component 323 to prevent dust from accumulating on the light-transmitting and water-proof component 323 in the vertical direction. Before the camera 320 takes pictures, the driving component 350 drives the dustproof baffle 340 to move to the second position. At this time, the light-transmitting and water-proof component 323 is exposed. The illumination light emitted by the light source 330 enters the interior of the reagent container 110. After reflection and refraction, it is emitted from the bottom of the reagent container 110 and passes through the light-transmitting and water-proof component 323 to enter the lens of the camera 320 below.

[0125] Reference Figure 8 In one embodiment, the image acquisition module 300 further includes a position detection device 360 ​​for detecting the position of the dustproof baffle 340; the control module 400 is configured to:

[0126] Before the image acquisition module 300 acquires a reagent image of the bottom of the reagent container, the control drive 350 moves the dustproof baffle 340 from the first position to the second position. When the dustproof baffle 340 moves to the second position, it is detected by the position detection device 360.

[0127] The control module 400 is also configured to: after the control image acquisition module 300 acquires a reagent image of the bottom of the reagent container containing magnetic beads, control the drive unit 350 to move the dustproof baffle 340 from the second position to the first position.

[0128] In this embodiment, the position detection device 360 ​​can be an optocoupler. When the dustproof baffle 340 is not detected by the optocoupler, the optocoupler outputs a low level. When the dustproof baffle 340 is detected by the optocoupler, the optocoupler outputs a high level. Therefore, the dustproof baffle 340 can be determined to have moved to the second position by detecting the change in the high and low level of the optocoupler output.

[0129] In one embodiment, the control module 400 controls the dustproof baffle 340 to switch from a first position to a second position based on a predetermined timing sequence. For example, timing begins when the reagent container containing magnetic beads is loaded into the reagent loading module 700. After homogenization processing, when the reagent container containing magnetic beads is transferred to the image acquisition module 300, the control module 400 controls the drive unit 350 to drive the dustproof baffle 340 to move from the first position to the second position. When the dustproof baffle 340 reaches the second position, the position detection device 360 ​​can be triggered by the dustproof baffle 340 in the second position. Based on the triggering of the position detection device 360, the control module 400 controls the drive unit 350 to stop driving, thereby causing the dustproof baffle 340 to remain in the second position. After the image acquisition module 300 completes the detection of the reagent container containing magnetic beads, the control module 400 controls the drive unit 350 to drive the dustproof baffle 340 to move from the second position to the first position. The position detection device 360 ​​can be triggered by the dustproof baffle 340 in the first position. Based on the triggering of the position detection device 360, the control module 400 controls the drive unit 350 to stop driving, so that the dustproof baffle 340 stays in the first position.

[0130] In another embodiment, the image acquisition module 300 is equipped with a recognition device. After the recognition device detects that the reagent container is in place, the control module 400 controls the dustproof baffle 340 to switch from a first position to a second position. After the recognition device detects that the reagent container has left the image acquisition module 300, the control module 400 controls the dustproof baffle 340 to switch from the second position to the first position.

[0131] In one embodiment, identifying abnormal magnetic bead reagents based on reagent images includes:

[0132] Identify abnormal magnetic bead reagents based on the pixel grayscale of each pixel in the reagent image.

[0133] In this embodiment, when the magnetic bead reagent exhibits magnetic bead aggregation, the pixel grayscale values ​​of the aggregated parts in the reagent image acquired by the image acquisition module 300 will differ from those of the non-aggregated parts. Therefore, after acquiring the reagent image, the control module 400 extracts the pixel grayscale values ​​of each pixel from the reagent image, thereby determining whether the magnetic bead reagent is abnormal based on the pixel grayscale values ​​of each pixel.

[0134] More specifically, in one embodiment, determining abnormal magnetic bead reagents based on the pixel grayscale of each pixel in the reagent image can be done in a variety of different ways, including at least one of the following four methods.

[0135] Method 1: Based on the pixel grayscale of each pixel in the reagent image and the preset binarization threshold, the reagent image is segmented into magnetic bead agglomeration part and non-magnetic bead agglomeration part, and the abnormal magnetic bead reagent is determined according to the area of ​​the magnetic bead agglomeration part.

[0136] When magnetic beads aggregate, there is a certain boundary between the aggregated and non-aggregated parts. By setting a binarization threshold, the grayscale of each pixel in the reagent image is compared with the preset binarization threshold to segment the reagent image into aggregated and non-aggregated parts. Then, the area of ​​the aggregated part is identified, and the size of this area can be used to determine whether there is an abnormality in the magnetic bead reagent.

[0137] Method 2: Divide the reagent image into multiple target regions, and determine the abnormal magnetic bead reagents based on the average pixel gray value of each pixel in the multiple target regions and the preset gray value threshold.

[0138] When magnetic beads agglomerate, the grayscale value of each pixel in the agglomerated part will be lower. Therefore, the average grayscale value of each pixel in each target area will decrease. By setting a grayscale threshold, when the average grayscale value of each pixel in the target area is less than the preset grayscale threshold, it can be considered that magnetic bead agglomeration has occurred in the target area.

[0139] Method 3: Identify abnormal magnetic bead reagents based on the histogram of pixel grayscale values ​​of each pixel in the reagent image.

[0140] For a reagent container containing normal magnetic beads, the pixel grayscale distribution of each pixel in the reagent image at the bottom is uniform, and its histogram distribution range is relatively concentrated. When magnetic beads agglomerate, the pixel grayscale value of the pixel corresponding to the agglomerated part decreases, and a peak will appear in the low grayscale value area of ​​the histogram. Therefore, by identifying the histogram distribution structure of the pixel grayscale of each pixel in the reagent image, it is possible to detect whether magnetic beads agglomerate has occurred.

[0141] Method 4: Identify abnormal magnetic bead reagents based on the discrete distribution of pixel grayscale values ​​in the reagent image.

[0142] For a reagent container containing normal magnetic beads, the pixel grayscale distribution of each pixel in the reagent image at the bottom is uniform, and the discrete distribution of pixel grayscale is good, for example, the standard deviation, relative range, or coefficient of variation of pixel grayscale will be small. When magnetic beads agglomeration occurs, the discrete distribution of pixel grayscale deteriorates, and the standard deviation, relative range, or coefficient of variation of pixel grayscale will increase. Therefore, by setting a discrete distribution threshold, when the discrete index of pixel grayscale is greater than the discrete distribution threshold, it is determined that the magnetic beads have agglomerated, and the magnetic beads can be identified as abnormal.

[0143] Reference Figure 13 This application provides a sample analysis system, including a reagent storage module 100, an image acquisition module 300, and a control module 400, wherein:

[0144] The reagent storage module 100 is used to place reagent containers, which include at least a reagent container containing magnetic bead reagents;

[0145] The image acquisition module 300 is used to acquire reagent images from the bottom of the reagent container containing magnetic bead reagent;

[0146] The control module 400 is configured to acquire reagent images and determine whether the magnetic bead reagent is abnormal based on the reagent images.

[0147] The sample analysis system provided in this embodiment places a reagent container containing magnetic beads in a reagent storage module 100. An image acquisition module 300 captures an image of the magnetic beads from the bottom of the container. A control module 400 then identifies anomalies based on these images. Once anomalies are identified, they are processed to prevent their use in subsequent sample tests, which could lead to incorrect results. Alternatively, the system can prompt patients and medical staff to ignore test results obtained using the abnormal magnetic beads, thus avoiding misdiagnosis. It is understood that the sample analysis system in this embodiment, compared to… Figure 1The sample analysis system shown lacks the magnetic bead processing device 200. Therefore, the sample analysis system of this embodiment is suitable for operators to manually mix the reagent container containing the magnetic bead reagent, and then place the reagent container directly into the reagent storage module 100, the reagent loading module 700, or the image acquisition module 300.

[0148] In one embodiment, the sample analysis system further includes a magnetic bead processing device 200, which is used to homogenize the reagent container and improve the uniformity of the magnetic bead reagent. The magnetic bead processing device 200 may include a mixing module 210 for mixing the magnetic bead reagent in the reagent container and a mixing module 220 for mixing the magnetic bead reagent in the reagent container. The homogenization process includes mixing and mixing. The mixing process is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container, and the mixing process is used to drive the magnetic beads in the magnetic bead reagent to disperse. The mixing module 220 can work simultaneously with the mixing module 210 acting on the magnetic bead reagent, or it can act on the magnetic bead reagent after the mixing module 210 has finished acting on the magnetic bead reagent. After the magnetic beads detach from the deposition position, it is easier to mix the magnetic beads.

[0149] Reference Figure 14 This application provides a method for quality testing of magnetic bead reagents, including but not limited to steps S1410 to S1430.

[0150] Step S1410: The reagent container containing the magnetic bead reagent is homogenized to improve the uniformity of the magnetic bead reagent.

[0151] Step S1420: Acquire a reagent image from the bottom of the reagent container;

[0152] Step S1430: Determine whether the magnetic bead reagent is abnormal based on the reagent image.

[0153] In this embodiment, the magnetic beads in the magnetic bead reagent are homogenized to improve their uniformity. Then, an image of the homogenized magnetic bead reagent is captured from the bottom of the reagent container. Anomaly identification is performed based on the image. Once abnormal magnetic bead reagents are identified, they can be handled to prevent them from being used in subsequent sample tests and causing abnormal test results. Alternatively, patients and medical staff can be prompted to ignore test results obtained using abnormal magnetic bead reagents, thus avoiding incorrect test results and misdiagnosis of the patient's condition.

[0154] In one embodiment, when an abnormality is detected in the magnetic bead reagent, an abnormality alert signal is issued, and / or the reagent container is withdrawn.

[0155] In this embodiment, upon detecting an abnormality in the magnetic bead reagent, an abnormality alert signal is issued. This alerts medical staff or other operators to retrieve the abnormal magnetic bead reagent for manual observation to confirm whether there is obvious magnetic bead aggregation. The abnormal magnetic bead reagent can then be discarded or destroyed. The abnormality alert signal can take various forms, such as emitting a light signal, emitting a sound signal, displaying a warning sign on the sample analysis system's built-in display screen, or sending an abnormality alert message to a server or mobile terminal. Furthermore, retrieving the reagent container prevents the abnormal magnetic bead reagent from being used in subsequent sample testing and analysis, avoiding erroneous test results. Specifically, medical staff or other operators can observe the retrieved magnetic bead reagent to manually confirm whether there is obvious magnetic bead aggregation and can handle the abnormal magnetic bead reagent, such as discarding or destroying it.

[0156] For example, the reagent container containing the magnetic bead reagent can be withdrawn, for instance, by transferring the reagent container containing the magnetic bead reagent from the image acquisition module 300 to the reagent loading module 700 via the reagent transfer mechanism 500.

[0157] This application provides an operation control device, which includes a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the quality detection method for magnetic bead reagents as mentioned in any of the above embodiments.

[0158] This application provides a sample analysis system, including a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the quality detection method for magnetic bead reagents as described above.

[0159] This application provides a computer storage medium storing a computer program applied to a sample analysis system. When the computer program is executed by a processor, it implements the quality detection method for magnetic bead reagents as mentioned in any of the above embodiments.

[0160] This application provides a computer program product, which includes computer instructions stored in a computer-readable storage medium. A processor of a computer device reads the computer instructions from the computer-readable storage medium and executes the computer instructions, causing the computer device to perform the quality detection method for magnetic bead reagents as mentioned in any of the above embodiments.

[0161] In the several embodiments provided in this application, it should be understood that the disclosed systems, apparatuses, and methods can be implemented in other ways. For example, the apparatus embodiments described above are merely illustrative; for instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be through some interfaces, or indirect coupling or communication connection between apparatuses or units, and may be electrical, mechanical, or other forms.

[0162] The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0163] Furthermore, the functional units in the various embodiments of this application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit.

[0164] If the integrated unit is implemented as a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or all or part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods of the various embodiments of this application. The aforementioned storage medium includes various media capable of storing program code, such as USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.

[0165] It should also be understood that the various implementation methods provided in this application can be combined arbitrarily to achieve different technical effects.

[0166] The above provides a detailed description of the preferred embodiments of this application. However, this application is not limited to the above-described embodiments. Those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of this application. All such equivalent modifications or substitutions are included within the scope defined by the claims of this application.

Claims

1. A sample analysis system, characterized in that, include: A reagent storage module for holding reagent containers, wherein the reagent containers include at least a reagent container containing magnetic bead reagents; A magnetic bead processing device is used to homogenize the magnetic beads in the magnetic bead reagent. An image acquisition module is used to acquire a reagent image of the homogenized magnetic bead reagent from the bottom of the reagent container containing the magnetic bead reagent; The control module is configured to acquire the reagent image, identify abnormal magnetic bead reagents based on the reagent image, and process the abnormal magnetic bead reagents.

2. The sample analysis system according to claim 1, characterized in that, The magnetic bead processing device includes a mixing module for mixing the magnetic bead reagent in the reagent container containing the magnetic bead reagent. The homogenization process includes the mixing process, which is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container containing the magnetic bead reagent.

3. The sample analysis system according to claim 1, characterized in that, The magnetic bead processing device includes a mixing module for mixing the magnetic bead reagent in the reagent container containing the magnetic bead reagent. The homogenization process includes the mixing process, which drives the magnetic beads in the magnetic bead reagent to disperse.

4. The sample analysis system according to claim 1, characterized in that, It also includes a reagent transfer mechanism. The magnetic bead processing device includes a mixing module for mixing the magnetic beads in the reagent container containing the magnetic bead reagent and a homogenizing module for homogenizing the magnetic beads in the reagent container containing the magnetic bead reagent. The homogenization process includes the mixing process and the homogenizing process. The mixing process is used to drive the magnetic beads deposited in the magnetic bead reagent to detach from the deposition position in the reagent container containing the magnetic bead reagent. The homogenizing process is used to drive the magnetic beads in the magnetic bead reagent to disperse. The control module is further configured to: Before the image acquisition module acquires the reagent image of the bottom of the reagent container containing the magnetic bead reagent, the mixing module is controlled to perform the mixing process and the mixing module is controlled to perform the mixing process. The reagent transfer mechanism is controlled to transfer the reagent container, which has undergone the mixing and homogenization processes, to the image acquisition module.

5. The sample analysis system according to claim 4, characterized in that, The control of the mixing module to perform the mixing process and the control of the mixing module to perform the mixing process include: The mixing module is controlled to perform the mixing process; The reagent transfer mechanism is controlled to transfer the reagent container that has undergone the mixing treatment to the mixing module; The mixing module is controlled to perform the mixing process.

6. The sample analysis system according to claim 5, characterized in that, The sample analysis system also includes a pre-opening mechanism, and the control module is further configured to: After the initial mixing process and before the homogenization process, the reagent transfer mechanism is controlled to transfer the reagent container that has undergone the initial mixing process to the pre-opening mechanism, and the pre-opening mechanism is controlled to perform a pre-opening operation on the reagent container.

7. The sample analysis system according to claim 6, characterized in that, The image acquisition module is positioned at the location where the pre-opening operation is performed.

8. The sample analysis system according to claim 1, characterized in that, The sample analysis system further includes a reagent loading module and a reagent transfer mechanism. The control module is also configured to: when it is detected that the reagent loading module has placed the reagent container containing magnetic bead reagents, control the reagent transfer mechanism to transfer the reagent container containing magnetic bead reagents to the magnetic bead processing device. Alternatively, the sample analysis system may further include a reagent transfer mechanism, and the control module may be configured to control the reagent transfer mechanism to transfer the reagent container containing magnetic bead reagents placed in the reagent storage module to the magnetic bead processing device. Alternatively, the magnetic bead processing device may include a mixing module disposed within the reagent storage module, the mixing module being used to homogenize the reagent container containing the magnetic bead reagent placed in the reagent storage module.

9. The sample analysis system according to claim 8, characterized in that, The treatment of the abnormal magnetic bead reagent includes: The reagent transfer mechanism is controlled to transfer the reagent container containing magnetic beads to the reagent loading module.

10. The sample analysis system according to claim 1 or 8, characterized in that, It also includes a reagent anomaly alert module, wherein the processing of the abnormal magnetic bead reagent includes: The reagent abnormality alert module is controlled to issue an abnormality alert signal.

11. The sample analysis system according to claim 3 or 4, characterized in that, The mixing module is located within the reagent storage module.

12. The sample analysis system according to claim 1, characterized in that, The image acquisition module includes an absorbent component for contacting the bottom of the reagent container containing magnetic beads, a camera located below the absorbent component, and a light source located above the absorbent component for illuminating the side wall of the reagent container containing magnetic beads.

13. The sample analysis system according to claim 12, characterized in that, The image acquisition module further includes a housing for partially accommodating the camera, a lens barrel extending from the camera lens to below the water-absorbing component, a light-transmitting and water-blocking component disposed on the top of the lens barrel, a dustproof baffle movable between a first position and a second position, and a driving component for moving the dustproof baffle; wherein, in the first position, the dustproof baffle blocks the light-transmitting and water-blocking component; and in the second position, the light-transmitting and water-blocking component is exposed.

14. The sample analysis system according to claim 13, characterized in that, The image acquisition module further includes a position detection device for detecting the position of the dustproof baffle; the control module is configured to: Before the image acquisition module acquires the reagent image of the bottom of the reagent container containing magnetic beads, the driving component moves the dustproof baffle from the first position to the second position; and after the image acquisition module acquires the reagent image of the bottom of the reagent container containing magnetic beads, the driving component moves the dustproof baffle from the second position to the first position.

15. The sample analysis system according to claim 1, characterized in that, The step of identifying abnormal magnetic bead reagents based on the reagent image includes: The abnormal magnetic bead reagent is determined based on the pixel grayscale of each pixel in the reagent image.

16. The sample analysis system according to claim 15, characterized in that, The method of determining the abnormal magnetic bead reagent based on the pixel grayscale of each pixel in the reagent image includes at least one of the following: Based on the pixel grayscale of each pixel in the reagent image and the preset binarization threshold, the reagent image is segmented into magnetic bead agglomeration part and non-magnetic bead agglomeration part, and the abnormal magnetic bead reagent is determined based on the area of ​​the magnetic bead agglomeration part. Multiple target regions are divided from the reagent image, and the abnormal magnetic bead reagent is determined based on the average pixel gray value of each pixel in the multiple target regions and a preset gray value threshold. Based on the histogram of pixel grayscale values ​​of each pixel in the reagent image, the abnormal magnetic bead reagent is identified; Based on the discrete distribution of pixel grayscale values ​​in the reagent image, the abnormal magnetic bead reagent is identified.

17. A sample analysis system, characterized in that, include: A reagent storage module for holding reagent containers, wherein the reagent containers include at least a reagent container containing magnetic bead reagents; An image acquisition module is used to acquire reagent images from the bottom of the reagent container containing magnetic bead reagents; The control module is configured to acquire the reagent image and determine whether the magnetic bead reagent is abnormal based on the reagent image.

18. The sample analysis system according to claim 17, characterized in that, It also includes a magnetic bead processing device, which is used to homogenize the reagent container containing magnetic bead reagent, and the homogenization process is used to improve the uniformity of the magnetic bead reagent.

19. A method for quality testing of magnetic bead reagents, characterized in that, include: The reagent container containing magnetic beads is subjected to a homogenization treatment, which is used to improve the uniformity of the magnetic beads. Acquire reagent images from the bottom of the reagent container; Determine whether the magnetic bead reagent is abnormal based on the reagent image.

20. The quality inspection method according to claim 19, characterized in that, When the magnetic bead reagent is determined to be abnormal, an abnormality alert signal is issued, and / or the reagent container is withdrawn.

Images