Detector and supercritical fluid chromatography detector

Abstract

The application relates to a detector and a supercritical fluid chromatography detector, which comprises a mixing mechanism, a charging mechanism, an ion trap and an electrostatic detection mechanism. The mixing mechanism has a mixing space, a sample inlet port and a makeup liquid inlet port which are in communication with the mixing space. The sample inlet port is connected to a detection sample containing target particles, and the makeup liquid inlet port is connected to a makeup liquid atomization fluid. The two form a mixed fluid in the mixing space. The charging mechanism can charge the mixed fluid. The ion trap receives the charged mixed fluid and separates the charges carried by non-target particles. The electrostatic detection mechanism is used to detect the amount of charges carried by the mixed fluid after being separated by the ion trap. The above-mentioned detector can mix the detection sample and the makeup liquid atomization fluid to form a mixed fluid in the form of aerosol, so that the aerosol particles containing target particles are easily charged and pass through the ion trap and are detected by the electrostatic detection mechanism. In this way, the detector has a wider range of applicable detection targets, lower cost and lower use requirements.

Description

Technical Field

[0001] This application relates to the field of detection equipment technology, and in particular to a detector and a supercritical fluid chromatography detector. Background Technology

[0002] Supercritical fluid chromatography (SFC) is a highly efficient chromatographic technique that uses a supercritical fluid as the mobile phase to separate and analyze compounds. SFC utilizes a supercritical fluid (such as carbon dioxide) as the mobile phase, and by adjusting the pressure and temperature, the density of the mobile phase is controlled, thereby controlling the retention time of the solute and the separation efficiency. SFC combines the advantages of gas chromatography (GC) and liquid chromatography (LC), featuring high diffusion coefficients and low viscosity, resulting in fast separation speeds and high efficiency. Compared to LC, SFC typically offers higher column efficiency and faster analysis speeds. Compared to GC, SFC can analyze compounds that are difficult to volatilize or thermally unstable.

[0003] In related technologies, the detection of samples obtained from SFC separation mainly relies on ultraviolet (UV) or mass spectrometry. However, due to their inherent characteristics, UV detectors do not respond well to substances with weak UV absorption, while mass spectrometry is expensive and has relatively high requirements for the operating environment and operators, resulting in high operating costs. Therefore, developing an SFC detector that is highly compatible with SFC, has high detection sensitivity, and is easy to use is of great value. Summary of the Invention

[0004] Therefore, it is necessary to provide a detector and supercritical fluid chromatography detector with a wider range of applications and lower usage requirements and costs to address the above-mentioned problems.

[0005] A detector, comprising:

[0006] A mixing mechanism having a mixing space and having a sample inlet port and a replenishment port communicating with the mixing space; the sample inlet port is used to introduce a detection sample containing target particles, and the replenishment port is used to introduce a replenishment atomizing fluid; the detection sample and the replenishment atomizing fluid can form a mixed fluid within the mixing space;

[0007] A charging mechanism, connected to the mixing space, is configured to charge the mixing fluid;

[0008] An ion trap, disposed downstream of the mixing mechanism along the flow direction of the mixed fluid, is used to receive the mixed fluid after it has been charged by the charging mechanism and to separate the charge carried by non-target particles; and

[0009] An electrostatic detection mechanism is located downstream of the ion trap along the flow direction of the mixed fluid, and is used to detect the amount of charge carried by the mixed fluid after separation by the ion trap.

[0010] In one embodiment, the charging mechanism is located downstream of the mixing mechanism along the flow direction of the mixed fluid, and has a charging space communicating with the mixing space and a discharge electrode located at least partially within the charging space, the discharge electrode being used to charge the mixed fluid flowing through the charging space.

[0011] In one embodiment, the charging mechanism has a charging space, a discharge electrode, a carrier gas port, and a discharge space;

[0012] The carrier gas port is connected to the discharge space and is used to introduce a charging carrier gas; the discharge electrode is at least partially located in the discharge space and is used to charge the charging carrier gas flowing through the discharge space; the charging space is connected to both the discharge space and the mixing space, and is located downstream of the discharge space along the flow direction of the charging carrier gas and downstream of the mixing space along the flow direction of the mixing fluid.

[0013] In one embodiment, the charging mechanism has a discharge space, a discharge electrode, and a carrier gas port;

[0014] The carrier gas port is connected to the discharge space and is used to introduce a charging carrier gas; the discharge electrode is at least partially located in the discharge space and is used to charge the charging carrier gas flowing through the discharge space; the discharge space is connected to the mixing space and is located upstream of the mixing space along the flow direction of the charging carrier gas.

[0015] In one embodiment, the detector further includes an atomizing mechanism, which includes an atomizing nozzle and an atomizing cavity communicating with the replenishment port; the atomizing nozzle is used to introduce atomizing carrier gas and liquid to be atomized, and sprays out toward the atomizing cavity to form the replenishment atomized fluid.

[0016] In one embodiment, the atomizing nozzle includes a first pipe and a second pipe, the inlet of the first pipe is used to introduce atomizing carrier gas, the inlet of the second pipe is used to introduce liquid to be atomized, and the outlets of the first pipe and the second pipe intersect at an oblique direction.

[0017] In one embodiment, one of the first pipeline and the second pipeline is sleeved on the outside of the other, and the two pipelines are arranged to taper towards the outlet at one end;

[0018] The atomizing nozzle also includes a sheath gas tube, the inlet of which is used to introduce sheath gas, and the outlet of which intersects obliquely with the outlet of the second pipeline.

[0019] In one embodiment, the detector further includes an atomizing mechanism comprising an ultrasonic atomizing head connected to the replenishment port.

[0020] In one embodiment, the detector further includes a drift tube disposed downstream of the mixing mechanism along the flow direction of the mixed fluid, for heating the mixed fluid flowing out of the mixing mechanism.

[0021] A supercritical fluid chromatography detector includes a supercritical fluid chromatography apparatus and the detector described above, wherein the injection port of the detector is used to connect to the output port of the supercritical fluid chromatography apparatus.

[0022] The aforementioned detectors, including the supercritical fluid chromatography detector, allow the sample introduced into the mixing space from the injection port to mix with the replenishing atomized fluid introduced into the mixing space from the replenishing port, forming an aerosol-like mixture. This facilitates the charging of aerosol particles containing target particles, allowing them to pass through the ion trap and be detected by the electrostatic detection mechanism. Thus, compared to ultraviolet detection, this detection method does not require consideration of the substance's response to specific radiation, and can be applied to a wider range of detection targets. Furthermore, compared to mass spectrometry detection, this detection method has lower costs and fewer operational requirements. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the detector structure in the first embodiment of this application.

[0025] Figure 2 This is a schematic diagram of the detector structure in the second embodiment of this application.

[0026] Figure 3 This is a schematic diagram of the detector structure in the third embodiment of this application.

[0027] Figure 4 for Figure 1 The diagram shows the structure of the first type of atomizing nozzle in the detector.

[0028] Figure 5 for Figure 1 The diagram shows the structure of the second type of atomizing nozzle in the detector.

[0029] Figure 6 for Figure 1 The diagram shows the structure of the third type of atomizing nozzle in the detector.

[0030] Figure 7 for Figure 1 The diagram shows the structure of the fourth type of atomizing nozzle in the detector.

[0031] Figure 8 for Figure 1 The diagram shows the structure of the fifth type of atomizing nozzle in the detector.

[0032] Explanation of reference numerals in the attached figures: 100, detector; 10, mixing mechanism; 11, mixing space; 13, sample inlet port; 15, replenishment port; 30, charging mechanism; 31, charging space; 33, discharge electrode; 35, carrier gas port; 37, discharge space; 40, ion trap; 50, electrostatic detection mechanism; 71, atomizing nozzle; 711, first pipeline; 713, second pipeline; 715, sheath gas tube; 90, drift tube. Detailed Implementation

[0033] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0034] In the description of this application, it should be understood that if terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" appear, these terms indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0035] Furthermore, where the term "and / or" appears, it merely describes the relationship between related objects and indicates that three relationships can exist. For example, A and / or B can represent the relationship between A and B: A alone, A and B simultaneously, and B alone. Additionally, the character " / " in this document generally indicates an "or" relationship between the related objects before and after it. Where the terms "first" and "second" appear, these terms are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature specified with "first" or "second" may explicitly or implicitly include at least one of those features. In the description of this application, where the term "multiple" appears, "multiple" means at least two, such as two, three, four, five, etc., unless otherwise explicitly specified.

[0036] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0037] In this application, unless otherwise expressly specified and limited, the use of descriptions such as "above" or "below" the second feature indicates that the first and second features are in direct contact or indirect contact via an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. Similarly, "below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0038] It should be noted that if an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. If an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. If so, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application are for illustrative purposes only and do not represent the only possible implementation.

[0039] Please see Figure 1An embodiment of this application provides a detector 100, including a mixing mechanism 10, a charging mechanism 30, an ion trap 40, and an electrostatic detection mechanism 50. The mixing mechanism 10 has a mixing space 11 and a sample inlet 13 and a replenishment port 15 communicating with the mixing space 11. The sample inlet 13 is used to introduce a detection sample containing target particles, and the replenishment port 15 is used to introduce a replenishment atomizing fluid. The detection sample and the replenishment atomizing fluid can form a mixed fluid within the mixing space 11. The charging mechanism 30 communicates with the mixing space 11 and is configured to charge the mixed fluid. The ion trap 40 is located downstream of the mixing mechanism 10 along the flow direction of the mixed fluid and is used to receive the mixed fluid charged by the charging mechanism 30 and separate the charge carried by non-target particles. The electrostatic detection mechanism 50 is located downstream of the ion trap 40 along the flow direction of the mixed fluid and is used to detect the amount of charge carried by the mixed fluid after separation by the ion trap 40.

[0040] The detector 100 can be used in conjunction with a supercritical fluid chromatography (SCLC) apparatus to detect the sample obtained by separating the target from the supercritical fluid chromatography apparatus. Specifically, the injection port 13 of the detector 100 is connected to the output port of the supercritical fluid chromatography apparatus to input the sample into the mixing space 11. The sample is the fluid sample obtained by the supercritical fluid chromatography apparatus using supercritical fluid as the mobile phase to separate the target particles from the target sample.

[0041] Understandably, the supercritical fluid (such as carbon dioxide) that serves as the mobile phase in the sample to be tested will rapidly vaporize after output, leaving behind solid target particles.

[0042] The detector 100 may further include an atomizing mechanism for atomizing the liquid to be atomized, forming a replenishing atomized fluid, which is then input into the mixing space 11 from the replenishing port 15. The liquid to be atomized can be selected according to the target particles and may be, but is not limited to, water. The replenishing atomized fluid is a mixture containing small liquid particles. The replenishing atomized fluid input into the mixing space 11 mixes with the target particles input into the mixing space 11 to form a mixed fluid in the form of an aerosol.

[0043] The mixed fluid is charged by the charging mechanism 30. The charging mechanism 30 charges the mixed fluid by means of direct charging and indirect charging. Direct charging refers to the charging mechanism 30 directly discharging to the mixed fluid, while indirect charging refers to the charging mechanism 30 charging the carrier gas and then using the charged carrier gas to collide with the mixed fluid to make it charged.

[0044] The charged fluid mixture is received by an ion trap 40, which is configured to generate a trap electric field. It is known that the non-target particles contained in the fluid mixture include supercritical fluid molecules, molecules of the liquid to be atomized, and possibly other carrier gas molecules. These molecules have masses much smaller than the aerosol particles containing the target particles. When these small charged molecules pass through the trap electric field, they are significantly deflected by the electric field force and eventually collide with the surface of the ion trap 40, where their charge is transferred and neutralized. In other words, the charge carried by the non-target particles is separated and captured by the ion trap 40. As for the charged target aerosol particles, although they are also affected by the electric field force when passing through the trap electric field, due to their large mass and momentum, their deflection acceleration is much smaller than that of the charged carrier gas, and the deflection is not significant. They can smoothly follow other uncharged ions through the trap electric field.

[0045] The electrostatic detection unit 50 receives the mixed fluid separated by the ion trap 40 downstream. As the charge carried by non-target particles in the mixed fluid is separated by the ion trap 40, the electrostatic detection unit 50 can more accurately capture the charge carried by aerosol particles containing target particles in the mixed fluid, so as to determine the charge carried by all aerosols containing target particles, convert it into voltage or current signals and transmit them to the host computer software, thereby determining the content of target particles in the detected target.

[0046] The detector 100 described above enables the sample input from the sample inlet port 13 to be mixed with the replenishing atomized fluid input from the replenishing port 15 within the mixing space 11, forming an aerosol-like mixed fluid. This facilitates the charging of aerosol particles containing target particles, allowing them to pass through the ion trap 40 and be detected by the electrostatic detection mechanism 50. Thus, compared to ultraviolet detection, this detection method of the detector 100 does not require consideration of the substance's response to specific radiation, and can be applied to a wider range of detection targets. Furthermore, compared to mass spectrometry detection, this detection method of the detector 100 has lower costs and less stringent usage requirements.

[0047] In some embodiments, the detector 100 further includes an atomizing mechanism, which includes an atomizing nozzle 71 and an atomizing cavity (not shown) communicating with the replenishment port 15. The atomizing nozzle 71 is used to introduce atomizing carrier gas and liquid to be atomized, and sprays it toward the atomizing cavity to form a replenishment atomized fluid.

[0048] Understandably, the atomizing nozzle 71 employs a two-fluid atomization principle, utilizing a flowing atomizing carrier gas to disperse the liquid to be atomized into small liquid particles, forming a replenishing atomized fluid. The atomizing carrier gas can be, but is not limited to, gases such as nitrogen, helium, carbon dioxide, and compressed air; the resulting replenishing atomized fluid can also be referred to as a humidifying carrier gas.

[0049] Thus, when the atomizing nozzle 71 is supplied with atomizing carrier gas, it can atomize the liquid to be atomized using the two-fluid atomization principle, and also adjust the flow rate of the mixed fluid by controlling the flow rate of the atomizing carrier gas.

[0050] Furthermore, the atomizing nozzle 71 includes a first pipe 711 and a second pipe 713. The inlet of the first pipe 711 is used to introduce atomizing carrier gas, and the inlet of the second pipe 713 is used to introduce liquid to be atomized. The outlets of the first pipe 711 and the outlets of the second pipe 713 intersect at an oblique angle.

[0051] Understandably, the outlets of both the first pipe 711 and the second pipe 713 face into the atomizing chamber, and their outlets are close to each other. The angle at which the atomizing carrier gas is ejected from the outlet of the first pipe 711 is roughly the same as the direction of the outlet of the first pipe 711, and the angle at which the liquid to be atomized is ejected from the outlet of the second pipe 713 is roughly the same as the direction of the outlet of the second pipe 713.

[0052] Thus, the initial velocity of the atomizing carrier gas introduced into the first pipeline 711 after being ejected from the outlet intersects with the initial velocity of the liquid to be atomized introduced into the second pipeline 713 after being ejected from the outlet. The atomizing carrier gas can better penetrate the liquid to be atomized, so as to disperse it into small liquid particles and form a replenishing atomized fluid.

[0053] In some embodiments, one of the first conduit 711 and the second conduit 713 is sleeved outside the other, and the two conduits form an outlet at one end, which is gradually narrowed towards the outlet.

[0054] Understandably, the first conduit 711 and the second conduit 713 are at least partially spaced apart, and are capable of allowing fluid to flow normally from the inlet to the outlet between them.

[0055] The first pipe 711 and the second pipe 713 are nested together, and their outlets can also be formed at the same location. The fluid entering through the inlet of the outer pipe flows between the first pipe 711 and the second pipe 713, and the outlet is correspondingly the portion between the first pipe 711 and the second pipe 713.

[0056] In this way, the liquid to be atomized and the atomizing carrier gas can better converge at the outlet. The outlets of the first pipeline 711 and the second pipeline 713 are tapered at one end, which can accelerate the flow of fluid on the one hand, and on the other hand, the fluid blown out of the inner pipeline can maintain a roughly axial flow direction, while the fluid between the two pipelines flows in the direction of contraction towards the axis, so that the atomizing carrier gas and the liquid to be atomized can naturally form an angle.

[0057] In some embodiments, the atomizing nozzle 71 further includes a sheath gas tube 715, the inlet of which is used to introduce sheath gas, and the outlet of which intersects obliquely with the outlet of the second conduit 713.

[0058] The sheath gas tube 715 can be an additional conduit or nested with the first conduit 711 and the second conduit 713. The sheath gas can supplement the atomizing carrier gas and can be heated before being introduced. Thus, by introducing sheath gas through the sheath gas tube 715, the atomization effect can be improved, and the flow rate of the introduced sheath gas can be controlled to regulate the flow rate of the mixed fluid.

[0059] Specifically, the atomizing nozzles 71 include, but are not limited to, the following five categories:

[0060] Please see Figure 4 The first type: the first pipe 711 is nested outside the second pipe 713 to form a nested pipe. The two form an inlet at one end of the nested pipe and gradually narrow to form an outlet at the other end of the nested pipe.

[0061] Please see Figure 5 The second type: the first pipe 711 and the second pipe 713 are set independently of each other. The first pipe 711 is axially inclined relative to the second pipe 713. The outlet of the first pipe 711 and the outlet of the second pipe 713 are set close to each other, and the outlets of the two intersect obliquely.

[0062] Please see Figure 6 The third type: The first pipe 711 is nested outside the second pipe 713 to form a nested pipe. The two pipes form an inlet at one end of the nested pipe and a gradually narrowing outlet at the other end. The sheath pipe 715 is set separately and is inclined relative to the axial direction of the nested pipe. The outlet of the sheath pipe 715 is set close to the outlet of the nested pipe, and the outlets of the two pipes intersect obliquely.

[0063] Please see Figure 7 Category 4: The first pipe 711 is fitted outside the second pipe 713, and the sheath pipe 715 is fitted outside the first pipe 711. The three form a nested pipe, with an inlet at one end of the nested pipe and an outlet at the other end of the nested pipe.

[0064] Please see Figure 8 Category 5: The second pipe 713 is fitted outside the first pipe 711, and the sheath pipe 715 is fitted outside the second pipe 713. The three form a nested pipe, with an inlet at one end and an outlet at the other end.

[0065] It is understood that in some other embodiments, the first pipeline 711, the second pipeline 713, and the sheath gas tube 715 may be configured in other ways, as long as they can effectively atomize the liquid to be atomized, and no specific limitation is made here.

[0066] In another embodiment, the atomizing mechanism includes an ultrasonic atomizing head (not shown) connected to the replenishment port 15.

[0067] The ultrasonic atomizing head uses the principle of ultrasonic atomization, which uses ultrasound to turn the liquid to be atomized into small droplets, and can further mix with the flowing carrier gas to form a replenishing atomized fluid.

[0068] In this way, the ultrasonic atomizing head produces fine droplets in the replenishing fluid, and the demand for carrier gas is low, or even no carrier gas is needed.

[0069] In some embodiments, the detector 100 further includes a drift tube 90, which is disposed downstream of the mixing mechanism 10 along the flow direction of the mixed fluid and is used to heat the mixed fluid flowing out of the mixing mechanism 10.

[0070] Thus, heating the aerosol-form mixed fluid using the drift tube 90 can improve its uniformity, which is beneficial for improving the accuracy of subsequent detection.

[0071] In the first embodiment, the charging mechanism 30 is located downstream of the mixing mechanism 10 along the flow direction of the mixed fluid, and has a charging space 31 communicating with the mixing space 11 and a discharge electrode 33 located at least partially within the charging space 31. The discharge electrode 33 is used to charge the mixed fluid flowing through the charging space 31.

[0072] The discharge electrode 33 is connected to a high-voltage power supply to generate a sufficient voltage to directly discharge to the mixed fluid, thereby charging the particles contained in the mixed fluid.

[0073] In this way, the mixed gas flow entering the charging space 31 can directly contact the discharge electrode 33 and be charged by it, greatly increasing the charge conduction efficiency and the proportion of charged target particles. Furthermore, the charging mechanism 30 does not require an additional gas path, reducing gas consumption. This reduction in gas consumption naturally also reduces the degree to which the sample is diluted by the carrier gas, resulting in narrower peaks and improved sensitivity.

[0074] Please see Figure 2 In the second embodiment, the charging mechanism 30 has a charging space 31, a discharge electrode 33, a carrier gas port 35, and a discharge space 37.

[0075] The carrier gas port 35 is connected to the discharge space 37 and is used to introduce the charging carrier gas. The discharge electrode 33 is at least partially located within the discharge space 37 and is used to charge the charging carrier gas flowing through the discharge space 37. The charging space 31 is connected to both the discharge space 37 and the mixing space 11, and is located downstream of the discharge space 37 along the flow direction of the charging carrier gas and downstream of the mixing space 11 along the flow direction of the mixed fluid.

[0076] The discharge electrode 33 discharges the charged carrier gas flowing through the discharge space 37, thus charging it. Then, the charged carrier gas and the mixed fluid formed in the mixing space 11 flow together into the charging space 31 located downstream of both. The charged carrier gas and the mixed fluid collide in the charging space 31, allowing the charge to be transferred to the mixed fluid, thereby charging the mixed fluid.

[0077] In this way, while charging the mixed fluid with the carrier gas, the flow rate of the mixed fluid can also be adjusted by controlling the flow rate of the carrier gas.

[0078] Please see Figure 3 In the third embodiment, the charging mechanism 30 has a discharge space 37, a discharge electrode 33, and a carrier gas port 35.

[0079] The carrier gas port 35 is connected to the discharge space 37 and is used to introduce the charging carrier gas. The discharge electrode 33 is at least partially located within the discharge space 37 and is used to charge the charging carrier gas flowing through the discharge space 37. The discharge space 37 is connected to the mixing space 11 and is located upstream of the mixing space 11 along the flow direction of the charging carrier gas.

[0080] Understandably, the sample to be tested, the replenishing atomizing fluid, and the charged carrier gas are all introduced into the mixing space 11. In other words, the mixed fluid is both formed and charged within the mixing space 11. Furthermore, the charging carrier gas can also be humidified before charging.

[0081] Thus, the structure of detector 100 is further simplified, and the airflow configuration is also simpler.

[0082] The detector 100 described above mixes and charges the replenishing atomized fluid with the sample to obtain a charged aerosol mixture. Simultaneously, a drift tube 90 improves the uniformity of the aerosol mixture, and an ion trap 40 reduces interference from non-target particle charges. Finally, the charge quantity is detected. Thus, the detector 100 has advantages such as wide applicability, accurate detection results, and low cost.

[0083] This application also provides a supercritical fluid chromatography detector, including a supercritical fluid chromatography apparatus and the detector 100 described above, wherein the injection port 13 of the detector 100 is used to connect to the output port of the supercritical fluid chromatography apparatus.

[0084] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0085] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A detector, characterized in that, The detector includes: A mixing mechanism (10) has a mixing space (11) therein, and has an inlet port (13) and a replenishment port (15) communicating with the mixing space (11). The inlet port (13) is used to introduce a detection sample containing target particles, and the replenishment port (15) is used to introduce a replenishment atomizing fluid. The detection sample and the replenishment atomizing fluid can form a mixed fluid in the mixing space (11). A charging mechanism (30) is connected to the mixing space (11) and is configured to charge the mixing fluid; An ion trap (40), disposed downstream of the mixing mechanism (10) along the flow direction of the mixed fluid, is used to receive the mixed fluid charged by the charging mechanism (30) and to separate the charge carried by non-target particles; and An electrostatic detection mechanism (50) is located downstream of the ion trap (40) along the flow direction of the mixed fluid, and is used to detect the amount of charge carried by the mixed fluid after separation by the ion trap (40).

2. The detector according to claim 1, characterized in that, The charging mechanism (30) is located downstream of the mixing mechanism (10) along the flow direction of the mixed fluid, and has a charging space (31) communicating with the mixing space (11) and a discharge electrode (33) located at least partially in the charging space (31), the discharge electrode (33) being used to charge the mixed fluid flowing through the charging space (31).

3. The detector according to claim 1, characterized in that, The charging mechanism (30) has a charging space (31), a discharge electrode (33), a carrier gas port (35), and a discharge space (37). The carrier gas port (35) is connected to the discharge space (37) and is used to introduce the charging carrier gas; the discharge electrode (33) is at least partially located in the discharge space (37) and is used to charge the charging carrier gas flowing through the discharge space (37); the charging space (31) is connected to the discharge space (37) and the mixing space (11) respectively, and is located downstream of the discharge space (37) along the flow direction of the charging carrier gas and downstream of the mixing space (11) along the flow direction of the mixing fluid.

4. The detector according to claim 1, characterized in that, The charging mechanism (30) has a discharge space (37), a discharge electrode (33), and a carrier gas port (35); The carrier gas port (35) is connected to the discharge space (37) and is used to introduce the charging carrier gas; the discharge electrode (33) is at least partially located in the discharge space (37) and is used to charge the charging carrier gas flowing through the discharge space (37); the discharge space (37) is connected to the mixing space (11) and is located upstream of the mixing space (11) along the flow direction of the charging carrier gas.

5. The detector according to claim 1, characterized in that, The detector also includes a drift tube (90), which is located downstream of the mixing mechanism (10) along the flow direction of the mixed fluid and is used to heat the mixed fluid flowing out of the mixing mechanism (10).

6. The detector according to claim 1, characterized in that, The detector also includes an atomizing mechanism, which includes an atomizing nozzle (71) and an atomizing cavity connected to the replenishment port (15). The atomizing nozzle (71) is used to introduce atomizing carrier gas and liquid to be atomized, and sprays out toward the atomizing cavity to form the replenishment atomized fluid.

7. The detector according to claim 6, characterized in that, The atomizing nozzle (71) includes a first pipe (711) and a second pipe (713). The inlet of the first pipe (711) is used to introduce atomizing carrier gas, and the inlet of the second pipe (713) is used to introduce liquid to be atomized. The outlets of the first pipe (711) and the outlets of the second pipe (713) intersect obliquely.

8. The detector according to claim 7, characterized in that, One of the first pipe (711) and the second pipe (713) is sleeved on the outside of the other, and the two pipes are arranged with the outlet end gradually narrowing towards the outlet; The atomizing nozzle (71) also includes a sheath gas tube (715), the inlet of which is used to introduce sheath gas, and the outlet of which intersects obliquely with the outlet of the second pipeline (713).

9. The detector according to claim 1, characterized in that, The detector also includes an atomizing mechanism, which includes an ultrasonic atomizing head connected to the replenishment port (15).

10. A supercritical fluid chromatography detector, characterized in that, It includes a supercritical fluid chromatography apparatus and a detector as described in any one of claims 1-9, wherein the injection port of the detector is used to connect to the output port of the supercritical fluid chromatography apparatus.

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