Use of parabacteroides distasonii in the preparation of a preparation for preventing and / or treating intestinal diseases caused by methylphenidate hydrochloride

By using a preparation of *Pseudomonas difficile* to alleviate intestinal adverse reactions caused by methylphenidate hydrochloride, the problems of diarrhea and intestinal flora imbalance caused by methylphenidate hydrochloride were resolved, improving medication safety and compliance without affecting the treatment effect of ADHD.

CN122229888APending Publication Date: 2026-06-19CHONGQING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING MEDICAL UNIVERSITY
Filing Date
2026-04-28
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively control the intestinal adverse reactions caused by methylphenidate hydrochloride, especially diarrhea and intestinal flora imbalance, which affects patient medication adherence.

Method used

Preparations for the prevention and/or treatment of intestinal diseases caused by methylphenidate hydrochloride, including live bacteria, inactivated bacteria or metabolites, are prepared using Parabacteroides distasonis (ATCC: 8503) for the purpose of relieving diarrhea, repairing colonic mucosa, reducing inflammatory response and maintaining intestinal barrier function.

Benefits of technology

It significantly improved intestinal damage caused by methylphenidate hydrochloride, reduced colonic inflammation, restored intestinal flora balance, improved medication safety and compliance, and did not affect the therapeutic effect of methylphenidate hydrochloride on ADHD.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention provides the application of *Parabacteroides distasonis* in the preparation of formulations for the prevention and / or treatment of intestinal diseases caused by methylphenidate hydrochloride. It belongs to the interdisciplinary fields of pharmaceutical formulation and microbiology. This invention utilizes *Parabacteroides distasonis* ATCC:8503 to effectively alleviate intestinal adverse reactions caused by methylphenidate hydrochloride, specifically by relieving diarrhea, repairing pathological damage to the colonic mucosa, reducing colonic tissue inflammation, downregulating the expression of pro-inflammatory factors TNF-α and IL-6, upregulating the level of the anti-inflammatory factor IL-10, and increasing the expression of the tight junction protein Ocln to repair intestinal barrier function. Simultaneously, experiments have demonstrated that the combined use of ATCC:8503 and methylphenidate hydrochloride does not alter the efficacy of methylphenidate hydrochloride, providing an effective solution for the subsequent treatment of attention deficit hyperactivity disorder and the management of adverse reactions to methylphenidate hydrochloride.
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