A cream for treating erythrodermic psoriasis and a method for preparing the same

Abstract

This invention discloses a cream for treating erythrodermic psoriasis and its preparation method, belonging to the field of psoriasis drug technology. This cream is made from the following raw materials in parts by weight: 20-50 parts of *Cassia tora*, 30 parts of *Dictamnus dasycarpus* root bark, 30 parts of *Sophora flavescens* root bark, 20 parts of *Kochia scoparia* fruit, 20 parts of *Salvia miltiorrhiza* root bark, 2 parts of borneol, 30 parts of catechu, 5 parts of *Euphorbia fischeriana* root bark, 200-260 parts of water, 40-50 parts of emulsifier, and 0.05-0.1 parts of preservative. The preparation method includes: boiling *Cassia tora*, *Dictamnus dasycarpus* root bark, *Sophora flavescens* root bark, *Kochia scoparia* fruit, *Salvia miltiorrhiza* root bark, borneol, catechu, and *Euphorbia fischeriana* root bark in water, then removing the herbs to obtain a medicinal paste; mixing the medicinal paste, emulsifier, and preservative and adding them to an emulsifier for emulsification to obtain the product. This formula can treat erythrodermic psoriasis. As a topical cream for psoriasis, this invention has the effects of inhibiting various fungi and viruses, clearing heat and cooling blood, astringing and promoting tissue regeneration, inhibiting epidermal cell proliferation, slowing down the epidermal metabolic cycle, promoting keratinization, inhibiting sebum secretion, inhibiting the growth environment of bacteria and fungi, and dissipating inflammatory cells and relieving itching.

Description

Technical Field

[0001] This invention belongs to the field of psoriasis drug technology, and relates to a cream for treating erythrodermic psoriasis and its preparation method. Background Technology

[0002] Psoriasis, also known as silver scale disease, commonly occurs on the extensor surfaces of the limbs, scalp, sacrum, and trunk, often in symmetrical areas. The main lesions are erythematous plaques and scaling, causing itching. While it doesn't seriously affect health, it can be very bothersome for those concerned about their appearance. Psoriasis can resolve spontaneously, but it tends to recur, lasting for years or even decades. It is not contagious. This disease is easy to diagnose but difficult to cure.

[0003] There are two common types of psoriasis: plaque psoriasis and erythrodermic psoriasis. Plaque psoriasis is characterized by rashes that typically appear on the scalp, trunk, and extensor surfaces of the limbs. These rashes are red papules that gradually enlarge and merge into plaques or patches, covered with thick, irregularly shaped, silvery-white scales. Erythrodermic psoriasis, on the other hand, can occur anywhere on the body, but is most common on the back and extensor surfaces of the limbs. It presents as diffuse redness of the skin, with abundant bran-like, scaly, and infiltrated swelling.

[0004] As people pay more attention to psoriasis as a health condition, a wide variety of psoriasis medications are emerging on the market.

[0005] Currently, there are various products available, including psoriasis medications, with varying effects. Some may contain hormones, which can cause side effects such as dependence during use.

[0006] How to provide a safe, side-effect-free cream for treating erythrodermic psoriasis and its preparation method is a problem that urgently needs to be solved by those in the field. Summary of the Invention

[0007] In view of this, the present invention provides a cream for treating erythrodermic psoriasis and a method for preparing the same.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] A cream for treating erythrodermic psoriasis is prepared from the following raw materials in the indicated weight percentages: 20-50 parts of Cassia tora, 30 parts of Dictamnus dasycarpus root bark, 30 parts of Sophora flavescens root, 20 parts of Kochia scoparia fruit, 20 parts of Salvia miltiorrhiza root, 2 parts of borneol, 30 parts of catechu, 5 parts of Euphorbia fischeriana root, 200-260 parts of water, 40-50 parts of emulsifier, and 0.05-0.1 parts of preservative.

[0010] The beneficial effects of this invention: As a topical cream for psoriasis, this invention has the effects of inhibiting various fungi and viruses, clearing heat and cooling blood, astringing and promoting tissue regeneration, inhibiting epidermal cell proliferation, slowing down the epidermal metabolic cycle, promoting keratinization, inhibiting sebum secretion, inhibiting the growth environment of bacteria and fungi, and dissipating inflammatory cells and relieving itching.

[0011] The combination of Cassia tora, Dictamnus dasycarpus root bark, Sophora flavescens root, Kochia scoparia fruit, Salvia miltiorrhiza root, borneol, catechu, and Euphorbia fischeriana root is highly effective in treating erythrodermic psoriasis. Its main effects on erythrodermic psoriasis include clearing heat and cooling blood, stopping bleeding, antibacterial and anti-inflammatory properties, controlling pathogens on the skin, reducing pain and itching, promoting skin repair, and possessing antiviral and antifungal properties, inhibiting the reproduction of viruses and bacteria. This invention has no side effects.

[0012] Among them, senna seed pods have antibacterial and anti-inflammatory effects that can effectively control pathogens on the skin, reduce pain and itching, and decrease peeling and redness. Furthermore, senna seed pods also have anti-inflammatory and antibacterial properties, which can inhibit the reproduction of viruses and bacteria and reduce inflammation.

[0013] Dictamnus dasycarpus root bark contains dictamnus alkaloids, dictamnus lactones, and other components. It has anti-inflammatory, antibacterial, and anti-allergic activities, which can reduce skin inflammation and exudation, and improve the symptoms of erythema, desquamation, and itching in erythrodermic psoriasis.

[0014] Sophora flavescens: It clears heat and dries dampness, kills parasites and promotes diuresis. Sophora flavescens contains matrine and oxymatrine, which have anti-inflammatory and immunomodulatory effects. It can intervene in the immune-mediated pathogenesis of psoriasis and inhibit overactive immune responses.

[0015] Kochia scoparia fruit: Clears heat and promotes diuresis, dispels wind and relieves itching, has anti-inflammatory and anti-allergic effects, can relieve symptoms such as skin itching and redness, and inhibit the release of inflammatory factors.

[0016] Danshen (Salvia miltiorrhiza): It can promote blood circulation, remove blood stasis, relieve pain, cool blood and reduce swelling. It can improve microcirculation and inhibit the abnormal proliferation of keratinocytes, and is especially effective for psoriasis with blood stasis.

[0017] Borneol: It can open the orifices and refresh the mind, clear heat and relieve pain, reduce swelling and promote tissue regeneration. It can also promote the transdermal absorption of drugs and enhance the local permeability of other Chinese medicine ingredients. At the same time, it has the effects of cooling and relieving itching and relieving burning sensation. It is suitable for patients with red and burning skin in the acute phase of erythrodermic psoriasis.

[0018] Catechu: It has the effects of astringing and healing sores, promoting blood circulation and relieving pain, promoting tissue regeneration and stopping bleeding. It can astringe wounds, reduce exudation, and promote skin repair.

[0019] Wolfsbane: It has insecticidal, nodule-dispersing, dampness-removing, itch-relieving, detoxifying, and swelling-reducing effects. It also has inhibitory effects on skin fungi and inflammation, and can inhibit the growth of bacteria and viruses.

[0020] This formula can treat erythrodermic psoriasis, which can occur anywhere on the body, but is most common on the back and extensor surfaces of the limbs.

[0021] Furthermore, the emulsifier mentioned above is glyceryl monostearate.

[0022] The beneficial effects of adopting the above-mentioned further technical solutions are: ease of use and better skin absorption.

[0023] Furthermore, the aforementioned preservative is ethylparaben.

[0024] The beneficial effects of adopting the above-mentioned further technical solution are as follows: the addition of 0.05-0.1 parts of preservative ensures that the shelf life of the erythrodermic psoriasis cream reaches 24 months.

[0025] This invention provides a method for preparing a cream for treating erythrodermic psoriasis, comprising the following steps: (1) Weigh out the raw materials according to the above-mentioned cream for treating erythrodermic psoriasis; (2) Boil Cassia tora, Dictamnus dasycarpus root bark, Sophora flavescens root, Kochia scoparia fruit, Salvia miltiorrhiza root, borneol, catechu and Euphorbia fischeriana root in water, then remove the herbs to obtain a medicinal liquid; (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier to emulsify, and obtain the above-mentioned cream for treating erythrodermic psoriasis.

[0026] Furthermore, in step (2), the above cooking process is as follows: first boil at 110°C-120°C, then simmer at 80°C-90°C for 20-30 minutes.

[0027] The beneficial effects of adopting the above-mentioned further technical solutions are: it ensures the success rate of the medicine and prevents it from burning.

[0028] Furthermore, in step (3), the speed of the emulsifier is 30-60 rpm and the emulsification time is 30-60 minutes.

[0029] The beneficial effects of adopting the above-mentioned further technical solutions are: this rotation speed and time produce the best emulsification effect. Detailed Implementation

[0030] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0031] Example 1 A method for preparing a cream for treating erythrodermic psoriasis includes the following steps: (1) Weigh out 20kg of Cassia tora, 30kg of Dictamnus dasycarpus root bark, 30kg of Sophora flavescens root, 20kg of Kochia scoparia fruit, 20kg of Salvia miltiorrhiza root, 2kg of borneol, 30kg of catechu, 5kg of Euphorbia fischeriana root, 200kg of water, 65kg of glyceryl monostearate, and 0.05kg of ethylparaben. (2) Add water to cassia seed, white peony root bark, sophora flavescens, kochia scoparia, salvia miltiorrhiza, borneol, catechu and wolfsbane, boil first at 110°C, then reduce to 80°C and simmer for 20 minutes, then remove the herbs to obtain the medicinal liquid. (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier for emulsification. The speed of the emulsifier is 30 rpm and the emulsification time is 30 minutes to obtain the cream for treating erythrodermic psoriasis.

[0032] Example 2 The preparation method of the cream for treating erythrodermic psoriasis includes the following steps: (1) weigh 35kg of cassia seed, 30kg of dictamnus root bark, 30kg of sophora flavescens root, 20kg of kochia fruit, 20kg of salvia miltiorrhiza root, 2kg of borneol, 30kg of catechu, 5kg of euphorbia fischeriana root, 240kg of water, 78kg of glyceryl monostearate, and 0.07kg of ethylparaben. (2) Add water to cassia seed, white peony root bark, sophora flavescens, kochia scoparia, salvia miltiorrhiza, borneol, catechu and wolfsbane, boil first at 115°C, then reduce to 85°C and simmer for 25 minutes, then remove the herbs to obtain the medicinal liquid. (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier for emulsification. The speed of the emulsifier is 40 revolutions / minute and the emulsification time is 40 minutes to obtain the cream for treating psoriasis vulgaris.

[0033] Example 3 The preparation method of the cream for treating erythrodermic psoriasis includes the following steps: (1) Weigh 50 kg of Cassia tora, 30 kg of Dictamnus dasycarpus, 30 kg of Sophora flavescens, 20 kg of Kochia scoparia, 20 kg of Salvia miltiorrhiza, 2 kg of borneol, 30 kg of catechu, 5 kg of Euphorbia lathyris, 260 kg of water, 95 kg of glyceryl monostearate, and 0.1 kg of ethylparaben; (2) Add water to cassia seed, white peony root bark, sophora flavescens, kochia scoparia, salvia miltiorrhiza, borneol, catechu and wolfsbane, boil first at 120°C, then reduce to 90°C and simmer for 30 minutes, then remove the herbs to obtain the medicinal liquid; (3) Mix the medicine, emulsifier and preservative and add them to the emulsifier for emulsification. The speed of the emulsifier is 60 revolutions / minute and the emulsification time is 60 minutes to obtain the cream for treating psoriasis vulgaris.

[0034] Effect test 1. Typical Cases Instructions for use: Apply as needed, once a day. The longer the ointment remains on the skin, the better the absorption. During treatment, avoid certain foods and medications, including any traditional Chinese medicine. Maintain good hygiene and exercise regularly.

[0035] Case 1: Mr. Zhou, male, 53 years old, a psoriasis patient for 21 years.

[0036] Case Analysis: The patient presented with moderate erythrodermic psoriasis on the back. Example 1 cream was applied once daily. Itching disappeared after half a month of treatment, the number of lesions significantly decreased after 20 days, and the condition was completely cured after two months. Before complete recovery, three small, rice-grain-sized spots reappeared on the body. The patient continued treatment for a period to consolidate the results, and did not relapse after dietary restrictions were implemented. A total of 50 ml of cream was used over the two months.

[0037] Case 2: Ms. Zheng, 25 years old, has been a psoriasis patient for 8 years.

[0038] Case Analysis: Mild erythrodermic psoriasis was observed on the back and limbs. The patient was treated with the cream described in Example 2 once daily. After initial improvement, treatment was delayed, and the condition resolved after two and a half months of treatment. A total of 60 ml of cream was used over the two and a half months. After one week of treatment, itching disappeared, the number of lesions significantly decreased, and there were no recurrences on the back and limbs. No recurrence was observed after dietary restrictions were implemented.

[0039] Case 3: Ms. Chen, 52 years old, has been a psoriasis patient for more than ten years.

[0040] Case Analysis: The patient presented with moderate erythrodermic psoriasis on the back and limbs. The cream described in Example 3 was applied once daily, resulting in complete recovery within three months. A total of 180 ml of cream was used over the three months. Itching disappeared after 10 days of treatment, and the number of lesions significantly decreased after one month. The patient experienced two recurrences of 7-8 lesions on the back and limbs before complete recovery, but no further recurrence occurred after dietary restrictions were implemented.

[0041] Case 4: Mr. Cai, male, 43 years old, a psoriasis patient for 14 years.

[0042] Case Analysis: The patient presented with erythrodermic psoriasis on the back and limbs. The cream described in Example 3 was applied once daily. After two months of treatment, the condition was cured, but the relapse period has not yet ended; it has only recurred once, and the medication has been continued.

[0043] 2. Application method: Apply as needed, once a day. The longer the ointment remains on the skin, the better the absorption effect. During the treatment period, avoid certain foods and medications, and maintain good hygiene through regular exercise.

[0044] This invention was used in twenty clinical cases in Cambodia. The patients were aged 17 to 38 years old, and all twenty cases were male. The patients recovered one after another within five months.

[0045] 3. Application method: Apply as needed, once a day, using only Cassia Seed Cream. The longer the cream remains on the skin, the better the absorption. During treatment, avoid certain foods and medications, and maintain good hygiene through regular exercise.

[0046] In 2024, the formula for the erythrodermic psoriasis cream was upgraded, and more than 30 clinical cases have been conducted. Patients ranged in age from 14 to 78 years old, including 17 men and 13 women. Results over six months showed that 50% of patients were cured, primarily those with mild to moderate psoriasis and younger individuals; 10% showed significant improvement, but the medication supply became insufficient; and 40% showed little improvement. Severe cases were primarily older patients with a long history of the disease (most having 20 to 40 years of illness), who often lacked awareness, trust, and proper use of the medication, leading to insufficient medication and requiring longer treatment durations.

[0047] Conclusion: Mild to moderate erythrodermic psoriasis patients, mainly affecting the back and limbs, typically recover after about one month of medication. Moderate to severe patients recover after about two months, and moderate to severe patients recover after about three months.

[0048] 4. Animal experiments: The cream from Example 1 was applied to the skin diseases on the bodies and cervical spines of three dogs and two cats respectively. The skin diseases on the dogs were completely cleared up in 15-20 days.

[0049] 5. We have applied for two patents for psoriasis, psoriasis vulgaris and psoriasis erythroderma. Our cases have confirmed that only by using both psoriasis vulgaris and psoriasis erythroderma creams together can the virus in psoriasis patients be suppressed, and recurrence will not occur after recovery.

[0050] The description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A cream for treating erythrodermic psoriasis, characterized in that, It is prepared from the following raw materials in parts by weight: 20-50 parts of Cassia tora, 30 parts of Dictamnus dasycarpus root bark, 30 parts of Sophora flavescens root, 20 parts of Kochia scoparia fruit, 20 parts of Salvia miltiorrhiza root, 2 parts of borneol, 30 parts of catechu, 5 parts of Euphorbia fischeriana root, 200-260 parts of water, 40-50 parts of emulsifier, and 0.05-0.1 parts of preservative.

2. The cream for treating erythrodermic psoriasis according to claim 1, characterized in that, The emulsifier is glyceryl monostearate.

3. The cream for treating erythrodermic psoriasis according to claim 1, characterized in that, The preservative is ethylparaben.

4. A method for preparing a cream for treating erythrodermic psoriasis, characterized in that, Includes the following steps: (1) Weigh the raw materials of the cream for treating erythrodermic psoriasis according to any one of claims 1-3: (2) Add water to boil cassia seed, white peony root bark, sophora flavescens, kochia fruit, salvia miltiorrhiza, borneol, catechu and wolfsbane, then remove the herbs to obtain a medicinal liquid; (3) Mix the medicated paste, emulsifier and preservative and add them to an emulsifier for emulsification to obtain the cream for treating erythrodermic psoriasis.

5. The method for preparing a cream for treating erythrodermic psoriasis according to claim 4, characterized in that, In step (2), the cooking process is as follows: first boil at 110°C-120°C, then simmer at 80°C-90°C for 20-30 minutes.

6. The method for preparing a cream for treating erythrodermic psoriasis according to claim 4, characterized in that, In step (3), the speed of the emulsifier is 30-60 rpm and the emulsification time is 30-60 minutes.