Water-based lubricant and use on polyurethane condoms

Abstract

The present application relates to the technical field of condom lubricant, in particular to a water-based lubricant and its application on polyurethane condoms, which comprises the following raw materials: deionized water, glycerol, hydroxymethyl cellulose, polyquaternium-51, disodium ethylenediaminetetraacetate, phenoxyethanol and other additives.In the present application, the carbomer in the other additives is activated by 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide, and then reacts with the amine group of 3-aminopropyltrimethoxysilane to realize the grafting of silane coupling agent to the carbomer chain, and then copolymerizes with N-vinylpyrrolidone under the action of azobisdimethylaminoformamidine hydrochloride, introducing polyvinylpyrrolidone segments, effectively improving the hydrophilicity and hydration capacity of the material, making the lubricating layer strongly adhere to the substrate and not easy to be erased, thereby improving the lubricating performance of the water-based lubricant.

Description

Technical Field

[0001] This invention relates to the field of condom lubricant technology, specifically to a water-based lubricant and its application in polyurethane condoms. Background Technology

[0002] Lubricants were first used in clinical medicine for human examinations. Many medical devices cause mechanical damage to varying degrees when they penetrate the human body. Lubricants can minimize damage to body tissues and mucous membranes.

[0003] In existing technologies, water-based lubricants used in condoms are prone to evaporation in the air and absorption by the skin due to their water-soluble components, resulting in a short duration of action and affecting lubrication effectiveness. Therefore, this invention provides a water-based lubricant and its application in polyurethane condoms. Summary of the Invention

[0004] The purpose of this invention is to provide a water-based lubricant and its application in polyurethane condoms. The water-based lubricant prepared by this invention not only has good lubrication performance but also excellent moisturizing performance, effectively improving the performance of the water-based lubricant.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] A water-based lubricant comprises the following raw materials: deionized water, glycerin, hydroxymethyl cellulose, polyquaternium-51, disodium ethylenediaminetetraacetate, phenoxyethanol, and other additives, wherein the weight percentages of each raw material are: 3-6% glycerin, 0.8-1.5% hydroxymethyl cellulose, 0.5-1% polyquaternium-51, 0.05-0.1% disodium ethylenediaminetetraacetate, 0.2-0.3% phenoxyethanol, 1-1.5% other additives, and the balance is made up to 100% by deionized water;

[0007] The other additives are prepared by the following method:

[0008] S1: Preparation of the first mixture, the raw materials of the first mixture include carbomer, deionized water, anhydrous ethanol, sodium hydroxide solution, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride;

[0009] S2: Preparation of the second mixture, the raw materials of the second mixture include sodium polyglutamate, xylitol and deionized water, and the mass of the second mixture is 25-35% of the mass of the first mixture;

[0010] S3: Mixing process, the first mixture and the second mixture are mixed to obtain other additives.

[0011] Further, the method for preparing the first mixture is as follows: Carbomer is dispersed in a mixture of deionized water and anhydrous ethanol. Under ice-water bath conditions, 1M sodium hydroxide solution is added dropwise to adjust the pH value to 5.5-6.0 to obtain a first premix. 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added sequentially to the first premix. After mixing, the mixture is allowed to stand at room temperature for 25-30 minutes to obtain a second premix. The treatment solution is added dropwise to the second premix, and the mixture is stirred and reacted for 10-12 hours under water bath conditions at 40°C to obtain the product. The sample was transferred to a 3500 Da dialysis bag and dialyzed with deionized water for 3 days, changing the water 3-5 times a day. The obtained product was freeze-dried to obtain a powder. The powder was dissolved in deionized water, and N-vinylpyrrolidone was added. Nitrogen gas was bubbled for 20-25 minutes, followed by the addition of azobisisobutyramidine hydrochloride. The mixture was heated to 58-62°C under a nitrogen atmosphere and stirred for 4-6 hours. The obtained product was transferred to an 8000 Da dialysis bag and dialyzed with deionized water for 4 days, changing the water 3-5 times a day. The obtained product was freeze-dried to obtain the first mixture.

[0012] Further, the mass ratio of carbomer, deionized water and anhydrous ethanol is 5:(130-150):(45-55), the mass ratio of the first premix, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide is 100:(0.8-1):(0.6-0.8), the mass of the treatment solution is 6-8% of the mass of the second premix, and the mass ratio of powder material, deionized water, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride is 5:(80-100):(3-5):(0.25-0.4). Carbomer 974P is selected.

[0013] Furthermore, the treatment solution is prepared by mixing 3-aminopropyltrimethoxysilane and anhydrous ethanol.

[0014] Furthermore, the mass ratio of 3-aminopropyltrimethoxysilane to anhydrous ethanol is 1:(5-5.5).

[0015] Further, the method for preparing the second mixture is as follows: sodium polyglutamate and xylitol are dissolved in deionized water at 60-65℃, stirred at 300-500 rpm for 20-30 min, the resulting product is frozen at -50℃ for 6-8 h, then freeze-dried for 24-36 h, the resulting product is ground and sieved through a 200-mesh sieve to obtain the second mixture.

[0016] Furthermore, the mass ratio of sodium polyglutamate, xylitol, and deionized water is 1:(0.6-0.8):(18-20).

[0017] Further, the mixing process is as follows: the first mixture and the second mixture are stirred at 200-400 rpm for 30-40 minutes at a temperature of 25-30°C to complete the mixing process and obtain other additives.

[0018] Furthermore, the preparation method of the water-based lubricant includes the following steps: weighing each raw material as needed and adding it into a mixer, stirring at 400-600 rpm for 20-30 minutes, homogenizing the resulting product at 5000-6000 rpm for 5-10 minutes, and then performing vacuum degassing treatment to obtain the water-based lubricant.

[0019] Furthermore, the water-based lubricant prepared by the method is applied to polyurethane condoms. The water-based lubricant is applied to the surface of the polyurethane condom by quantitative atomization spraying, with a coating amount of 400mg.

[0020] Compared with the prior art, the beneficial effects of the present invention are:

[0021] 1. In this invention, glycerin is used as the main lubricating and moisturizing component in the preparation of the water-based lubricant. This reduces the surface tension of water and increases the spreadability and slipperiness of the lubricant. Carbomer in other additives is treated with 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to activate the carboxyl group of carbomer. It then undergoes an amidation reaction with the amino group of 3-aminopropyltrimethoxysilane, thereby grafting the silane coupling agent onto the carbomer chain. Subsequently, it copolymerizes with N-vinylpyrrolidone under the action of azobisisobutyramidine hydrochloride, introducing polyvinylpyrrolidone segments. This effectively enhances the hydrophilicity and hydration capacity of the material, allowing the lubricating layer to adhere strongly to the substrate and be difficult to wipe off, thereby improving the lubrication performance of the water-based lubricant.

[0022] 2. In this invention, sodium polyglutamate, as an anionic natural biopolymer, has good moisturizing ability. It locks in moisture by forming strong hydrogen bonds between multiple carboxylate ions and water molecules. Combined with the hygroscopic properties of xylitol, it further enhances the moisturizing effect. After the first mixture and the second mixture are mixed, a stable hydrophilic moisturizing structure can be formed, effectively integrating sodium polyglutamate and xylitol into a macromolecular skeleton that can firmly adhere to the substrate, further improving the lubrication and moisturizing performance of the water-based lubricant. Attached Figure Description

[0023] Figure 1 This invention provides a formulation diagram of a water-based lubricant and its application in polyurethane condoms. Detailed Implementation

[0024] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0025] It should be noted that the raw materials used in the following embodiments are all commercially available.

[0026] Example 1:

[0027] Raw material preparation: 3% glycerin, 0.8% hydroxymethyl cellulose, 0.5% polyquaternium-51, 0.05% disodium ethylenediaminetetraacetate, 0.2% phenoxyethanol, 1% other additives, with the balance made up to 100% by deionized water;

[0028] Preparation of other additives:

[0029] S1: Preparation of the first mixture, the raw materials of the first mixture include carbomer, deionized water, anhydrous ethanol, sodium hydroxide solution, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride;

[0030] The method for preparing the first mixture is as follows: Carbomer is dispersed in a mixture of deionized water and anhydrous ethanol. Under ice-water bath conditions, 1M sodium hydroxide solution is added dropwise to adjust the pH to 5.5, resulting in a first premix. 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added sequentially to the first premix. After mixing, the mixture is allowed to stand at room temperature for 25 minutes to obtain a second premix. A treatment solution is added dropwise to the second premix, and the mixture is stirred and reacted for 10 hours under 40°C water bath conditions. The resulting product is then converted to... The product was transferred to a 3500Da dialysis bag and dialyzed with deionized water for 3 days, with the water changed 3 times a day. The obtained product was freeze-dried to obtain a powder material. The powder material was dissolved in deionized water, N-vinylpyrrolidone was added, and the mixture was bubbled with nitrogen for 20 minutes. Then, azobisisobutyramidine hydrochloride was added, and the mixture was heated to 58°C under a nitrogen atmosphere and stirred for 4 hours. The obtained product was transferred to an 8000Da dialysis bag and dialyzed with deionized water for 4 days, with the water changed 3 times a day. The obtained product was freeze-dried to obtain the first mixture.

[0031] The mass ratio of carbomer, deionized water, and anhydrous ethanol is 5:130:45; the mass ratio of the first premix, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide is 100:0.8:0.6; the mass of the treatment solution is 6% of the mass of the second premix; the mass ratio of powder material, deionized water, N-vinylpyrrolidone, and azobisisobutyramidine hydrochloride is 5:80:3:0.25; and carbomer 974P is selected.

[0032] The treatment solution was prepared by mixing 3-aminopropyltrimethoxysilane and anhydrous ethanol, with a mass ratio of 1:5 between the two.

[0033] S2: Preparation of the second mixture, the raw materials of the second mixture include sodium polyglutamate, xylitol and deionized water, and the mass of the second mixture is 25% of the mass of the first mixture;

[0034] The second mixture is prepared as follows: sodium polyglutamate and xylitol are dissolved in deionized water at 60°C, stirred at 300 rpm for 20 min, the resulting product is frozen at -50°C for 6 h, then freeze-dried for 24 h, the resulting product is ground and sieved through a 200-mesh sieve to obtain the second mixture. The mass ratio of sodium polyglutamate, xylitol and deionized water is 1:0.6:18.

[0035] S3: Mixing process, the first mixture and the second mixture are mixed to obtain other additives;

[0036] The mixing process is as follows: the first mixture and the second mixture are stirred at 200 rpm for 30 minutes at 25°C to complete the mixing process and obtain other additives;

[0037] Preparation of finished product: Weigh each raw material as needed and add it to the mixer. Set the mixer to 400 rpm and stir for 20 minutes. Then, homogenize the product at 5000 rpm for 5 minutes and then perform vacuum degassing to obtain the water-based lubricant.

[0038] Example 2:

[0039] Raw material preparation: 4.5% glycerol, 1.2% hydroxymethyl cellulose, 0.7% polyquaternium-51, 0.07% disodium ethylenediaminetetraacetate, 0.25% phenoxyethanol, 1.2% other additives, with the balance supplemented by deionized water to 100%;

[0040] Preparation of other additives:

[0041] S1: Preparation of the first mixture, the raw materials of the first mixture include carbomer, deionized water, anhydrous ethanol, sodium hydroxide solution, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride;

[0042] The method for preparing the first mixture is as follows: Carbomer is dispersed in a mixture of deionized water and anhydrous ethanol. Under ice-water bath conditions, 1M sodium hydroxide solution is added dropwise to adjust the pH to 5.5, resulting in a first premix. 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added sequentially to the first premix. After mixing, the mixture is allowed to stand at room temperature for 27 minutes to obtain a second premix. A treatment solution is added dropwise to the second premix, and the mixture is stirred and reacted for 11 hours under 40°C water bath conditions. The resulting product is then converted to... The product was transferred to a 3500 Da dialysis bag and dialyzed with deionized water for 3 days, with the water changed 4 times a day. The obtained product was freeze-dried to obtain a powder material. The powder material was dissolved in deionized water, N-vinylpyrrolidone was added, and the mixture was bubbled with nitrogen for 22 minutes. Then, azobisisobutyramidine hydrochloride was added, and the mixture was heated to 60°C under a nitrogen atmosphere and stirred for 5 hours. The obtained product was transferred to an 8000 Da dialysis bag and dialyzed with deionized water for 4 days, with the water changed 4 times a day. The obtained product was freeze-dried to obtain the first mixture.

[0043] The mass ratio of carbomer, deionized water, and anhydrous ethanol is 5:140:50; the mass ratio of the first premix, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide is 100:0.9:0.7; the mass of the treatment solution is 7% of the mass of the second premix; the mass ratio of powder material, deionized water, N-vinylpyrrolidone, and azobisisobutyramidine hydrochloride is 5:90:4:0.3; and carbomer 974P is selected.

[0044] The treatment solution was prepared by mixing 3-aminopropyltrimethoxysilane and anhydrous ethanol, with a mass ratio of 1:5.2 between the two.

[0045] S2: Preparation of the second mixture, the raw materials of the second mixture include sodium polyglutamate, xylitol and deionized water, and the mass of the second mixture is 30% of the mass of the first mixture;

[0046] The second mixture is prepared as follows: sodium polyglutamate and xylitol are dissolved in deionized water at 62°C, stirred at 400 rpm for 25 min, the resulting product is frozen at -50°C for 7 h, then freeze-dried for 30 h, the resulting product is ground and sieved through a 200-mesh sieve to obtain the second mixture. The mass ratio of sodium polyglutamate, xylitol and deionized water is 1:0.7:19.

[0047] S3: Mixing process, the first mixture and the second mixture are mixed to obtain other additives;

[0048] The mixing process is as follows: the first mixture and the second mixture are stirred at 300 rpm for 35 minutes at 27°C to complete the mixing process and obtain other additives;

[0049] Preparation of finished product: Weigh each raw material as needed and add it to the mixer. Set the mixer to 500 rpm and stir for 25 minutes. Then, homogenize the product at 5500 rpm for 7 minutes and then perform vacuum degassing to obtain the water-based lubricant.

[0050] Example 3:

[0051] Raw material preparation: 6% glycerin, 1.5% hydroxymethyl cellulose, 1% polyquaternium-51, 0.1% disodium EDTA, 0.3% phenoxyethanol, 1.5% other additives, with the balance supplemented by deionized water to 100%;

[0052] Preparation of other additives:

[0053] S1: Preparation of the first mixture, the raw materials of the first mixture include carbomer, deionized water, anhydrous ethanol, sodium hydroxide solution, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride;

[0054] The method for preparing the first mixture is as follows: Carbomer is dispersed in a mixture of deionized water and anhydrous ethanol. Under ice-water bath conditions, 1M sodium hydroxide solution is added dropwise to adjust the pH to 6.0, resulting in a first premix. 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added sequentially to the first premix. After mixing, the mixture is allowed to stand at room temperature for 30 minutes to obtain a second premix. A treatment solution is added dropwise to the second premix, and the mixture is stirred and reacted for 12 hours under 40°C water bath conditions. The resulting product is then converted to... The product was transferred to a 3500 Da dialysis bag and dialyzed with deionized water for 3 days, with the water changed 5 times a day. The obtained product was freeze-dried to obtain a powder material. The powder material was dissolved in deionized water, N-vinylpyrrolidone was added, and the mixture was bubbled with nitrogen for 25 minutes. Then, azobisisobutyramidine hydrochloride was added, and the mixture was heated to 62°C under a nitrogen atmosphere and stirred for 6 hours. The obtained product was transferred to an 8000 Da dialysis bag and dialyzed with deionized water for 4 days, with the water changed 5 times a day. The obtained product was freeze-dried to obtain the first mixture.

[0055] The mass ratio of carbomer, deionized water, and anhydrous ethanol is 5:150:55; the mass ratio of the first premix, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and N-hydroxysuccinimide is 100:1:0.8; the mass of the treatment solution is 8% of the mass of the second premix; the mass ratio of powder material, deionized water, N-vinylpyrrolidone, and azobisisobutyramidine hydrochloride is 5:100:5:0.4; and carbomer 974P is selected.

[0056] The treatment solution was prepared by mixing 3-aminopropyltrimethoxysilane and anhydrous ethanol, with a mass ratio of 1:5.5 between the two.

[0057] S2: Preparation of the second mixture, the raw materials of the second mixture include sodium polyglutamate, xylitol and deionized water, and the mass of the second mixture is 35% of the mass of the first mixture;

[0058] The second mixture is prepared as follows: Sodium polyglutamate and xylitol are dissolved in deionized water at 65°C, stirred at 500 rpm for 30 min, the resulting product is frozen at -50°C for 8 h, then freeze-dried for 36 h, the resulting product is ground and sieved through a 200-mesh sieve to obtain the second mixture. The mass ratio of sodium polyglutamate, xylitol and deionized water is 1:0.8:20.

[0059] S3: Mixing process, the first mixture and the second mixture are mixed to obtain other additives;

[0060] The mixing process is as follows: the first mixture and the second mixture are stirred at 400 rpm for 40 minutes at a temperature of 30°C to complete the mixing process and obtain other additives;

[0061] Preparation of finished product: Weigh each raw material as needed and add it to the mixer. Set the mixer to 600 rpm and stir for 30 minutes. Then, homogenize the product at 6000 rpm for 10 minutes and then perform vacuum degassing to obtain the water-based lubricant.

[0062] Comparative Example 1: The difference between this comparative example and Example 1 is that this comparative example does not contain a second mixture.

[0063] Comparative Example 2 differs from Example 1 in that it does not contain the first mixture.

[0064] Comparative Example 3: The difference between this comparative example and Example 1 is that this comparative example does not contain any other additives.

[0065] Performance testing: The water-based lubricants prepared in Examples 1-3 and Comparative Examples 1-3 were subjected to performance testing, and the test data are recorded in the table below:

[0066] Table 1

[0067]

[0068] In the performance test, the test method for the relative friction coefficient is as follows: referring to the test method in ASTM D5183-2005 (2011), the water-based lubricant of each embodiment and comparative example is used instead of lubricating oil as the sample, and the friction coefficient is tested. Then, the ratio between the friction coefficient of each embodiment and comparative example and the friction coefficient of comparative example 3 is calculated, and this ratio is recorded as the relative friction coefficient. The lower the relative friction coefficient, the better the lubrication performance of the water-based lubricant.

[0069] The method for testing the moisturizing rate is as follows: Take 0.2g of the water-based lubricant from each example and comparative example, apply it to a 7.5cm×7.5cm glass plate covered with 3M tape, place it in a desiccator containing a saturated potassium acetate solution, with a relative humidity of 62% inside the desiccator, and weigh it after 4 hours. Calculate the moisturizing rate. The formula for calculating the moisturizing rate is: Moisturizing rate % = m2 / m1 × 100%, where m1 is the water content of the sample before placement, and m2 is the water content of the sample after placement. The higher the moisturizing rate, the better the moisturizing performance of the water-based lubricant.

[0070] It is evident that the lubrication and moisturizing properties of the water-based lubricants prepared in Comparative Examples 1-3 are lower than those in Examples 1-3. This indicates that glycerol is used as the main lubricating and moisturizing component in the preparation of water-based lubricants, reducing the surface tension of water and increasing the spreadability and slipperiness of the lubricant. In other additives, carbomer is treated with 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to activate its carboxyl group, which then undergoes an amidation reaction with the amino group of 3-aminopropyltrimethoxysilane, grafting the silane coupling agent onto the carbomer chain. Subsequently, it copolymerizes with N-vinylpyrrolidone under the action of azobisisobutyramidine hydrochloride, introducing... Polyvinylpyrrolidone segments effectively enhance the hydrophilicity and hydration capacity of the material, allowing the lubricating layer to adhere strongly to the substrate and be difficult to wipe off, thereby improving the lubrication performance of water-based lubricants. Sodium polyglutamate, as an anionic natural biopolymer, has good moisturizing ability. It locks in moisture by forming strong hydrogen bonds between multiple carboxylate ions and water molecules. Combined with the hygroscopic properties of xylitol, the moisturizing effect is further enhanced. After the first and second mixtures are mixed, a stable hydrophilic moisturizing structure can be formed, effectively integrating sodium polyglutamate and xylitol into a macromolecular backbone that can firmly adhere to the substrate, further improving the lubrication and moisturizing performance of water-based lubricants.

[0071] By comparing and analyzing the relevant data in the table, it can be seen that the water-based lubricant prepared by this invention not only has good lubrication performance, but also excellent moisturizing performance.

[0072] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0073] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A water-based lubricant, characterized in that: The product comprises the following raw materials: deionized water, glycerin, hydroxymethyl cellulose, polyquaternium-51, disodium EDTA, phenoxyethanol, and other additives. The weight percentages of each raw material are: 3-6% glycerin, 0.8-1.5% hydroxymethyl cellulose, 0.5-1% polyquaternium-51, 0.05-0.1% disodium EDTA, 0.2-0.3% phenoxyethanol, and 1-1.5% other additives, with the balance made up to 100% by deionized water. The other additives are prepared by the following method: S1: Preparation of the first mixture, the raw materials of the first mixture include carbomer, deionized water, anhydrous ethanol, sodium hydroxide solution, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, N-hydroxysuccinimide, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride; The method for preparing the first mixture is as follows: Carbomer is dispersed in a mixture of deionized water and anhydrous ethanol. Under ice-water bath conditions, 1M sodium hydroxide solution is added dropwise to adjust the pH value to 5.5-6.0 to obtain a first premix. 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide are added sequentially to the first premix. After mixing, the mixture is allowed to stand at room temperature for 25-30 minutes to obtain a second premix. The treatment solution is added dropwise to the second premix, and the mixture is stirred and reacted for 10-12 hours under water bath conditions at 40°C. The resulting product is then converted to... The product was transferred to a 3500Da dialysis bag and dialyzed with deionized water for 3 days, with the water changed 3-5 times a day. The obtained product was freeze-dried to obtain a powder. The powder was dissolved in deionized water, N-vinylpyrrolidone was added, and the mixture was bubbled with nitrogen for 20-25 minutes. Then, azobisisobutyramidine hydrochloride was added, and the mixture was heated to 58-62℃ under a nitrogen atmosphere and stirred for 4-6 hours. The obtained product was transferred to an 8000Da dialysis bag and dialyzed with deionized water for 4 days, with the water changed 3-5 times a day. The obtained product was freeze-dried to obtain the first mixture. The treatment solution was prepared by mixing 3-aminopropyltrimethoxysilane and anhydrous ethanol; S2: Preparation of the second mixture, the raw materials of the second mixture include sodium polyglutamate, xylitol and deionized water, and the mass of the second mixture is 25-35% of the mass of the first mixture; S3: Mixing process, the first mixture and the second mixture are mixed to obtain other additives.

2. The water-based lubricant according to claim 1, characterized in that, The mass ratio of carbomer, deionized water and anhydrous ethanol is 5:(130-150):(45-55). The mass ratio of the first premix, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide is 100:(0.8-1):(0.6-0.8). The mass of the treatment solution is 6-8% of the mass of the second premix. The mass ratio of powder material, deionized water, N-vinylpyrrolidone and azobisisobutyramidine hydrochloride is 5:(80-100):(3-5):(0.25-0.4). Carbomer 974P is selected.

3. The water-based lubricant according to claim 1, characterized in that, The mass ratio of 3-aminopropyltrimethoxysilane to anhydrous ethanol is 1:(5-5.5).

4. The water-based lubricant according to claim 1, characterized in that, The second mixture is prepared by dissolving sodium polyglutamate and xylitol in deionized water at 60-65℃, stirring at 300-500 rpm for 20-30 minutes, freezing the resulting product at -50℃ for 6-8 hours, then freeze-drying for 24-36 hours, grinding the resulting product and sieving it through a 200-mesh sieve to obtain the second mixture.

5. The water-based lubricant according to claim 4, characterized in that, The mass ratio of sodium polyglutamate, xylitol and deionized water is 1:(0.6-0.8):(18-20).

6. The water-based lubricant according to claim 1, characterized in that, The mixing process is as follows: the first mixture and the second mixture are stirred at 200-400 rpm for 30-40 minutes at a temperature of 25-30℃ to complete the mixing process and obtain other additives.

7. The method for preparing the water-based lubricant according to any one of claims 1-6, characterized in that, The process includes the following steps: Weigh each raw material as needed and add it to a mixer, set the mixer speed to 400-600 rpm and stir for 20-30 minutes, then homogenize the resulting product at 5000-6000 rpm for 5-10 minutes, and finally perform vacuum degassing to obtain a water-based lubricant.

8. The application of the water-based lubricant prepared according to the method of claim 7 in polyurethane condoms, characterized in that, The water-based lubricant was applied to the surface of the polyurethane condom by quantitative atomization spraying, with a coating amount of 400mg.

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