Carbamate-containing polyamine poly-ester bond cationic lipids, compositions comprising the same, and uses
By using a combination of cationic lipids containing carbamate structures and polyester bonds with neutral lipids and polymer-conjugated lipids, the safety and targeting deficiencies of lipid nanoparticles in delivering bioactive substances have been addressed, achieving efficient and safe drug delivery.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
- Filing Date
- 2026-05-20
- Publication Date
- 2026-06-19
AI Technical Summary
Existing lipid nanoparticles (LNPs) have safety and targeting issues when delivering bioactive substances, especially in nucleic acid delivery where they are prone to off-target accumulation. Furthermore, the increased complexity of their production may lead to toxicity, limiting their clinical applications.
A composition is formed by combining cationic lipids containing carbamate structures and polyester bonds with neutral lipids and polymer conjugated lipids to improve transfection efficiency and targeting, reduce cytotoxicity, and optimize drug delivery safety.
This approach achieves drug delivery with high transfection efficiency and low cytotoxicity, improves spleen targeting and in vivo delivery efficiency, and reduces the toxicity of lipid nanoparticles.
Smart Images
Figure CN122234006A_ABST