A nanobody against rabbit hemorrhagic disease virus type 2 and application thereof

CN122234192APending Publication Date: 2026-06-19JIANGSU ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGSU ACAD OF AGRI SCI
Filing Date
2026-04-02
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively prevent and treat rabbit hemorrhagic disease virus type 2, and there is a lack of effective treatments and vaccines, resulting in a high mortality rate.

Method used

A nanobody Nb783G against rabbit hemorrhagic disease virus type 2 was developed. By constructing a nanobody containing a specific CDR3 amino acid sequence, it can specifically recognize and neutralize the VP60 protein of rabbit hemorrhagic disease virus type 2. A nanobody library was constructed using phage display technology and recombinantly expressed. Highly efficient nanobodies were screened for prevention and treatment.

Benefits of technology

The nanobody Nb783G exhibits good neutralizing activity and can effectively prevent and treat rabbit hemorrhagic disease virus type 2, showing potential as a rapid diagnostic and emergency treatment agent.

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Abstract

This invention provides a nanobody against rabbit hemorrhagic virus type 2 (RHBV2) and its applications, belonging to the field of biomedical technology. The invention provides a nanobody against RHBV2, wherein the complementarity-determining region (CDR) of the nanobody includes CDR3; the amino acid sequence of CDR3 is shown in SEQ ID NO. 3. This invention constructs a neutralizing nanobody Nb783G against RHBV2 using molecular biology methods, and experiments demonstrate that Nb783G can specifically recognize the RHBV2 VP60 protein, exhibiting good neutralizing activity against RHBV2 and showing potential for application in the prevention and treatment of RHBV2.
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