Ston2 gene related to proliferation of ovine ovarian granulosa cells and application thereof

CN122235153APending Publication Date: 2026-06-19YANGZHOU UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANGZHOU UNIV
Filing Date
2026-03-20
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing research has not fully explored new regulatory factors in the proliferation regulation mechanism of sheep ovarian granulosa cells, resulting in limited improvement in sheep reproductive performance.

Method used

By overexpressing or inhibiting the STON2 gene and utilizing its positive regulatory effect in sheep ovarian granulosa cells, a recombinant vector and siRNA interference reagent were constructed to regulate the proliferation of sheep ovarian granulosa cells and affect their reproductive performance.

Benefits of technology

It can significantly promote or inhibit the proliferation of sheep ovarian granulosa cells, regulate follicle development and ovulation rate, improve the multiparity and number of lambs born, provide molecular breeding and in vivo targeted intervention methods, and enhance sheep reproductive performance.

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Abstract

This invention discloses a STON2 gene associated with the proliferation of sheep ovarian granulosa cells, the nucleotide sequence of which is shown in SEQ ID NO.1. The STON2 gene regulates the proliferation of sheep ovarian granulosa cells. This invention investigated the effects of STON2 gene overexpression and inhibition on sheep ovarian granulosa cell proliferation. The results showed that STON2 gene overexpression significantly promoted sheep ovarian granulosa cell proliferation, while significant inhibition of STON2 gene expression inhibited sheep ovarian granulosa cell proliferation. Therefore, the STON2 gene can serve as a regulatory element for sheep myoblasts, providing a new approach for sheep molecular breeding.
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