A vacuum filtration degassing device and method for mobile phase preparation

Abstract

The application belongs to the field of filtration degassing devices, and particularly relates to a vacuum filtration degassing device and method for mobile phase preparation. The device comprises a bottom container, a filter tank, a filter membrane assembly, at least two groups of filter membrane roller devices arranged on a support fixed to the output end of a second lifting device, and a filter membrane mechanism comprising a filter membrane roller and a winding roller. The filter membrane is drawn from the filter membrane roller and wound on the winding roller, and an open filter membrane section is formed between the filter membrane roller and the winding roller. The device is provided with multiple groups of transversely switchable filter membrane roller devices, and two-stage lifting devices are sequentially actuated to clamp the filter membrane section between the filter tank outlet and a filter membrane support plate, so that the winding and unwinding of the same type of filter membrane is continuously updated, and the automatic switching of different types of filter membranes is realized, thereby achieving the automatic continuous filtration degassing of multiple mobile phases.

Description

Technical Field

[0001] This invention belongs to the field of vacuum filtration and degassing devices, specifically relating to a vacuum filtration and degassing device and method for preparing a mobile phase. Background Technology

[0002] In the preparation of mobile phase reagents in pharmaceutical research and development, chemical production, and laboratories, vacuum filtration and degassing are crucial steps. Traditional vacuum filtration and degassing devices mainly consist of a Buchner funnel, a filtration flask, and a vacuum pump, along with a filter membrane clamping device. During operation, filter membranes with different pore sizes must be manually replaced according to the mobile phase formulation to meet different filtration precision requirements. Safety bottles or buffer bottles are also installed in the vacuum pipeline, employing a "short inlet, long outlet" connection rule to achieve basic passive anti-backflow protection. In recent years, some improved solutions have emerged in the industry, such as continuous vacuum filtration devices that use multiple switchable filter membranes to achieve filter membrane replacement without stopping the system. However, these are mainly geared towards continuous sample injection scenarios and have limited adaptability to batch-type mobile phase preparation needs.

[0003] However, existing filtration and degassing devices still generally suffer from the following technical problems: First, the degree of automation is insufficient. Filter membrane replacement relies on manual operation, which requires stopping the machine to disassemble, clean, and reinstall the filter membrane. The process is time-consuming and labor-intensive. At the same time, continuous monitoring by personnel is required during the filtration process. Second, the utilization rate of filter membranes is low and the integration is not high. Manual replacement of filter membranes often results in the disposal of some underutilized filter membranes, which increases the cost of consumables. In addition, the components such as filtration, degassing, and filter membrane storage are scattered, occupying a lot of space and being cumbersome to operate.

[0004] Therefore, there is an urgent need in this field for a vacuum filtration and degassing device for mobile phase preparation that can achieve automatic switching and continuous use of filter membranes and has a high degree of structural integration, in order to meet the needs of efficient, automated and continuous production of multiple varieties and batches of mobile phases. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a vacuum filtration and degassing device and method for preparing mobile phase. By setting up multiple sets of horizontally switchable filter membrane roller devices, and cooperating with two-stage lifting devices to clamp the filter membrane section between the filter tank outlet and the filter membrane support plate in sequence, the continuous winding and unwinding of the same type of filter membrane and the automatic switching of different types of filter membranes are realized, thereby completing the automated continuous filtration and degassing of multiple mobile phases.

[0006] This invention provides a vacuum filtration and degassing apparatus for mobile phase preparation, comprising: A bottom container with a filter membrane support plate on top, and the bottom container is connected to a vacuum device; A filter tank for containing liquid to be filtered and having an outlet, the filter tank being mounted on a first lifting device and driven by the first lifting device to move closer to or away from the bottom container; A filter membrane assembly includes a second lifting device, a bracket fixed to the output end of the second lifting device, and at least two sets of filter membrane roller assemblies disposed on the bracket; each set of filter membrane roller assemblies includes a lateral moving mechanism and a filter membrane mechanism mounted on the lateral moving mechanism, the lateral moving mechanism being used to drive the filter membrane mechanism to move between an extended position and a retracted position; the filter membrane mechanism includes a filter membrane roller and a take-up roller, the filter membrane being drawn out from the filter membrane roller and wound onto the take-up roller, and an open filter membrane segment being formed between the filter membrane roller and the take-up roller; In the extended position, the filter membrane segment is located above the filter membrane support plate; the second lifting device is used to drive the bracket to lift and lower, so that the filter membrane segment of the filter membrane mechanism in the extended position presses against the filter membrane support plate or moves away from the filter membrane support plate; the first lifting device is used to drive the filter canister to descend, so that the outlet of the filter canister presses the filter membrane segment against the filter membrane support plate. During filtration, one of the lateral moving mechanisms drives the corresponding filter membrane mechanism to the extended position, and the second lifting device and the first lifting device operate sequentially to clamp the filter membrane segment. The vacuum device operates to perform filtration. When replacing the same type of filter membrane, the take-up roller and the filter membrane roller rotate synchronously to move the new filter membrane segment to the working position. When replacing a different type of filter membrane, the current filter membrane mechanism retracts to the retracted position, and another lateral moving mechanism drives the corresponding other filter membrane mechanism to switch to the extended position.

[0007] Furthermore, a one-way valve is provided at the outlet of the filter tank. The one-way valve is configured to open under negative pressure during vacuum filtration, allowing the liquid in the filter tank to flow normally to the bottom container, and to automatically close after the vacuum is turned off to prevent backflow.

[0008] Furthermore, the filter membrane mechanism also includes two guide rollers disposed between the filter membrane roller and the take-up roller, the filter membrane being tensioned by the two guide rollers, and the open filter membrane segment being formed between the two guide rollers.

[0009] Furthermore, the first lifting device includes a column and a guide rail assembly arranged longitudinally along the column, and the filter canister is slidably mounted on the column via the guide rail assembly; the first lifting device also includes an elastic element and a linear movement mechanism, the elastic element acts on the filter canister, causing it to tend to move away from the bottom container, and the linear movement mechanism is arranged on the column to drive the filter canister to move towards the bottom container against the force of the elastic element.

[0010] Furthermore, the output end of the linear motion mechanism is provided with a buffer pad, which is used to elastically press the filter membrane segment when the filter can moves toward the bottom container.

[0011] Furthermore, the filter membrane support plate is provided with a limiting ring, which is located outside the channel of the filter membrane support plate; the bottom of the outlet of the filter can is provided with a limiting engagement ring that cooperates with the limiting ring; when the filter can descends and presses the filter membrane segment onto the filter membrane support plate, the limiting ring and the limiting engagement ring engage with each other and fix the filter membrane segment.

[0012] Furthermore, the bottom container includes a small diameter section, a first large diameter section, and a first conical constriction section arranged sequentially from top to bottom. The filter membrane support plate is disposed on the end face of the small diameter section. A funnel is provided inside the small diameter section, and the outlet of the funnel extends into the first large diameter section. An openable and closable discharge port is provided at the bottom of the first conical constriction section. The filter tank includes a second large-diameter section and a second conical constriction section arranged in sequence. The outlet of the second conical constriction section of the filter tank corresponds to the small-diameter section of the bottom container. The top plate of the second large-diameter section is provided with a liquid inlet and a spray head. The spray head is used to clean the device after the filter membrane section is removed, and the spray head is configured to sequentially spray the second large-diameter section, the second conical converging section, the funnel, and converge to the first conical converging section.

[0013] Furthermore, the filter membrane mechanism also includes a tension control mechanism, which includes a magnetic powder brake or a tension sensor for real-time monitoring and adjustment of the tension of the filter membrane segment during the retraction and extension process.

[0014] Furthermore, the filter membrane assembly also includes a filter membrane positioning system, which includes a photoelectric sensor or a visual recognition system for detecting the position and status of the filter membrane segment, ensuring that the filter membrane segment is accurately positioned above the filter membrane support plate.

[0015] The present invention also provides a vacuum filtration and degassing method for mobile phase preparation, which uses the above-mentioned vacuum filtration and degassing apparatus for mobile phase preparation and includes the following steps: S1. The lateral moving mechanism drives the corresponding filter membrane mechanism to move to the extended position, so that the filter membrane segment is located above the filter membrane support plate; S2. The second lifting device drives the bracket to descend, so that the filter membrane section of the filter membrane mechanism in the extended position presses against the filter membrane support plate; S3. The first lifting device drives the filter canister to descend, so that the outlet of the filter canister presses the filter membrane section against the filter membrane support plate, thus completing the preparation work; S4. Inject the liquid to be filtered into the filter tank, start the vacuum device to perform filtration, and let the filtrate enter the bottom container after being filtered through the filter membrane section. S5. After filtration is completed, the vacuum device is turned off, the first lifting device drives the filter tank to rise and reset, and the second lifting device drives the support to rise and reset. S6. When it is necessary to replace the same type of filter membrane, the take-up roller and the filter membrane roller rotate synchronously to move the new filter membrane segment to the working position; when it is necessary to replace the filter membrane of a different type, the current filter membrane mechanism retracts to the retracted position, and another lateral movement mechanism drives the corresponding other filter membrane mechanism to switch to the extended position, repeating steps S2 to S5.

[0016] The beneficial effects of this invention are: The vacuum filtration and degassing apparatus for mobile phase preparation provided by this invention integrates at least two sets of filter membrane rollers into a filter membrane assembly. Combined with a lateral movement mechanism, it automatically switches between extended and retracted positions for filter membranes of different specifications. This eliminates the need for manual operation when changing different types of filter membranes, significantly improving filter membrane switching efficiency. When processing liquids with different formulations, the apparatus can be pre-loaded with filter membranes of corresponding pore sizes. The control system automatically calls the appropriate filter membrane mechanism to the working position, thereby achieving automated continuous filtration of various liquids without manual intervention, significantly improving the production efficiency of multi-batch, multi-variety mobile phase preparation.

[0017] When replacing the same type of filter membrane, the new membrane segment only needs to be moved to the working position by the synchronous rotation of the take-up roller and the filter membrane roller. This enables continuous use of the filter membrane and avoids the waste caused by the manual replacement of the entire filter membrane in traditional methods, which results in the filter membrane being discarded before it is fully used. This effectively improves the utilization rate of a single roll of filter membrane and reduces consumable costs. After one filtration cycle, if the filter membrane segment becomes clogged due to the trapping of solid particles, causing a decrease in filtration efficiency, the take-up roller can automatically rewind the used filter membrane segment, while the filter membrane roller releases a new filter membrane segment, restoring the filtration performance to its initial state. The entire process does not require machine downtime, ensuring the continuity of the filtration operation.

[0018] When changing to different types of filter membranes, the currently working filter membrane mechanism is driven to retract to the retracted position by the lateral moving mechanism, while another filter membrane mechanism loaded with filter membranes of different pore sizes is pushed out to the extended position by the corresponding lateral moving mechanism. The switching process is automatically completed by the control system, which greatly shortens the switching time and avoids the cumbersome operation of disassembling, cleaning, and reinstalling filter membranes that traditional equipment requires to stop the machine, thus meeting the production needs of frequent switching of multiple mobile phases.

[0019] The filter membrane section is clamped between the filter canister outlet and the filter membrane support plate by the sequential action of the first and second lifting devices, ensuring reliable sealing during the filtration process. This clamping method utilizes a two-stage lifting mechanism: first, the second lifting device pre-presses the filter membrane section onto the filter membrane support plate for positioning; then, the first lifting device drives the filter canister downwards to achieve a final seal. This ensures that all liquid to be filtered in the filter canister is filtered by the filter membrane section before entering the bottom container, preventing side leakage and guaranteeing filtration accuracy and product quality. The system is compact, easy to operate, and suitable for automated continuous filtration of various mobile phase formulations. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 This is a schematic diagram of a partial structure in this invention; Figure 3 This is a frontal sectional view of a partial structure in this invention; Figure 4 This is a schematic diagram of the filter membrane assembly in this invention; Figure 5 This is a schematic diagram of the filter membrane roller device in this invention.

[0021] In the diagram, 1-bottom container; 11-filter membrane support plate; 111-limiting ring; 12-small diameter section; 13-first large diameter section; 14-first conical contraction section; 15-funnel; 16-discharge port; 2-vacuum device; 3-filter tank; 31-outlet; 311-limiting fitting ring; 32-one-way valve; 33-second large diameter section; 34-second conical contraction section; 35-top plate; 36-liquid inlet; 37-spray head; 4-first lifting device; 41-column; 42-guide rail assembly; 43-linear movement mechanism; 431-buffer pad; 5-filter membrane assembly; 51-second lifting device; 52-support; 53-filter membrane roller assembly; 531-lateral movement mechanism; 532-filter membrane mechanism; 5321-filter membrane roller; 5322-winding roller; 5323-guide roller. Detailed Implementation

[0022] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0023] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indication will also change accordingly.

[0024] Furthermore, in this invention, descriptions involving "first," "second," etc., are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0025] In this invention, unless otherwise explicitly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "fixed" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection, an electrical connection, a physical connection, or a wireless communication connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two elements or the interaction between two elements, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0026] Furthermore, the technical solutions of the various embodiments of the present invention can be combined with each other, but only if they are feasible for those skilled in the art. If the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by the present invention.

[0027] like Figures 1-5 As shown, the present invention provides a vacuum filtration and degassing device for mobile phase preparation, comprising a bottom container 1, a filter tank 3, a filter membrane assembly 5, and a vacuum device 2.

[0028] The bottom container 1 is equipped with a filter membrane support plate 11 at its top. The filter membrane support plate 11 is a flat plate structure, and its upper surface is used to support the filter membrane section. The bottom container 1 is connected to a vacuum device 2, which is connected to the internal space of the bottom container 1 through a pipeline. The vacuum device 2 is used to create a vacuum inside the bottom container 1 during filtration, forming a negative pressure environment.

[0029] The filter tank 3 is used to contain the liquid to be filtered, and the bottom of the filter tank 3 has an outlet 31. The filter tank 3 is mounted on the first lifting device 4 and is driven by the first lifting device 4 to move closer to or further away from the bottom container 1. The first lifting device 4 drives the filter tank 3 to move up and down in the vertical direction. When the filter tank 3 descends to the working position, its outlet 31 is directly opposite the filter membrane support plate 11 on the top of the bottom container 1; when the filter tank 3 rises to reset, the outlet 31 moves away from the filter membrane support plate 11 to facilitate the filter membrane switching operation of the filter membrane assembly 5.

[0030] The filter membrane assembly 5 includes a second lifting device 51, a support 52, and at least two sets of filter membrane roller assemblies 53. The support 52 is fixed to the output end of the second lifting device 51, which can drive the support 52 to lift as a whole. At least two sets of filter membrane roller assemblies 53 are mounted on the support 52, and multiple sets of filter membrane roller assemblies 53 can be loaded with filter membranes of different pore sizes to meet different filtration accuracy requirements.

[0031] Each filter membrane roller assembly 53 includes a lateral moving mechanism 531 and a filter membrane mechanism 532, with the filter membrane mechanism 532 mounted on the lateral moving mechanism 531. The lateral moving mechanism 531 drives the filter membrane mechanism 532 to move between an extended position and a retracted position. When a filter membrane mechanism 532 needs to be put into operation, its corresponding lateral moving mechanism 531 pushes the filter membrane mechanism 532 to the extended position, positioning its filter membrane section directly above the filter membrane support plate 11; when the filter membrane mechanism 532 needs to be withdrawn from operation, the lateral moving mechanism 531 pulls it back to the retracted position to avoid interference with other filter membrane mechanisms 532 that are currently in operation.

[0032] The membrane filtration mechanism 532 includes a membrane unwinding roller 5321 and a winding roller 5322. The membrane is drawn from the membrane unwinding roller 5321 and wound onto the winding roller 5322, forming an open membrane section between the membrane unwinding roller 5321 and the winding roller 5322. The membrane unwinding roller 5321 is an unwinding roller on which unused membrane is wound; the winding roller 5322 is a winding roller used to collect used membrane. The membrane section is horizontally tensioned between the membrane unwinding roller 5321 and the winding roller 5322, and this membrane section is the actual working area involved in filtration.

[0033] In the extended position, the filter membrane segment is located above the filter membrane support plate 11. The second lifting device 51 drives the bracket 52 to rise and fall, so that the filter membrane segment of the filter membrane mechanism 532 in the extended position presses against or moves away from the filter membrane support plate 11. When it is time to prepare for filtration, the second lifting device 51 drives the bracket 52 to fall, causing the entire filter membrane mechanism 532 to move downward, so that the filter membrane segment is against the upper surface of the filter membrane support plate 11; when the filter membrane needs to be switched or replaced, the second lifting device 51 drives the bracket 52 to rise, so that the filter membrane segment moves away from the filter membrane support plate 11, making room for the operation of the lateral movement mechanism 531.

[0034] The first lifting device 4 drives the filter tank 3 to descend, causing the outlet 31 of the filter tank 3 to press the filter membrane section tightly against the filter membrane support plate 11. With the filter membrane section already pressed against the filter membrane support plate 11 by the second lifting device 51, the first lifting device 4 further drives the filter tank 3 downwards, pressing the edge of the outlet 31 of the filter tank 3 tightly against the filter membrane support plate 11. This achieves a sealed connection between the outlet 31 of the filter tank 3 and the bottom container 1, ensuring that the liquid to be filtered can only enter the bottom container 1 after being filtered by the filter membrane section, preventing liquid leakage from the bypass.

[0035] During operation, before filtration, a lateral moving mechanism 531 drives the corresponding filter membrane mechanism 532 to the extended position, aligning the filter membrane segment of the filter membrane mechanism 532 with the filter membrane support plate 11. Subsequently, the second lifting device 51 and the first lifting device 4 operate sequentially. The second lifting device 51 first drives the bracket 52 to descend, pressing the filter membrane segment against the filter membrane support plate 11. Then, the first lifting device 4 drives the filter tank 3 to descend, pressing the outlet 31 against the filter membrane segment, completing the clamping of the filter membrane segment. Then, the vacuum device 2 operates, drawing a vacuum inside the bottom container 1, creating a pressure difference between the filter tank 3 and the bottom container 1. Under the action of the pressure difference, the liquid to be filtered in the filter tank 3 passes through the filter membrane segment and enters the bottom container 1, completing the filtration.

[0036] When it is necessary to replace the filter membrane of the same type, the take-up roller 5322 and the filter membrane roller 5321 rotate synchronously to move the new filter membrane segment to the working position. Specifically, the take-up roller 5322 actively rotates to take up the used filter membrane segment, while the filter membrane roller 5321 rotates to release the new filter membrane until the unused filter membrane segment moves above the filter membrane support plate 11, thereby achieving continuous replacement of the filter membrane without replacing the filter membrane roller device 53.

[0037] When it is necessary to replace different types of filter membranes, the current filter membrane mechanism 532 is driven back to the retracted position by the corresponding lateral moving mechanism 531, and another lateral moving mechanism 531 pushes another set of filter membrane mechanisms 532 loaded with filter membranes of different pore sizes to the extended position. Then the above clamping and filtration process is repeated, thereby realizing automatic switching between filter membranes of different specifications without stopping the machine for manual replacement.

[0038] The vacuum filtration and degassing apparatus for mobile phase preparation provided in this embodiment integrates at least two sets of filter membrane roller devices 53 into a filter membrane assembly 5. This, along with a lateral movement mechanism 531, enables automatic switching between extended and retracted positions of filter membrane mechanisms 532 of different specifications. This eliminates the need for manual operation when changing different types of filter membranes, significantly improving filter membrane switching efficiency. When processing liquids with different formulations, the apparatus can pre-load filter membranes with corresponding pore sizes. The control system automatically calls the appropriate filter membrane mechanism 532 to the working position, thereby achieving automated continuous filtration of various liquids without manual intervention, significantly improving the production efficiency of multi-batch, multi-variety mobile phase preparation.

[0039] When replacing the same type of filter membrane, the new filter membrane segment can be moved to the working position simply by the synchronous rotation of the take-up roller 5322 and the filter membrane roller 5321. This enables continuous use of the filter membrane and avoids the waste caused by the manual replacement of the entire filter membrane in traditional methods, which results in the filter membrane being discarded before it is fully used. This effectively improves the utilization rate of a single roll of filter membrane and reduces consumable costs. After one filtration cycle, if the filter membrane segment becomes clogged due to the trapping of solid particles, causing a decrease in filtration efficiency, the take-up roller 5322 can automatically rewind the used filter membrane segment, while the filter membrane roller 5321 releases a new filter membrane segment, restoring the filtration performance to its initial state. The entire process does not require machine downtime, ensuring the continuity of the filtration operation.

[0040] When changing to different types of filter membranes, the currently working filter membrane mechanism 532 is driven back to the retracted position by the lateral moving mechanism 531, while another set of filter membrane mechanisms 532 loaded with filter membranes of different pore sizes is pushed out to the extended position by the corresponding lateral moving mechanism 531. The switching process is automatically completed by the control system, which greatly shortens the switching time and avoids the cumbersome operation of disassembling, cleaning and reinstalling filter membranes that traditional equipment requires to stop the machine, meet the production needs of frequent switching of multiple mobile phases.

[0041] Through the sequential action of the first lifting device 4 and the second lifting device 51, the filter membrane section is clamped between the outlet 31 of the filter tank 3 and the filter membrane support plate 11, ensuring reliable sealing during the filtration process. This clamping method utilizes a two-stage lifting mechanism: first, the second lifting device 51 pre-presses the filter membrane section onto the filter membrane support plate 11 for positioning; then, the first lifting device 4 drives the filter tank 3 downwards to achieve final sealing. This ensures that all the liquid to be filtered in the filter tank 3 is filtered by the filter membrane section before entering the bottom container 1, preventing side leakage and guaranteeing filtration accuracy and product quality. The structure is compact, the operation is simple, and it is suitable for automated continuous filtration of various mobile phase formulations.

[0042] In one embodiment, a one-way valve 32 is provided on the outlet 31 of the filter tank 3. The one-way valve 32 is configured to be opened under negative pressure during vacuum filtration, so that the liquid in the filter tank 3 flows normally to the bottom container 1, and is automatically closed after the vacuum is closed to prevent backflow.

[0043] Specifically, the one-way valve 32 is installed in the outlet 31 channel of the filter tank 3. It contains a valve core that can be opened in one direction. Under normal conditions, the valve core is kept closed by spring force or gravity. During vacuum filtration, the vacuum device 2 creates a negative pressure inside the bottom container 1. The valve core of the one-way valve 32 opens under the pressure difference between the filter tank 3 side and the bottom container 1 side, overcoming the spring force or gravity. The liquid to be filtered in the filter tank 3 enters the bottom container 1 through the one-way valve 32 and the filter membrane section. The liquid flows from top to bottom, and the one-way valve 32 is in a forward-biased state.

[0044] When the vacuum device 2 stops working, the negative pressure in the bottom container 1 disappears, and the pressure difference between the filter tank 3 and the bottom container 1 rapidly decreases or disappears. The valve core of the one-way valve 32 automatically closes under the action of the reset force, blocking the liquid flow path. At this time, even if reverse pressure fluctuations occur in the vacuum pipeline due to factors such as water pressure fluctuations, sudden water outages, or vacuum pump shutdowns, the one-way valve 32 can effectively prevent the liquid or gas in the bottom container 1 from flowing back into the filter tank 3, avoiding contamination of the filtered liquid and preventing backflow of liquid from damaging the vacuum device 2.

[0045] By adopting this one-way valve 32, the device does not need to be equipped with additional passive anti-backflow components such as safety bottles and buffer bottles in traditional solutions. While simplifying the system structure, it achieves the effect of preventing vacuum backflow from the source.

[0046] This embodiment utilizes a one-way valve 32 installed at the outlet 31 of the filter tank 3. The negative pressure environment during vacuum filtration allows for automatic opening and closing of the valve, replacing the passive anti-backflow method relying on safety bottles and buffer bottles found in traditional solutions. The one-way valve 32 automatically opens under negative pressure during filtration, without affecting the normal filtration flow of the liquid; it automatically closes when the vacuum is closed or the system pressure is abnormal, fundamentally blocking the liquid backflow path and effectively preventing backflow from contaminating the raw materials and damaging the vacuum device 2. This structure features high integration, rapid response, and requires no additional control intervention, improving the stability and safety of the device operation.

[0047] In one embodiment, the filter membrane mechanism 532 further includes two guide rollers 5323 disposed between the filter membrane roller 5321 and the winding roller 5322, the filter membrane being tensioned by the two guide rollers 5323, and the open filter membrane segment being formed between the two guide rollers 5323.

[0048] Specifically, two guide rollers 5323 are spaced apart between the filter membrane roller 5321 and the take-up roller 5322. After the filter membrane is released from the filter membrane roller 5321, it first passes under the first guide roller 5323, then extends horizontally and passes under the second guide roller 5323, and finally is wound up to the take-up roller 5322. The filter membrane section between the two guide rollers 5323 is horizontally open, and this horizontal section is the actual working area involved in filtration, directly opposite the filter membrane support plate 11 at the top of the bottom container 1.

[0049] The guide rollers 5323 ensure that the filter membrane section maintains a stable tension and flatness between the two guide rollers 5323, preventing the filter membrane from becoming loose, wrinkled, or shifted during winding and unwinding, and ensuring that the filter membrane section is accurately positioned directly above the filter membrane support plate 11. When the second lifting device 51 drives the bracket 52 to descend and press the filter membrane section against the filter membrane support plate 11, the tension provided by the two guide rollers 5323 makes the filter membrane section adhere flatly to the filter membrane support plate 11, ensuring the uniformity of the seal when the filter membrane section is pressed at the outlet 31 of the filter canister 3, and avoiding side leakage or uneven filtration caused by filter membrane wrinkles.

[0050] In addition, the guide roller 5323 also plays a guiding and transitioning role. When the winding roller 5322 and the filter membrane roller 5321 rotate synchronously to change the filter membrane section, the guide roller 5323 rotates with the movement of the filter membrane, reducing the frictional resistance of the filter membrane during the process of travel, and making the filter membrane switching process smoother and more stable.

[0051] This embodiment solves the problems of slackness, wrinkles, and misalignment that easily occur in the filter membrane during unwinding and winding by setting two guide rollers 5323 between the filter membrane roller 5321 and the take-up roller 5322. The two guide rollers 5323 provide stable tension, ensuring that the filter membrane section is flatly attached to the filter membrane support plate 11, improving the sealing uniformity and filtration reliability when the outlet 31 of the filter tank 3 is pressed and sealed. At the same time, the guide rollers 5323 play a guiding and drag-reducing role during filter membrane switching, making filter membrane replacement smoother and more stable, reducing the risk of filter membrane deviation or breakage, and further improving the stability and automation level of the device operation.

[0052] In one embodiment, the first lifting device 4 includes a column 41 and a guide rail assembly 42 arranged longitudinally along the column 41. The filter canister 3 is slidably mounted on the column 41 via the guide rail assembly 42. The first lifting device 4 also includes an elastic element and a linear movement mechanism 43. The elastic element acts on the filter canister 3, causing it to tend to move away from the bottom container 1. The linear movement mechanism 43 is disposed on the column 41 and is used to drive the filter canister 3 to move towards the bottom container 1 against the force of the elastic element.

[0053] Specifically, the column 41 is vertically fixed to the frame of the device, providing a supporting foundation for the lifting and lowering movement of the filter tank 3. The guide rail assembly 42 is arranged along the longitudinal direction of the column 41, including a guide rail and a slider that cooperate with each other. The guide rail is fixed to the column 41, and the slider is fixedly connected to the outer wall of the filter tank 3 or the connecting bracket, so that the filter tank 3 can slide smoothly in the vertical direction along the column 41.

[0054] An elastic element acts on the filter canister 3, causing it to tend to move away from the bottom container 1. In one embodiment, the elastic element is a tension spring, one end of which is fixed to the upper part or top of the column 41, and the other end is connected to the filter canister 3 or the connecting bracket of the filter canister 3. In its natural state, it pulls the filter canister 3 upward, keeping it in a high position away from the bottom container 1. In another embodiment, the elastic element can also be a compression spring, located below the filter canister 3, pushing the filter canister 3 upward to achieve the same resetting effect.

[0055] A linear motion mechanism 43 is mounted on the column 41 and is used to drive the filter canister 3 to move towards the bottom container 1 against the force of the elastic element. The linear motion mechanism 43 can be a linear drive element such as a cylinder, electric push rod, or lead screw motor, and its output end is set towards the filter canister 3. When a vacuum filtration operation is required, the output end of the linear motion mechanism 43 extends, pushing or pulling the filter canister 3 downward along the guide rail assembly 42, and the elastic element is stretched or compressed to store energy; when the vacuum filtration is completed or the filter membrane needs to be replaced, the output end of the linear motion mechanism 43 retracts, the potential energy stored in the elastic element is released, and the filter canister 3 is driven to slide upward along the guide rail assembly 42 to reset, automatically moving away from the bottom container 1.

[0056] This structural design allows the linear motion mechanism 43 to provide active and controllable downward pressure when the filter membrane section needs to be compressed, ensuring a reliable seal between the outlet 31 and the filter membrane support plate 11. When the filter membrane section needs to be released, the elastic element provides an automatic reset force, allowing the filter canister 3 to quickly rise without additional power, simplifying the control logic and reducing energy consumption. At the same time, the buffering effect of the elastic element avoids rigid impact when the filter canister 3 resets.

[0057] This embodiment achieves precise guidance and automatic reset of the lifting motion of the filter tank 3 through the coordinated operation of the column 41, guide rail assembly 42, elastic element, and linear motion mechanism 43 in the first lifting device 4. The guide rail assembly 42 ensures the straightness and stability of the filter tank 3 during the lifting process, preventing misalignment between the outlet 31 and the filter membrane support plate 11 caused by deviation. The elastic element allows the filter tank 3 to automatically move away from the bottom container 1 when the linear motion mechanism 43 retracts, eliminating the need for additional return drive, resulting in a simple structure and rapid response. The elastic buffering characteristics of the elastic element provide a flexible clamping force when the filter tank 3 presses against the filter membrane section, preventing hard impacts from damaging the filter membrane or sealing surface; it absorbs kinetic energy during reset, reducing impact and noise. The overall structure is compact, easy to control, and reliable in operation, further improving the automation level and service life of the device.

[0058] In one embodiment, the output end of the linear motion mechanism 43 is provided with a buffer pad 431, which is used to elastically press the filter membrane segment when the filter canister 3 moves toward the bottom container 1.

[0059] Specifically, the buffer pad 431 is fixedly installed at the output end of the linear motion mechanism 43, and the linear motion mechanism 43 indirectly acts on the filter tank 3 or the filter membrane section through the buffer pad 431. The buffer pad 431 is made of an elastic material, such as rubber, silicone or polyurethane, which has good elasticity and wear resistance, and can produce elastic deformation when compressed, providing cushioning and flexible clamping effect.

[0060] As the filter canister 3 moves toward the bottom container 1, the output end of the linear moving mechanism 43 drives the buffer pad 431 to move down synchronously. The buffer pad 431 first contacts the corresponding pressure-bearing part of the filter canister 3. As the linear moving mechanism 43 continues to advance, the buffer pad 431 is gradually compressed, and the clamping force is transmitted through the filter canister 3 to the filter membrane section between the outlet 31 and the filter membrane support plate 11.

[0061] Due to the elastic properties of the buffer pad 431, the clamping force is applied gradually, avoiding instantaneous impact damage to the filter membrane section caused by rigid contact. At the same time, the elastic deformation of the buffer pad 431 can compensate for the assembly error or flatness deviation between the filter tank 3 and the filter membrane support plate 11, making the clamping force distribution of the outlet 31 on the filter membrane section more uniform and ensuring the sealing reliability of the entire contact surface.

[0062] When the linear motion mechanism 43 retracts, the buffer pad 431 rises along with the output end, and its elasticity returns to its natural state. The filter canister 3 automatically resets under the action of the elastic element, and the buffer pad 431 separates from the filter canister 3.

[0063] This embodiment converts rigid clamping into elastic clamping by setting a buffer pad 431 at the output end of the linear motion mechanism 43. This effectively avoids the instantaneous impact when the filter tank 3 clamps the filter membrane section, protecting the filter membrane section from puncture or damage and extending the service life of the filter membrane. The elastic deformation of the buffer pad 431 can adaptively compensate for assembly errors between contact surfaces, making the clamping force distribution between the outlet 31 and the filter membrane support plate 11 more uniform, improving the sealing effect of the filter membrane section and preventing liquid leakage. At the same time, the buffer pad 431 can also absorb vibrations generated during operation, reduce noise, and further improve the stability and reliability of the device operation.

[0064] In one embodiment, the filter membrane support plate 11 is provided with a limiting ring 111, which is located outside the channel of the filter membrane support plate 11; the bottom of the outlet 31 of the filter canister 3 is provided with a limiting engagement ring 311 that cooperates with the limiting ring 111; when the filter canister 3 descends and presses the filter membrane segment onto the filter membrane support plate 11, the limiting ring 111 and the limiting engagement ring 311 engage with each other and fix the filter membrane segment.

[0065] Specifically, the limiting ring 111 is located on the upper surface of the filter membrane support plate 11 and in the outer area of ​​the central channel of the filter membrane support plate 11. It has an annular protrusion structure and is arranged around the channel opening. The limiting mating ring 311 is located on the bottom end face of the outlet 31 of the filter tank 3. It has an annular groove or an annular protrusion structure. Its shape and size match the limiting ring 111. The two form a convex-concave or nested mating relationship.

[0066] During the descent of the filter canister 3, the first lifting device 4 drives the filter canister 3 to move downward along the guide rail assembly 42. The outlet 31 of the filter canister 3 gradually approaches the filter membrane support plate 11. The limiting ring 311 on the bottom end face of the outlet 31 first contacts the filter membrane section. As the filter canister 3 continues to move downward, the limiting ring 311 presses the filter membrane section against the limiting ring 111 on the filter membrane support plate 11. When the filter canister 3 descends to the working position, the limiting ring 311 and the limiting ring 111 engage, and the filter membrane section is firmly clamped and fixed under the action of the engaging force of the two.

[0067] The engaging structure of the limiting ring 111 and the limiting mating ring 311 ensures that the filter membrane section is not only sealed by the flat surface but also positioned and locked in the circumferential direction by the annular engaging structure. This prevents the filter membrane section from lateral slippage or wrinkling due to liquid flow or pressure fluctuations during filtration. Simultaneously, this engaging structure forms an annular mechanical seal barrier, which, together with the flat surface pressing of the outlet 31, constitutes a double seal, further reducing the risk of liquid leakage from the edges of the filter membrane section.

[0068] When the filtration is completed and the first lifting device 4 drives the filter tank 3 to rise and reset, the limiting ring 311 moves up with the filter tank 3 and disengages from the limiting ring 111, releasing the filter membrane section and providing free space for subsequent filter membrane switching operations.

[0069] In this embodiment, a limiting ring 111 is provided on the filter membrane support plate 11, and a matching limiting ring 311 is provided at the bottom of the outlet 31 of the filter tank 3. When the filter tank 3 presses the filter membrane section, the two are mutually engaged, which can achieve high-precision positioning and engagement between the filter tank 3 and the bottom container 1, and can also firmly fix the filter membrane section in the working position. This engaging structure effectively prevents the filter membrane section from lateral slippage, wrinkling or loosening caused by liquid flow impact or negative pressure fluctuation during the filtration process, ensuring that the filter membrane section maintains a flat and stable filtration state throughout the filtration process. At the same time, the engagement of the limiting ring 111 and the matching limiting ring 311 forms a ring-shaped mechanical seal structure, which works in conjunction with the end face seal of the outlet 31 to significantly improve the sealing reliability of the filter membrane section edge, preventing the liquid to be filtered from leaking into the bottom container 1 from the edge of the filter membrane section, thus ensuring filtration accuracy and product quality.

[0070] In one embodiment, the bottom container 1 includes a small diameter section 12, a first large diameter section 13, and a first conical constriction section 14 arranged sequentially from top to bottom. The filter membrane support plate 11 is disposed on the end face of the small diameter section 12. A funnel 15 is provided inside the small diameter section 12. The outlet of the funnel 15 extends into the first large diameter section 13. The bottom of the first conical constriction section 14 is provided with an openable and closable discharge port 16. The filter tank 3 includes a second large diameter section 33 and a second conical constriction section 34 arranged in sequence. The outlet 31 of the second conical constriction section 34 of the filter tank 3 corresponds to the small diameter section 12 of the bottom container 1. The top plate 35 of the second large diameter section 33 is provided with a liquid inlet 36 and a spray head 37. The spray head 37 is used to clean the device after the filter membrane section is removed. The spray head 37 is configured to spray the second large diameter section 33, the second conical constriction section 34, and the funnel 15 in sequence and then converge to the first conical constriction section 14.

[0071] Specifically, the bottom container 1 adopts a segmented structure. The inner diameter of the smaller diameter segment 12 is relatively small and directly corresponds to the outlet 31 of the filter tank 3, ensuring that the filtrate can be collected and flow smoothly downwards after filtration through the membrane section. The funnel 15 set in the smaller diameter segment 12 receives the filtrate flowing down from the channel of the membrane support plate 11 and guides it into the inner cavity of the first larger diameter segment 13. The first larger diameter segment 13 provides a large volume space for temporarily storing the filtered liquid and performing degassing treatment in a vacuum environment. The bottom of the first conical contraction section 14 is provided with an openable and closable discharge port 16. During the filtration and degassing process, the discharge port 16 is closed to maintain a sealed negative pressure environment inside the bottom container 1; after degassing is completed, the discharge port 16 can be opened to discharge the treated liquid to the next process, making the operation convenient.

[0072] The filter tank 3 also adopts a segmented structure. The inner diameter of the second large-diameter section 33 is relatively large, which is used to accommodate the liquid to be filtered and provide sufficient liquid storage space. The inner diameter of the second conical constriction section 34 gradually decreases from top to bottom, which gradually draws the liquid to be filtered to the outlet 31, which is conducive to smooth liquid outflow and reduces residue. The liquid inlet 36 provided on the top plate 35 of the second large-diameter section 33 is used to inject the liquid to be filtered or cleaning fluid into the filter tank 3, which can realize closed liquid inlet and reduce external contamination.

[0073] Spray head 37 is mounted on top plate 35. After a batch of filtration is completed and the filter membrane section is removed, spray head 37 can be connected to a cleaning liquid source for automatic cleaning of the device interior. The cleaning liquid sprayed from spray head 37 first flushes the inner wall of the second large-diameter section 33, washing away any residual material adhering to the wall surface; then the cleaning liquid flows downward along the inner wall of the second conical contraction section 34, rinsing the area around outlet 31; next, the cleaning liquid flows through filter membrane support plate 11 and enters funnel 15, cleaning the inner surface of funnel 15; finally, the cleaning waste liquid flows into the first conical contraction section 14 of bottom container 1 and is discharged through outlet 16. The entire cleaning process covers all critical parts in contact with the liquid, achieving online automatic cleaning without disassembly, ensuring that the next batch of filtration is not cross-contaminated.

[0074] This embodiment optimizes the liquid flow path and containment space by designing the bottom container 1 and filter tank 3 as segmented structures, allowing the filtered liquid to be smoothly collected and vacuum degassed. The small-diameter section 12 of the bottom container 1 corresponds to the outlet 31 of the second conical constriction section 34 of the filter tank 3, ensuring concentrated flow of the filtrate. The funnel 15 further guides the liquid to flow smoothly into the first large-diameter section 13, reducing splashing and bubble generation. The openable and closable discharge port 16 facilitates the discharge of the liquid after treatment. The spray head 37 enables the device to thoroughly clean the inner wall of the filter tank 3, the outlet 31, the funnel 15, and the bottom container 1 after the filter membrane section is removed. The cleaning liquid is sprayed sequentially and flows to the bottom container 1 for discharge, realizing an online automatic cleaning function. This effectively prevents cross-contamination between different batches of mobile phase, improves the cleanliness and applicability of the device, and is especially suitable for applications that require frequent changes in mobile phase formulations.

[0075] In embodiments with a one-way valve 32, the one-way valve 32 may also be equipped with a manual or automatic control switch. This switch is used to forcibly open the valve core of the one-way valve 32 in cleaning mode, so that the one-way valve 32 is in the normally open state. After the filtration and degassing are completed, the filter membrane section is moved away from the working position, and the device enters the cleaning mode. At this time, the vacuum device 2 stops working. The one-way valve 32, which should be in the closed state under no negative pressure conditions, can be opened by operating the switch, allowing the cleaning liquid to flow smoothly from the filter tank 3 through the outlet 31 and the one-way valve 32 to the bottom container 1, achieving thorough cleaning of the outlet 31 pipeline and the internal flow channel of the one-way valve 32, avoiding material residue and cross-contamination. After cleaning is completed, the switch is turned off, and the one-way valve 32 returns to its normal working state of automatically opening and closing based on pressure difference.

[0076] In one embodiment, the filter membrane mechanism 532 further includes a tension control mechanism, which includes a magnetic powder brake or a tension sensor, for real-time monitoring and adjustment of the tension of the filter membrane segment during the unwinding and winding process. Specifically, the tension control mechanism is integrated into the filter membrane mechanism 532 and is used to apply and maintain appropriate tension on the filter membrane segment throughout the entire process of the filter membrane being unwound from the filter membrane roller 5321, tensioned by two guide rollers 5323, and finally wound up to the take-up roller 5322.

[0077] In one embodiment, the tension control mechanism employs a magnetic powder brake, which is mounted on the shaft of the filter membrane roller 5321. The braking torque output by the magnetic powder brake is controlled by adjusting the magnitude of the excitation current, thereby adjusting the resistance of the filter membrane roller 5321 during unwinding and thus controlling the unwinding tension of the filter membrane section. When it is necessary to increase the tension, the excitation current is increased, and the magnetic powder brake outputs a larger braking torque, increasing the unwinding resistance of the filter membrane roller 5321 and pulling the filter membrane section tighter. When it is necessary to decrease the tension, the excitation current is reduced, the braking torque decreases accordingly, unwinding becomes smoother, and the tension of the filter membrane section decreases accordingly.

[0078] In another embodiment, the tension control mechanism employs a tension sensor, which can be mounted on the shaft end of one of the guide rollers 5323. This sensor detects the pressure applied to the guide roller 5323 by the filter membrane section in real time and feeds the detection signal back to the control system. Based on the signal from the tension sensor, the control system adjusts the speed of the drive motor of the take-up roller 5322 or the braking torque of the filter membrane roller 5321 to form a closed-loop control, ensuring that the tension of the filter membrane section is always maintained within a preset range.

[0079] In actual operation, when the take-up roller 5322 and the filter membrane roller 5321 rotate synchronously to replace the filter membrane section, the tension control mechanism adjusts the tension of the take-up and unwinding in real time to ensure that the filter membrane section will not be stretched or even broken due to excessive tension during movement, nor will it become loose and wrinkled due to insufficient tension. When the second lifting device 51 presses the filter membrane section against the filter membrane support plate 11, the appropriate tension allows the filter membrane section to be flatly attached to the surface of the filter membrane support plate 11, ensuring the uniformity of the sealing of the outlet 31 of the filter tank 3.

[0080] In addition, during the filtration process, as the number of solid particles trapped on the surface of the filter membrane gradually increases, the resistance to liquid flow increases, and the filter membrane may undergo slight deformation due to the increase in pressure difference. The tension control mechanism can dynamically adjust the tension to maintain the stable state of the filter membrane and ensure the continuous and stable operation of the filtration process.

[0081] This embodiment incorporates a tension control mechanism within the filter membrane mechanism 532. A magnetic powder brake or tension sensor is used to monitor and adjust the tension of the filter membrane segment during unwinding and rewinding in real time, ensuring that the filter membrane segment maintains an appropriate tension state at all times. The magnetic powder brake achieves precise control of the unwinding tension by adjusting the excitation current, offering rapid response and a wide adjustment range. The tension sensor, combined with closed-loop control, achieves automatic and stable tension adjustment. The tension control mechanism effectively avoids tensile deformation or breakage of the filter membrane segment due to excessive tension, as well as slack and wrinkling problems caused by insufficient tension. This ensures that the filter membrane segment adheres smoothly to the filter membrane support plate 11, improving sealing reliability and filtration uniformity. Simultaneously, during filter membrane switching, the tension control mechanism ensures smooth movement of the filter membrane segment, reducing the risk of filter membrane deviation or jamming, further enhancing the automated operation stability of the device and the service life of the filter membrane.

[0082] In one embodiment, the filter membrane assembly 5 further includes a filter membrane positioning system, which includes a photoelectric sensor or a visual recognition system for detecting the position and status of the filter membrane segment to ensure that the filter membrane segment is accurately positioned above the filter membrane support plate 11.

[0083] Specifically, the filter membrane positioning system is integrated into the filter membrane assembly 5. It is used to accurately detect and calibrate the position of the filter membrane segment after the filter membrane mechanism 532 is driven to the extended position by the lateral moving mechanism 531, and after the winding roller 5322 and the filter membrane roller 5321 rotate synchronously to replace the filter membrane segment.

[0084] In one embodiment, the filter membrane positioning system employs a photoelectric sensor mounted on the bracket 52 or on the side of the filter membrane support plate 11. Its detection optical path is aligned with the edge of the filter membrane segment or a specific marked position. When the filter membrane segment moves to the extended position, the photoelectric sensor detects whether the segment has reached the preset position. If the edge or mark of the filter membrane segment is detected, a position signal is sent to the control system to confirm that the filter membrane segment is accurately positioned above the filter membrane support plate 11. If there is a deviation in the position of the filter membrane segment, the photoelectric sensor fails to detect the preset mark, or detects an abnormal edge position, the control system controls the take-up roller 5322 and the filter membrane roller 5321 to perform fine-tuning rotation until the filter membrane segment moves to the correct position.

[0085] In another embodiment, the filter membrane positioning system employs a visual recognition system, which includes a camera and an image processing unit. The camera is mounted above or to the side of the filter membrane support plate 11 to acquire image information of the filter membrane segment in real time. The image processing unit analyzes and processes the acquired images to identify the edge position, tension status, and whether there are wrinkles or damage on the surface of the filter membrane segment. When the position of the filter membrane segment deviates from the working area, the control system drives the lateral movement mechanism 531 or the winding roller 5322 to perform position compensation based on the deviation feedback from the visual recognition system, ensuring that the filter membrane segment is accurately aligned with the filter membrane support plate 11.

[0086] In practical applications, when a new set of filter membrane mechanisms 532 is switched to the extended position, the filter membrane positioning system first performs position detection on the filter membrane segment to confirm whether the filter membrane segment is aligned with the channel opening of the filter membrane support plate 11 in both the horizontal and vertical directions. Only after the filter membrane positioning system confirms that the filter membrane segment is accurately positioned will the control system allow the second lifting device 51 and the first lifting device 4 to operate sequentially for clamping operations, thereby avoiding problems such as sealing failure or insufficient filtration area caused by the positional deviation of the filter membrane segment.

[0087] In addition, during continuous filtration, the membrane positioning system continuously monitors the status of the membrane segment. Once abnormal displacement, wrinkles, or damage to the membrane segment is detected, the control system can promptly issue an alarm and automatically trigger the membrane switching program to replace the membrane segment with a new one, ensuring the stability of the filtration process and the reliability of the filtration quality.

[0088] This embodiment incorporates a filter membrane positioning system within the filter membrane assembly 5. A photoelectric sensor or visual recognition system is used to monitor the position and status of the filter membrane segment in real time, ensuring that the segment is accurately positioned above the filter membrane support plate 11 after each switch. The photoelectric sensor solution is simple in structure, has a fast response speed, and is low in cost, reliably detecting the positioning status of the filter membrane segment. The visual recognition system not only detects positional deviations but also identifies the tension status and surface defects of the filter membrane segment, providing more comprehensive status monitoring. The filter membrane positioning system effectively avoids problems such as sealing failure, reduced filtration area, or liquid leakage caused by filter membrane segment misalignment, improving the accuracy and reliability of automatic filter membrane switching. Simultaneously, the filter membrane positioning system can promptly detect abnormal states of the filter membrane segment and trigger alarms or automatic replacement, further enhancing the automation level and operational safety of the device.

[0089] This embodiment provides a vacuum filtration and degassing method for mobile phase preparation, employing the aforementioned vacuum filtration and degassing apparatus for mobile phase preparation, and includes the following steps: S1. The lateral moving mechanism 531 drives the corresponding filter membrane mechanism 532 to move to the extended position, so that the filter membrane segment is located above the filter membrane support plate 11.

[0090] Specifically, before the filtration begins, the control system selects the corresponding filter membrane roller device 53 according to the preset filter membrane type or pore size requirements, and sends an action command to the lateral movement mechanism 531 in the filter membrane roller device 53. After receiving the command, the lateral movement mechanism 531 horizontally pushes the filter membrane mechanism 532 mounted on it from the retracted position to the extended position, so that the filter membrane section opened between the two guide rollers 5323 in the filter membrane mechanism 532 is directly above the filter membrane support plate 11 on the top of the bottom container 1, and the center area of ​​the filter membrane section is aligned with the channel opening of the filter membrane support plate 11. If the device is equipped with a filter membrane positioning system, the photoelectric sensor or visual recognition system detects the position of the filter membrane section at this time, and the next step can only be carried out after confirming that the filter membrane section has been accurately positioned.

[0091] S2. The second lifting device 51 drives the bracket 52 to descend, so that the filter membrane section of the filter membrane mechanism in the extended position presses against the filter membrane support plate 11.

[0092] Specifically, once the filter membrane mechanism 532 is positioned in the extended position, the second lifting device 51 is activated, driving the support 52 at its output end to move downwards as a whole. The support 52 drives the entire filter membrane mechanism 532 to descend synchronously, and the filter membrane section between the two guide rollers 5323 moves downwards accordingly until the lower surface of the filter membrane section is against and pressed against the upper surface of the filter membrane support plate 11. At this time, the tension control mechanism maintains the filter membrane section in an appropriate tension state, so that the filter membrane section is laid flat on the filter membrane support plate 11 without wrinkles or warping. After the filter membrane section is pre-pressed onto the filter membrane support plate 11, the initial positioning and fixing of the filter membrane section is completed.

[0093] S3. The first lifting device 4 drives the filter tank 3 to descend, so that the outlet 31 of the filter tank 3 presses the filter membrane section onto the filter membrane support plate 11, thus completing the preparation work.

[0094] Specifically, after the filter membrane section is pre-pressed onto the filter membrane support plate 11 by the second lifting device 51, the linear movement mechanism 43 of the first lifting device 4 is activated, overcoming the force of the elastic element and driving the filter tank 3 to slide downward along the guide rail assembly 42 on the column 41. The outlet 31 of the second conical contraction section 34 of the filter tank 3 gradually approaches the filter membrane support plate 11, and the bottom end face of the outlet 31 presses the filter membrane section onto the filter membrane support plate 11. When the device is equipped with a limiting ring 111 and a limiting mating ring 311, the two engage with each other when the filter tank 3 descends to the working position, further fixing the filter membrane section and forming an annular seal. The buffer pad 431 at the output end of the linear movement mechanism 43 provides elastic buffering during the pressing process, so that the pressing force is evenly distributed and damage to the filter membrane section is avoided. At this point, the outlet 31 of the filter tank 3 and the bottom container 1 are sealed together through the filter membrane section, and the preparation work is completed.

[0095] S4. Inject the liquid to be filtered into the filter tank 3, start the vacuum device 2 to perform filtration, and let the filtrate enter the bottom container 1 after being filtered by the filter membrane section.

[0096] Specifically, the liquid to be filtered is injected into the second large-diameter section 33 through the inlet 36 on the top plate 35 of the filter tank 3. Under the action of gravity, the liquid flows along the second conical contraction section 34 to the outlet 31. The vacuum device 2 is activated to evacuate the inside of the bottom container 1, creating a negative pressure environment inside the bottom container 1. A pressure difference is formed between the liquid to be filtered, which is under normal or positive pressure inside the filter tank 3, and the negative pressure inside the bottom container 1. Driven by this pressure difference, the liquid passes through the filter membrane section, and solid particles are trapped on the upper surface of the filter membrane section. The filtrate then passes through the filter membrane section into the small-diameter section 12 of the bottom container 1, and after being guided by the funnel 15, it enters the first large-diameter section 13. If a one-way valve 32 is provided at the outlet 31 of the filter tank 3, the one-way valve 32 will automatically open under the action of the pressure difference, and the filtrate will pass smoothly. When the vacuum fluctuates, the one-way valve 32 can still maintain a stable conduction state. During the filtration process, the vacuum device 2 works continuously, and the filtrate is simultaneously degassed in the first large diameter section 13 and the first conical contraction section 14 to remove the gas dissolved in the liquid.

[0097] S5. After the filtration is completed, the vacuum device 2 is turned off, the first lifting device 4 drives the filter tank 3 to rise and reset, and the second lifting device 51 drives the support 52 to rise and reset.

[0098] Specifically, when the set filtration time is reached or the liquid in the filter tank 3 is detected to be emptied, the control system shuts off the vacuum device 2, and the pressure in the bottom container 1 returns to normal. If a one-way valve 32 is provided, it automatically closes due to the disappearance of the pressure difference, preventing backflow of liquid or gas in the bottom container 1. Subsequently, the linear movement mechanism 43 of the first lifting device 4 retracts, the elastic element releases the stored potential energy, and drives the filter tank 3 to slide upward and reset along the guide rail assembly 42, so that the outlet 31 of the filter tank 3 leaves the filter membrane section. Next, the second lifting device 51 drives the support 52 to rise, causing the filter membrane mechanism 532 to move upward as a whole, so that the filter membrane section leaves the surface of the filter membrane support plate 11. At this point, both the filter tank 3 and the filter membrane section have returned to their initial positions, providing space for subsequent operations.

[0099] S6. When it is necessary to replace the same type of filter membrane, the take-up roller 5322 and the filter membrane roller 5321 rotate synchronously to move the new filter membrane segment to the working position; when it is necessary to replace the filter membrane of a different type, the current filter membrane mechanism 532 retracts to the retracted position, and the other transverse moving mechanism 531 drives the corresponding other filter membrane mechanism 532 to switch to the extended position, and repeats steps S2 to S5.

[0100] Specifically, when replacing the same type of filter membrane, the control system determines the usage level of the current filter membrane segment. When the filter membrane segment becomes clogged, causing a decrease in filtration efficiency and reaching the preset replacement condition, the drive motor of the take-up roller 5322 starts. The take-up roller 5322 and the filter membrane roller 5321 rotate synchronously. The used filter membrane segment is taken up by the take-up roller 5322, while the filter membrane roller 5321 releases a new filter membrane of the same length. The new filter membrane segment is tensioned by two guide rollers 5323 and moves to the top of the filter membrane support plate 11, completing the continuous replacement of the same type of filter membrane. During the entire replacement process, the lateral movement mechanism 531 does not need to move, and the filter membrane mechanism 532 remains in the extended position. The replacement time is short and does not affect the normal operation of the device.

[0101] When changing to a different type of filter membrane, the control system determines the required pore size of the filter membrane based on the formulation requirements of the next batch of liquid to be filtered. The filter membrane mechanism 532, currently in the extended position, is driven by its corresponding lateral movement mechanism 531 to retract from the extended position to the retracted position, completely disengaging the filter membrane mechanism 532 from the area above the filter membrane support plate 11. Subsequently, the lateral movement mechanism 531 in another set of filter membrane roller devices 53 loaded with filter membranes of the target pore size is activated, pushing the corresponding filter membrane mechanism 532 from the retracted position to the extended position, aligning the new filter membrane segment with the filter membrane support plate 11. Then, steps S2 to S5 are repeated to sequentially complete operations such as filter membrane segment pre-pressing, filter tank 3 pressure sealing, filtration and degassing, and resetting, achieving fully automatic switching and continuous production between different types of filter membranes.

[0102] The vacuum filtration degassing method for mobile phase preparation provided in this embodiment achieves fully automated operation of the filtration process by employing the aforementioned filtration degassing device, which integrates multiple sets of filter membrane roller devices 53, a lateral moving mechanism 531, a first lifting device 4, and a second lifting device 51. When replacing the same type of filter membrane, only the synchronous rotation of the winding roller 5322 and the filter membrane roller 5321 is required to complete the replacement of the filter membrane section. The replacement process does not require machine downtime, ensuring the continuity of the filtration operation and making full use of each roll of filter membrane, thus reducing consumable costs. When replacing different types of filter membranes, the corresponding filter membrane mechanism 532 is switched between the retracted and extended positions by different lateral moving mechanisms 531. This enables automatic replacement of filter membranes with different pore sizes in a very short time, eliminating the need for manual disassembly and cleaning, and significantly improving the production efficiency of multi-variety, multi-batch mobile phase preparation. The entire method has clear steps and is easy to operate. The sequential action of the two-stage lifting device, combined with the automatic switching of the filter membrane, ensures the reliability of the filter membrane section clamping and sealing, making it suitable for automated continuous filtration degassing needs in the pharmaceutical, chemical, and laboratory fields.

[0103] The above description is merely an embodiment and does not constitute any limitation on the present invention. Any person skilled in the art can make many possible variations, modifications, or alterations to the technical solutions of the present invention without departing from the scope of the present invention. Therefore, any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention, without departing from the scope of the present invention, should fall within the protection scope of the present invention.

Claims

1. A vacuum filtration and degassing apparatus for mobile phase preparation, characterized in that, include: The bottom container (1) has a filter membrane support plate (11) on its top, and the bottom container (1) is connected to a vacuum device (2). A filter tank (3) for holding the liquid to be filtered and having an outlet (31) is mounted on a first lifting device (4) and driven by the first lifting device (4) to move closer to or away from the bottom container (1). The filter membrane assembly (5) includes a second lifting device (51), a bracket (52) fixed to the output end of the second lifting device (51), and at least two sets of filter membrane roller assemblies (53) disposed on the bracket (52); each set of filter membrane roller assemblies (53) includes a lateral moving mechanism (531) and a filter membrane mechanism (532) mounted on the lateral moving mechanism (531), the lateral moving mechanism (531) being used to drive the filter membrane mechanism (532) to move between an extended position and a retracted position; the filter membrane mechanism (532) includes a filter membrane roller (5321) and a take-up roller (5322), the filter membrane is drawn out from the filter membrane roller (5321) and wound up to the take-up roller (5322), and an open filter membrane segment is formed between the filter membrane roller (5321) and the take-up roller (5322); In the extended position, the filter membrane segment is located above the filter membrane support plate (11); the second lifting device (51) is used to drive the bracket (52) to lift and lower, so that the filter membrane segment of the filter membrane mechanism (532) in the extended position presses against the filter membrane support plate (11) or moves away from the filter membrane support plate (11); the first lifting device (4) is used to drive the filter canister (3) to descend, so that the outlet (31) of the filter canister (3) presses the filter membrane segment against the filter membrane support plate (11); During filtration, one of the lateral moving mechanisms (531) drives the corresponding filter membrane mechanism (532) to the extended position. The second lifting device (51) and the first lifting device (4) operate in sequence to clamp the filter membrane segment. The vacuum device (2) operates to perform filtration. When replacing the same type of filter membrane, the winding roller (5322) and the filter membrane roller (5321) rotate synchronously to move the new filter membrane segment to the working position. When replacing a different type of filter membrane, the current filter membrane mechanism (532) retracts to the retracted position, and another lateral moving mechanism (531) drives the corresponding other filter membrane mechanism (532) to switch to the extended position.

2. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, A one-way valve (32) is provided on the outlet (31) of the filter tank (3). The one-way valve (32) is configured to be opened under negative pressure during vacuum filtration, so that the liquid in the filter tank (3) flows normally to the bottom container (1), and is automatically closed after the vacuum is closed to prevent backflow.

3. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, The filter membrane mechanism (532) further includes two guide rollers (5323) disposed between the filter membrane roller (5321) and the winding roller (5322), the filter membrane is tensioned by the two guide rollers (5323), and the open filter membrane segment is formed between the two guide rollers (5323).

4. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, The first lifting device (4) includes a column (41) and a guide rail assembly (42) arranged longitudinally along the column (41). The filter canister (3) is slidably mounted on the column (41) via the guide rail assembly (42). The first lifting device (4) also includes an elastic element and a linear movement mechanism (43). The elastic element acts on the filter canister (3) to make it tend to move away from the bottom container (1). The linear movement mechanism (43) is arranged on the column (41) to drive the filter canister (3) to move toward the bottom container (1) against the force of the elastic element.

5. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 4, characterized in that, The output end of the linear motion mechanism (43) is provided with a buffer pad (431), which is used to elastically press the filter membrane segment when the filter tank (3) moves toward the bottom container (1).

6. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, The filter membrane support plate (11) is provided with a limiting ring (111), which is located outside the channel of the filter membrane support plate (11); the bottom of the outlet (31) of the filter tank (3) is provided with a limiting engagement ring (311) that cooperates with the limiting ring (111); when the filter tank (3) descends and presses the filter membrane segment onto the filter membrane support plate (11), the limiting ring (111) and the limiting engagement ring (311) engage with each other and fix the filter membrane segment.

7. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, The bottom container (1) includes a small diameter section (12), a first large diameter section (13) and a first conical shrinkage section (14) arranged sequentially from top to bottom. The filter membrane support plate (11) is located on the end face of the small diameter section (12). A funnel (15) is provided inside the small diameter section (12). The outlet of the funnel (15) extends into the first large diameter section (13). The bottom of the first conical shrinkage section (14) is provided with an openable and closable discharge port (16). The filter tank (3) includes a second large diameter section (33) and a second conical constriction section (34) arranged in sequence. The outlet (31) of the second conical constriction section (34) of the filter tank (3) corresponds to the small diameter section (12) of the bottom container (1). The top plate (35) of the second large diameter section (33) is provided with a liquid inlet (36) and a spray head (37). The spray head (37) is used to clean the device after the filter membrane section is removed. The spray head (37) is configured to spray the second large diameter section (33), the second conical constriction section (34), the funnel (15) in sequence and converge to the first conical constriction section (14).

8. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, The filter membrane mechanism (532) also includes a tension control mechanism, which includes a magnetic powder brake or a tension sensor for real-time monitoring and adjustment of the tension of the filter membrane segment during the winding and unwinding process.

9. The vacuum filtration and degassing apparatus for mobile phase preparation according to claim 1, characterized in that, The filter membrane assembly (5) also includes a filter membrane positioning system, which includes a photoelectric sensor or a visual recognition system for detecting the position and status of the filter membrane segment and ensuring that the filter membrane segment is accurately positioned above the filter membrane support plate (11).

10. A vacuum filtration and degassing method for preparing a mobile phase, characterized in that, The vacuum filtration and degassing apparatus for mobile phase preparation as described in any one of claims 1-9 includes the following steps: S1. The lateral moving mechanism (531) drives the corresponding filter membrane mechanism (532) to move to the extended position, so that the filter membrane segment is located above the filter membrane support plate (11); S2. The second lifting device (51) drives the bracket (52) to descend, so that the filter membrane section of the filter membrane mechanism in the extended position presses against the filter membrane support plate (11); S3. The first lifting device (4) drives the filter tank (3) to descend, so that the outlet (31) of the filter tank (3) presses the filter membrane section onto the filter membrane support plate (11) to complete the preparation work. S4. Inject the liquid to be filtered into the filter tank (3), start the vacuum device (2) to perform filtration, so that the filtrate enters the bottom container (1) after being filtered through the filter membrane section. S5. After the filtration is completed, the vacuum device (2) is turned off, the first lifting device (4) drives the filter tank (3) to rise and reset, and the second lifting device (51) drives the support (52) to rise and reset. S6. When it is necessary to replace the same type of filter membrane, the take-up roller (5322) and the filter membrane roller (5321) rotate synchronously to move the new filter membrane segment to the working position; when it is necessary to replace the filter membrane of a different type, the current filter membrane mechanism (532) retracts to the retracted position, and another lateral moving mechanism (531) drives the corresponding other filter membrane mechanism (532) to switch to the extended position, repeating steps S2 to S5.

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