A hair care essence composition with oil control, odor removal and scalp anti-aging functions

Abstract

This invention relates to the field of biomedical nursing technology, specifically to a hair care essence composition that combines oil control, odor removal, and scalp anti-aging functions. The composition comprises stearic acid-modified porous hollow hydroxyapatite adsorbent material (oil control and odor removal component), polypeptide-rhSOD premix (antioxidant and antibacterial component), and polydeoxyribonucleotides (anti-inflammatory and repairing component). The modified porous hollow hydroxyapatite can adsorb excess sebum and odor substances from the scalp; the polypeptide-rhSOD premix can inhibit the proliferation of abnormal microorganisms and reduce oxidative stress levels; and PDRN can improve the scalp microenvironment and promote tissue repair. Experimental results show that the composition of this invention has good oil control, odor removal, antibacterial, antioxidant, and anti-inflammatory and repairing effects, and the combined use of each functional component has a significant synergistic effect, making it suitable for scalp health care and scalp anti-aging applications.

Description

Technical Field

[0001] This invention belongs to the field of biomedical nursing technology, and in particular relates to a hair care essence composition that combines oil control, odor removal and scalp anti-aging functions. Background Technology

[0002] With the fast pace of life and the continuous impact of environmental factors, oily scalp and seborrheic scalp problems are becoming increasingly common. Excessive scalp oil secretion not only affects the cleanliness and comfort of hair, but also easily causes clogged hair follicles, scalp inflammation, and microecological imbalance, further inducing problems such as hair loss and scalp sensitivity. At the same time, long-term oil accumulation can lead to increased oxidative stress levels on the scalp, accelerating scalp tissue aging, reducing hair follicle activity, and weakening the scalp barrier function.

[0003] Abnormal scalp sebum secretion and the resulting metabolic imbalance are significant factors contributing to various scalp problems, including scalp odor, inflammation, itching, and hair follicle dysfunction. Studies have shown that scalp odor formation is primarily related to the following processes: excessive sebum secretion leads to lipid peroxidation, followed by the breakdown of lipids by scalp microorganisms, producing various volatile small molecules. Simultaneously, inflammatory responses and oxidative stress further promote lipid oxidation and odor-causing substance production, thus creating a vicious cycle.

[0004] Most existing oil-control products only achieve short-term oil removal through physical adsorption, failing to regulate sebum metabolism at its root. Odor-eliminating products largely rely on antibacterial agents to suppress bacteria and eliminate odor, without addressing the lipid oxidation and metabolic imbalance mechanisms involved in odor formation. Repairing products struggle to function stably in high-oil environments, lacking synergistic regulation of multiple mechanisms including oil control, anti-oxidation, odor suppression, and barrier repair. Therefore, developing a composition capable of synergistically regulating the entire chain of scalp sebum metabolism, oxidative stress, microecological balance, and barrier repair has significant research value and application implications. Summary of the Invention

[0005] The purpose of this invention is to provide a hair care essence composition that combines oil control, odor removal, and scalp anti-aging functions.

[0006] To achieve the above objectives, the present invention provides the following technical solution: In a first aspect, the present invention provides a hair care essence composition that combines oil control and odor removal with scalp anti-aging functions. The hair care essence composition comprises: an oil control and odor removal component: 2-5 parts by weight; an antioxidant and antibacterial component: 1-5 parts by weight; an anti-inflammatory and repairing component: 0.2-2 parts by weight; a moisturizing system: 48.1-81 parts by weight; and an aqueous phase system: 5.2-21 parts by weight. The oil-controlling and deodorizing component is a stearic acid-modified porous hollow hydroxyapatite adsorbent material. The antioxidant and antibacterial component is a polypeptide-rhSOD premix, which is composed of acetyl tetrapeptide-3, acetyl hexapeptide-1 and recombinant human superoxide dismutase (rhSOD). The weight ratio of acetyl tetrapeptide-3 to acetyl hexapeptide-1 to rhSOD is 1:(1-5):(0.1-0.5), and the rhSOD enzyme activity is 10000 U / mg. The anti-inflammatory repairing component is a polydeoxyribonucleotide obtained by purifying fish milt sample through enzymatic hydrolysis, salting out, and ethanol precipitation.

[0007] Preferably, the preparation method of the porous hollow hydroxyapatite adsorbent material includes the following steps: (1) Preparation of porous hollow hydroxyapatite particles: Sodium carbonate solution and an equal volume of calcium nitrate solution were mixed, sodium polystyrene sulfonate was added, and the mixture was stirred at 30°C to produce calcium carbonate particles. After centrifuging and washing the calcium carbonate particles, they were added to a disodium hydrogen phosphate solution for a hydrothermal reaction. After the reaction is complete, acid solution is added and stirred continuously to remove calcium carbonate particles, thereby obtaining porous hollow hydroxyapatite particles. (2) Surface stearic acid modification: Stearic acid and thionyl chloride were mixed in 0.5 times their mass of the porous hollow hydroxyapatite particles and refluxed at 80°C to react a. After removing the residual reagents, the reaction solution was obtained. Hydroxyapatite powder, dimethylformamide, and triethylamine were added to the reaction solution, and the mixture was refluxed at 60°C. After the reaction was completed, the mixture was washed and dried to obtain the porous hollow hydroxyapatite adsorbent material.

[0008] Preferably, in step (1), the concentrations of the sodium carbonate solution and the calcium nitrate solution are both 0.1 mol / L, the amount of sodium polystyrene sulfonate added is 150 mg / 40 mL of the mixture, the hydrothermal reaction is carried out at 140°C for 4 h, and the acid treatment is carried out by continuous stirring for 2 h. In step (2), the amount of stearic acid used is 0.5 times the mass of the porous hollow hydroxyapatite particles, the amount of thionyl chloride used is 0.042 mol, the reflux reaction a time is 2 h; the amount of hydroxyapatite powder added is 2 g, the amount of triethylamine added is 0.005 mol, and the reflux reaction b time is 12 h.

[0009] Preferably, the method for preparing the polydeoxyribonucleotide includes the following steps: The fish milt sample was placed in the lysis buffer and enzymatically digested in a constant temperature water bath at 55℃ for 18 hours. After enzymatic hydrolysis, centrifuge to collect the supernatant, add NaCl, mix well, and centrifuge again; Collect the supernatant and add anhydrous ethanol to precipitate it. Wash the precipitate with 75% ethanol and dry it at 65°C for 5 hours to obtain the polydeoxyribonucleotide. The lysis buffer contains Tris-HCl, EDTA, NaCl, SDS, and proteinase K.

[0010] Preferably, the hair care essence composition further comprises a moisturizing system and an aqueous phase system: The moisturizing system comprises: glycerin: 5-12 parts by weight; butylene glycol: 3-8 parts by weight; sodium hyaluronate: 0.1-1 parts by weight; deionized water: 40-60 parts by weight; The aqueous phase system comprises: carbomer: 0.2 to 1 part by weight; deionized water: 5 to 20 parts by weight.

[0011] Preferably, the method for preparing the hair care essence composition includes the following steps: 1) Preparation of moisturizing system: Add 5-12 parts by weight of glycerin and 3-8 parts by weight of butanediol to 60 parts by weight of deionized water and stir to dissolve to obtain solution A; Then add 0.1 to 1 part by weight of sodium hyaluronate to 2 parts by weight of glycerin, stir slowly until completely soaked, then slowly add to solution A, stir to hydrate for 60 minutes, and defoam to obtain the moisturizing system; 2) Preparation of aqueous system: Take 0.2-1 parts by weight of carbomer and add it to 5-20 parts by weight of deionized water. Stir for 20 minutes to obtain an aqueous system. Heat it to 70℃ and keep it at that temperature to obtain an aqueous system. 3) Introduce oil-controlling and deodorizing components: Add 2-5 parts by weight of porous hollow hydroxyapatite to 10 parts by weight of deionized water for pre-dispersion, and disperse at high speed for 10 min to form a uniform suspension. Add 48.1-81 parts by weight of moisturizing system and 5.2-21 parts by weight of aqueous system at 70℃, and stir for 20 min to obtain mixture A; 4) Introducing antioxidant and antibacterial components: At room temperature (25±2℃), add 1 to 5 parts by weight of peptide-rhSOD to mixture A and stir for 15 min to obtain mixture B; 5) Introducing anti-inflammatory and repairing components and shaping: Add 0.2-2 parts by weight of polydeoxyribonucleotide (PDRN) to 40 parts by weight of deionized water, adjust the pH of the system to 6.0, stir at room temperature for 10 min to defoam, and obtain the hair care essence composition.

[0012] Secondly, the present invention provides a hair gel that combines oil control, odor removal, and scalp anti-aging functions, wherein the hair gel is made from the following raw materials in parts by weight: Hair care essence composition: 60-80 parts; Carbomer 940: 0.3–2 parts; Triethanolamine: 0.1–1 part; Deionized water: 5-20 parts; The pH value of the hair gel is 5.5 to 6.5.

[0013] Preferably, the preparation method of the hair gel includes the following steps: (a) Gel matrix preparation: 0.8 parts by weight of carbomer were added to 20 parts by weight of deionized water, stirred at 500 r / min for 20 min, and allowed to stand for 30 min to fully hydrate, to obtain gel matrix A; (b) Addition of active essence: 80 parts by weight of the hair care essence composition are slowly added to the gel matrix A and stirred at 400 r / min for 15 min to obtain mixture B; (c) Neutralization and thickening: Triethanolamine is slowly added to mixture B and the pH of the system is adjusted to 6.0 to allow the carbomer to undergo a neutralization and thickening reaction to form a gel; (d) Curing and degassing: Continue stirring at low speed for 10 min to degas, and let stand for 12 h to cure, thus obtaining hair gel.

[0014] Thirdly, the present invention provides a scalp care cream that combines oil control, odor removal, and scalp anti-aging functions. The scalp care cream comprises the aforementioned hair care essence composition and an O / W type emulsifying matrix, and is made from the following raw materials in parts by weight: Hair care essence composition: 50-70 parts; Oil phase emollient component: 5-15 parts, wherein the oil phase emollient component is composed of caprylic / capric triglyceride and jojoba oil, wherein the weight ratio of caprylic / capric triglyceride to jojoba oil is 8:1; Emulsifier: 1 to 5 parts, wherein the emulsifier is composed of polysorbate-60 and PPG-5-cetyl polyether-20, and the weight ratio of polysorbate-60 to PPG-5-cetyl polyether-20 is 1:2; Cetyl alcohol: 1-5 parts; Stabilizing thickener: 0.1 to 1 part, wherein the stabilizing thickener is composed of xanthan gum and carbomer, and the weight ratio of xanthan gum to carbomer is 4:1; Deionized water: 10-20 parts; The pH value of the scalp care cream is 5.5 to 6.5.

[0015] Preferably, the preparation method of the scalp care cream includes the following steps: (A) Preparation of oil phase: 9 parts by weight of the oil phase emollient component, 3 parts by weight of emulsifier and 3 parts by weight of cetyl alcohol are mixed, heated to 80°C and stirred until completely melted to obtain oil phase A; (B) Preparation of aqueous phase: 15 parts by weight of deionized water and 0.5 parts by weight of stabilizer thickener were mixed, dispersed for 15 min, and then heated to 80℃ and kept at that temperature to obtain aqueous phase B; (C) Emulsification: At 80°C, oil phase A is slowly added to aqueous phase B, and homogenization is carried out at 5000 r / min for 10 min to obtain cream matrix C; (D) Finished product shaping: After cooling the cream base C to 40°C, add 70 parts by weight of the hair care essence composition and stir for 10 min; The mixture was then cooled to room temperature, stirred at low speed for 10 minutes to remove bubbles, and the pH was adjusted to 6.0 to obtain the scalp care cream.

[0016] The beneficial effects of this invention are as follows: This invention provides a hair care composition that combines oil control, odor removal, and scalp anti-aging functions. Through the synergistic combination of modified porous hollow hydroxyapatite, peptide-rhSOD, and polydeoxyribonucleotides (PDRN), it achieves comprehensive regulation of scalp sebum metabolism, microecological balance, oxidative stress, and inflammation repair. Specifically, modified porous hollow hydroxyapatite effectively adsorbs excess sebum and odor-related substances from the scalp and enhances the retention of active ingredients on the scalp surface; peptide-rhSOD premix inhibits the proliferation of abnormal microorganisms such as Malassezia and reduces reactive oxygen species (ROS) levels; PDRN improves the local microenvironment of the scalp, promotes scalp tissue repair, and reduces inflammatory responses. Experimental results show that the composition of this invention exhibits excellent effects in antibacterial, oil control, odor removal, antioxidant, and anti-inflammatory repair, and the three functional components show a significant synergistic effect when used together. In addition, the present invention also provides different dosage forms such as hair care gel and scalp care cream, which not only have good stability, spreadability and comfort of use, but also good skin tolerance and safety, and have broad application prospects in scalp care and scalp anti-aging. Attached Figure Description

[0017] Figure 1 A schematic diagram illustrating the scalp metabolism regulation mechanism of the hair care essence composition provided for the invention; Figure 2 Scanning electron microscope image of the microstructure of modified hydroxyapatite; Figure 3 Scanning electron microscope image of the pore structure on the surface of modified hydroxyapatite; Figure 4 A comparison chart of the test results of TNF-α content and downregulation rate in each group; Figure 5 A comparison chart of the test results of IL-6 content and downregulation rate in each group; Figure 6 A comparison chart of the test results of IL-10 content and upregulation rate for each group. Detailed Implementation

[0018] The present invention will be further described in detail below with reference to embodiments and examples, but these embodiments and examples do not constitute a limitation on the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

[0019] Example 1 A hair care essence composition that combines oil control, odor removal, and scalp anti-aging functions. Preparation of S1 oil-controlling and deodorizing components (1) Preparation of porous hollow hydroxyapatite particles Mix 20 mL of 0.1 mol / L sodium carbonate solution with an equal volume of 0.1 mol / L calcium nitrate solution, add 150 mg of sodium polystyrene sulfonate, and stir magnetically for 30 min at 30 °C to generate calcium carbonate particles by rapid precipitation. The obtained calcium carbonate particles were centrifuged at 8000 rpm for 3 min and washed three times with deionized water. The washed calcium carbonate particles were then added to 30 mL of 0.8 mol / L disodium hydrogen phosphate solution, transferred to a high-pressure reactor, and subjected to a hydrothermal reaction at 140 °C for 4 h. After the reaction was completed, 15 mL of 0.1 mol / L hydrochloric acid solution was added to the system, and the mixture was stirred continuously at room temperature (25±2℃) for 2 h to remove the calcium carbonate template and obtain porous hollow hydroxyapatite particles.

[0020] (2) Preparation of modified hydroxyapatite Stearic acid in 0.5 times the mass of porous hollow hydroxyapatite particles was mixed with 0.042 mol of thionyl chloride and refluxed at 80 °C for 2 h to obtain product A. Product A was mixed with dichloroethane at a mass-to-volume ratio of 1:10 (g:mL). Each time, 20 mL of dichloroethane was added and rotary evaporated. This process was repeated 3 times to obtain reaction solution A. Subsequently, 2 g of hydroxyapatite powder, 10 mL of dimethylformamide and 0.005 mol of triethylamine were added to reaction solution A, and the mixture was refluxed at 60 °C for 12 h. After the reaction was completed, the product was washed with dichloromethane and dried overnight in a vacuum drying oven to obtain stearic acid-modified porous hollow hydroxyapatite adsorbent material.

[0021] Preparation of S2 Antioxidant and Antibacterial Components Acetyl tetrapeptide-3 (CAS: 827306-88-7), acetyl hexapeptide-1 (CAS: 448944-47-6), and recombinant human superoxide dismutase (rhSOD, specific activity 10000 U / mg) were dissolved in deionized water at a mass ratio of 1:2:0.1 to prepare a polypeptide-rhSOD premix with a total concentration of 5 mg / mL.

[0022] S3 Anti-inflammatory Repairing Component Preparation Enzymatic hydrolysis: Take 0.5 g of salmon milt sample (from Dandong, Liaoning) and place it in a 15 mL centrifuge tube. Add 10 mL of lysis buffer [10 mM Tris-HCl (pH 8.0), 10 mM EDTA (pH 8.0), 0.2 M NaCl, 0.5% SDS and 0.1 mg / mL proteinase K] and enzymatically hydrolyze in a 55℃ constant temperature water bath for 18 h. Impurity removal: After the enzymatic hydrolysis is completed, centrifuge at 10000 r / min for 1 h at room temperature, take the supernatant into a new centrifuge tube, add 0.5 times the volume of 5 M NaCl, mix well, and centrifuge again at 10000 r / min for 1 h. Alcohol precipitation: After collecting the supernatant, anhydrous ethanol was added to precipitate the product. The volume ratio of supernatant to anhydrous ethanol was 1:2. The product was placed in a refrigerator at 2-8℃ for 12 hours. The precipitate was washed 5 times with 75% ethanol. The final alcohol precipitation product was dried at 65℃ for 5 hours to obtain polydeoxyribonucleotide (PDRN) (the purity obtained by the diphenylamine method was 99%).

[0023] S4 Preparation of a hair care essence composition with oil control, odor removal, and scalp anti-aging functions (1) Preparation of moisturizing system Add 8 parts by weight of glycerin and 5 parts by weight of butylene glycol to 60 parts by weight of deionized water and stir to dissolve. Then add 0.3 parts by weight of sodium hyaluronate to 1.5 parts by weight of glycerin and stir slowly (300 rpm) until fully saturated. Then slowly add the glycerin to the system and stir to hydrate for 60 min. Defoaming is then performed to obtain the moisturizing system.

[0024] (2) Preparation of aqueous system Take 0.5 parts by weight of carbomer and add it to 15 parts by weight of deionized water. Stir at 500 r / min for 20 min at room temperature, heat to 70℃ and keep warm to obtain an aqueous phase system.

[0025] (3) Add oil-controlling and deodorizing components Four parts by weight of the oil-controlling and deodorizing component were added to 10 parts by weight of deionized water for pre-dispersion, and then dispersed at 8000 rpm for 10 min using a high-speed disperser to form a uniform suspension. Subsequently, it was slowly added to 10–25 parts by weight of the moisturizing system and 10–40 parts by weight of the aqueous system at 70°C, and stirred for 20 min at 600 r / min to obtain mixture A.

[0026] (4) Antioxidant and antibacterial components added At room temperature (25±2℃), 3 parts by weight of the antioxidant and antibacterial component were added to mixture A and stirred for 15 min to obtain mixture B.

[0027] (5) Anti-inflammatory and repairing components added Introducing anti-inflammatory and repairing components and shaping: Add 0.5 parts by weight of anti-inflammatory and repairing components to 40 parts by weight of deionized water, adjust the pH of the system to 6.0, stir at room temperature for 10 minutes to defoam, and obtain a hair care essence composition with oil control, odor suppression and scalp anti-aging functions.

[0028] Example 2 This embodiment is based on the preparation of the S1 oil-controlling and deodorizing component, the S2 antioxidant and antibacterial component, and the S3 anti-inflammatory and repairing component in Example 1, and is used to prepare a hair care essence composition.

[0029] (1) Preparation of moisturizing system Add 3 parts by weight of glycerin and 3 parts by weight of butylene glycol to 60 parts by weight of deionized water and stir to dissolve. Then add 0.1 parts by weight of sodium hyaluronate to 2 parts by weight of glycerin and stir slowly (300 rpm) until fully saturated. Then slowly add the hyaluronic acid to the system and stir to hydrate for 60 min. Defoaming is then performed to obtain the moisturizing system.

[0030] (2) Preparation of aqueous system Take 0.2 parts by weight of carbomer and add it to 5 parts by weight of deionized water. Stir at 500 r / min for 20 min at room temperature, heat to 70℃ and keep warm to obtain an aqueous phase system.

[0031] (3) Add oil-controlling and deodorizing components Two parts by weight of the oil-controlling and deodorizing component were added to 10 parts by weight of deionized water for pre-dispersion, and then dispersed at 8000 rpm for 10 min using a high-speed disperser to form a uniform suspension. Subsequently, it was slowly added to 10 parts by weight of the moisturizing system and 10 parts by weight of the aqueous system at 70°C, and stirred for 20 min at 600 r / min to obtain mixture A.

[0032] (4) Antioxidant and antibacterial components added At room temperature (25±2℃), 1 part by weight of the antioxidant and antibacterial component was added to mixture A and stirred for 15 min to obtain mixture B.

[0033] (5) Anti-inflammatory and repairing components added Introducing anti-inflammatory and repairing components and shaping: Add 0.2 parts by weight of anti-inflammatory and repairing components to 40 parts by weight of deionized water, adjust the pH of the system to 6.0, stir at room temperature for 10 minutes to defoam, and obtain a hair care essence composition with oil control, odor suppression and scalp anti-aging functions.

[0034] Example 3 This embodiment is based on the preparation of the S1 oil-controlling and deodorizing component, the S2 antioxidant and antibacterial component, and the S3 anti-inflammatory and repairing component in Example 1, and is used to prepare a hair care essence composition.

[0035] (1) Preparation of moisturizing system Add 10 parts by weight of glycerin and 8 parts by weight of butylene glycol to 60 parts by weight of deionized water and stir to dissolve. Then add 1 part by weight of sodium hyaluronate to 2 parts by weight of glycerin and stir slowly (300 rpm) until fully saturated. Then slowly add the hyaluronic acid to the system and stir to hydrate for 60 minutes. Defoaming is then performed to obtain the moisturizing system.

[0036] (2) Preparation of aqueous system Take 1 part by weight of carbomer and add it to 20 parts by weight of deionized water. Stir at 500 r / min for 20 min at room temperature, heat to 70℃ and keep warm to obtain an aqueous phase system.

[0037] (3) Add oil-controlling and deodorizing components Five parts by weight of the oil-controlling and deodorizing component were added to 10 parts by weight of deionized water for pre-dispersion, and then dispersed at 8000 rpm for 10 min using a high-speed disperser to form a uniform suspension. Subsequently, it was slowly added to 25 parts by weight of the moisturizing system and 40 parts by weight of the aqueous system at 70°C, and stirred for 20 min at 600 r / min to obtain mixture A.

[0038] (4) Antioxidant and antibacterial components added At room temperature (25±2℃), 5 parts by weight of the antioxidant and antibacterial component were added to mixture A and stirred for 15 min to obtain mixture B.

[0039] (5) Anti-inflammatory and repairing components added Introducing anti-inflammatory and repairing components and shaping: Add 2 parts by weight of anti-inflammatory and repairing components to 40 parts by weight of deionized water, adjust the pH of the system to 6.0, stir at room temperature for 10 minutes to defoam, and obtain a hair care essence composition with oil control, odor suppression and scalp anti-aging functions.

[0040] Example 4 A hair gel that combines oil control, odor removal, and scalp anti-aging functions. This embodiment further adds a gel-forming component to the hair care essence composition of Example 1 to improve product adhesion and scalp retention time.

[0041] The composition of this hair gel is: Example 1: Hair care essence composition: 80 parts; Carbomer 940 (CAS: 9007-20-9): 0.8 parts; Triethanolamine (CAS: 102-71-6): 0.2 parts; Deionized water: 20 parts.

[0042] The preparation method of this hair care gel is as follows: S1 Gel Matrix Preparation Add 0.8 parts by weight of carbomer to 20 parts by weight of deionized water, stir at 500 r / min for 20 min, and let stand for 30 min to fully hydrate to obtain gel matrix A.

[0043] S2 active essence added 80 parts by weight of the hair care essence composition of Example 1 were slowly added to gel matrix A and stirred at 400 r / min for 15 min to obtain mixture B.

[0044] S3 Neutralizing Thickening Slowly add 0.2 parts by weight of triethanolamine to mixture B and adjust the pH of the system to 6.0 to allow the carbomer to undergo a neutralization and thickening reaction, forming a gel.

[0045] S4 Curing and Degassing Continue stirring at low speed for 10 minutes to remove bubbles, and let stand for 12 hours to mature, thus obtaining the hair gel product.

[0046] Example 5 A hair gel that combines oil control, odor removal, and scalp anti-aging functions. This embodiment further adds a gel-forming component to the hair care essence composition of Example 1.

[0047] The hair gel is composed of: hair essence composition from Example 1: 60 parts; carbomer 940: 0.3 parts; triethanolamine: 1 part; deionized water: 5 parts. The preparation method used is the same as in Example 4.

[0048] Example 6 A scalp care cream that combines oil control, odor removal, and scalp anti-aging functions. This embodiment adds an O / W type emulsifying matrix to the hair care essence composition of Example 1 to improve the product's spreadability and moisturizing properties.

[0049] The ingredients of this scalp care cream are: Example 1: Hair care essence composition: 70 parts; Oil phase emollient component: 9 parts, of which the weight ratio of caprylic / capric triglyceride (CAS: 73398-61-5) to jojoba oil (CAS: 61789-91-1) is 8:1; Emulsifier: 3 parts, wherein the weight ratio of polysorbate-60 (CAS: 61789-91-1) to PPG-5-cetyl polyether-20 (CAS: 68439-49-6) is 1:2; Cetyl alcohol (CAS: 36653-82-4): 3 parts; Stabilizing thickener: 0.5 parts, wherein the weight ratio of xanthan gum (CAS: 11138-66-2) to carbomer (CAS: 9003-01-4) is 4:1; Deionized water: 5 parts.

[0050] The preparation method of this scalp care cream is as follows: S1 Oil Phase Preparation Nine parts by weight of the oil phase moisturizing component, three parts by weight of the emulsifier and three parts by weight of cetyl alcohol are mixed, heated to 80°C and stirred until completely melted to obtain oil phase A.

[0051] S2 Aqueous Phase Preparation Add 5 parts of deionized water to an emulsifying pot and 0.5 parts of a stabilizing thickener. After dispersing for 15 minutes, heat to 80°C and keep warm to obtain aqueous phase B.

[0052] S3 Emulsification At 80°C, oil phase A was slowly added to aqueous phase B, and homogenization was carried out at 5000 r / min for 10 min to obtain a milky white cream matrix C.

[0053] S4 Function Essence Added After cooling the cream matrix C to 40°C, add 70 parts by weight of the hair care essence composition from Example 1 and continue stirring for 10 minutes.

[0054] S5 Cooling Finished Product After cooling to room temperature, stir at low speed for 10 minutes to defoam and adjust the pH to 6.0 to obtain the scalp care cream product.

[0055] Example 7 A scalp care cream that combines oil control, odor removal, and scalp anti-aging functions. This embodiment adds an O / W type emulsifying matrix to the hair care essence composition of Example 1.

[0056] The scalp care cream is composed of: Example 1 hair essence composition: 50 parts; oil phase moisturizing component: 5 parts, wherein the weight ratio of caprylic / capric triglyceride to jojoba oil is 8:1; emulsifier: 1 part, wherein the weight ratio of polysorbate-60 to PPG-5-cetyl polyether-20 is 1:2; cetyl alcohol: 1 part; stabilizer and thickener: 0.2 parts, wherein the weight ratio of xanthan gum to carbomer is 4:1; deionized water: 20 parts. The preparation method used is the same as in Example 6.

[0057] Comparative Example 1 The difference between this comparative example and Example 1 is that no oil-controlling and deodorizing components were added to this comparative example, while the composition of other raw materials and preparation methods are the same as those in Example 1.

[0058] Comparative Example 2 The difference between this comparative example and Example 1 is that no antioxidant or antibacterial components were added to this comparative example, while the composition of the remaining raw materials and the preparation method are the same as those in Example 1.

[0059] Comparative Example 3 The difference between this comparative example and Example 1 is that no anti-inflammatory repair components were added to this comparative example, while the composition of other raw materials and preparation methods are the same as those in Example 1.

[0060] Comparative Example 4 The difference between this comparative example and Example 1 is that only modified hydroxyapatite is added, and polypeptide-rhSOD premix and polydeoxyribonucleotides are not added. The composition of other raw materials and preparation methods are the same as in Example 1.

[0061] Comparative Example 5 The difference between this comparative example and Example 1 is that only peptide-rhSOD premix is ​​added, and modified hydroxyapatite and polydeoxyribonucleotides are not added. The composition of other raw materials and preparation methods are the same as in Example 1.

[0062] Comparative Example 6 The difference between this comparative example and Example 1 is that only polydeoxyribonucleotides are added, and modified hydroxyapatite and polypeptide-rhSOD premix are not added. The composition of other raw materials and preparation methods are the same as in Example 1.

[0063] Experimental testing Test Example 1 Evaluation of antibacterial synergistic effect To verify the inhibitory effect of the composite system of the present invention on scalp inflammation-related microorganisms, Malassezia was used as the test strain, the diameter of the inhibition zone and the inhibition rate were used as evaluation indicators, and the Bliss independent model was used to evaluate the antibacterial synergistic effect of each functional component and its combination.

[0064] The specific testing method is as follows: After heating and melting the modified Dixon medium, pour it into a 9 cm diameter petri dish and allow it to cool and solidify at room temperature for later use. Take 0.2 mL of the activated Malassezia bacterial suspension with a bacterial concentration of 2 × 10^6 cfu / mL, spread it evenly on the surface of the culture medium, and let it stand to dry.

[0065] The samples from Example 1 and Comparative Examples 1-6 were diluted 10-fold with sterile water and used as test samples. Sterile filter paper discs with a diameter of 6 mm were soaked in the test samples. After saturation, they were removed, drained, and then attached to the surface of the inoculated culture medium. Three discs were attached to each plate, with a spacing of not less than 2 cm between the discs. Ten plates were prepared for each sample, and a blank control group was also set up.

[0066] The petri dishes were incubated at 35℃ in the dark for 7 days. After the inhibition zone became clear, the diameter of the inhibition zone was measured using calipers. The diameter of the inhibition zone included the diameter of the filter paper, and the average value was calculated. An inhibition zone diameter of not less than 7 mm was considered to have an antibacterial effect. The antibacterial rate was calculated as the proportion of filter paper with antibacterial effect to the total number of filter paper. The results are shown in Table 1.

[0067] Among them, component A is the sample obtained in Comparative Example 4 (oil-controlling and odor-removing component); component B is the sample obtained in Comparative Example 5 (antioxidant and antibacterial component); component C is the sample obtained in Comparative Example 6 (anti-inflammatory and repairing component). Group AB is the sample obtained in Comparative Example 3 (without anti-inflammatory and repairing component); group AC is the sample obtained in Comparative Example 2 (without antioxidant and antibacterial component); group BC is the sample obtained in Comparative Example 1 (without oil-controlling and odor-removing component). The ABC combination group is the sample obtained in Example 1.

[0068] Table 1. Results of antibacterial effect test

[0069] Bliss Independent Model: When the two components are used in combination, the expected effect is calculated according to the following formula: E AB =E A +E B -E A E B When the three components are used in combination, their expected effect is calculated according to the following formula: E ABC =E A +E B +E C-E A E B -E A E C -E B E C +E A E B E C Table 1 shows that the actual inhibition rates of groups AB, AC, and BC were 60.0%, 46.7%, and 63.3%, respectively, which are close to the theoretical expected values ​​of 59.1%, 46.3%, and 62.7% calculated by the Bliss model, indicating that no significant synergistic effect was observed when any two components were used in combination. However, the theoretical expected inhibition rate of group ABC was 71.4%, while the actual inhibition rate reached 93.3%, significantly higher than the theoretical expected value. This indicates that the combined use of modified hydroxyapatite, polypeptide-rhSOD premix, and PDRN has a significant synergistic inhibitory effect on Malassezia.

[0070] Test Example 2 Evaluation of ROS inhibition and scalp anti-aging effects To verify the synergistic effect of the composite system of the present invention in anti-oxidation and anti-aging of the scalp, an oxidative stress model was established by inducing HaCaT cells with UVB, and the intracellular ROS inhibition rate was used as the evaluation index.

[0071] After sterilization, the test samples were extracted with serum-containing DMEM medium at a ratio of 0.2 g / mL at 37°C for 12 h to prepare the test solution; the stock solution (i.e., 100% concentration) was used as the sample group. The test samples were diluted with serum-free DMEM medium. Vitamin E was used as the positive control, and a positive control working solution with a final concentration of 0.05% was prepared. HaCaT cells in the logarithmic growth phase were seeded at 1×10^5 cells / well in 24-well plates, with 1 mL of cell suspension added to each well, and cultured at 37°C and 5% CO2 for 24 h.

[0072] After cultivation, the groups were divided into two groups: the blank control group received no UVB irradiation but only ordinary culture medium; the model group received UVB irradiation followed by ordinary culture medium; the positive control group received UVB irradiation followed by culture medium containing 0.05% vitamin E; and the sample groups received UVB irradiation followed by culture medium containing the test solutions of groups A, B, C, AB, AC, BC, and ABC, respectively. The UVB irradiation dose was 12 mJ / cm², and the irradiation time was 5 min. After irradiation, each group was incubated in the dark for 24 h.

[0073] After incubation, the culture medium was discarded, and 500 μL of 10 μmol / L DCFH-DA working solution was added to each well. The wells were incubated at 37°C in the dark for 30 min. The cells were then gently washed three times with PBS buffer to remove any undeclared probes. Images were acquired using a fluorescence microscope, and fluorescence intensity was analyzed using ImageJ software.

[0074] ROS inhibition rate is calculated using the following formula: ROS inhibition rate (%) = (average fluorescence intensity of model group - average fluorescence intensity of sample group) / (average fluorescence intensity of model group - average fluorescence intensity of blank control group) × 100%.

[0075] The results of ROS content and ROS inhibition rate are shown in Table 2.

[0076] Table 2 Results of ROS Inhibition Rate Test

[0077] Table 2 shows that the actual ROS inhibition rates of groups AB, AC, and BC were 56.9%, 52.3%, and 63.3%, respectively, which are close to the theoretical expected values ​​of 55.3%, 51.1%, and 62.3% calculated by the Bliss model, indicating that the antioxidant synergistic effect of the two-component combination was not significant. However, the theoretical expected ROS inhibition rate of group ABC was 71.3%, while the actual ROS inhibition rate reached 82.6%, significantly higher than the theoretical expected value. This indicates that the combined use of modified hydroxyapatite, peptide-rhSOD premix, and PDRN can significantly synergistically inhibit excessive ROS accumulation, reduce scalp oxidative stress levels, and thus help delay scalp aging.

[0078] Test Example 3 Evaluation of anti-inflammatory and repairing effects To verify the anti-inflammatory and repairing effects of the composition of the present invention, an LPS-induced RAW264.7 cell inflammation model was established, and the expression levels of TNF-α, IL-6 and IL-10 were detected.

[0079] RAW264.7 cells were seeded in culture dishes containing complete culture medium and cultured at 37°C and 5% CO2. When cell confluence reached 80%–90%, cells were passaged, and stable cells in the logarithmic growth phase were selected for experiments. A cell suspension of 9 × 10^4 cells / mL was prepared and seeded into 24-well plates, with 1 mL of cell suspension added to each well, and cultured for 24 h.

[0080] After the culture was completed, the medium was replaced with fresh complete medium and the samples were divided into groups: the negative control group was given ordinary medium; the positive control group was given medium containing 50 μg / mL dexamethasone; and the sample groups were given medium containing the test solutions of Examples 1-7 and Comparative Examples 1-3, respectively. After 2 h of pretreatment, each group was stimulated with LPS at a final concentration of 1 μg / mL and incubated for another 18 h.

[0081] After incubation, the cell culture supernatant of each group was collected, and the contents of TNF-α, IL-6 and IL-10 were detected by ELISA. The downregulation rate of TNF-α, the downregulation rate of IL-6 and the upregulation rate of IL-10 were calculated. The results are shown in Table 3.

[0082] Table 3. Results of TNF-α, IL-6 and IL-10 expression level assay

[0083] As shown in Table 3, compared with the negative control group, Examples 1-3 significantly reduced TNF-α and IL-6 levels and significantly increased IL-10 levels, indicating that the composition of the present invention can effectively inhibit the release of inflammatory factors and promote the expression of anti-inflammatory factors, thus exhibiting good anti-inflammatory and repairing effects. Compared with Comparative Examples 1-3, the overall anti-inflammatory effect of the Example group was better, indicating that the combined action of modified hydroxyapatite, peptide-rhSOD premix, and PDRN is beneficial to improving the inflammatory microenvironment of the scalp.

[0084] Test Example 4 Heavy metal safety assessment According to the "Cosmetic Safety Technical Specifications" (2015 edition), the products obtained in Examples 1-7 were tested for lead, arsenic, and mercury content after microwave digestion. The testing instruments included an electronic balance, a microwave digester, and an inductively coupled plasma mass spectrometer (ICP-MS).

[0085] The test results showed that lead content was not detected in any of the samples in Examples 1-7, with a detection limit of <0.09 mg / kg; arsenic content was not detected in any of the samples, with a detection limit of <0.0033 mg / L; and mercury content was not detected in any of the samples, with a detection limit of <0.0033 mg / L. The results indicate that the product of this invention meets the requirements for heavy metal limits in the Cosmetic Safety Technical Specifications.

[0086] Test Example 5 Oil control effect evaluation The oil-controlling effect of the samples from Examples 1-7 and Comparative Examples 1-3 was evaluated. The experiment was conducted according to TPYKT-SOP-0016 "Evaluation Method for Consumer Use Testing of Cosmetics". Fifty subjects were selected and divided into 10 groups of 5 people each.

[0087] Subjects were instructed to use unscented shampoo for 48 hours prior to the test, refrain from using perfumes or hair care products for 48 hours prior to the test, avoid consuming spicy foods (such as onions and garlic) for 48 hours prior to the test, and refrain from strenuous exercise for 12 hours prior to the test.

[0088] The test sample was used under constant environmental conditions of (25±2)℃ and (50±5)% relative humidity. The test area was an area of ​​about 50 cm² on the top of the head. The sample application method was to take 1.0±0.2g of sample for each group, apply it evenly to the test area, and massage for 2 minutes until absorbed.

[0089] A 5-point questionnaire was used for evaluation. The evaluation questions included: Q1, "Scalp oiliness significantly improved after use"; Q2, "Scalp still felt fresh after 12 hours of use"; and Q3, "The product has a long-lasting oil-control effect." The rating criteria were: 1 point for strongly disagreeing, 2 points for somewhat disagreeing, 3 points for neutral or no effect, 4 points for somewhat agreeing, and 5 points for strongly agreeing. For statistical analysis, a score of ≥4 was considered a valid evaluation. Satisfaction was calculated based on the proportion of respondents who scored ≥4. The results are shown in Table 4.

[0090] Table 4 Evaluation Results of Oil Control Effect

[0091] As shown in Table 4, this test case verified the effective effects of the hair care essence, hair care gel, and scalp conditioning cream provided by this invention. They all performed well in improving scalp oiliness, maintaining a fresh feeling for 12 hours, and providing long-lasting oil control after use. In particular, the satisfaction rate of Examples 4 (hair care gel) and 6 (scalp conditioning cream) reached 100%. However, in Comparative Example 1, without the addition of modified hydroxyapatite, the oil control effect was significantly reduced, indicating that modified hydroxyapatite plays an important role in absorbing sebum and improving scalp oiliness.

[0092] Test Example 6 Evaluation of odor removal effect Forty subjects with healthy scalps but prone to odor were selected and divided into 10 groups of 4 people each, including 2 men and 2 women; another 5 people with normal sense of smell were selected to form the evaluation panel.

[0093] All subjects used unscented shampoo for 48 hours prior to the test, and were prohibited from using perfume, hair care products, or consuming spicy foods (onions, garlic, etc.) for 48 hours prior to the test. Strenuous exercise was also prohibited for 12 hours prior to the test. By the time the samples were used, all subjects had a noticeable odor from their scalps.

[0094] The test sample was used under constant environmental conditions of (25±2)℃ and (50±5)% relative humidity. The test area was an area of ​​about 50 cm² on the top of the head. The sample application method was to take 1.0±0.2g of sample for each group, apply it evenly to the test area, and massage for 2 minutes until absorbed.

[0095] At 0.5 h, 8 h, and 24 h after using the sample, the judging panel manually smelled and scored the odor of the subjects' scalps. The maximum score was 5 points, with higher scores indicating better odor removal. The test results were averaged from each group, and the results are shown in Table 5.

[0096] Table 5 Evaluation of Odor Removal Effect

[0097] As shown in Table 5, Examples 1-7 all exhibited high odor removal scores at 0.5 h, 8 h, and 24 h, indicating that the product of this invention not only rapidly improves scalp odor but also possesses good long-lasting odor removal capabilities. Compared with the comparative examples, the Example group showed significantly better results, indicating that the modified hydroxyapatite, polypeptide-rhSOD premix, and PDRN work together to reduce scalp odor production through a process of "adsorbing odor substances—inhibiting microbial metabolism—repairing the scalp microenvironment."

[0098] Test Example 7: Using Security Evaluation The safety of the products obtained in Examples 1-7 for human use was observed. During the experiment, dermatologists or researchers asked subjects whether they experienced discomfort such as dry skin, erythema, peeling, stinging, itching, and burning while using the test products, and observed whether adverse reactions such as rash and swelling appeared in the test areas.

[0099] Test results showed that no symptoms such as dry skin, erythema, peeling, stinging, itching, or burning occurred in the subjects during use of the test product, and no adverse reactions such as rash or swelling were observed in the tested areas. The results indicate that the product of this invention has good skin tolerance and safety.

[0100] In summary, based on evaluations of antibacterial properties, ROS inhibition, anti-inflammatory repair, oil control and odor removal, and safety, Examples 1-7 of this invention all exhibit excellent and balanced scalp care effects. Compared to the comparative examples, this invention, through the rational combination of modified hydroxyapatite, peptide-rhSOD premix, and PDRN, achieves a multi-mechanism synergistic effect in controlling oil adsorption, inhibiting abnormal proliferation of Malassezia, reducing ROS levels, regulating the expression of inflammatory factors, and improving scalp odor.

[0101] The Bliss independent model analysis showed that when any two components were used in combination, the actual effect was close to the theoretical expectation, and no significant synergistic effect was observed. However, when all three components were used in combination, the antibacterial rate and ROS inhibition rate were significantly higher than the theoretical expectation, indicating that the composite system of this invention has a significant synergistic effect. Therefore, this invention can achieve comprehensive regulation of scalp sebum metabolism, microecological balance, oxidative stress, and inflammation repair, and has good application value for scalp health maintenance and anti-aging.

Claims

1. A hair care essence composition that combines oil control, odor removal, and scalp anti-aging functions, characterized in that, The hair care essence composition comprises: oil-controlling and odor-eliminating components: 2-5 parts by weight; antioxidant and antibacterial components: 1-5 parts by weight; anti-inflammatory and repairing components: 0.2-2 parts by weight; moisturizing system: 48.1-81 parts by weight; and aqueous system: 5.2-21 parts by weight. The oil-controlling and deodorizing component is a stearic acid-modified porous hollow hydroxyapatite adsorbent material; The antioxidant and antibacterial component is a polypeptide-rhSOD premix, which is composed of acetyl tetrapeptide-3, acetyl hexapeptide-1 and recombinant human superoxide dismutase (rhSOD). The weight ratio of acetyl tetrapeptide-3 to acetyl hexapeptide-1 to rhSOD is 1:(1-5):(0.1-0.5), and the specific activity of rhSOD is 10000 U / mg. The anti-inflammatory and repairing component is a polydeoxyribonucleotide obtained by purifying fish milt samples through enzymatic hydrolysis, salting out, and ethanol precipitation.

2. The hair care essence composition according to claim 1, characterized in that, The preparation method of the porous hollow hydroxyapatite adsorbent material includes the following steps: (1) Preparation of porous hollow hydroxyapatite particles: Sodium carbonate solution and an equal volume of calcium nitrate solution were mixed, sodium polystyrene sulfonate was added, and the mixture was stirred at 30°C to produce calcium carbonate particles. After centrifuging and washing the calcium carbonate particles, they were added to a disodium hydrogen phosphate solution for a hydrothermal reaction. After the reaction is complete, acid solution is added and stirred continuously to remove calcium carbonate particles, thereby obtaining porous hollow hydroxyapatite particles. (2) Surface stearic acid modification: Stearic acid and thionyl chloride were mixed at 0.5 times their mass of the porous hollow hydroxyapatite particles and refluxed at 80°C to react a. After removing the residual reagents, the reaction solution was obtained. Hydroxyapatite powder, dimethylformamide, and triethylamine were added to the reaction solution, and the mixture was refluxed at 60°C. After the reaction was completed, the mixture was washed and dried to obtain the porous hollow hydroxyapatite adsorbent material.

3. The hair care essence composition according to claim 2, characterized in that, In step (1), the concentrations of the sodium carbonate solution and the calcium nitrate solution are both 0.1 mol / L, the amount of sodium polystyrene sulfonate added is 150 mg / 40 mL of the mixture, the hydrothermal reaction is carried out at 140°C for 4 h, and the acid treatment is carried out by continuous stirring for 2 h. In step (2), the amount of stearic acid used is 0.5 times the mass of the porous hollow hydroxyapatite particles, the amount of thionyl chloride used is 0.042 mol, the reflux reaction a time is 2 h; the amount of hydroxyapatite powder added is 2 g, the amount of triethylamine added is 0.005 mol, and the reflux reaction b time is 12 h.

4. The hair care essence composition according to claim 3, characterized in that, The method for preparing the polydeoxyribonucleotide includes the following steps: The fish milt sample was placed in the lysis buffer and enzymatically digested in a constant temperature water bath at 55℃ for 18 hours. After enzymatic hydrolysis, centrifuge to collect the supernatant, add NaCl, mix well, and centrifuge again; Collect the supernatant and add anhydrous ethanol to precipitate it. Wash the precipitate with 75% ethanol and dry it at 65°C for 5 hours to obtain the polydeoxyribonucleotide. The lysis buffer contains Tris-HCl, EDTA, NaCl, SDS, and proteinase K.

5. The hair care essence composition according to claim 1, characterized in that, The hair care essence composition also includes a moisturizing system and an aqueous phase system: The moisturizing system comprises: glycerin: 5-12 parts by weight; butylene glycol: 3-8 parts by weight; sodium hyaluronate: 0.1-1 parts by weight; deionized water: 40-60 parts by weight; The aqueous phase system comprises: carbomer: 0.2 to 1 part by weight; deionized water: 5 to 20 parts by weight.

6. The hair care essence composition according to claim 5, characterized in that, The preparation method of the hair care essence composition includes the following steps: 1) Preparation of moisturizing system: Add 5-12 parts by weight of glycerin and 3-8 parts by weight of butanediol to 60 parts by weight of deionized water and stir to dissolve to obtain solution A; Then add 0.1 to 1 part by weight of sodium hyaluronate to 2 parts by weight of glycerin, stir slowly until completely soaked, and then slowly add to solution A, stir to hydrate for 60 minutes, and defoam to obtain the moisturizing system; 2) Preparation of aqueous system: Take 0.2-1 parts by weight of carbomer and add it to 5-20 parts by weight of deionized water, stir for 20 min to obtain aqueous system, heat it to 70℃ and keep it at the temperature to obtain aqueous system; 3) Introduce oil-controlling and deodorizing components: Add 2-5 parts by weight of porous hollow hydroxyapatite to 10 parts by weight of deionized water for pre-dispersion, and disperse at high speed for 10 min to form a uniform suspension. Add 48.1-81 parts by weight of moisturizing system and 5.2-21 parts by weight of aqueous system at 70℃, and stir for 20 min to obtain mixture A; 4) Introducing antioxidant and antibacterial components: At room temperature (25±2℃), add 1 to 5 parts by weight of peptide-rhSOD premix to mixture A and stir for 15 min to obtain mixture B; 5) Introducing anti-inflammatory and repairing components and shaping: Add 0.2-2 parts by weight of polydeoxyribonucleotide (PDRN) to 40 parts by weight of deionized water, adjust the pH of the system to 6.0, stir at room temperature for 10 min to defoam, and obtain the hair care essence composition.

7. A hair gel that combines oil control, odor removal, and scalp anti-aging functions, characterized in that, The hair gel is made from the following ingredients in parts by weight: The hair care essence composition according to any one of claims 1-6: 60-80 parts; Carbomer 940: 0.3–2 parts; Triethanolamine: 0.1–1 part; Deionized water: 5-20 parts; The pH value of the hair gel is 5.5 to 6.

5.

8. The hair care gel according to claim 7, characterized in that, The preparation method of the hair care gel includes the following steps: (a) Gel matrix preparation: 0.8 parts by weight of carbomer were added to 20 parts by weight of deionized water, stirred at 500 r / min for 20 min, and allowed to stand for 30 min to fully hydrate, to obtain gel matrix A; (b) Addition of active essence: 80 parts by weight of the hair care essence composition are slowly added to the gel matrix A and stirred at 400 r / min for 15 min to obtain mixture B; (c) Neutralization and thickening: Triethanolamine is slowly added to mixture B and the pH of the system is adjusted to 6.0 to allow the carbomer to undergo a neutralization and thickening reaction to form a gel; (d) Curing and degassing: Continue stirring at low speed for 10 min to degas, and let stand for 12 h to cure, thus obtaining hair gel.

9. A scalp care cream that combines oil control, odor removal, and scalp anti-aging functions, characterized in that, The scalp care cream comprises the hair care essence composition according to any one of claims 1-6 and an O / W type emulsion base, and is made from the following raw materials in parts by weight: The hair care essence composition according to any one of claims 1-6: 50-70 parts; Oil phase emollient component: 5-15 parts, wherein the oil phase emollient component is composed of caprylic / capric triglyceride and jojoba oil, wherein the weight ratio of caprylic / capric triglyceride to jojoba oil is 8:1; Emulsifier: 1 to 5 parts, wherein the emulsifier is composed of polysorbate-60 and PPG-5-cetyl polyether-20, and the weight ratio of polysorbate-60 to PPG-5-cetyl polyether-20 is 1:2; Cetyl alcohol: 1-5 parts; Stabilizing thickener: 0.1 to 1 part, wherein the stabilizing thickener is composed of xanthan gum and carbomer, and the weight ratio of xanthan gum to carbomer is 4:1; Deionized water: 10-20 parts; The pH value of the scalp care cream is 5.5 to 6.

5.

10. The method for preparing the scalp care cream according to claim 9, characterized in that, The preparation method of the scalp care cream includes the following steps: (A) Preparation of oil phase: 9 parts by weight of the oil phase emollient component, 3 parts by weight of emulsifier and 3 parts by weight of cetyl alcohol are mixed, heated to 80°C and stirred until completely melted to obtain oil phase A; (B) Preparation of aqueous phase: 15 parts by weight of deionized water and 0.5 parts by weight of stabilizer thickener were mixed, dispersed for 15 min, and then heated to 80℃ and kept at that temperature to obtain aqueous phase B; (C) Emulsification: At 80°C, oil phase A was slowly added to aqueous phase B, and homogenized at 5000 r / min for 10 min to obtain cream matrix C; (D) Finished product shaping: After cooling the cream base C to 40°C, add 70 parts by weight of the hair care essence composition and stir for 10 min; The mixture was then cooled to room temperature, stirred at low speed for 10 minutes to remove bubbles, and the pH was adjusted to 6.0 to obtain the scalp care cream.

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