Benzothiazole derivatives and uses thereof

By developing benzothiazole derivatives as TREK-1 potassium channel modulators, the shortcomings of existing drugs in the treatment of depression and pain have been addressed, providing a safe and effective treatment option suitable for various routes of administration and dosage forms, and achieving effective regulation of TREK-1 channels.

CN122272575APending Publication Date: 2026-06-26EAST CHINA NORMAL UNIV +1
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EAST CHINA NORMAL UNIV
Filing Date
2025-12-25
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing antidepressants and analgesics have problems such as slow onset of action, large side effects, large individual differences, and unsatisfactory treatment effects. In particular, their effects on major depressive disorder and treatment-resistant depression and pain are limited, and traditional analgesics have addictive and side effects.

Method used

Develop benzothiazole derivatives as TREK-1 potassium channel modulators for the preparation of drugs to relieve and/or eliminate pain, and for the prevention and treatment of depression, administered via oral, nasal, skin, pulmonary, or gastrointestinal routes. The compositions contain pharmaceutically acceptable carriers and excipients and are suitable for preparation in tablet, capsule, powder, solution, suspension, and aerosol forms.

Benefits of technology

It provides a high-performance TREK-1 modulator that can effectively relieve pain and treat depression, with good safety and selectivity, and is suitable for various routes of administration and dosage forms to meet the treatment needs of different individuals.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122272575A_ABST
    Figure CN122272575A_ABST
Patent Text Reader

Abstract

This disclosure relates to a benzothiazole derivative of formula (I) or a pharmaceutically acceptable salt thereof, its tautomers or stereoisomers thereof, methods of preparation and uses thereof, and pharmaceutical compositions thereof. It also provides the use of the compounds of the present invention as TREK-1 potassium channel modulators, and their use in alleviating and / or eliminating neuropsychiatric disorders. Furthermore, it provides the use of the compounds of the present invention in the preparation of medicaments for neuropsychiatric disorders. The present invention also provides treatment methods for diseases related to TREK-1 potassium channels.
Need to check novelty before this filing date? Find Prior Art