A pharmaceutical composition comprising a heterocyclic compound

CN122295086APending Publication Date: 2026-06-26SAGIMET BIOSCIENCES INC
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Patent Information

Application Number
CN202480048342.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2024-05-10
Filing Date
2024-07-13
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Among the existing pharmaceutical preparations, preparations containing low-melting drugs have poor stability and need to be stored at low temperatures, which leads to inconvenience in taking medications in patients and increases production costs due to low temperature storage.

Method used

The drug composition containing a hybrid compound is used to mix the formula (i) compound with the hydroxylopyaline cellulose or co -polystone, and prepare through the hot melt or spray drying process to form a stable at room temperature at room temperature. Drug composition stored.

Benefits of technology

A long -term stable storage of drugs under room temperature and high relative humidity conditions has been achieved, and the dissolution effect of the drug is improved and the production cost is reduced.

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Abstract

This invention discloses a pharmaceutical composition comprising a heterocyclic compound, the pharmaceutical composition comprising the following components: (a) a compound of formula (I); and (b) hydroxypropyl methylcellulose acetate succinate or copovidone; wherein components (a) and (b) are mixed and subjected to thermal melt extrusion, wherein the weight ratio of component (b) to component (a) is 0.4 to 0.8. The pharmaceutical composition of this invention exhibits stable storage over extended periods under conditions of room temperature and high relative humidity, and demonstrates significantly improved dissolution performance.
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