Fluticasone propionate cream and a method for preparing the same

By using a mixture of hexanediol and propylene glycol as solvents and a composite stabilizer, the problem of inappropriate retention in fluticasone propionate cream was solved, achieving appropriate drug retention and penetration in the skin, improving the stability and therapeutic effect of the cream, and making it suitable for industrial production.

CN122297368APending Publication Date: 2026-06-30FRONT PHARM PLC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FRONT PHARM PLC
Filing Date
2024-12-30
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In existing fluticasone propionate creams, the poor solubility of fluticasone propionate leads to an inappropriate amount remaining in the skin, affecting the efficacy of the drug and increasing the risk of systemic adverse reactions. Furthermore, the quality stability of existing creams is insufficient.

Method used

Fluticasone propionate cream was formulated using a mixture of hexanediol and propylene glycol as solvents and a composite stabilizer (EDTA series salts and pH buffers). Combined with penetration enhancers (such as isopropyl myristate, laurocapram, and oleic acid oil), the cream was prepared through a specific process to ensure that the amount of drug retained and permeated in the skin was appropriate, thereby improving stability.

Benefits of technology

It achieves an appropriate retention and penetration rate of the drug in the skin, reduces the risk of adverse reactions, and improves the stability and therapeutic effect of the cream, making it suitable for industrial production.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to fluticasone propionate cream, belonging to the field of topical pharmaceutical preparations. By using a mixed solvent of hexanediol and propylene glycol, along with a composite stabilizer, this invention solves the problem in existing fluticasone propionate creams where inappropriate intradermal retention leads to insufficient therapeutic efficacy. Simultaneously, it ensures the stability of the cream; the cream of this invention remains stable under high temperature, high temperature, light, low temperature, and freeze-thaw conditions, with no significant increase in related substances. The preparation process of the fluticasone propionate cream of this invention is simple and suitable for industrial production.
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