A rapid method for detecting blood drug concentrations in emergency patients

By constructing an analysis interval and a baseline linear reference sequence in an emergency setting, combined with a two-dimensional concentration compensation table, the diffusion barrier caused by high hematocrit was resolved, thereby improving the accuracy and reliability of blood drug concentration detection.

CN122307097APending Publication Date: 2026-06-30ZHONGCHUANG YUNKE (BEIJING) INFORMATION TECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHONGCHUANG YUNKE (BEIJING) INFORMATION TECHNOLOGY CO LTD
Filing Date
2026-04-21
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In emergency medical settings, high hematocrit (HCT) hinders the diffusion of drug molecules in whole blood samples, causing existing portable in vitro physicochemical analyzers to be unable to accurately measure blood drug concentrations within a short time window, resulting in falsely low test results.

Method used

By constructing an analysis interval with a preset cutoff time as the endpoint, a baseline linear reference sequence is generated to determine the time of maximum deviation. The drug concentration value of hematocrit is corrected by querying a preset two-dimensional concentration compensation table in conjunction with the endpoint value. The signal is then processed using moving average filtering and bilinear interpolation algorithms.

Benefits of technology

Without adding centrifugation pretreatment or complex hardware, it significantly improves the accuracy and reliability of blood drug concentration detection, and accurately offsets the false low concentration bias caused by dense cell aggregation.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the field of drug concentration detection technology, specifically to a rapid method for detecting blood drug concentrations in emergency patients. The method involves collecting time-series biochemical reaction signals from whole blood samples within a fixed time window, obtaining a net signal sequence after benchmark removal; constructing a baseline linear reference sequence connecting the zero point and the endpoint using a preset cutoff time endpoint value; calculating the vertical difference between the net signal and this reference to determine the time of maximum deviation; and finally, using the endpoint value and the time of maximum deviation as a two-dimensional index to query a preset compensation table and output the drug concentration corrected for hematocrit. This method utilizes reaction kinetic morphology characteristics to decouple the diffusion hindrance effect caused by high hematocrit, avoiding false low concentration results due to incomplete reaction equilibrium. It significantly improves the accuracy and reliability of blood drug concentration detection in emergency settings under conditions of no centrifugation and direct whole blood measurement.
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