A traditional Chinese medicine composition for strengthening bones, relieving pain, repairing cartilage, improving osteoporosis and calming the heart and soothing the nerves

Abstract

This invention discloses a traditional Chinese medicine composition that strengthens bones and relieves pain, repairs cartilage, improves osteoporosis, and calms the mind, belonging to the field of traditional Chinese medicine technology. This composition is derived from Guizhi Shaoyao Zhimu Decoction and Huanglian Ejiao Decoction, containing components such as cinnamon twig, white peony root, anemarrhena rhizome, prepared aconite root, coptis rhizome, scutellaria root, psoralea fruit, eucommia bark, and calcined oyster shell. It restores blood and qi supply to bones and joints by warming yang and dispelling cold, eliminating wind and dampness, and promoting blood circulation. Combined with tonifying the kidneys and strengthening bones, nourishing blood and softening tendons, it achieves cartilage repair, bone strengthening, and improvement of osteoporosis. It also clears heat and calms the mind, and can be used to treat bone pain, muscle and bone pain, cartilage wear, and osteoporosis caused by wind-cold-dampness obstruction, accompanied by symptoms such as irritability and insomnia. It has comprehensive therapeutic effects and high clinical application value.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition modified from a classic prescription, which has the effects of strengthening bones and relieving pain, repairing cartilage, improving osteoporosis, and calming the mind and soothing the nerves, as well as its preparation method and clinical application. Background Technology

[0002] When wind, cold, and dampness invade the body, they easily obstruct the meridians and collaterals of the muscles, bones, and joints, leading to poor blood and qi circulation, meridian blockage, and symptoms of rheumatic bone disease such as muscle and bone pain, joint heaviness, and difficulty in flexion and extension. Long-term meridian blockage can cause insufficient blood and qi in the joints and bones, hindering nutrient delivery. Joint cartilage, due to long-term malnutrition, undergoes continuous wear and tear and is difficult to repair itself. If areas such as the femoral head are chronically ischemic and malnourished, there is a risk of ischemic injury or even necrosis. Simultaneously, the lack of blood and qi nourishment can gradually lead to decreased bone density, osteoporosis, and muscle weakness, resulting in limb weakness, joint instability, and a significant increase in the likelihood of falls and fragility fractures. The core pathogenesis of these bone diseases lies in the obstruction of wind, cold, and dampness, meridian blockage, and malnutrition of qi, blood, and kidney essence, rather than simply kidney deficiency or a simple excess of pathogenic factors. In clinical practice, using only kidney-tonifying and bone-strengthening drugs is insufficient to eliminate pathogenic factors and unblock meridians, and the essential nutrients cannot truly reach the affected area. Similarly, merely dispelling wind, dampness, cold, and pain cannot repair damaged cartilage, improve osteoporosis, or promote bone regeneration; the treatment approach is too simplistic and fails to address both the symptoms and the root cause. Furthermore, patients with rheumatic bone pain often experience persistent pain, especially at night, which can easily lead to internal heat and disturbance of the mind, commonly resulting in insomnia and restlessness, thus creating a vicious cycle of "unresolved pain—insomnia and irritability—disordered qi and blood—impaired bone and tendon repair." Currently, there is a lack of integrated traditional Chinese medicine formulas that can simultaneously dispel wind and dampness, unblock meridians, repair cartilage, strengthen bones, improve osteoporosis, and calm the mind. Among classic formulas, Guizhi Shaoyao Zhimu Tang is a representative formula for treating rheumatic bone pain and joint pain, excelling at dispelling wind and dampness, unblocking meridians, and relieving pain; Huanglian Ejiao Tang is a classic formula for clearing heat, nourishing blood, and calming the mind. Current technologies have not organically combined the two approaches to achieve a comprehensive treatment of bone diseases caused by wind-cold-dampness obstruction and meridian blockage, while simultaneously calming the mind, promoting sleep, and disrupting the pathological cycle. Traditional Chinese medicine classics have long clearly stated that bones, cartilage, and bone tissue are not irreversibly damaged once damaged, but possess the physiological characteristics of periodic growth, repair, and regeneration. The *Ling Shu* (Spiritual Pivot) states, "When blood is harmonious, the meridians flow smoothly, nourishing yin and yang, strengthening tendons and bones, and making joints flexible." This indicates that when qi and blood flow smoothly and nutrition is adequate, tendons and bones are nourished, joints become smooth, and worn cartilage and damaged bone can be gradually repaired. The *Su Wen* (Plain Questions) states, "The kidneys generate bone marrow." The *Su Wen* also states, "When kidney qi is abundant, marrow is full; when marrow is full, bones are strong." This reveals that when kidney essence is abundant and bone marrow has a source of production, bones can continuously grow, become denser, and stronger, and osteoporosis can be improved and reversed. Ye Tianshi said, "If arthralgia persists for a long time, pathogenic factors will enter the meridians and damage the tendons and bones. It is not enough to simply dispel wind; one must nourish the blood and tendons, and replenish the kidneys and marrow so that the tendons and bones can be restored to health." This theory directly points out the key to rheumatic bone arthralgia: the obstruction of wind, cold, and dampness is the superficial symptom, while the root cause is the lack of nourishment to the tendons and bones, and the deficiency of marrow and weakness of bones. Simply dispelling wind, cold, and dampness can only temporarily relieve the pain and cannot repair damaged cartilage, osteoporosis, and worn-down bone. It is essential to first dispel pathogenic factors and unblock the meridians, followed by nourishing the blood and tendons, and replenishing the kidneys and strengthening the bones. Only by ensuring that the qi and blood nourish the tendons and bones, and the kidney essence replenishes the bone marrow, can damaged bones be restored, cartilage repaired, and bone density increased. Summary of the Invention

[0003] This invention addresses the core pathogenesis of bone diseases—wind-cold-dampness obstruction and meridian blockage—by providing a meticulously formulated and effective traditional Chinese medicine composition. Based on dispelling wind and dampness and unblocking meridians, it nourishes and moistens, repairs cartilage, strengthens bones, and improves osteoporosis. Simultaneously, it calms the mind and improves sleep, fundamentally resolving the clinical challenge of rheumatic bone pain accompanied by insomnia and irritability. This formula is derived from the core combinations of Guizhi Shaoyao Zhimu Tang and Huanglian Ejiao Tang. It uses warming and dispersing herbs to eliminate wind-cold-dampness and unblock obstructed meridians, restoring blood and qi circulation and nutrient supply to the bones and joints. It uses kidney-tonifying and bone-strengthening herbs to promote bone strength and increase bone density. It uses blood-nourishing and blood-activating herbs to promote cartilage repair and prevent continuous cartilage wear and ischemic injury to the femoral head. Finally, it uses heat-clearing and fire-reducing herbs to clear stagnant heat and calm the mind. This formula combines tonifying and purging methods, eliminating pathogens without harming the body's vital energy, achieving the combined effects of strengthening bones and relieving pain, repairing tendons and bones, and calming the mind and spirit. The formula omits the cloying and stomach-damaging ingredients like donkey-hide gelatin and egg yolk to avoid promoting dampness and retaining pathogens, which could hinder the elimination of rheumatism. Eucommia bark is added to tonify the liver and kidneys and strengthen tendons and bones; combined with psoralea corylifolia and calcined oyster shell, it enhances the kidney-tonifying, marrow-replenishing, bone-strengthening, and repairing effects. Calcined oyster shell has a mild medicinal property, possessing both calming and kidney-tonifying effects; its high dosage further strengthens the bone-strengthening effect.

[0004] The traditional Chinese medicine composition of the present invention is made from the following raw materials in parts by weight: 8-15 parts of cinnamon twig, 10-18 parts of white peony root, 8-12 parts of anemarrhena rhizome, 4-8 parts of ephedra, 8-12 parts of atractylodes rhizome, 8-12 parts of saposhnikovia root, 6-10 parts of fresh ginger, 6-10 parts of prepared aconite root, 4-8 parts of prepared licorice root, 3-6 parts of coptis rhizome, 6-10 parts of scutellaria root, 8-12 parts of apricot kernel, 8-12 parts of angelica root, 10-15 parts of psoralea fruit, 10-15 parts of eucommia bark, and 15-50 parts of calcined oyster shell. The preferred embodiment is as follows: 20 parts of cinnamon twig, 16 parts of white peony root, 12 parts of prepared licorice root, 12 parts of prepared aconite root, 12 parts of ephedra, 20 parts of atractylodes macrocephala, 20 parts of anemarrhena asphodeloides, 20 parts of saposhnikovia divaricata, 16 parts of fresh ginger, 4 parts of coptis chinensis, 8 parts of scutellaria baicalensis, 12 parts of apricot kernel, 10 parts of angelica sinensis, 12 parts of psoralea corylifolia, 12 parts of eucommia ulmoides, and 30 parts of calcined oyster shell. Detailed Implementation

[0005] The decoction method of the herbal composition of this invention is as follows: When decocting this formula, the prepared aconite root should be brought to a boil over high heat, then simmered over low heat for 1-2 hours. After tasting and finding no numbness on the tongue, the remaining herbs are added and decocted for another 30-40 minutes. The decoction is then filtered to obtain the final product. This method ensures the safety of using prepared aconite root while preserving the effective components of each herb to the greatest extent.

[0006] This invention addresses bone and joint pain, cartilage wear, osteoporosis, and joint dysfunction caused by wind-cold-dampness obstruction, blocked meridians, and insufficient qi and blood flow. It restores blood and qi supply to the bones and joints by dispelling wind and dampness and promoting blood circulation. Based on this, it achieves cartilage repair, bone strengthening, and increased bone density, effectively preventing further cartilage wear and the risk of ischemic femoral head injury. The formula includes Eucommia ulmoides, Psoralea corylifolia, and calcined oyster shell to tonify the kidneys and strengthen bones, enhancing the bone and joint repair effect. Simultaneously, it clears heat and calms the mind, promoting sleep and alleviating common insomnia and restlessness in patients with rheumatic bone diseases. This allows for simultaneous treatment of bone and joint problems and mental well-being, resulting in comprehensive efficacy and a rational formula with high clinical application and translational value.

Claims

1. A Chinese medicinal composition for strengthening bones, relieving pain, clearing heart and tranquilizing mind, characterized in that, The ingredients include the following parts by weight: cinnamon twig 8-20 parts, white peony root 10-18 parts, anemarrhena rhizome 8-20 parts, ephedra 4-12 parts, atractylodes rhizome 8-20 parts, saposhnikovia root 8-20 parts, fresh ginger 6-16 parts, prepared aconite root 6-12 parts, prepared licorice root 4-12 parts, coptis rhizome 3-6 parts, scutellaria root 6-10 parts, apricot kernel 8-12 parts, angelica root 8-12 parts, psoralea root 10-15 parts, eucommia bark 10-15 parts, and calcined oyster shell 15-50 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, This composition is based on Guizhi Shaoyao Zhimu Decoction and Huanglian Ejiao Decoction, and is modified to form a five-fold synergistic structure that warms the yang and dispels cold, tonifies the kidney and strengthens bones, nourishes blood and promotes blood circulation, clears heat and relieves irritability, strengthens the spleen and removes dampness.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The weight parts of each ingredient are as follows: 20 parts cinnamon twig, 16 parts white peony root, 20 parts anemarrhena rhizome, 12 parts ephedra, 20 parts atractylodes rhizome, 20 parts saposhnikovia root, 16 parts fresh ginger, 12 parts prepared aconite root, 12 parts prepared licorice root, 4 parts coptis rhizome, 8 parts scutellaria root, 12 parts apricot kernel, 10 parts angelica root, 12 parts psoralea root, 12 parts eucommia bark, and 30 parts calcined oyster shell.

4. The traditional Chinese medicine composition according to claim 1, characterized in that, This medicine is used to prepare drugs for treating degenerative joint diseases, wind-cold-dampness syndrome, muscle and bone pain, cartilage wear, osteoporosis, joint dysfunction, and also for treating irritability, insomnia, and restless sleep.

5. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4 in the preparation of a medicine for strengthening bones and relieving pain, repairing cartilage, improving osteoporosis, preventing ischemic injury of the femoral head, and calming the mind and soothing the nerves.

6. The traditional Chinese medicine composition according to any one of claims 1-5, characterized in that, The traditional Chinese medicine composition is a pharmaceutically acceptable decoction or oral preparation, including granules, capsules, tablets, pills, powders, and oral liquids.