Application of Hdac3 gene knockout preparation or Ikk alpha gene knockout preparation in preparation of medicine for inhibiting tumor metastasis
By knocking out the Hdac3 or Ikkα gene using CRISPR-Cas9 gene editing technology, TNF-α-mediated apoptosis is regulated, which solves the problem of poor treatment efficacy for tumor metastasis and achieves the inhibition of tumor metastasis and the extension of survival.
CN122321177APending Publication Date: 2026-07-03SUZHOU INST OF SYST MEDICINE
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Patent Information
- Application Number
- CN202610683100.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-18
- Publication Date
- 2026-07-03
AI Technical Summary
Technical Problem
Current technology has not fully understood the role of HDAC3 in tumor metastasis, resulting in poor treatment outcomes and low survival rates in tumor metastasis.
Method used
By using CRISPR-Cas9 gene editing technology to knock out the Hdac3 or Ikkα gene, TNF-α-mediated apoptosis sensitivity can be regulated, thereby inhibiting tumor metastasis and progression.
Benefits of technology
It significantly inhibits tumor metastasis, prolongs the survival of mice, enhances the sensitivity of tumor cells to TNF-α by downregulating the NF-κB pathway, and promotes tumor cell apoptosis.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the field of tumor immunotherapy, and provides application of a preparation for knocking out an Hdac3 gene or a preparation for knocking out an Ikk alpha gene in preparation of a medicine for inhibiting tumor metastasis. Research results show that Hdac3 and Ikk alpha gene mutation significantly inhibits tumor lung metastasis and prolongs the lifetime of mice, and the metastasis inhibition does not depend on T, B and NK cells. Meanwhile, the invention also finds that Hdac3 and Ikk alpha mutations influence the sensitivity of tumor cells to tumor necrosis factors, so that the tumor cells are easier to apoptosis, further tumor lung metastasis is inhibited, and a method for continuously killing the tumor cells in vivo is provided. The invention also provides a mutation vector. The provided mutation vector has a good effect of inhibiting tumor metastasis.
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