A behavioral evaluation device for measuring neurodevelopment in animals
By designing a behavior evaluation device with multimodal stimulation and synchronous acquisition modules, the problems of limited functionality and inefficient data processing in existing devices are solved, realizing multi-dimensional behavior evaluation and efficient data processing, and adapting to the needs of different experimental animals.
Patent Information
- Application Number
- CN202610683930.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-18
- Publication Date
- 2026-07-10
AI Technical Summary
Existing animal neurodevelopmental behavior assessment devices have limited functionality, cannot simultaneously cover multi-dimensional behavioral assessments, have limited stimulation modes, poor adjustability of experimental scenarios, asynchronous acquisition of behavioral and physiological data, low degree of automation in data processing, and weak versatility.
A behavior evaluation device was designed, comprising a multimodal stimulation module, a behavior and physiological synchronous acquisition module, and a central control module. By adjusting the experimental area and stimulation module through adjustment components, multidimensional behavior evaluation can be achieved, behavior and physiological signals can be acquired synchronously, and automated data processing can be performed.
It improves the comprehensiveness and accuracy of animal neurodevelopmental behavior evaluation, adapts to experimental animals of different body sizes and growth stages, and achieves simultaneous recording of behavioral and physiological signals and efficient data processing.
Smart Images
Figure CN122350693A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of animal behavior evaluation technology, specifically a behavior evaluation device for measuring animal neurodevelopment. Background Technology
[0002] In neuroscience research, behavioral assessment of animal neurodevelopment is a core tool for exploring neurodevelopmental mechanisms, screening neuroprotective drugs, and studying neurodevelopmental disorders (such as autism, cerebral palsy, and intellectual disability). Currently, existing animal neurodevelopmental behavioral assessment devices often suffer from the following shortcomings: 1. Limited functionality: Most devices can only detect a single behavioral indicator (such as motor ability or cognitive memory), failing to simultaneously cover multi-dimensional neurodevelopmental behaviors related to exploration, motor coordination, cognitive memory, and stress response, making it difficult to comprehensively evaluate the animal's neurodevelopmental status. 2. Limited stimulation modes: Existing devices mostly provide only visual or auditory stimulation, unable to simulate the multimodal stimulation (visual, auditory, tactile, olfactory) of the animal's natural environment. This results in a significant deviation between the experimental scenario and the actual physiological environment, leading to insufficient reliability and authenticity of the experimental results. 3. Asynchronous acquisition of behavioral and physiological data: Existing devices often... Behavioral capture and physiological data acquisition are separated into two independent systems, making it impossible to simultaneously record behavioral responses and physiological signals (EEG, EMG, ECG, etc.), which makes it difficult to establish the correlation between behavioral performance and neurophysiological mechanisms and affects the depth of research; 4. The automation level of data processing is low. Most devices can only collect raw data, requiring manual data processing, analysis and quantification, which is not only inefficient but also prone to human error, resulting in poor repeatability of experimental data; 5. The adjustability of experimental scenarios is poor. It is impossible to flexibly switch experimental scenarios and adjust stimulation parameters according to the body size and experimental needs of different experimental animals (such as young mice, adult mice, young rabbits), resulting in weak versatility.
[0003] Therefore, this invention proposes a behavioral evaluation device for measuring animal neurodevelopment to compensate for and improve the shortcomings of existing technologies. Summary of the Invention
[0004] To overcome the shortcomings of existing technologies, this invention proposes a behavioral evaluation device for measuring animal neural development.
[0005] To achieve the above objectives, the present invention employs the following technical solution: A behavioral evaluation device for measuring the neural development of animals includes a base plate, with vertical plates fixedly connected to both sides of the top surface of the base plate, and two partition plates between the two vertical plates. The two partition plates are connected to the vertical plates through a first adjustment component. Two baffles distributed front and back are fixedly connected to the top surface of the base plate, and the two baffles are fixedly connected to the two vertical plates. Each of the vertical plates has two rectangular through slots distributed front and back. Each rectangular through slot is equipped with a mounting plate. Each mounting plate is connected to the corresponding rectangular through slot through a second adjustment component. The mounting plate is equipped with a multimodal stimulation module.
[0006] Preferably, the first adjusting component includes: a strip-shaped through slot formed on the vertical plate, two strip-shaped blocks slidably connected in each strip-shaped through slot, one end of each strip-shaped block being fixedly connected to a corresponding partition plate, and a movable block being fixedly connected to the other end of each strip-shaped block; two fixed plates distributed front and back are fixedly connected to one side of each vertical plate; an adjusting screw is rotatably connected between the two fixed plates on the same vertical plate; each adjusting screw has opposite threads at both ends; and each adjusting screw passes through the corresponding two movable blocks and is threadedly connected to the movable blocks.
[0007] Preferably, the second adjustment component includes: a vertical rod, which is rotatably connected to a rectangular through slot and fixedly connected to a mounting plate; a horizontal plate is fixedly connected to the top of the vertical rod; two insert rods are slidably connected to the horizontal plate; a pull block is fixedly connected between the tops of the two insert rods; a spring is fitted around the outer periphery of the top of each insert rod; the top of each spring is fixedly connected to the pull block; the bottom of each spring is connected to the top surface of the horizontal plate; and the bottom of each insert rod can be inserted into a slot opened on the top surface of the vertical plate.
[0008] Preferably, the multimodal stimulation module includes a visual stimulation unit, an auditory stimulation unit, and an olfactory stimulation unit; the visual stimulation unit is an embedded LED display screen, fixedly connected to two mounting plates, and can output visual signals of different frequencies, brightness, and patterns; the auditory stimulation unit is a high-fidelity speaker, mounted on the same mounting plate as the visual stimulation unit, and can output sound signals of different decibels and frequencies in the range of 20Hz-20kHz; the olfactory stimulation unit includes a placement box with an opening on the top surface, several vents on one side of the placement box, and odor reagents placed inside the placement box, the odor reagents including animal predator odors, food odors, and unfamiliar environment odors.
[0009] Preferably, a sound insulation component is fixedly connected to the top surface of the base plate. The sound insulation component is located between two partition plates. The inner layer of the sound insulation component is sound insulation cotton, and the outer side of the sound insulation cotton is wrapped with tin foil.
[0010] Preferably, several evenly distributed high-definition cameras are fixedly connected to the opposite surfaces of the two baffles. The frame rate of the high-definition high-speed cameras can be adjusted between 30fps and 1000fps, and can capture behavioral parameters such as the animal's movement trajectory, limb movements, and reaction time. The top surface of the base plate is equipped with a pressure sensor, which can collect parameters such as the animal's gait pressure, standing time, and movement speed, so as to achieve multi-dimensional capture of behavioral indicators.
[0011] Preferably, a physiological synchronous acquisition module is also included: the physiological synchronous acquisition module includes an electroencephalogram (EEG) acquisition unit, an electromyography (EMG) acquisition unit, and an electrocardiogram (ECG) acquisition unit; the EEG acquisition unit is a non-invasive EEG electrode cap, which can be adapted to experimental animals of different sizes and is used to acquire animal EEG signals; the EMG acquisition unit is a patch-type EMG sensor, which can be attached to the muscles of the animal's limbs to acquire muscle electrical activity signals; the ECG acquisition unit is a flexible ECG patch, which is attached to the animal's chest to acquire ECG signals; all physiological signals are transmitted to the central control module wirelessly to achieve synchronous acquisition of behavioral and physiological signals.
[0012] Preferably, the system also includes a central control module and a data processing module. The central control module includes a main control chip, a touch operation panel, and a wireless transmission module. The main control chip uses an ARM architecture. The device features a Cortex-M4 core and can preset various neurodevelopmental behavioral evaluation paradigms, including exploratory behavior tests, motor coordination tests, cognitive memory tests, and stress response tests. A touch control panel is located on the outside of one of the baffles and is used for parameter setting, program start / stop, and real-time data viewing. The wireless transmission module supports both WiFi and Bluetooth dual-mode transmission, enabling real-time transmission of collected behavioral and physiological data to the data processing module. It can also receive feedback commands from the data processing module to adjust the operating parameters of each module. The data processing module includes a data storage unit, a data preprocessing unit, and a data analysis unit. The data storage unit can store at least 1000 sets of experimental data and supports local storage and cloud backup. The data preprocessing unit performs noise reduction, filtering, and normalization on the collected behavioral and physiological data, removing abnormal data. The data analysis unit incorporates a neurodevelopmental behavioral evaluation algorithm, which can quantitatively analyze the processed data, generating behavioral scores, physiological indicator curves, and a comprehensive neurodevelopmental evaluation report, intuitively reflecting the animal's neurodevelopmental status.
[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. This invention, through the combination of two vertical plates, two partition plates, and two baffles, can form two experimental areas, thereby enabling the simultaneous setting of a control group during the evaluation process, thus improving the evaluation effect; 2. By adjusting the first adjustment component, the two partition plates can be moved, thereby adjusting the distance between the two partition plates to adjust the size of the experimental area, thus meeting the needs of experimental mice with different growth cycles and body sizes, and improving the applicability of this device. 3. By setting up a multimodal stimulation module, the device can evaluate animals using multiple modal stimuli, further improving its applicability. The second adjustment component can be used to switch between the multimodal stimulation modules, thereby avoiding mutual interference between different stimuli and improving the accuracy of the device's evaluation. Attached Figure Description
[0014] The invention will now be further described with reference to the accompanying drawings.
[0015] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 yes Figure 1 The right view; Figure 3 This is a schematic diagram showing the connection between the base plate and the vertical plate; Figure 4 yes Figure 3 A magnified view of a portion of the I; Figure 5 This is a schematic diagram of the partition structure; Figure 6 This is a schematic diagram of the first adjustment component structure; Figure 7 This is a schematic diagram of the second adjustment component structure; Figure 8 This is a structural diagram of the mounting plate. The following are the labels shown in the diagram: 1. Base plate; 2. Vertical plate; 3. Divider plate; 4. Baffle plate; 5. Rectangular through-hole; 6. Mounting plate; 7. Strip through-hole; 8. Strip block; 9. Fixing plate; 10. Adjusting screw; 11. Vertical rod; 12. Horizontal plate; 13. Insert rod; 14. Pull block; 15. Spring; 16. Slot; 17. Placement box; 18. Vent hole; 19. Sound insulation component; 20. High-definition camera; 21. Moving block; 22. LED display screen; 23. High-fidelity speaker. Detailed Implementation
[0016] To make the technical means, creative features, achieved objectives, and effects of this invention readily understandable, the invention will be further described below in conjunction with the accompanying drawings and specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, it should be understood that after reading the teachings of this invention, those skilled in the art can make various modifications or alterations to the invention, and these equivalent forms also fall within the scope defined by this application.
[0017] like Figure 1-8As shown, the present invention discloses a behavioral evaluation device for measuring animal neural development, comprising a base plate 1, with vertical plates 2 fixedly connected to both sides of the top surface of the base plate 1. Two partition plates 3 are provided between the two vertical plates 2, and the two partition plates 3 are connected to the vertical plates 2 through a first adjustment component. Two baffles 4 distributed front and back are fixedly connected to the top surface of the base plate 1, and the two baffles 4 are fixedly connected to the two vertical plates 2. Through the cooperation of the two vertical plates, the two partition plates, and the two baffles, two experimental areas can be formed, so that a control can be set up simultaneously during the evaluation process, thereby improving the evaluation effect. By adjusting the first adjustment component, the two partition plates can be moved, thereby adjusting the distance between the two partition plates to adjust the size of the experimental area, thus meeting the needs of experimental mice with different growth stages and different body sizes, improving the applicability of the device. Each vertical plate 2 has two rectangular through slots 5 distributed front and back. Each rectangular through slot 5 is equipped with a mounting plate 6. Each mounting plate 6 is connected to the corresponding rectangular through slot 5 through a second adjustment component. The mounting plate 6 is equipped with a multimodal stimulation module. By setting the multimodal stimulation module, the animal can be evaluated by multiple modal stimuli, which further improves the applicability of the device. By adjusting the second adjustment component, the multimodal stimulation module can be switched, thereby avoiding mutual interference between different stimuli and improving the accuracy of the evaluation by the device.
[0018] like Figure 1 , Figure 5 and Figure 6 As shown, the first adjustment component includes: a strip-shaped through slot 7 formed on the vertical plate 2, two strip-shaped blocks 8 slidably connected in each strip-shaped through slot 7, one end of each strip-shaped block 8 being fixedly connected to a corresponding partition plate 3, and the other end of each strip-shaped block 8 being fixedly connected to a moving block 21, two fixed plates 9 distributed front and back being fixedly connected to one side of each vertical plate 2, and an adjustment screw 10 being rotatably connected between the two fixed plates 9 located on the same vertical plate 2, each adjustment screw 10 having opposite threads at both ends, and each adjustment screw 10 passing through the corresponding two moving blocks 21 and being threadedly connected to the moving blocks 21.
[0019] Specifically, rotating the adjusting bolt 10, which is threadedly connected to the moving block 21, causes the moving block 21 to move along the adjusting bolt 10 as the bolt rotates. The movement of the moving block 21 causes the strip block 8 to move along the strip through groove 7, which in turn causes the partition plate 3 to move, thereby adjusting the distance between the two partition plates 3 to adjust the size of the experimental area. This allows the device to meet the needs of experimental mice with different growth cycles and body sizes, thus improving its applicability.
[0020] like Figure 1 , Figure 7 and Figure 8 As shown, the second adjustment component includes: a vertical rod 11, which is rotatably connected to a rectangular through slot 5 and fixedly connected to a mounting plate 6. A horizontal plate 12 is fixedly connected to the top of the vertical rod 11. Two insert rods 13 are slidably connected to the horizontal plate 12. A pull block 14 is fixedly connected between the tops of the two insert rods 13. A spring 15 is fitted around the outer periphery of the top of each insert rod 13. The top of each spring 15 is fixedly connected to the pull block 14. The bottom of each spring 15 is connected to the top surface of the horizontal plate 12. The bottom of each insert rod 13 can be inserted into a slot 16 opened on the top surface of the vertical plate 2.
[0021] Specifically, rotating the vertical rod 11 causes the corresponding mounting plate 6 to rotate, which in turn causes the multimodal stimulation module mounted on it to rotate, thereby adjusting the position of the multimodal stimulation module for different stimulus evaluation analyses. Under the elastic force of the spring 15, the insertion rod 13 can be inserted into the corresponding slot 16, thereby limiting the mounting plate 6 and ensuring its stability.
[0022] like Figure 1 , Figure 5 and Figure 6 As shown, the multimodal stimulation module includes a visual stimulation unit, an auditory stimulation unit, and an olfactory stimulation unit. The visual stimulation unit is an embedded LED display screen 22, fixedly connected to two mounting plates 6, and can output visual signals of different frequencies, brightness, and patterns. The auditory stimulation unit is a high-fidelity speaker 23, mounted on the same mounting plate 6 as the visual stimulation unit, and can output sound signals of different decibels and frequencies in the range of 20Hz-20kHz. The olfactory stimulation unit includes a placement box 17 with an opening on the top surface. Several vents 18 are opened on one side of the placement box 17. Odor reagents are placed inside the placement box 17, including animal predator odors, food odors, and unfamiliar environment odors.
[0023] Specifically, the visual stimulation unit is an embedded LED display screen 22, fixedly connected to two mounting plates 6, which can output visual signals of different frequencies, brightness, and patterns to evaluate visual stimulation during experiments. The high-fidelity speaker 23 can output sound signals of different decibels and frequencies in the range of 20Hz-20kHz, thereby enabling auditory stimulation evaluation of the experimental mice. The odor reagent includes animal predator odors, food odors, and unfamiliar environment odors, which can emit different odors to evaluate the olfactory sense of the experimental mice.
[0024] like Figure 1 and Figure 2As shown, the top surface of the base plate 1 is fixedly connected to the sound insulation component 19, which is located between the two partition plates 3. The inner layer of the sound insulation component 19 is sound insulation cotton, and the outer side of the sound insulation cotton is wrapped with tin foil.
[0025] Specifically, the sound insulation components can block noise in the test area and reduce the impact between the mice in the two test areas.
[0026] like Figure 1 and Figure 2 As shown, several evenly distributed high-definition cameras 20 are fixedly connected to the opposite surfaces of the two baffles 4. The frame rate of the high-definition high-speed cameras 20 is adjustable between 30fps and 1000fps, and can capture behavioral parameters such as the animal's movement trajectory, limb movements, and reaction time. The top surface of the base plate 1 is equipped with a pressure sensor, which can collect parameters such as the animal's gait pressure, standing time, and movement speed, so as to realize multi-dimensional capture of behavioral indicators.
[0027] like Figure 1 and Figure 2 As shown, it also includes a physiological synchronous acquisition module: the physiological synchronous acquisition module includes an EEG acquisition unit, an EMG acquisition unit, and an ECG acquisition unit; the EEG acquisition unit is a non-invasive EEG electrode cap, which can be adapted to experimental animals of different sizes and is used to acquire animal EEG signals; the EMG acquisition unit is a patch-type EMG sensor, which can be attached to the animal's limb muscles to acquire muscle electrical activity signals; the ECG acquisition unit is a flexible ECG patch, which is attached to the animal's chest to acquire ECG signals; all physiological signals are transmitted to the central control module wirelessly to achieve synchronous acquisition of behavioral and physiological signals.
[0028] like Figure 1 and Figure 2As shown, it also includes a central control module and a data processing module. The central control module includes a main control chip, a touch operation panel, and a wireless transmission module; the main control chip uses an ARM architecture. The device features a Cortex-M4 core and can preset various neurodevelopmental behavioral evaluation paradigms, including exploratory behavior tests, motor coordination tests, cognitive memory tests, and stress response tests. A touch control panel is located on the outside of one of the baffles 4, used for parameter setting, program start / stop, and real-time data viewing. The wireless transmission module supports both WiFi and Bluetooth dual-mode transmission, enabling real-time transmission of collected behavioral and physiological data to the data processing module. It can also receive feedback commands from the data processing module to adjust the operating parameters of each module. The data processing module includes a data storage unit, a data preprocessing unit, and a data analysis unit. The data storage unit can store at least 1000 sets of experimental data, supporting local storage and cloud backup. The data preprocessing unit performs noise reduction, filtering, and normalization on the collected behavioral and physiological data, removing abnormal data. The data analysis unit incorporates a neurodevelopmental behavioral evaluation algorithm, which can quantitatively analyze the processed data, generating behavioral scores, physiological indicator curves, and a comprehensive neurodevelopmental evaluation report, intuitively reflecting the animal's neurodevelopmental status.
[0029] Working principle: First, according to the size and growth cycle of the experimental mouse, rotate the adjusting bolt 10. The adjusting bolt 10 is threadedly connected to the moving block 21. As the adjusting bolt 10 rotates, the moving block 21 moves along the adjusting bolt 10. The movement of the moving block 21 drives the strip block 8 to move along the strip through groove 7. The movement of the strip block 8 drives the partition plate 3 to move, thereby adjusting the distance between the two partition plates 3 so as to adjust the size of the experimental area. This allows the experimental mouse with different growth cycles and different sizes to meet the needs of the experimental mouse, thus improving the applicability of the device. When olfactory stimulation evaluation is required, rotate the two vertical rods 11 on the right. The rotation of the vertical rods 11 causes the corresponding mounting plate 6 to rotate, which in turn causes the LED display screen 22 and the high-fidelity speaker 23 to rotate, thus turning the LED display screen 22 and the high-fidelity speaker 23 to the outside of the vertical plate 2. Then, under the elastic force of the spring 15, the insertion rod 13 is inserted into the slot 16, which limits the mounting plate 6. Then, the odor reagent is placed into the placement box 17, and then the experimental mouse is placed in one of the experimental areas away from the odor reagent. A control mouse is placed in the other experimental area to evaluate the odor stimulation. When visual and auditory stimulation is required, rotate the left... Two vertical rods 11 on the side rotate, causing the corresponding mounting plate 6 to rotate. The rotation of the mounting plate 6 causes the placement box 7 to rotate, turning the placement box 7 to the outside of the vertical plate 2. Then, the LED display screen 22 and the high-fidelity speaker 23 are activated sequentially. The experimental mice are then placed in one experimental area away from the odor reagents, while control mice are placed in the other experimental area to evaluate visual and auditory stimuli. During the experiment, the high-definition camera 20 can capture behavioral parameters such as the animal's movement trajectory, limb movements, and reaction time. The pressure sensor can collect parameters such as the animal's gait pressure, standing time, and movement speed, achieving multi-dimensional capture of behavioral indicators. Simultaneously, the EEG acquisition unit collects the animal's brain signals; the EMG acquisition unit collects muscle electrical activity signals; and the ECG acquisition unit collects ECG signals. All physiological signals are transmitted wirelessly to the central control module, achieving synchronous acquisition of behavioral and physiological signals. The collected behavioral and physiological data can be transmitted to the data processing module in real time. The data processing module can also receive feedback instructions from the data processing module, adjust the working parameters of each module, and perform quantitative analysis on the processed data to generate behavioral scores, physiological index curves, and a comprehensive evaluation report on neurodevelopment, which intuitively reflects the animal's neurodevelopment status.
[0030] The terms "front," "back," "left," "right," "top," and "bottom" all refer to the figures in the accompanying drawings. Figure 1 Based on the perspective of the observer, the side of the device facing the observer is defined as the front, the left side of the observer is defined as the left, and so on.
[0031] In the description of this invention, it should be understood that the terms "upper," "side," "inner," etc., indicating orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the elements referred to must have a specific orientation, or be constructed and operated in a specific orientation. In addition, it should be noted that unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; they can refer to the internal communication of two elements or the interaction relationship between two elements. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.
[0032] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of the present invention is defined by the appended claims and their equivalents.
Claims
1. A behavioral evaluation device for measuring animal neural development, comprising a base plate (1), characterized in that, The bottom plate (1) has two vertical plates (2) fixedly connected to both sides of its top surface. Two partition plates (3) are provided between the two vertical plates (2). The two partition plates (3) are connected to the vertical plates (2) through the first adjustment component. Two baffles (4) distributed in front and behind are fixedly connected to the top surface of the bottom plate (1). The two baffles (4) are fixedly connected to the two vertical plates (2). Two rectangular through slots (5) are provided on each vertical plate (2) and distributed in front and behind. Each rectangular through slot (5) is provided with an installation plate (6). Each installation plate (6) is connected to the corresponding rectangular through slot (5) through a second adjustment component. The installation plate (6) is provided with a multimodal stimulation module.
2. The behavioral evaluation device for measuring animal neural development according to claim 1, characterized in that, The first adjustment component includes: a strip-shaped through slot (7) opened on the vertical plate (2), two strip blocks (8) are slidably connected in each strip-shaped through slot (7), one end of each strip block (8) is fixedly connected to the corresponding partition plate (3), the other end of each strip block (8) is fixedly connected to the moving block (21), two fixed plates (9) distributed in front and behind are fixedly connected on one side of each vertical plate (2), and an adjustment screw (10) is rotatably connected between the two fixed plates (9) located on the same vertical plate (2), each adjustment screw (10) has opposite threads at both ends, and each adjustment screw (10) passes through the corresponding two moving blocks (21) and is threadedly connected to the moving blocks (21).
3. The behavioral evaluation device for measuring animal neural development according to claim 1, characterized in that, The second adjustment component includes: a vertical rod (11), which is rotatably connected to a rectangular through slot (5), and is fixedly connected to a mounting plate (6). A horizontal plate (12) is fixedly connected to the top of the vertical rod (11), and two insert rods (13) are slidably connected on the horizontal plate (12). A pull block (14) is fixedly connected between the tops of the two insert rods (13). A spring (15) is fitted around the outer periphery of the top of each insert rod (13). The top of each spring (15) is fixedly connected to the pull block (14), and the bottom of each spring (15) is connected to the top surface of the horizontal plate (12). The bottom of each insert rod (13) can be inserted into a slot (16) opened on the top surface of the vertical plate (2).
4. The behavioral evaluation device for measuring animal neural development according to claim 3, characterized in that, The multimodal stimulation module includes a visual stimulation unit, an auditory stimulation unit, and an olfactory stimulation unit. The visual stimulation unit is an embedded LED display screen (22), which is fixedly connected to two mounting plates (6) and can output visual signals of different frequencies, brightness, and patterns. The auditory stimulation unit is a high-fidelity speaker (23), which is installed on the same mounting plate (6) as the visual stimulation unit and can output sound signals of different decibels and frequencies in the range of 20Hz-20kHz. The olfactory stimulation unit includes a placement box (17) with an opening on the top surface. Several air vents (18) are opened on one side of the placement box (17). Odor reagents are placed inside the placement box (17). The odor reagents include animal predator odors, food odors, and unfamiliar environment odors.
5. The behavioral evaluation device for measuring animal neural development according to claim 4, characterized in that, The top surface of the base plate (1) is fixedly connected to the sound insulation component (19), which is located between two partition plates (3). The inner layer of the sound insulation component (19) is sound insulation cotton, and the outer side of the sound insulation cotton is wrapped with tin foil.
6. The behavioral evaluation device for measuring animal neural development according to claim 5, characterized in that, Several uniformly distributed high-definition cameras (20) are fixedly connected to the opposite surfaces of the two baffles (4). The frame rate of the high-definition high-speed cameras (20) is adjustable between 30fps and 1000fps, and can capture the animal's movement trajectory, limb movements, reaction time and other behavioral parameters. The top surface of the base plate (1) is equipped with a pressure sensor, which can collect the animal's gait pressure, standing time, moving speed and other parameters, and realize multi-dimensional capture of behavioral indicators.
7. A behavioral evaluation device for measuring animal neural development according to claim 6, characterized in that, It also includes a physiological synchronous acquisition module: the physiological synchronous acquisition module includes an electroencephalogram (EEG) acquisition unit, an electromyogram (EMG) acquisition unit, and an electrocardiogram (ECG) acquisition unit; the EEG acquisition unit is a non-invasive EEG electrode cap that can be adapted to experimental animals of different sizes and is used to acquire animal EEG signals. The electromyography (EMG) acquisition unit is a patch-type EMG sensor that can be attached to the muscles of an animal's limbs to collect muscle electrical activity signals; the electrocardiogram (ECG) acquisition unit is a flexible ECG patch that fits into the animal's chest to collect ECG signals; all physiological signals are transmitted wirelessly to the central control module to achieve synchronous acquisition of behavioral and physiological signals.
8. The behavioral evaluation device for measuring animal neural development according to claim 7, characterized in that, It also includes a central control module and a data processing module. The central control module includes a main control chip, a touch operation panel, and a wireless transmission module. The main control chip adopts an ARM Cortex-M4 core and can preset a variety of neurodevelopmental behavior evaluation paradigms, including exploratory behavior test, motor coordination test, cognitive memory test, and stress response test. The touch operation panel is located on the outside of one of the baffles (4) and is used for parameter setting, program start and stop, and real-time data viewing. The wireless transmission module supports WiFi and Bluetooth dual-mode transmission and can transmit the collected behavioral and physiological data to the data processing module in real time. At the same time, it can receive feedback instructions from the data processing module and adjust the working parameters of each module. The data processing module includes a data storage unit, a data preprocessing unit, and a data analysis unit. The data storage unit can store at least 1,000 sets of experimental data and supports local storage and cloud backup. The data preprocessing unit is used to denoise, filter, and normalize the collected behavioral and physiological data and remove abnormal data. The data analysis unit has a built-in neurodevelopmental behavior evaluation algorithm, which can perform quantitative analysis on the processed data and generate behavioral scores, physiological index curves, and comprehensive neurodevelopment evaluation reports, which can intuitively reflect the neurodevelopment status of animals.