A precise quantitative blood sample collection device and method of use

Abstract

This invention relates to the field of medical device auxiliary equipment, specifically to a precise quantitative blood sample collection device and its usage method. The device includes a needle holder body, which is a transparent cylindrical structure. An intelligent control module is threadedly connected to the top surface of the needle holder body. A needle insertion hole is located at the center of the top surface of the intelligent control module. A longitudinal slide rail is provided on the side of the needle holder body, arranged along the axial direction of the needle holder body. A sensing slider is slidably connected to the longitudinal slide rail. Several elastic limiting springs are located inside the needle holder body at its bottom. The needle insertion hole coincides with the axis around which the elastic limiting springs are arranged. This invention, through the linkage of optical sensing and RFID, achieves precise quantitative collection of blood collection tubes of various sizes, automatic tube removal reminders, and real-time data traceability without changing clinical operating habits, thereby improving the standardization level of biobank construction.

Description

Technical Field

[0001] This invention relates to the field of medical device auxiliary equipment, specifically to a precise quantitative blood sample collection device and its usage method. Background Technology

[0002] Currently, blood collection in biobanks mainly relies on standard vacuum blood collection tube systems.

[0003] (1) Structural composition: It consists of a disposable blood collection needle, a plastic needle holder, and a vacuum blood collection tube with preset negative pressure.

[0004] (2) Implementation scheme: The blood collection personnel insert the blood collection needle into the blood vessel, and insert the other end into the blood collection tube in the needle holder. Blood is automatically drawn in by the preset negative pressure in the tube. When the pressure in the tube reaches equilibrium with the venous pressure, the blood flow stops.

[0005] (3) Management method: The collection volume is usually fixed by the tube specification (e.g., 5ml, 10ml). If it is necessary to collect a non-full amount (e.g., only 3ml is collected from a 10ml tube), it depends entirely on the collector to observe the scale on the tube with the naked eye and manually pull out the tube.

[0006] The existing technology currently has the following problems:

[0007] (1) Poor quantitative accuracy: Existing vacuum blood collection tubes rely entirely on the pre-set negative pressure inside the tube to draw in blood. However, the vacuum negative pressure is easily affected by ambient temperature, altitude, and storage time (aging) of consumables. This instability of physical characteristics leads to fluctuations of more than ±10% in the actual blood collection volume. Inaccurate blood collection directly results in an imbalance between the pre-set anticoagulant and the blood dilution ratio, which in turn causes hemolysis, microclots, or deviations in biochemical indicators, seriously damaging the standardized quality of the biobank.

[0008] (2) Difficulty in achieving non-full data collection:

[0009] In practical applications of biobanks, it is often necessary to collect reduced volumes for specific experiments (e.g., collecting only 3 ml from a 10 ml tube). Because current technology lacks an automatic cutoff mechanism, collectors must rely on visual observation of the tube markings. However, blood foam generated during blood collection, label obstruction, and viewing angle deviations (parallax) make manual determination of the fluid level extremely inaccurate. The inability to achieve precise cutoff leads to over-collection of rare clinical samples, resulting in resource waste, or insufficient collection, causing subsequent experimental failures.

[0010] (3) Specification compatibility and lack of measurement benchmarks:

[0011] Existing needle holders are mostly passive plastic sleeves, lacking intelligent recognition capabilities. Because they cannot identify whether a 5ml or 10ml tube is inserted, the system cannot automatically adjust its measurement algorithm for different tube diameters (13mm or 16mm). Forcing a uniform standard will lead to significant measurement deviations due to differences in meniscus height caused by different tube diameters, making it impossible for the sample library to manage multiple sample sizes under the same workflow.

[0012] (4) There are gaps in information records:

[0013] Due to the lack of digital monitoring during the collection process, key metadata such as collection volume and time cannot be generated in real time. This necessitates manual secondary data entry by operators after collection. The inherent delays and error rates of manual entry can lead to discrepancies between the data in the LIMS (Library of Samples Management System) and the physical samples, severely impacting the traceability of samples throughout their entire lifecycle. Summary of the Invention

[0014] The purpose of this invention is to provide a precise quantitative blood sample collection device and method to solve the above-mentioned problems. By linking optical sensing and RFID, it can achieve precise quantitative collection of blood collection tubes of various sizes, automatic tube removal reminders, and real-time data traceability without changing clinical operating habits, thereby improving the standardization level of biobank construction.

[0015] To achieve the above objectives, the present invention provides the following solution:

[0016] A precise quantitative blood sample collection device includes a needle holder body, which is a transparent cylindrical structure. An intelligent control module is threadedly connected to the top surface of the needle holder body. A needle insertion hole is located at the center of the top surface of the intelligent control module. A longitudinal slide rail is provided on the side of the needle holder body, and the longitudinal slide rail is arranged along the axial direction of the needle holder body. A sensing slider is slidably connected to the longitudinal slide rail. Several elastic limiting springs are provided inside the needle holder body, and the elastic limiting springs are located at the bottom of the needle holder body. The needle insertion hole coincides with the axis around which the elastic limiting springs are arranged.

[0017] Preferably, an infrared emitting tube and an infrared receiving tube are installed inside the sensing slider. The emitting end of the infrared emitting tube faces the axis of the circumferential distribution of the plurality of elastic limiting springs, and the receiving end of the infrared receiving tube faces the axis of the circumferential distribution of the plurality of elastic limiting springs. The infrared emitting tube and the infrared receiving tube are electrically connected to the intelligent control module.

[0018] The needle holder body is equipped with an RFID module located at the bottom of the needle holder body. The RFID module, infrared transmitter, infrared receiver are electrically connected to the intelligent control module.

[0019] Preferably, the infrared emitting tube is configured with a wavelength of 850nm or 940nm.

[0020] Preferably, the intelligent control module is an MCU microprocessor.

[0021] Preferably, the needle holder body is equipped with an audio-visual reminder module, which includes a light-emitting diode and a buzzer, and the light-emitting diode and the buzzer are electrically connected to the intelligent control module.

[0022] Preferably, the outer side of the longitudinal slide rail is provided with volume scale.

[0023] A method for using a precise quantitative blood sample collection device, the method being implemented based on the aforementioned device, specifically including the following steps:

[0024] The sample collection personnel open the main body of the needle holder and insert the blood collection tube with the RFID tag through the needle hole. The radio frequency identification module reads the RFID tag, identifies the specifications of the blood collection tube, and presets the corresponding collection task according to the specifications of the blood collection tube.

[0025] The data acquisition personnel adjust the position of the sensing slider to meet the corresponding data acquisition requirements.

[0026] Before blood collection begins, the intelligent control module records the infrared transmission intensity of the empty blood collection tube as an environmental background reference.

[0027] During the blood collection process, the intelligent control module alternately controls the infrared emitting tube to emit infrared light of two wavelengths at a fixed frequency;

[0028] The intelligent control module determines whether the acquisition requirements are met based on the signal from the infrared receiver.

[0029] The present invention has the following technical effects:

[0030] 1. High-precision quantification using micro-level sensors, which monitor liquid levels in real time, replaces unstable vacuum negative pressure quantification. Because optical sensing is unaffected by ambient temperature, altitude, or negative pressure attenuation, and combined with a lead compensation algorithm, blood collection errors can be controlled at the microliter (μl) level. This ensures a constant ratio of blood to anticoagulant, guaranteeing standardized quality of the sample bank from the source.

[0031] 2. Flexible and precise non-full volume collection: By setting a sliding sensor slider, this invention achieves physical pre-setting of the target volume. Thanks to the use of a dual-wavelength infrared differential algorithm, the system can automatically filter out foam and label interference, and provide a multi-modal audio-visual alert to manually remove the tube the instant the liquid level is reached. This eliminates the random errors of visual observation, achieving reduced-volume and precise collection of rare samples.

[0032] 3. Full-specification automatic compatibility and algorithm self-calibration: This invention utilizes an internal elastic limiting structure to ensure center alignment of pipes with different diameters, combined with RFID automatic identification of pipe specifications. Because the system can automatically switch the meniscus correction factor based on the identification results, both 5ml and 10ml pipes can achieve extremely high measurement accuracy on the same device. This solves the problem of unified management of multiple pipe specifications in the sample library and reduces equipment investment costs.

[0033] 4. The entire process is digitally closed-loop managed. This invention integrates a wireless communication module, automatically uploading metadata the instant data collection is completed. Because data generation and collection are completed synchronously, manual data entry is completely eliminated. This ensures the real-time performance, accuracy, and traceability of sample data within the LIMS system, meeting the requirements of international standards such as ISO 20387 for biobanks. Attached Figure Description

[0034] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0035] Figure 1 This is a schematic diagram of the main structure of the needle holder of the present invention;

[0036] Figure 2 This is a schematic diagram of the structure of the present invention with the intelligent control module installed;

[0037] Figure 3 This is a schematic diagram showing the connection between the intelligent control module of the present invention and its other components;

[0038] Figure 4 This is a circuit connection diagram of the intelligent control module of the present invention with the infrared emitting tube and the infrared receiving tube;

[0039] Figure 5 This is a schematic diagram of the main structure of the needle holder according to Embodiment 2 of the present invention.

[0040] Among them, 10 is the needle holder body; 11 is the longitudinal slide rail; 12 is the dual volume scale; 13 is the elastic limiting spring; 20 is the sensing slider; 30 is the intelligent control module; 31 is the needle hole; and 4 is the distance sensor. Detailed Implementation

[0041] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0042] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0043] Example 1:

[0044] Reference Figures 1 to 4 As shown, this embodiment provides a precise quantitative blood sample collection device, including a needle holder body 10. The needle holder body 10 is a transparent cylindrical structure. An intelligent control module 30 is threadedly connected to the top surface of the needle holder body 10. A needle hole 31 is opened at the center of the top surface of the intelligent control module 30. A longitudinal slide rail 11 is provided on the side of the needle holder body 10. The longitudinal slide rail 11 is arranged along the axial direction of the needle holder body 10. A sensing slider 20 is slidably connected on the longitudinal slide rail 11. A plurality of elastic limiting springs 13 are provided inside the needle holder body 10. The elastic limiting springs 13 are located at the bottom of the needle holder body 10. The needle hole 31 coincides with the axis around which the plurality of elastic limiting springs 13 are arranged.

[0045] Further optimization of the scheme: an infrared emitting tube and an infrared receiving tube are installed inside the sensing slider 20. The emitting end of the infrared emitting tube is oriented toward the axis of several elastic limiting springs 13 distributed circumferentially, and the receiving end of the infrared receiving tube is oriented toward the axis of several elastic limiting springs 13 distributed circumferentially. The infrared emitting tube and the infrared receiving tube are electrically connected to the intelligent control module 30.

[0046] The needle holder body 10 is equipped with an RFID module, which is located at the bottom of the needle holder body 10. The RFID module, infrared transmitter, infrared receiver are electrically connected to the intelligent control module 30.

[0047] The scheme was further optimized, and the infrared emitting tubes were configured with wavelengths of 850nm and 940nm.

[0048] The solution has been further optimized, and the intelligent control module 30 is an MCU microprocessor.

[0049] The design has been further optimized by installing an audio-visual reminder module on the needle holder body 10. The audio-visual reminder module includes an LED and a buzzer, and the LED and buzzer are electrically connected to the intelligent control module 30.

[0050] The design has been further optimized by adding volume scale 12 on the outer side of the longitudinal slide rail 11.

[0051] Furthermore, the intelligent control module 30 also includes a wireless communication module and a power management module. The power management module is equipped with a battery, and the wireless communication module uses Bluetooth. The wireless communication is used to transmit the collected data to an external laboratory information management system (LIMS).

[0052] A method for using a precise quantitative blood sample collection device, the method being implemented based on the aforementioned device, specifically including the following steps:

[0053] The sample collection personnel open the needle holder body 10, insert the blood collection tube with RFID tag through the needle hole 31, the radio frequency identification module reads the RFID tag, identifies the specifications of the blood collection tube, and presets the corresponding collection task according to the specifications of the blood collection tube.

[0054] As the blood collection tube is inserted, it will gradually be inserted into the axis where several elastic limiting springs 13 are distributed, and the several elastic limiting springs 13 will lock the blood collection tube.

[0055] The data acquisition personnel adjust the position of the sensor slider 20 to meet the data acquisition requirements of the corresponding specifications.

[0056] Before blood collection begins, the intelligent control module 30 records the infrared transmission intensity of the current blood collection tube in its empty tube state as an environmental background benchmark.

[0057] During the blood collection process, the intelligent control module 30 alternately controls the infrared emitting tube to emit infrared light of two wavelengths at a fixed frequency;

[0058] The intelligent control module 30 determines whether the acquisition requirements are met based on the signal from the infrared receiver tube.

[0059] Example 2:

[0060] Reference Figure 5As shown, the difference between this embodiment and embodiment one is that a distance sensor 4 is installed on the top surface of the longitudinal slide rail 11. The distance sensor 4 is embedded in the side wall of the needle holder body 10. Several contact telescopic spring needles are installed on the threaded end face of the needle holder body (10). The contact telescopic spring needles are connected to the distance sensor 4 through wires. Metal contact points are installed at corresponding positions on the bottom surface of the intelligent control module 30. The metal contact points are connected to the intelligent control module 30 through wires. With this setting, the height of the sensing slider 20 can be detected by the transmitter of the distance sensor 4. In combination with the specifications of the blood collection tube, the amount of blood to be collected can be read. The relative position of the sensing slider 20 can be precisely controlled by matching the height of the sensing slider 20 detected by the distance sensor 4, thereby controlling the amount of blood collected more accurately.

[0061] In the description of this invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0062] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A precise quantitative blood sample collection device, characterized in that, The device includes a needle holder body (10), which is a transparent cylindrical structure. A smart control module (30) is threadedly connected to the top surface of the needle holder body (10). A needle hole (31) is opened at the center of the top surface of the smart control module (30). A longitudinal slide rail (11) is provided on the side of the needle holder body (10). The longitudinal slide rail (11) is arranged along the axial direction of the needle holder body (10). A sensor slider (20) is slidably connected on the longitudinal slide rail (11). Several elastic limiting springs (13) are provided inside the needle holder body (10). The elastic limiting springs (13) are located at the bottom of the needle holder body (10). The needle hole (31) coincides with the axis around which the several elastic limiting springs (13) are arranged.

2. The precise quantitative blood sample collection device according to claim 1, characterized in that, The sensing slider (20) is equipped with an infrared emitting tube and an infrared receiving tube. The emitting end of the infrared emitting tube is oriented toward the axis of the several elastic limiting springs (13) distributed circumferentially, and the receiving end of the infrared receiving tube is oriented toward the axis of the several elastic limiting springs (13) distributed circumferentially. The infrared emitting tube and the infrared receiving tube are electrically connected to the intelligent control module (30). The needle holder body (10) is equipped with an RFID module. The RFID module is located at the bottom of the needle holder body (10). The RFID module, infrared transmitter, infrared receiver are electrically connected to the intelligent control module (30).

3. The precise quantitative blood sample collection device according to claim 2, characterized in that, The infrared emitting tube is configured with wavelengths of 850nm and 940nm.

4. The precise quantitative blood sample collection device according to claim 1, characterized in that, The intelligent control module (30) is an MCU microprocessor.

5. The precise quantitative blood sample collection device according to claim 1, characterized in that, The needle holder body (10) is equipped with an audio-visual reminder module, which includes a light-emitting diode and a buzzer. The light-emitting diode and the buzzer are electrically connected to the intelligent control module (30).

6. The precise quantitative blood sample collection device according to claim 2, characterized in that, The longitudinal slide rail (11) has volume scale (12) on its outer side.

7. A method of using a precise quantitative blood sample collection device, characterized in that, The method is implemented based on the apparatus according to any one of claims 2-6, and specifically includes the following steps: The sample collection personnel open the main body of the needle holder (10), insert the blood collection tube with RFID tag through the needle hole (31), the radio frequency identification module reads the RFID tag, identifies the specifications of the blood collection tube, and presets the corresponding collection task according to the specifications of the blood collection tube; The data acquisition personnel adjust the position of the sensing slider (20) to meet the corresponding data acquisition requirements; Before blood collection begins, the intelligent control module (30) records the infrared transmission intensity of the current empty blood collection tube as an environmental background reference. During the blood collection process, the intelligent control module (30) alternately controls the infrared emitting tube to emit infrared light of two wavelengths at a fixed frequency; The intelligent control module (30) determines whether the acquisition requirements are met based on the signal from the infrared receiver tube.

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