A cell dispersion carrier, a method of preparing the same, and an application thereof

A cell dispersion carrier was prepared by combining microwave and ultrasound dispersion, magnetic separation, and ultrasound-induced self-assembly. This solved the problems of cell sedimentation and aggregation in hydrogels and MOF nanoparticle aggregation, achieving uniform cell distribution and nutrient transport, and improving cell culture results.

CN122376845APending Publication Date: 2026-07-14PEOPLES HOSPITAL OF INNER MONGOLIA AUTONOMOUS REGION
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
PEOPLES HOSPITAL OF INNER MONGOLIA AUTONOMOUS REGION
Filing Date
2026-06-17
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Traditional hydrogels suffer from problems such as cell sedimentation and aggregation, limited nutrient transport, and limited functionality during cell culture. Furthermore, MOF nanoparticles tend to aggregate or precipitate in hydrogels, leading to cytotoxicity hotspots.

Method used

By using microwave and ultrasound to synergistically disperse hydrophobic peptides and magnetic MOF nanoparticles, combined with stable magnetic field separation and ultrasound-induced self-assembly, a cell dispersion carrier was prepared, achieving uniform dispersion of nano-magnetic MOF particles in a hydrogel.

Benefits of technology

It improves the dispersibility of cell dispersion carriers, promotes uniform cell distribution, enhances nutrient transport and microenvironment regulation capabilities, and avoids the formation of cytotoxic hotspots.

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Abstract

The application relates to the technical field of medical carriers, in particular to a cell dispersion carrier and a preparation method and application thereof. The preparation method comprises the following steps: dissolving a hydrophobic peptide segment in an organic solvent, adding nano-magnetic particles containing a magnetic metal organic framework to perform microwave and ultrasonic synergistic dispersion, and obtaining a composite of the magnetic particles and the hydrophobic peptide segment; in a stable magnetic field, the composite is subjected to magnetic separation to obtain a magnetic separation product; the magnetic separation product is dispersed in an aqueous buffer to obtain a magnetic dispersion liquid; the self-assembled short peptide is dissolved in the magnetic dispersion liquid to perform ultrasonic induction to obtain the cell dispersion carrier. The preparation method is connected through four steps of microwave+ultrasonic synergistic dispersion, anchoring of the hydrophobic peptide segment, magnetic separation in a stable magnetic field and ultrasonic induction self-assembly, and finally, a uniform distribution state is dynamically locked in a gelation process, so that the nano-magnetic MOF particles are uniformly dispersed in the hydrogel matrix from the molecular to the macroscopic full-scale.
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