A composite bone cement with local anti-tumor activity and promoting bone integration and its preparation method and application
By introducing NaCl particles with a particle size of 200~500 μm into PMMA bone cement, a micron-sized porous structure is formed, which solves the problems of mechanical compatibility, biocompatibility and anti-tumor properties in the repair of tumor-induced bone defects, and achieves a synergistic effect of bone integration and tumor suppression.
CN122399104APending Publication Date: 2026-07-17PEOPLES HOSPITAL PEKING UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- PEOPLES HOSPITAL PEKING UNIV
- Filing Date
- 2026-06-09
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing bone cements cannot simultaneously meet the requirements of mechanical compatibility, biocompatibility, and anti-tumor properties in the repair of tumor-related bone defects, leading to stress concentration, difficulty in bone integration, and a high risk of tumor recurrence.
Method used
By introducing NaCl particles with a particle size of 200~500 μm into PMMA bone cement, a micron-scale porous structure is formed. Combined with the anti-tumor effect of NaCl, the mechanical properties and biological functions are synergistically improved.
Benefits of technology
While maintaining mechanical support, it promotes bone integration and locally inhibits tumor cells, reducing the risk of tumor recurrence, and has minimal impact on normal cells.
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Figure CN122399104A_ABST
Abstract
本发明提供了一种具有局部抗肿瘤活性并促进骨整合的复合骨水泥及其制备方法与应用，属于生物医学材料技术领域。该复合骨水泥的固相组分包括NaCl 13~15%和PMMA骨水泥固相组分85~87%，其中NaCl颗粒粒径为200~500μm。NaCl作为可溶出功能性组分引入PMMA骨水泥体系后，在植入后可逐渐释放并形成微米级孔隙结构，有利于组织液交换、细胞迁移、骨长入和骨整合；同时，该复合骨水泥对多种肿瘤细胞具有较明显抑制作用，并可诱导肿瘤细胞凋亡，对正常细胞影响相对较小。该复合骨水泥在抗压和抗弯性能满足相关标准要求的同时，可用于骨缺损修复，尤其适用于骨肿瘤切除后的骨缺损修复。
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