A process for the preparation of 2,2'-dibromobiphenyl
By using 2,2'-dihydroxybiphenyl as a raw material and employing a hydroxytrifluoromethanesulfonation-palladium-catalyzed cross-coupling reaction, the problems of harsh reaction conditions, significant safety hazards, and high raw material costs in the synthesis of 2,2'-dibromobiphenyl have been solved, enabling industrial production with high yield and high purity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI HUIYIN CHEMICAL TECHNOLOGY CO LTD
- Filing Date
- 2026-05-13
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing 2,2'-dibromobiphenyl suffer from problems such as harsh reaction conditions, significant safety risks, high raw material costs, and unstable yields, making it difficult to achieve industrial-scale production.
Using 2,2'-dihydroxybiphenyl as the starting material, 2,2'-dibromobiphenyl was prepared via a two-step reaction of hydroxytrifluoromethanesulfonation-palladium-catalyzed cross-coupling, avoiding ultra-low temperature conditions and using inexpensive and readily available chemicals and an optimized catalyst system.
This method enables the safe and economical preparation of high-purity 2,2'-dibromobiphenyl at normal temperatures, with yields ranging from 60% to 90%. It avoids the equipment investment and operational risks associated with traditional methods and is suitable for industrial production.
Smart Images
Figure SMS_1 
Figure SMS_2 
Figure SMS_3