A holographic detection device and method for single molecule scattering signals
By using a holographic detection device and method for single-molecule scattering signals and utilizing phase modulation of multiple imaging optical paths, the problems of insufficient single-molecule detection sensitivity and difficulty in obtaining phase information in existing technologies are solved, achieving high sensitivity and rapid phase information acquisition.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INSTITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
- Filing Date
- 2025-11-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies cannot achieve high-sensitivity detection at the single-molecule level, nor can they easily and quickly acquire single-molecule phase information.
A holographic detection device and method for single-molecule scattering signals is employed. By setting up an illumination module, a detection light forming and separation module, a beam splitting and phase modulation module, and a signal receiving and processing module, scattered light and reflected light are collected and separated. The amplitude and phase information of the scattered light are obtained by using phase modulation of multiple imaging optical paths.
It achieves high-sensitivity holographic detection at the single-molecule level, enabling simple and rapid acquisition of amplitude and phase information of scattered light, avoiding complex wavefront reconstruction processes. The device has a simple structure, low cost, and is easy to maintain.
Smart Images
Figure CN122409587A_ABST