Compositions and methods for targeted delivery of therapeutic agents
By using a macromolecular composition of IL-22 peptides that binds to the IL-22 receptor, the undesirable off-target effects of therapeutic targets in healthy and diseased tissues are resolved, achieving targeted delivery of therapeutic agents and reduced toxicity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FLAGSHIP ENTREPRENEURSHIP & INNOVATION NO 7 CO LTD
- Filing Date
- 2024-11-08
- Publication Date
- 2026-07-17
AI Technical Summary
In the prior art, therapeutic targets exhibit undesirable off-target effects in both healthy and diseased tissues, leading to unintended delivery of therapeutic agents to non-target cells, tissues, or organs, which may cause toxicity and side effects.
A macromolecular composition containing an IL-22 peptide or fragments or variants thereof is used to target and deliver therapeutic agents to the desired site by binding to the IL-22 receptor and through the address-binding domain, while reducing the binding affinity to IL-10 family address targets and avoiding undesirable off-target effects.
This enables the specific delivery of therapeutic agents to target cells, tissues, or organs, reduces unwanted delivery to other cells, tissues, or organs, and lowers the risk of toxicity, such as avoiding cardiovascular disease.
Smart Images
Figure CN122422342A_ABST