Albumin-nanoprotease drug delivery system, preparation method and application thereof

By utilizing the albumin-nanozyme drug delivery system, the targeted accumulation of albumin and the antioxidant and anti-inflammatory effects of nanozymes are leveraged to solve the safety and efficacy issues of existing nanomedicine delivery systems, achieving efficient, long-term drug release and high bioavailability at atherosclerotic plaques.

CN122440595APending Publication Date: 2026-07-24RESEARCH INSTITUTE OF TRANSVASCULAR IMPLANTATION EQUIPMENT ZHEJIANG MEDICAL SECOND HOSPITAL BINJIANG DISTRICT HANGZHOU
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Patent Information

Application Number
CN202610640296.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-11
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing nanomedicine delivery systems face a trade-off between safety and efficacy in the treatment of atherosclerosis, including limitations in near-infrared light release, immune risks associated with xenotransplantation, and limited drug utilization.

Method used

The albumin-nanozyme drug delivery system is used to encapsulate the drug with albumin, thereby improving drug bioavailability by utilizing the targeted accumulation effect of albumin and the antioxidant and anti-inflammatory effects of nanozymes.

Benefits of technology

It significantly improves drug retention rate and efficacy at atherosclerotic plaques, reduces toxic side effects, and achieves targeted co-delivery and long-term local release of multiple drugs.

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Abstract

The application discloses an albumin-nanoprotease drug delivery system, a preparation method thereof and application of the albumin-nanoprotease drug delivery system in preparation of a medicine for treating atherosclerotic plaques. The albumin-nanoprotease drug delivery system comprises drug-loaded nanoproteases and albumin coated on surfaces of the drug-loaded nanoproteases. The preparation method comprises the following steps: adding precursors, drugs, solvents and organic ligands into a reaction kettle, reacting at 80-200 DEG C, taking out solid products, drying the solid products to obtain drug-loaded nanoproteases, wherein the precursors contain two elements selected from Fe, Cu, Co, Ni, V, Mg, Mn, Zn, Ce and Se; and coating albumin on surfaces of the drug-loaded nanoproteases to obtain the albumin-nanoprotease drug delivery system. The albumin is coated on the drug-loaded nanoproteases for the first time, targets atherosclerotic plaques, relies on a targeted accumulation effect of the albumin on the atherosclerotic plaques, and synergistically improves a drug bioavailability by virtue of antioxidant and anti-inflammatory effects of the nanoproteases, so that the drug efficacy is increased and side effects are reduced.
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Citation Information

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