A method for synthesizing 3-butenoic acid compounds based on carboxylation reaction of allyl carbon-hydrogen bond
By using the allyl C-H bond carboxylation reaction and a photo/copper synergistic catalyst under a CO2 atmosphere, 3-butenoic acid compounds were synthesized, overcoming the problems of harsh reaction conditions and limited substrate range in existing technologies, and achieving efficient synthesis and good selectivity under mild conditions.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SICHUAN UNIV
- Filing Date
- 2026-03-23
- Publication Date
- 2026-07-24
AI Technical Summary
Existing technologies for the carboxylation of allyl C-H bonds have harsh reaction conditions, limited substrate range and product types, and poor functional group compatibility, making it difficult to achieve the catalytic transformation of various allyl C-H bonds under mild conditions.
The allylic C-H bond carboxylation reaction is employed, in which an olefin reaction substrate, a photosensitizer, a copper catalyst, and an alkaline substance are mixed in a CO2 atmosphere and stirred under visible light irradiation to generate 3-butenoic acid compounds.
This method enables the efficient synthesis of various 3-butenoic acid compounds under mild conditions. It features mild reaction conditions, a wide range of applicable substrates, good functional group compatibility, and good chemical and regioselectivity, making it suitable for the synthesis of a variety of natural products, bioactive molecules, and drug molecules.
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