An adaptive chromatograph sample injection speed control method and system

Abstract

The application relates to a self-adaptive chromatograph sample injection speed control method and system, and relates to the technical field of chromatograph sample injection control.The method comprises the following steps: controlling a preset sample injection pump device to deliver a preset sample to be measured to a preset chromatograph, and collecting real-time sample injection speed and real-time sample injection viscosity of the sample to be measured; judging whether the real-time sample injection speed meets the requirement of a preset sample injection speed threshold value; if yes, continuing to control the sample injection pump device to deliver the sample to be measured to the chromatograph, and continuing to collect the real-time sample injection speed and the real-time sample injection viscosity of the sample to be measured for cyclic judgment; and if not, analyzing the real-time sample injection speed, the sample injection speed threshold value and the real-time sample injection viscosity to generate sample injection adjustment parameters; and controlling a preset sample injection auxiliary component to assist the sample injection pump device to deliver the sample to be measured to the chromatograph according to the sample injection adjustment parameters.The application has the effect of improving the analysis efficiency of the chromatograph.

Description

Technical Field

[0001] This application relates to the technical field of chromatograph injection control, and in particular to an adaptive chromatograph injection rate control method and system. Background Technology

[0002] A chromatograph is a scientific instrument that uses chromatographic analysis to separate, qualitatively and quantitatively analyze complex mixtures. It mainly uses a mobile phase to carry the sample into the chromatographic column, so that different components are separated according to their differences in physical or chemical properties. The results are then converted into electrical signals by a detector to complete the analysis of each component.

[0003] In related technologies, chromatograph injection rate control technology refers to the technology that can control the injection volume, injection rate, and gradient injection, and can push complex mixtures into the chromatograph. It can push complex mixtures into the chromatograph through fixed parameters so that the chromatograph can complete the analysis of complex mixtures.

[0004] Regarding the aforementioned technologies, when the sample to be tested is a complex mixture with high viscosity and poor flowability, problems such as poor injection and pipeline blockage are likely to occur when the sample is pushed into the chromatographic column according to fixed parameters. This results in sample residue in the pipeline and excessive injection time, thereby reducing the analytical efficiency of the chromatograph. There is still room for improvement. Summary of the Invention

[0005] To improve the efficiency of chromatograph analysis, this application provides an adaptive chromatograph injection rate control method and system.

[0006] In a first aspect, this application provides an adaptive chromatograph injection rate control method, which adopts the following technical solution: An adaptive chromatograph injection rate control method includes: The preset injection pump device is controlled to deliver the preset sample to the preset chromatograph, and the real-time injection speed and real-time injection viscosity of the sample are collected. Determine whether the real-time injection rate meets the preset injection rate threshold. If the conditions are met, the injection pump device will continue to be controlled to deliver the sample to the chromatograph, and the real-time injection speed and real-time injection viscosity of the sample will continue to be collected for cyclic judgment. If not, the real-time injection rate, injection rate threshold, and real-time injection viscosity are analyzed to generate injection adjustment parameters. The injection pump device, controlled by the preset injection auxiliary components according to the injection adjustment parameters, delivers the sample to be tested to the chromatograph.

[0007] Optionally, the steps of analyzing real-time injection rate, injection rate threshold, and real-time injection viscosity to generate injection adjustment parameters include: Calculate the difference between the real-time injection rate and the injection rate threshold to generate the current rate difference; Calculate the difference between the real-time injection viscosity and the preset injection viscosity threshold to generate the current viscosity difference; The relationship between the current velocity difference, the current viscosity difference, and the preset temperature-viscosity is analyzed to generate the initial adjustment temperature; Collect the corresponding relationship of sample component type proportion, historical heating rate and historical injection angle of the sample to be tested; The initial conditioning temperature, the relationship between the proportion of sample component types, the historical heating rate, and the historical injection angle were analyzed to generate injection conditioning parameters.

[0008] Optionally, the step of analyzing the current velocity difference, the current viscosity difference, and the preset temperature-viscosity correspondence to generate the initial adjustment temperature includes: The relationship between real-time injection viscosity and temperature viscosity is analyzed to generate viscosity-temperature adjustment values; Determine whether the real-time injection viscosity is greater than the injection viscosity threshold; If it is not greater than, then the viscosity temperature adjustment value is determined as the initial adjustment temperature; If it is greater than the preset speed influence coefficient, the product between the current speed difference and the preset speed temperature compensation value is calculated to generate the speed temperature compensation value. The sum of the velocity temperature compensation value and the viscosity temperature adjustment value is calculated to generate the initial conditioning temperature.

[0009] Optionally, the step of analyzing the real-time injection viscosity and temperature-viscosity correlation to generate viscosity-temperature adjustment values ​​includes: Collect the real-time heating temperature of the sample to be tested; Determine whether the real-time heating temperature meets the preset effective lookup temperature requirement; If the conditions are met, the viscosity-temperature adjustment value is found in the temperature-viscosity correspondence based on the real-time injection viscosity. If the conditions are not met, the sum of the product of the current viscosity difference and the preset viscosity influence coefficient and the real-time heating temperature is calculated to generate a viscosity-temperature adjustment value.

[0010] Optionally, the steps of analyzing the initial conditioning temperature, the correspondence between sample component types and proportions, historical heating rates, and historical injection angles to generate injection conditioning parameters include: Find the percentage of each sample component in the corresponding relationship between sample component types; The sample components are sorted according to their proportions to generate the main sample component types. Determine whether the main sample component type is a preset heat-sensitive component type, a preset volatile component type, or a preset normal viscosity component type. If it is a thermosensitive component type, the initial conditioning temperature, historical heating rate and historical injection angle are analyzed to generate injection conditioning parameters; If it is a volatile component type, the product between the historical heating rate and the preset volatile component rate correction parameter is calculated to generate the actual heating rate. The actual heating rate, initial conditioning temperature, and historical injection angle are summarized to generate injection conditioning parameters; If it is a normal viscous component type, the historical heating rate, historical injection angle and initial conditioning temperature are summarized to generate injection conditioning parameters.

[0011] Optionally, the steps of analyzing the initial conditioning temperature, historical heating rate, and historical injection angle to generate injection conditioning parameters include: Determine whether the initial adjustment temperature is greater than the preset upper limit of the temperature of the thermosensitive component; If it is not greater than, then the initial adjustment temperature will be determined as the final adjustment temperature; The final set temperature, historical injection angle, and historical heating rate are summarized to generate injection control parameters; If it is greater than the initial adjustment temperature, the difference between the initial adjustment temperature and the upper limit of the temperature of the thermosensitive component is calculated to generate a temperature compensation value. The temperature compensation value, injection rate threshold, historical heating rate, and historical injection angle are analyzed to generate injection adjustment parameters.

[0012] Optionally, the steps of analyzing temperature compensation values, injection rate thresholds, historical heating rates, and historical injection angles to generate injection adjustment parameters include: The temperature compensation value, historical injection angle, and real-time injection viscosity are substituted into the preset velocity prediction formula for calculation to generate the predicted injection velocity. Calculate the difference between the predicted injection rate and the injection rate threshold to generate an injection rate compensation value; Calculate the product of the injection speed compensation value and the preset speed angle correction parameter to generate the angle compensation value; The sum of the angle compensation value and the historical injection angle is calculated to generate the actual injection angle; The actual injection angle, historical heating rate, and upper temperature limit of the thermosensitive component are summarized to generate injection adjustment parameters.

[0013] Secondly, this application provides an adaptive chromatograph injection speed control system, which adopts the following technical solution: An adaptive chromatograph injection rate control system includes: The data acquisition module is used to collect real-time injection speed and real-time injection viscosity. A memory for storing a program for an adaptive chromatograph injection rate control method as described in any of the preceding claims; The processor and the program in the memory can be loaded and executed by the processor to implement an adaptive chromatograph injection rate control method as described in any of the above.

[0014] In summary, this application includes at least one of the following beneficial technical effects: 1. By controlling the preset injection pump device to deliver the sample to the chromatograph, it is determined whether the real-time injection rate meets the injection rate threshold requirement. If it does, the injection pump device continues to deliver the sample to the chromatograph, and the real-time injection rate and real-time injection viscosity of the sample are continuously collected for cyclic judgment. If it does not meet the requirements, the real-time injection rate, injection rate threshold, and real-time injection viscosity are analyzed to obtain the injection adjustment parameters. Based on the injection adjustment parameters, the injection auxiliary component is controlled to assist the injection pump device in delivering the sample to the chromatograph, thereby avoiding sample residue in the pipeline and excessive injection time, and improving the analysis efficiency of the chromatograph. 2. By calculating the difference between the real-time injection rate and the injection rate threshold, the current rate difference is obtained. By calculating the difference between the real-time injection viscosity and the injection viscosity threshold, the current viscosity difference is obtained. The relationship between the current rate difference, the current viscosity difference, and temperature-viscosity is analyzed to obtain the initial adjustment temperature. Then, the relationship between the initial adjustment temperature, the proportion of sample component types, the historical heating rate, and the historical injection angle is analyzed to obtain the injection adjustment parameters. Based on the injection adjustment parameters, the injection auxiliary component is controlled to assist the injection pump device in delivering the sample to be tested to the chromatograph. 3. By finding the proportion of sample components in the corresponding relationship between sample component types, the proportions of sample components are sorted according to the relationship to obtain the main sample component types. The main sample component type is then determined to be a thermosensitive component, a volatile component, or a normal viscous component. If it is a thermosensitive component, the initial conditioning temperature, historical heating rate, and historical injection angle are analyzed to obtain the injection conditioning parameters. If it is a volatile component, the product of the historical heating rate and the volatile component rate correction parameter is calculated to obtain the actual heating rate. The actual heating rate, initial conditioning temperature, and historical injection angle are then summarized to obtain the injection conditioning parameters. If it is a normal viscous component, the historical heating rate, historical injection angle, and initial conditioning temperature are summarized to obtain the injection conditioning parameters. This provides data support for subsequent control of the injection auxiliary component and auxiliary injection pump device to deliver the sample to the chromatograph based on the injection conditioning parameters, thereby avoiding sample residue in the pipeline and excessive injection time, and improving the analytical efficiency of the chromatograph. Attached Figure Description

[0015] Figure 1 This is a flowchart of an adaptive chromatograph injection rate control method according to an embodiment of this application.

[0016] Figure 2 This is a flowchart illustrating the steps in this application embodiment to analyze real-time injection speed, injection speed threshold, and real-time injection viscosity to generate injection adjustment parameters.

[0017] Figure 3 This is a flowchart of the steps for generating an initial temperature adjustment process by analyzing the current speed difference, the current viscosity difference, and the preset temperature-viscosity correspondence in this embodiment of the application.

[0018] Figure 4 This is a flowchart of the steps in this application embodiment to analyze the real-time injection viscosity and temperature-viscosity correspondence to generate viscosity-temperature adjustment values.

[0019] Figure 5 This is a flowchart of the steps in this application embodiment to analyze the initial adjustment temperature, the corresponding relationship of sample component type proportion, historical heating rate and historical injection angle to generate injection adjustment parameters.

[0020] Figure 6 This is a flowchart of the steps in this application embodiment to analyze the initial adjustment temperature, historical heating rate and historical injection angle to generate injection adjustment parameters.

[0021] Figure 7 This is a flowchart of the steps in this application embodiment to analyze temperature compensation values, injection rate thresholds, historical heating rates, and historical injection angles to generate injection adjustment parameters. Detailed Implementation

[0022] To make the purpose, technical solution, and advantages of this application clearer, the following description is provided in conjunction with the appendix. Figures 1 to 7 The present application will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are for illustrative purposes only and are not intended to limit the scope of the application.

[0023] This application discloses an adaptive chromatograph injection rate control method, which mainly addresses the problem of improving chromatograph analysis efficiency. Specifically, it discloses a sample to be tested, an injection pump, a chromatograph, and an injection auxiliary component. A processing terminal is communicatively connected to the injection pump and the injection auxiliary component to achieve data interaction and control. The processing terminal controls the injection pump to deliver the sample to the chromatograph. After determining the real-time injection rate and real-time injection viscosity of the sample, the processing terminal compares the real-time injection rate with a set injection rate range. When the real-time injection rate is outside the set range, the processing terminal determines injection adjustment parameters based on the real-time injection rate and real-time injection viscosity, and controls the injection auxiliary component to assist the injection pump in delivering the sample to the chromatograph based on the injection adjustment parameters. This aims to quickly and rationally control the injection auxiliary component for assisted injection, thereby avoiding sample residue in the pipeline and excessive injection time, thus improving chromatograph analysis efficiency.

[0024] Reference Figure 1 This application discloses an adaptive chromatograph injection rate control method, comprising the following steps: Step S100: Control the preset injection pump device to deliver the preset sample to be tested to the preset chromatograph, and collect the real-time injection speed and real-time injection viscosity of the sample to be tested.

[0025] The real-time injection rate refers to the flow rate of the sample entering the chromatograph at the current moment. In one embodiment, it is measured in real time by a miniature ultrasonic flow rate sensor installed in the delivery pipeline, and the data is then read by a processing terminal.

[0026] Real-time sample viscosity refers to the viscosity of the sample to be tested at the current moment. In one embodiment, the viscosity is obtained by installing the detection probe of a miniature vibration viscosity sensor in the delivery pipeline and monitoring it in real time, and then reading the monitoring data through a processing terminal.

[0027] The sample to be tested refers to a complex mixture that needs to be detected by a chromatograph and is placed into the injection pump device by the operator.

[0028] A chromatograph is a scientific instrument that uses chromatographic analysis to separate, qualitatively and quantitatively analyze complex mixtures. It mainly uses a mobile phase to carry the sample into the chromatographic column, so that different components are separated according to their differences in physical or chemical properties. The results are then converted into electrical signals by a detector to complete the analysis of each component.

[0029] An injection pump is a delivery device used to deliver samples to a chromatograph. It mainly consists of a delivery pipeline, an injection auxiliary component, a drive motor, and a communication module. The injection pump controls the pipeline angle adjustment component to adjust the tilt angle of the delivery pipeline according to the received instructions, and controls the heating component to heat the delivery pipeline to assist the drive motor in pushing the sample into the chromatograph, thereby avoiding pipeline blockage or slow injection rate, and thus improving the analytical efficiency of the chromatograph.

[0030] The sample introduction auxiliary component refers to the device used to adjust the flow rate of the sample in the pipeline. It mainly includes a pipeline angle adjustment component and a heating component. The pipeline angle adjustment component is used to adjust the angle of the delivery pipeline. It mainly consists of a rotating seat, a rotating shaft, an angle locking component, and a base. The rotating seat is connected to the base through the rotating shaft to achieve up-down or left-right deflection. After receiving the angle adjustment command, the processing terminal controls the rotating shaft to rotate, thereby driving the delivery pipeline to adjust the angle. After adjusting to the appropriate position, it is locked in place by the angle locking component to prevent deviation during use, thus realizing the adjustable and positioning of the delivery pipeline angle.

[0031] The heating component is used to heat the delivery pipeline to increase the temperature of the sample to be tested, thereby regulating the flow rate of the sample in the delivery pipeline. It mainly consists of a temperature sensor, a heating film wrapped around the outer wall of the delivery pipeline, an insulation layer, and a temperature control module. After receiving the instruction transmitted from the processing terminal, when a heating operation is required, the heating component is controlled to heat according to the instruction temperature and heating rate. The temperature sensor measures the temperature of the delivery pipeline in real time, and the heating stops when the detected temperature matches the target temperature.

[0032] Step S101: Determine whether the real-time injection rate meets the preset injection rate threshold.

[0033] The injection rate threshold refers to the range of injection rates used to measure whether the injection rate of the sample to be tested is too slow. The requirement of the injection rate threshold is that the real-time injection rate is within the range of the injection rate threshold. In one embodiment, the operator finds a target injection rate in historical data based on the approximate type of the sample to be tested, then calculates 90% and 110% of the target injection rate, and inputs the calculated values ​​into the processing terminal to obtain the rate range. This rate range is the injection rate threshold. The requirement of the injection rate threshold is that the real-time injection rate is not greater than 90% of the target injection rate or not less than 110% of the target injection rate.

[0034] The processing terminal determines whether the real-time injection rate meets the injection rate threshold requirement, thereby determining whether the injection rate of the sample to be tested needs to be adjusted.

[0035] Step S1011: If satisfied, continue to control the injection pump device to deliver the sample to be tested to the chromatograph, and continue to collect the real-time injection speed and real-time injection viscosity of the sample to be tested for cyclic judgment.

[0036] If the processing terminal determines that the real-time injection speed meets the injection speed threshold requirement, it means that there is no need to adjust the injection speed of the sample to be tested. Therefore, the processing terminal continues to control the injection pump device to deliver the sample to be tested to the chromatograph, and collects the real-time injection speed and real-time injection viscosity of the sample to be tested for cyclic judgment, so as to realize real-time monitoring of the process of delivering the sample to the chromatograph, thereby avoiding the situation where the sample to be tested is blocked, which leads to a decrease in the analysis efficiency of the chromatograph.

[0037] Step S1012: If not satisfied, analyze the real-time injection rate, injection rate threshold, and real-time injection viscosity to generate injection adjustment parameters.

[0038] If the processing terminal determines that the real-time injection speed does not meet the injection speed threshold requirement, it means that the injection speed of the sample to be tested needs to be adjusted. Therefore, the processing terminal determines the injection adjustment parameters, thereby providing data support for the subsequent control of the injection auxiliary components to adjust the angle and heat the delivery pipeline, thereby improving the injection speed of the sample to be tested.

[0039] Injection adjustment parameters refer to the set of control parameters used to control the angle adjustment and heating of the delivery pipeline by the injection auxiliary components. For specific methods, please refer to [link / reference needed]. Figure 2 This process improves the sample injection speed.

[0040] Step S10121: Control the preset injection auxiliary component to assist the injection pump device to deliver the sample to be tested to the chromatograph according to the injection adjustment parameters.

[0041] In this process, after the injection adjustment parameters are determined by the processing terminal, the heating component in the injection auxiliary component is controlled to heat the delivery pipeline according to the injection adjustment parameters, and the pipeline angle adjustment component is controlled to adjust the tilt angle of the delivery pipeline, so that the real-time injection speed of the sample to be tested is within the normal speed range, thereby avoiding the blockage of the sample to be tested in the delivery pipeline and improving the analytical efficiency of the chromatograph.

[0042] The injection auxiliary components in this step are the same as those in step S100 above, and will not be described again here.

[0043] Reference Figure 2 The steps for analyzing real-time injection rate, injection rate threshold, and real-time injection viscosity to generate injection adjustment parameters include: Step S200: Calculate the difference between the real-time injection rate and the injection rate threshold to generate the current rate difference.

[0044] The current speed difference refers to the difference between the current injection speed of the sample and the set normal speed. The processing terminal subtracts the injection speed threshold from the real-time injection speed to obtain the current speed difference.

[0045] Step S201: Calculate the difference between the real-time injection viscosity and the preset injection viscosity threshold to generate the current viscosity difference.

[0046] The current viscosity difference refers to the difference between the viscosity of the sample to be tested at the current moment and the set normal viscosity range. The processing terminal subtracts the injection viscosity threshold from the real-time injection viscosity to obtain the current viscosity difference.

[0047] The injection viscosity threshold is a benchmark value used to measure the viscosity of the sample to be tested. In one embodiment, it is obtained by the operator from historical data based on the approximate type of the sample to be tested, and the injection viscosity threshold is 3 Pa·s.

[0048] Step S202: Analyze the current velocity difference, current viscosity difference and preset temperature-viscosity correspondence to generate the initial adjustment temperature.

[0049] The initial conditioning temperature refers to the temperature at which the delivery pipeline needs to be raised to increase the injection rate, without considering the component types in the sample and only aiming to reduce the sample viscosity. The processing terminal analyzes the current velocity difference, current viscosity difference, and the temperature-viscosity correlation to obtain the initial conditioning temperature. For specific methods, refer to [reference needed]. Figure 3 This process provides data support for controlling the heating components to heat the delivery pipeline.

[0050] The temperature-viscosity correspondence refers to the relationship between the temperature and viscosity of a sample obtained by an operator through experiments. In one embodiment, the operator extracts a portion of the sample and measures the corresponding viscosity values ​​at different temperatures using a viscometer. The temperature and the corresponding viscosity values ​​are then mapped one-to-one to form a mapping table, thus obtaining the temperature-viscosity correspondence. For example, at a temperature of 40°C, the viscosity value is 100 mPa·s, and at a temperature of 60°C, the viscosity value is 45 mPa·s.

[0051] Step S203: Collect the corresponding relationship of sample component type proportion, historical heating rate and historical injection angle of the sample to be tested.

[0052] The sample component type ratio correspondence refers to the correspondence between the sample component type and the proportion of the component type in all components. In one embodiment, it is obtained by the processing terminal collecting the analysis results of the sample to be tested from the previous cycle of the chromatograph.

[0053] The historical heating rate refers to the temperature rise of the heating component per unit time in the previous cycle; the historical injection angle refers to the angle between the delivery pipe and the horizontal plane in the previous cycle. In one embodiment, the historical heating rate and historical injection angle can be obtained by the processing terminal searching for the heating rate of the previous cycle and the tilt angle of the delivery pipe measured by the tilt sensor in the previous cycle in the historical data.

[0054] Historical data refers to data storage units used to store control parameters of the injection pump device and injection auxiliary components, as well as related sensor measurement data, during the sample injection process.

[0055] Step S204: Analyze the initial conditioning temperature, the corresponding relationship between sample component types and proportions, historical heating rates, and historical injection angles to generate injection conditioning parameters.

[0056] The injection adjustment parameters in this step are the same as those in step S1012 above. These parameters can be obtained by analyzing the initial adjustment temperature, the corresponding proportions of sample component types, historical heating rates, and historical injection angles using a processing terminal. The specific method is described in [reference needed]. Figure 5 This process provides data support for the subsequent control of the injection auxiliary component, the injection pump device, to deliver the sample to the chromatograph.

[0057] Reference Figure 3 The steps for analyzing the relationship between the current velocity difference, the current viscosity difference, and the preset temperature-viscosity to generate the initial adjustment temperature include: Step S300: Analyze the relationship between real-time injection viscosity and temperature viscosity to generate viscosity-temperature adjustment values.

[0058] The viscosity-temperature adjustment value refers to the temperature value that needs to be compensated to reduce the viscosity of the sample. This value can be obtained by analyzing the real-time injection viscosity and the temperature-viscosity correlation at the processing terminal. For specific methods, please refer to [link to relevant documentation]. Figure 4 This process provides data support for determining the initial conditioning temperature.

[0059] Step S301: Determine whether the real-time injection viscosity is greater than the injection viscosity threshold.

[0060] Among them, the process of determining whether the real-time injection viscosity is greater than the injection viscosity threshold by processing the terminal, thereby determining whether the viscosity of the sample to be tested is within the normal range, requires consideration of the influence of speed on temperature.

[0061] Step S3011: If it is not greater than, then the viscosity temperature adjustment value is determined as the initial adjustment temperature.

[0062] If the processing terminal determines that the real-time injection viscosity is not greater than the injection viscosity threshold, it means that the viscosity of the sample to be tested is within the normal range, and the influence of speed on temperature does not need to be considered. Therefore, the viscosity-temperature adjustment value is determined as the initial adjustment temperature through the processing terminal.

[0063] Step S3012: If it is greater than, calculate the product between the current speed difference and the preset speed influence coefficient to generate a speed temperature compensation value.

[0064] If the processing terminal determines that the real-time injection viscosity is greater than the injection viscosity threshold, it means that the viscosity of the sample to be tested is not within the normal range, and the influence of speed on temperature needs to be considered. Therefore, the speed-temperature compensation value is determined by the processing terminal.

[0065] The speed-temperature compensation value refers to the degree of influence of the injection speed of the sample on the temperature. The processing terminal multiplies the current speed difference by the speed influence coefficient to obtain the speed-temperature compensation value.

[0066] The velocity influence coefficient refers to the intensity of the reaction between the injection velocity of the sample and the temperature. In one embodiment, the velocity influence coefficient is 0.7℃ / (m / s), which means that for every 1m / s increase in velocity, the temperature of the delivery pipeline needs to be increased by 0.7℃.

[0067] Step S30121: Calculate the sum between the velocity temperature compensation value and the viscosity temperature adjustment value to generate the initial adjustment temperature.

[0068] In this step, the initial adjustment temperature is the same as that in step S300 above. The processing terminal adds the speed temperature compensation value and the viscosity temperature adjustment value to obtain the initial adjustment temperature.

[0069] Reference Figure 4 The steps for analyzing the relationship between real-time injection viscosity and temperature-viscosity to generate viscosity-temperature adjustment values ​​include: Step S400: Collect the real-time heating temperature of the sample to be tested.

[0070] The real-time heating temperature refers to the temperature inside the delivery pipeline at the current moment. The real-time heating temperature can be obtained by reading the real-time measurement data of the temperature sensor installed on the delivery pipeline through the processing terminal.

[0071] Step S401: Determine whether the real-time heating temperature meets the preset effective lookup table temperature requirements.

[0072] Among them, the effective lookup temperature requirement means that the real-time heating temperature must be within the mapping table of temperature-viscosity correspondence.

[0073] The processing terminal determines whether the real-time heating temperature meets the requirements of the effective lookup table temperature, thereby determining whether a temperature-viscosity experiment has been conducted on the sample to be tested based on the current real-time heating temperature to calibrate the correspondence between temperature and viscosity of the sample to be tested.

[0074] Step S4011: If satisfied, find the viscosity-temperature adjustment value in the temperature-viscosity correspondence based on the real-time injection viscosity.

[0075] If the processing terminal determines that the real-time heating temperature meets the effective lookup table temperature requirement, it means that a temperature-viscosity experiment has been conducted on the sample to be tested based on the real-time heating temperature at the current moment to calibrate the correspondence between temperature and viscosity of the sample to be tested. Therefore, the viscosity-temperature adjustment value is obtained by the processing terminal by looking up the real-time injection viscosity in the temperature-viscosity correspondence.

[0076] Step S4012: If not satisfied, calculate the sum between the product of the current viscosity difference and the preset viscosity influence coefficient and the real-time heating temperature to generate a viscosity temperature adjustment value.

[0077] If the processing terminal determines that the real-time heating temperature does not meet the effective lookup table temperature requirement, it means that a temperature-viscosity experiment has not been conducted on the sample to be tested based on the current real-time heating temperature to calibrate the correspondence between the temperature and the viscosity of the sample to be tested. Therefore, by multiplying the current viscosity difference and the viscosity influence coefficient by the processing terminal, and then adding the product to the real-time heating temperature, the viscosity-temperature adjustment value can be obtained.

[0078] The viscosity influence coefficient refers to the intensity of the reaction between the viscosity of the sample under test and the temperature. In one embodiment, the viscosity influence coefficient is 0.5℃ / mPa·s, which means that for every 1mPa·s increase in viscosity, the temperature of the conveying pipeline needs to be increased by 0.5℃.

[0079] Reference Figure 5 The steps for generating injection conditioning parameters include analyzing the initial conditioning temperature, the correspondence between sample component types and proportions, historical heating rates, and historical injection angles. Step S500: Find the percentage of sample components in the sample component type percentage correspondence relationship.

[0080] Among them, the sample component ratio refers to the proportion of each component in the total content of the sample to be tested. The processing terminal can obtain the sample component ratio by searching in the corresponding relationship of sample component type ratio.

[0081] Step S501: Sort the sample component proportions according to the corresponding relationship of sample component type proportions to generate the main sample component types.

[0082] The main sample component type refers to the component type corresponding to the largest percentage among the sample components. The processing terminal sorts the sample component percentages, extracts the data with the largest value in the sort, and then finds the corresponding sample component type in the sample component type percentage correspondence relationship based on the extracted data, thus obtaining the main sample component type.

[0083] Step S502: Determine whether the main sample component type is a preset heat-sensitive component type, a preset volatile component type, or a preset normal viscous component type.

[0084] Among them, the heat-sensitive component type refers to the component type in the sample that is easily affected by temperature, causing its structure to be destroyed; the volatile component type refers to the component type that is easily affected by temperature and volatilizes; and the normal viscous component type refers to the component that is neither a heat-sensitive component type nor a volatile component type.

[0085] By determining whether the main sample component type is a thermosensitive component, a volatile component, or a normal viscous component through the processing terminal, it can be determined whether a secondary correction of the initial conditioning temperature is needed and whether other control parameters in the sample injection auxiliary components need to be adjusted.

[0086] Step S5021: If it is a thermosensitive component type, analyze the initial conditioning temperature, historical heating rate and historical injection angle to generate injection conditioning parameters.

[0087] If the processing terminal determines that the main sample component type is a thermosensitive component, then the injection adjustment parameters can be obtained by analyzing the initial conditioning temperature, historical heating rate, and historical injection angle through the processing terminal. The specific method is described in [reference needed]. Figure 6 This process avoids the thermally sensitive components from having their structure destroyed due to excessively high temperatures, which in turn affects the chromatographic analysis results.

[0088] Step S5022: If it is a volatile component type, calculate the product between the historical heating rate and the preset volatile component rate correction parameter to generate the actual heating rate.

[0089] If the processing terminal determines that the main sample component type is a volatile component type, it means that the heating rate of the heating component needs to be adjusted. Therefore, the actual heating rate is determined by the processing terminal, thereby providing data support for subsequent control of the heating component to heat the delivery pipeline.

[0090] The actual heating rate refers to the temperature increase per unit time in the pipeline. The actual heating rate can be obtained by multiplying the historical heating rate by the correction parameter for the rate of volatile components through the processing terminal.

[0091] The volatile component rate correction parameter is a correction factor that corrects the heating rate of the heating element. It is used to avoid deviations in the chromatograph's detection results due to vaporization or boiling of volatile components caused by excessively rapid heating. In one embodiment, the volatile component rate correction parameter is 0.5.

[0092] Step S50221: Summarize the actual heating rate, initial conditioning temperature and historical injection angle to generate injection conditioning parameters.

[0093] The injection adjustment parameters in this step are the same as those in step S1012 above. The injection adjustment parameters can be obtained by summarizing the actual heating rate, initial adjustment temperature and historical injection angle through the processing terminal.

[0094] Step S5023: If it is a normal viscous component type, the historical heating rate, historical injection angle and initial conditioning temperature are summarized to generate injection conditioning parameters.

[0095] If the processing terminal determines that the main sample component type is a normal viscous component type, it means that there is no need to make a secondary correction to the initial adjustment temperature and no need to adjust other control parameters in the injection auxiliary component. Therefore, by summarizing the historical heating rate, historical injection angle and initial adjustment temperature by the processing terminal, the injection adjustment parameters can be obtained, thereby providing data support for the subsequent control of the injection auxiliary component to assist the injection pump device to allow the sample to enter the chromatograph.

[0096] Reference Figure 6 The steps for generating injection conditioning parameters by analyzing the initial conditioning temperature, historical heating rate, and historical injection angle include: Step S600: Determine whether the initial adjustment temperature is greater than the preset upper limit of the temperature of the thermosensitive component.

[0097] The upper limit of the temperature of the thermosensitive component refers to the highest temperature that the heating component can reach in order to avoid damage to the sample structure due to excessive temperature of the thermosensitive component. In one embodiment, the upper limit of the temperature of the thermosensitive component is 50°C.

[0098] The processing terminal determines whether the initial adjustment temperature is greater than the upper limit of the temperature of the thermosensitive component, thereby determining whether heating the delivery pipeline according to the initial adjustment temperature will cause the structure of the thermosensitive component in the sample to be tested to be destroyed.

[0099] Step S6001: If it is not greater than, then the initial adjustment temperature is determined as the final adjustment temperature.

[0100] If the processing terminal determines that the initial adjustment temperature is not greater than the upper limit of the temperature of the thermosensitive component, it means that if the heating component is controlled to heat the delivery pipeline according to the initial adjustment temperature, the structure of the thermosensitive component in the sample to be tested will not be destroyed. Therefore, the final adjustment temperature is determined by the processing terminal.

[0101] The final set temperature refers to the temperature after secondary correction of the initial set temperature, considering the influence of temperature on the components when the main sample component type is a thermosensitive component type. The final set temperature can be obtained by determining the initial set temperature as the final set temperature through the processing terminal.

[0102] Step S60011: Summarize the final adjusted temperature, historical injection angle, and historical heating rate to generate injection adjustment parameters.

[0103] The injection adjustment parameters in this step are the same as those in step S1012 above. The injection adjustment parameters can be obtained by summarizing the final adjustment temperature, historical injection angle and historical heating rate through the processing terminal.

[0104] Step S6002: If it is greater than, calculate the difference between the initial adjustment temperature and the upper limit of the temperature of the thermosensitive component to generate a temperature compensation value.

[0105] If the processing terminal determines that the initial adjustment temperature is greater than the upper limit of the temperature of the thermosensitive component, it means that if the heating component is controlled to heat the delivery pipeline according to the initial adjustment temperature, the structure of the thermosensitive component in the sample to be tested will be destroyed. Therefore, the processing terminal determines the temperature compensation value, thereby providing data support for subsequent compensation by adjusting the angle of the delivery pipeline to compensate for insufficient temperature, which causes the flow rate of the sample to be tested to not reach the target value.

[0106] The temperature compensation value refers to the temperature difference between the actual temperature reached by the heating element and the initial adjustment temperature in order to protect the structure of the thermosensitive component from damage. The processing terminal can obtain the temperature compensation value by subtracting the upper limit of the thermosensitive component temperature from the initial adjustment temperature.

[0107] Step S60021: Analyze the temperature compensation value, injection rate threshold, historical heating rate, and historical injection angle to generate injection adjustment parameters.

[0108] The injection adjustment parameters in this step are the same as those in step S1012 above. These parameters can be obtained by analyzing the temperature compensation value, injection rate threshold, historical heating rate, and historical injection angle using a processing terminal. The specific method is described in [reference needed]. Figure 7 This process provides data support for subsequent control of the injection auxiliary components to adjust the angle and heat the delivery pipeline, thereby improving the injection speed of the sample to be tested.

[0109] Reference Figure 7 The steps for generating injection adjustment parameters by analyzing temperature compensation values, injection rate thresholds, historical heating rates, and historical injection angles include: Step S700: Substitute the temperature compensation value, historical injection angle, and real-time injection viscosity into the preset velocity prediction formula to generate the predicted injection velocity.

[0110] The predicted injection velocity refers to the predicted flow velocity of the sample under test when the delivery pipeline is at the upper limit of the temperature of the thermosensitive component. The temperature compensation value, historical injection angle, and real-time injection viscosity are substituted into the velocity prediction formula through the processing terminal. By performing calculations, the predicted injection rate can be obtained, where, This refers to predicting the injection rate. This refers to the speed correction factor, in order to =0.003kg / (s) 2 Taking ℃ as an example, This refers to the temperature compensation value. This refers to the historical sampling perspective. This refers to the real-time injection viscosity.

[0111] Step S701: Calculate the difference between the predicted injection rate and the injection rate threshold to generate an injection rate compensation value.

[0112] The injection speed compensation value refers to the injection speed that the sample needs to increase in order to reach the injection speed threshold. The injection speed compensation value can be obtained by subtracting the predicted injection speed from the injection speed threshold through the processing terminal.

[0113] Step S702: Calculate the product of the injection speed compensation value and the preset speed angle correction parameter to generate the angle compensation value.

[0114] The angle compensation value refers to the angle that the delivery pipeline needs to be adjusted. The angle compensation value can be obtained by multiplying the injection speed compensation value and the speed angle correction parameter by the processing terminal.

[0115] The velocity angle correction parameter refers to the correction parameter that is adjusted by adjusting the angle to compensate for the temperature limitation of the thermosensitive component, which causes the injection velocity to fail to reach the target velocity. In one embodiment, the velocity angle correction parameter is 400° / (m / s).

[0116] Step S703: Calculate the sum between the angle compensation value and the historical injection angle to generate the actual injection angle.

[0117] The actual injection angle refers to the angle that the delivery pipeline actually needs to tilt. It is used to compensate for the insufficient temperature that causes the flow rate of the sample to be tested to not reach the injection rate threshold. The actual injection angle can be obtained by adding the angle compensation value with the historical injection angle through the processing terminal.

[0118] Step S704: Summarize the actual injection angle, historical heating rate, and upper limit temperature of the thermosensitive component to generate injection adjustment parameters.

[0119] The injection adjustment parameters in this step are the same as those in step S1012 above. The injection adjustment parameters can be obtained by summarizing the actual injection angle, historical heating rate and upper limit of temperature of the thermosensitive component through the processing terminal.

[0120] Based on the same inventive concept, embodiments of this application provide an adaptive chromatograph injection rate control system, including: The data acquisition module is used to collect real-time injection speed, real-time injection viscosity, the corresponding relationship between sample component types and proportions, historical heating rate, historical injection angle, and real-time heating temperature. A memory for storing a program for an adaptive chromatograph injection rate control method; The processor can load and execute programs in memory to implement an adaptive chromatograph injection rate control method.

[0121] Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the above-described division of functional modules is used as an example. In practical applications, the above functions can be assigned to different functional modules as needed, that is, the internal structure of the device can be divided into different functional modules to complete all or part of the functions described above. The specific working process of the system, device, and unit described above can be referred to the corresponding process in the foregoing method embodiments, and will not be repeated here.

[0122] This application provides a computer-readable storage medium storing a computer program that can be loaded by a processor and executed as an adaptive chromatograph injection rate control method.

[0123] Computer storage media include, for example, USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, optical disks, and other media that can store program code.

[0124] Based on the same inventive concept, embodiments of this application provide a smart terminal, including a memory and a processor, wherein the memory stores a computer program that can be loaded and executed by the processor to provide an adaptive chromatograph injection speed control method.

[0125] Those skilled in the art will clearly understand that, for the sake of convenience and brevity, the above-described division of functional modules is used as an example. In practical applications, the above functions can be assigned to different functional modules as needed, that is, the internal structure of the device can be divided into different functional modules to complete all or part of the functions described above. The specific working process of the system, device, and unit described above can be referred to the corresponding process in the foregoing method embodiments, and will not be repeated here.

[0126] The above are all preferred embodiments of this application and are not intended to limit the scope of protection of this application. Any feature disclosed in this specification (including the abstract and drawings) may be replaced by other equivalent or similar features unless specifically stated otherwise. That is, unless specifically stated otherwise, each feature is only one example of a series of equivalent or similar features.

Claims

1. An adaptive chromatograph injection rate control method, characterized in that, include: The preset injection pump device is controlled to deliver the preset sample to the preset chromatograph, and the real-time injection speed and real-time injection viscosity of the sample are collected. Determine whether the real-time injection rate meets the preset injection rate threshold. If the conditions are met, the injection pump device will continue to be controlled to deliver the sample to the chromatograph, and the real-time injection speed and real-time injection viscosity of the sample will continue to be collected for cyclic judgment. If not, the real-time injection rate, injection rate threshold, and real-time injection viscosity are analyzed to generate injection adjustment parameters. The injection pump device, controlled by the preset injection auxiliary components according to the injection adjustment parameters, delivers the sample to be tested to the chromatograph.

2. The adaptive chromatograph injection rate control method according to claim 1, characterized in that, The steps for analyzing real-time injection rate, injection rate threshold, and real-time injection viscosity to generate injection adjustment parameters include: Calculate the difference between the real-time injection rate and the injection rate threshold to generate the current rate difference; Calculate the difference between the real-time injection viscosity and the preset injection viscosity threshold to generate the current viscosity difference; The relationship between the current velocity difference, the current viscosity difference, and the preset temperature-viscosity is analyzed to generate the initial adjustment temperature; Collect the corresponding relationship of sample component type proportion, historical heating rate and historical injection angle of the sample to be tested; The initial conditioning temperature, the relationship between the proportion of sample component types, the historical heating rate, and the historical injection angle were analyzed to generate injection conditioning parameters.

3. The adaptive chromatograph injection rate control method according to claim 2, characterized in that, The steps for analyzing the relationship between the current velocity difference, the current viscosity difference, and the preset temperature-viscosity correlation to generate the initial conditioning temperature include: The relationship between real-time injection viscosity and temperature viscosity is analyzed to generate viscosity-temperature adjustment values; Determine whether the real-time injection viscosity is greater than the injection viscosity threshold; If it is not greater than, then the viscosity temperature adjustment value is determined as the initial adjustment temperature; If it is greater than the preset speed influence coefficient, the product between the current speed difference and the preset speed temperature compensation value is calculated to generate the speed temperature compensation value. The sum of the velocity temperature compensation value and the viscosity temperature adjustment value is calculated to generate the initial conditioning temperature.

4. The adaptive chromatograph injection rate control method according to claim 3, characterized in that, The steps for analyzing the relationship between real-time injection viscosity and temperature-viscosity to generate viscosity-temperature adjusted values ​​include: Collect the real-time heating temperature of the sample to be tested; Determine whether the real-time heating temperature meets the preset effective lookup table temperature requirement; If the conditions are met, the viscosity-temperature adjustment value is found in the temperature-viscosity correspondence based on the real-time injection viscosity. If the conditions are not met, the sum of the product of the current viscosity difference and the preset viscosity influence coefficient and the real-time heating temperature is calculated to generate a viscosity-temperature adjustment value.

5. The adaptive chromatograph injection rate control method according to claim 2, characterized in that, The steps for generating injection conditioning parameters by analyzing the initial conditioning temperature, the correspondence between sample component types and proportions, historical heating rates, and historical injection angles include: Find the percentage of each sample component in the corresponding relationship between sample component types; The sample components are sorted according to their proportions to generate the main sample component types. Determine whether the main sample component type is a preset heat-sensitive component type, a preset volatile component type, or a preset normal viscosity component type. If it is a thermosensitive component, the initial conditioning temperature, historical heating rate and historical injection angle are analyzed to generate injection conditioning parameters; If it is a volatile component type, the product between the historical heating rate and the preset volatile component rate correction parameter is calculated to generate the actual heating rate. The actual heating rate, initial conditioning temperature, and historical injection angle are summarized to generate injection conditioning parameters; If it is a normal viscous component type, the historical heating rate, historical injection angle and initial conditioning temperature are summarized to generate injection conditioning parameters.

6. The adaptive chromatograph injection rate control method according to claim 5, characterized in that, The steps for generating injection conditioning parameters by analyzing initial conditioning temperature, historical heating rate, and historical injection angle include: Determine whether the initial adjustment temperature is greater than the preset upper limit of the temperature of the thermosensitive component; If it is not greater than, then the initial adjustment temperature will be determined as the final adjustment temperature; The final set temperature, historical injection angle, and historical heating rate are summarized to generate injection control parameters; If it is greater than the initial adjustment temperature, the difference between the initial adjustment temperature and the upper limit of the temperature of the thermosensitive component is calculated to generate a temperature compensation value. The temperature compensation value, injection rate threshold, historical heating rate, and historical injection angle are analyzed to generate injection adjustment parameters.

7. The adaptive chromatograph injection rate control method according to claim 6, characterized in that, The steps for generating injection adjustment parameters by analyzing temperature compensation values, injection rate thresholds, historical heating rates, and historical injection angles include: The temperature compensation value, historical injection angle, and real-time injection viscosity are substituted into the preset velocity prediction formula for calculation to generate the predicted injection velocity. Calculate the difference between the predicted injection rate and the injection rate threshold to generate an injection rate compensation value; Calculate the product of the injection velocity compensation value and the preset velocity angle correction parameter to generate the angle compensation value; The sum of the angle compensation value and the historical injection angle is calculated to generate the actual injection angle; The actual injection angle, historical heating rate, and upper temperature limit of the thermosensitive component are summarized to generate injection adjustment parameters.

8. An adaptive chromatograph injection rate control system, characterized in that, include: The data acquisition module is used to collect real-time injection speed and real-time injection viscosity. A memory for storing a program for an adaptive chromatograph injection rate control method as described in any one of claims 1 to 7; The processor and the program in the memory can be loaded and executed by the processor to implement the adaptive chromatograph injection rate control method as described in any one of claims 1 to 7.

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