Freeze-drying container moving device
Through the design of the mobile device of the lyophilized container, the problem of high labor intensity and insufficient heat transfer of freeze-dried container bundling and handling is solved, and the bottom of the container is uniformly abutted during the lyophilization process is achieved, which improves the recovery rate of the lyophilized product.
Patent Information
- Application Number
- CN202420972163.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-07
- Publication Date
- 2024-12-10
- Estimated Expiration
- 2034-05-07
AI Technical Summary
In the prior art, the strapping and handling of lyophilized containers is very labor-intensive and the operation time is long. During the lyophilization process, some containers are suspended in the air, resulting in insufficient heat transfer, which reduces the recovery rate of lyophilized products.
A freeze-dried container moving device is designed, including relatively separate container holders and mounting parts. Through the design of the container holders above the mounting parts, the bottoms of multiple freeze-dried containers are uniformly abutted against the bottom plate, reducing the lyophilization process. The collision and suspension between the containers in the middle ensure sufficient heat transfer.
It enables the operator to carry a large number of freeze-dried containers at one time, reduces labor intensity and time, improves the recovery rate of freeze-dried products, and ensures sufficient heat transfer during the freeze-drying process.
Smart Images
Figure CN222137409U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of biological low-temperature freeze drying, in particular to a freeze drying container moving device. Background Art
[0002] Biological low-temperature freeze-drying technology is widely used in the preservation of microbial strains and cell seeds. Taking strain preservation as an example, it is common in the prior art to fill the strain into an ampoule (or similar freeze-drying container such as an ampoule tube), seal the ampoule, and then tie a group of ampoules (usually 7 or 10 ampoules as a group) with rubber bands, and manually put each bundle of ampoules into the front cabin of the freeze dryer one by one, so that the bottom of the ampoule is in contact with the shelf of the freeze dryer, so that the temperature change of the freeze dryer shelf can be well transmitted to the strain in the ampoule, first freeze the strain, and then directly heat and sublimate to obtain a qualified freeze-dried product.
[0003] However, this technology has the following problems:
[0004] First, the preparation of bacterial strains involves the bundling and transportation of a large number of ampoules. For example, this bacterial strain preparation requires 1,000 ampoules. If they are bundled in groups of 7, 142 bundles are needed. If they are bundled in groups of 10, 100 bundles are needed. After bundling, each bundle of ampoules must be manually placed on the shelf of the freeze dryer one by one, resulting in high labor intensity and long operation time for the operator.
[0005] Second, the freeze dryer will vibrate during the freeze drying process. During the vibration, the ampoules tied up by rubber bands will squeeze each other at the same time. The dual forces of vibration and squeezing often cause some ampoules in each bundle to be upward, resulting in the bottom of the ampoules hanging in the air. In this way, heat transfer is insufficient and the water in the ampoules cannot be fully sublimated. The freeze drying of the strains in these hanging ampoules often fails, reducing the recovery rate of the freeze-dried product. Utility Model Content
[0006] The technical problem to be solved by the utility model is to provide a freeze-drying container moving device in order to overcome the defects of the prior art that a large number of ampoules are bundled and carried, resulting in high labor intensity and long operation time for the operator, and some ampoules are suspended upward, which reduces the recovery rate of the freeze-dried product.
[0007] The utility model solves the above technical problems through the following technical solutions:
[0008] A freeze-drying container moving device comprises a container support and a mounting piece which can be relatively separated.
[0009] The container holder includes a first support member and a side support member, the mounting member includes a base plate, the container holder is located above the base plate, and the side support member is located between the upper surface of the base plate and the first support member, and is used to form a gap between the lower surface of the first support member and the upper surface of the base plate.
[0010] The bottoms of the plurality of freeze-drying containers can pass through the receiving portion of the first supporting member and abut against the upper surface of the bottom plate.
[0011] In the technical scheme, by providing a freeze-dried container moving device, before placing it into the freeze dryer, the container support is first placed on the mounting member, and then multiple freeze-dried containers are simultaneously inserted into the accommodating portion of the first support member, so that the bottoms of multiple freeze-dried containers are all against the upper surface of the base plate. Then, the container support and the freeze-dried container are sent into the freeze dryer together through the mounting member, and then the mounting member is extracted, so that the bottoms of multiple freeze-dried containers are against the freeze dryer shelf. In this way, the operator can carry a large number of freeze-dried containers at one time, with low labor intensity and short operation time. Due to the presence of the side support member, a gap is formed between the lower surface of the first support member and the upper surface of the base plate, so that the accommodating portion can be stably set in the middle of multiple freeze-dried containers, and in the process of carrying and freeze drying, multiple freeze-dried containers are simultaneously limited, reducing the collision and extrusion of freeze-dried containers with each other, and the problem of partial freeze-dried containers hanging upward during the freeze drying process, so that the heat transfer during the freeze drying process is sufficient, and the water in the freeze-dried container is fully sublimated, thereby improving the recovery rate of the freeze-dried product.
[0012] Preferably, the container holder further comprises a second support member, the second support member is located below the first support member and forms a gap with the first support member, and the plurality of first channels on the first support member correspond to the plurality of second channels on the second support member.
[0013] In the present technical solution, by arranging the second support member below the first support member and forming a gap between the second support member and the first support member, the freeze-drying container can be further limited; the several first channels on the first support member correspond to the several second channels on the second support member, further reducing the problem of skewing of the freeze-drying container during transportation, withdrawal of the mounting member, and freeze-drying.
[0014] Preferably, both ends of the side support member are connected to the first support member and the second support member respectively, the side support member can support the first support member and the second support member, and the side support member is a hollow structure; and / or,
[0015] The lower surface of the second supporting member abuts against the upper surface of the bottom plate.
[0016] In the technical solution, by setting the two ends of the side support to be connected to the first support and the second support respectively, the side support can support the first support and the second support, and the side support is a hollow structure, which can form a gap between the first support and the second support while preventing the side support from blocking the heat transfer inside and outside the container support. By setting the lower surface of the second support against the upper surface of the bottom plate, the bottom of the freeze-drying container can be limited to avoid the bottom of the freeze-drying container from shifting during the process of withdrawing the mounting member, further ensuring the sufficient degree of heat transfer.
[0017] Preferably, the mounting member further comprises a limiting portion, which can prevent the container holder from sliding toward the outside of the mounting member, and one end of the limiting portion is provided with an opening space, and the container holder can slide into or out of the interior of the limiting portion through the opening space.
[0018] In the present technical solution, through the above structural setting, the container holder can be prevented from sliding from the limiting part to the ground when the container holder and the freeze-drying container are sent into the freeze dryer together through the mounting part; and when the mounting part is pulled out, the container holder can slide out of the interior of the limiting part through the opening space, further facilitating the transportation of the freeze-drying container.
[0019] Preferably, the base plate is a rectangular plate-shaped member, and the limiting portion includes an end limiting plate and two first lateral limiting plates, the end limiting plate is connected to an end of the base plate away from the opening space, and the two first lateral limiting plates are respectively connected to the end limiting plate and the opposite sides of the base plate.
[0020] In the present technical solution, through the above structural arrangement, the container support can be limited in position with a relatively simple structure.
[0021] Preferably, ends of the two first lateral limiting plates extend out of an end of the bottom plate close to the open space.
[0022] In the present technical solution, by arranging the ends of the two first lateral limit plates to extend out of one end of the bottom plate close to the opening space, the portion of the container holder located outside the opening space can be guided when the container holder slides into or out of the interior of the limit portion through the opening space.
[0023] Preferably, the mounting member further comprises two handles, and the two handles are respectively fixed to two edges of the bottom plate connected to the first lateral limiting plate.
[0024] In the present technical solution, two handles are provided and respectively fixed to the two edges of the bottom plate connected to the first lateral limiting plate, so that the operator can hold and carry the installation part conveniently.
[0025] Preferably, the limiting portion further includes two corner limiting members, and the two corner limiting members are respectively connected to the upper edges of the corners where the end limiting plate and the two first lateral limiting plates are connected.
[0026] In the present technical solution, by providing two corner limiters respectively connected to the upper edge of the corner where the end limiter plate and the two first side limiter plates are connected, the risk of the freeze-drying container near the corner limiter, i.e., located at the corner of the container holder, slipping during the transportation of the installation part can be reduced.
[0027] Preferably, the limiting portion further includes two second lateral limiting plates, the two second lateral limiting plates are respectively connected to the upper edges of the two first lateral limiting plates, and the positions of the two second lateral limiting plates correspond to each other.
[0028] In the present technical solution, by providing two second lateral limit plates respectively connected to the upper edges of the two first lateral limit plates, and the positions of the two second lateral limit plates correspond to each other, the risk of the freeze-drying container near the second lateral limit plates, i.e., located in the middle of both sides of the container holder, slipping during the transportation of the installation parts can be reduced.
[0029] Preferably, a push-pull groove is provided in the middle of the upper edge of the end limit plate, and the push-pull groove is used for allowing a push-pull tool to enter and exit.
[0030] In this technical solution, a push-pull groove for the push-pull tool to enter and exit is provided in the middle of the upper edge of the end limit plate, so that when the mounting member is pulled out, the push-pull tool can be extended into the push-pull groove to push and pull the container bracket.
[0031] The positive and progressive effects of the utility model are:
[0032] By providing a freeze-dried container moving device, before placing it into the freeze dryer, the container support is first placed on the mounting member, and then multiple freeze-dried containers are simultaneously inserted into the accommodating portion of the first support member, so that the bottoms of multiple freeze-dried containers are all against the upper surface of the base plate. Then, the container support and the freeze-dried container are sent into the freeze dryer together through the mounting member, and then the mounting member is extracted, so that the bottoms of multiple freeze-dried containers are against the freeze dryer shelf. In this way, the operator can carry a large number of freeze-dried containers at one time, with low labor intensity and short operation time. Due to the presence of the side support member, a gap is formed between the lower surface of the first support member and the upper surface of the base plate, so that the accommodating portion can be stably set in the middle of multiple freeze-dried containers, and in the process of carrying and freeze drying, multiple freeze-dried containers are simultaneously limited, reducing the collision and extrusion of freeze-dried containers with each other, and the problem of partial freeze-dried containers hanging upwards during the freeze drying process, so that the heat transfer during the freeze drying process is sufficient, the water in the freeze-dried container is fully sublimated, and the recovery rate of the freeze-dried product is improved. BRIEF DESCRIPTION OF THE DRAWINGS
[0033] Figure 1 It is a schematic diagram of the three-dimensional structure of a mounting member according to an embodiment of the utility model.
[0034] Figure 2 It is a schematic side structural diagram of a mounting member according to an embodiment of the utility model.
[0035] Figure 3 The figure is a schematic diagram of the three-dimensional structure of a container support according to an embodiment of the present invention.
[0036] Figure 4 The figure is a schematic diagram of the exploded structure of a container support according to an embodiment of the present invention.
[0037] Figure 5 It is a schematic diagram of the three-dimensional structure of a freeze-drying container moving device according to an embodiment of the utility model.
[0038] Figure 6 The figure is a side structural schematic diagram of the main parts of the container support and the freeze-drying container according to one embodiment of the utility model.
[0039] Figure 7 It is a rear structural schematic diagram of the main parts of the freeze-drying container moving device and the freeze-drying container according to one embodiment of the utility model.
[0040] Figure 8 The schematic diagram of the exploded top view of the main parts of the freeze-drying container moving device and the push-pull tool according to one embodiment of the utility model.
[0041] Description of reference numerals:
[0042] Container support 1
[0043] The first support member 11
[0044] First channel 111
[0045] Side support 12
[0046] The second support member 13
[0047] Second channel 131
[0048] Mounting 2
[0049] Bottom plate 21
[0050] Open space 221
[0051] End stop plate 222
[0052] Push-pull groove 2221
[0053] First lateral limiting plate 223
[0054] Corner stopper 224
[0055] Second lateral limiting plate 225
[0056] Handle 23
[0057] Freeze drying container 3
[0058] Push and pull tools 4 DETAILED DESCRIPTION
[0059] A preferred embodiment is given below, and the present invention is described more clearly and completely in conjunction with the accompanying drawings.
[0060] like Figure 1-Figure 8 As shown, this embodiment provides a freeze-drying container 3 moving device, which includes a container support 1 and a mounting member 2 that can be relatively separated.
[0061] The container holder 1 includes a first support member 11 and a side support member 12, and the mounting member 2 includes a base plate 21. The container holder 1 is located above the base plate 21, and the side support member 12 is located between the upper surface of the base plate 21 and the first support member 11, so as to form a gap between the lower surface of the first support member 11 and the upper surface of the base plate 21.
[0062] The bottoms of the plurality of freeze-drying containers 3 can pass through the accommodating portion of the first support member 11 and abut against the upper surface of the bottom plate 21 .
[0063] Thus, by providing a device for moving freeze-dried containers 3, before placing them into the freeze dryer, the container holder 1 is first placed on the mounting member 2, and then multiple freeze-dried containers 3 are simultaneously inserted into the accommodating portion of the first support member 11, so that the bottoms of the multiple freeze-dried containers 3 are all against the upper surface of the bottom plate 21. Then, the container holder 1 and the freeze-dried containers 3 are sent into the freeze dryer together through the mounting member 2, and then the mounting member 2 is pulled out, so that the bottoms of the multiple freeze-dried containers 3 are against the freeze dryer shelf. In this way, the operator can carry a large number of freeze-dried containers 3 at a time, with low labor intensity and short operation time. Due to the presence of the side support member 12, a gap is formed between the lower surface of the first support member 11 and the upper surface of the bottom plate 21, so that the accommodating portion can be stably mounted in the middle of the multiple freeze-drying containers 3. During the transportation and freeze-drying process, the multiple freeze-drying containers 3 are limited at the same time, thereby reducing the problems of the freeze-drying containers 3 colliding and squeezing each other, and some freeze-drying containers 3 hanging upward during the freeze-drying process. Therefore, heat transfer is sufficient during the freeze-drying process, and the moisture in the freeze-drying container 3 is fully sublimated, thereby improving the recovery rate of the freeze-dried product.
[0064] In this embodiment, by arranging the second support member 13 to be located below the first support member 11 and forming a gap between the second support member 11, the freeze-drying container 3 can be further limited; the 448 first channels 111 on the first support member 11 correspond to the 448 second channels 131 on the second support member 13, further reducing the problem of the freeze-drying container 3 being skewed during transportation, extraction of the mounting member 2, and freeze-drying. Of course, in other embodiments, the number of the first channels and the second channels can be adaptively adjusted, and the freeze-drying container can also be limited by other upper and lower corresponding limiting structures such as snap rings.
[0065] In this embodiment, by setting the two ends of the side support member 12 to be respectively connected to the first support member 11 and the second support member 13, the side support member 12 can support the first support member 11 and the second support member 13. The side support member 12 is a hollow structure. While the side support member 12 forms a gap between the first support member 11 and the second support member 13, the side support member 12 can avoid blocking the heat transfer inside and outside the container holder 1.
[0066] In this embodiment, by setting the lower surface of the second support member 13 against the upper surface of the bottom plate 21, the bottom of the freeze-drying container 3 can be limited to avoid the bottom of the freeze-drying container 3 from shifting during the withdrawal of the mounting member 2, further ensuring the adequacy of heat transfer.
[0067] In this embodiment, the mounting member 2 further includes a limiting portion, which can prevent the container holder 1 from sliding toward the outside of the mounting member 2, and an opening space 221 is provided at one end of the limiting portion, through which the container holder 1 can slide into or out of the interior of the limiting portion. In this way, the container holder 1 can be prevented from sliding from the limiting portion to the ground when the container holder 1 and the freeze-drying container 3 are sent into the freeze dryer together through the mounting member 2; and when the mounting member 2 is pulled out, the container holder 1 can be allowed to slide out of the interior of the limiting portion through the opening space 221, further facilitating the transportation of the freeze-drying container 3.
[0068] In this embodiment, the bottom plate 21 is a rectangular plate-shaped member, and the limiting portion includes an end limiting plate 222 and two first lateral limiting plates 223. The end limiting plate 222 is connected to one end of the bottom plate 21 away from the opening space 221, and the two first lateral limiting plates 223 are respectively connected to the end limiting plate 222 and the opposite sides of the bottom plate 21. In this way, the container holder 1 can be limited with a relatively simple structure.
[0069] In this embodiment, the ends of the two first lateral limiting plates 223 extend out of one end of the bottom plate 21 close to the opening space 221. In this way, when the container holder 1 slides into or out of the limiting portion through the opening space 221, the portion of the container holder 1 located outside the opening space 221 can be guided.
[0070] In this embodiment, the mounting member 2 further includes two handles 23, which are respectively fixed to the two edges of the bottom plate 21 connected to the first lateral limit plate 223. In this way, it is convenient for the operator to hold and carry the mounting member 2. The mobile device for the freeze-drying container 3 in this embodiment weighs about 4.50 kg in an empty state and about 6.50 kg in a fully loaded state, so the handles 23 are needed to assist in the moving process. Of course, in other embodiments, it can also be set separately according to the needs of the site.
[0071] In this embodiment, the limiting portion further includes two corner limiting members 224, and the two corner limiting members 224 are respectively connected to the upper edges of the corners where the end limiting plate 222 and the two first lateral limiting plates 223 are connected. In this way, the risk of the freeze-drying container 3 near the corner limiting members 224, i.e., located at the corner of the container holder 1, slipping during the transportation of the mounting member 2 can be reduced.
[0072] In this embodiment, the limiting portion further includes two second lateral limiting plates 225, which are respectively connected to the upper edges of the two first lateral limiting plates 223, and the positions of the two second lateral limiting plates 225 correspond to each other. In this way, the risk of the freeze-drying container 3 near the second lateral limiting plates 225, i.e., located in the middle of both sides of the container holder 1, slipping during the transportation of the mounting member 2 can be reduced.
[0073] In this embodiment, a push-pull groove 2221 is provided in the middle of the upper edge of the end stop plate 222, and the push-pull groove 2221 is used for the push-pull tool 4 to enter and exit. In this way, when the mounting member 2 is pulled out, the push-pull tool 4 can be extended into the push-pull groove 2221 to push and pull the container bracket 1.
[0074] In this embodiment, a method for using the freeze-drying container 3 moving device is also provided:
[0075] S1. Place the container holder 1 into the mounting member 2 and sterilize the whole container (commonly used methods are to place the container holder 1 into a sterilization bag, sterilize it with high pressure steam, and then take it out under a Class A laminar flow hood or clean bench);
[0076] S2, transferring the container holder 1 to the operating table, and inserting a number of filled freeze-drying containers 3 (commonly used are ampoule tubes, ampoule bottles, etc.) into the first channel 111 and the second channel 131 one by one;
[0077] S3, transfer the container holder 1 to the front cabin of the freeze dryer (the common method is that one person holds the two handles 23 to transfer), and place the mounting member 2: the side with the opening space 221 faces the inside of the front cabin of the freeze dryer, and the part of the bottom plate 21 close to the side of the opening space 221 is located on the shelf of the freeze dryer;
[0078] S4, insert the push-pull tool 4 (usually a rod) into the push-pull groove 2221, push the container holder 1 together with the freeze-drying container 3 into the front compartment of the freeze dryer, at this time, the bottom of the freeze-drying container 3 and the lower surface of the second support member 13 are in close contact with the freeze dryer shelf, and remove the mounting member 2;
[0079] S5, start the freeze-drying process;
[0080] S6. After the freeze-drying process is completed, the mounting member 2 is placed such that the side of the opening space 221 faces the interior of the front cabin of the freeze dryer, and the portion of the bottom plate 21 close to the side of the opening space 221 is located on the shelf of the freeze dryer;
[0081] S7, insert the push-pull tool 4 into the push-pull groove 2221, pull the container holder 1 together with the freeze-drying container 3 into the mounting member 2, and then take out the mounting member 2 and the container holder 1 together;
[0082] S8, taking out the freeze-drying container 3 in sequence; or,
[0083] The container support 1 is gently lifted up, so that the freeze-drying container 3 remains in the mounting member 2 and converges toward the end limit plate 222, and then the freeze-drying container 3 is taken out.
[0084] In order to meet the aseptic requirements of biological operations, the container holder 1, the mounting part 2 and the push-pull tool 4 should be stored separately for use.
[0085] The container support 1 and the push-pull tool 4 are made of 304 stainless steel that can withstand high temperature sterilization and are formed by punching, folding, cutting, and seamless welding. The mounting member 2 can be directly punched, cut, and folded into one piece of 304 stainless steel plate.
[0086] Please refer to Figure 8 In this embodiment, the container support 1 can be formed by seamlessly welding six 304 stainless steel perforated plates to ensure that the relationship between the first channel 111 and the second channel 131 is corresponding. Its dimensions are: the long side is 43.5 cm, the wide side is 29.3 cm, each surface contains 448 holes, the upper and lower reserved holes are aligned, the hole size is 14 mm, and the center distance between two adjacent hole diameters is consistent, both 17.4 mm.
[0087] Of course, in other embodiments, the above settings can be adaptively adjusted according to on-site requirements.
[0088] Although the specific implementations of the utility model are described above, those skilled in the art should understand that this is only an example, and the protection scope of the utility model is defined by the attached claims. Those skilled in the art can make various changes or modifications to these implementations without departing from the principle and essence of the utility model, but these changes and modifications fall within the protection scope of the utility model.
Claims
1. A freeze-drying container moving device, characterized in that: It includes a container support and a mounting piece that can be relatively separated; The container support comprises a first support member and a side support member, the mounting member comprises a bottom plate, the container support is located above the bottom plate, and the side support member is located between the upper surface of the bottom plate and the first support member, and is used to form a gap between the lower surface of the first support member and the upper surface of the bottom plate; The bottoms of the plurality of freeze-drying containers can pass through the receiving portion of the first supporting member and abut against the upper surface of the bottom plate.
2. The freeze-drying container moving device according to claim 1, characterized in that: The container support also includes a second support member, which is located below the first support member and forms a gap with the first support member. The first holes on the first support member correspond to the second holes on the second support member.
3. The freeze-drying container moving device according to claim 2, characterized in that: The two ends of the side support member are respectively connected to the first support member and the second support member, the side support member can support the first support member and the second support member, and the side support member is a hollow structure; and / or, The lower surface of the second supporting member abuts against the upper surface of the bottom plate.
4. The freeze-drying container moving device according to claim 1, characterized in that: The mounting member further comprises a limiting portion, which can prevent the container holder from sliding outward from the mounting member, and an opening space is provided at one end of the limiting portion, through which the container holder can slide into or out of the interior of the limiting portion.
5. The freeze-drying container moving device according to claim 4, characterized in that: The bottom plate is a rectangular plate-shaped member, and the limiting portion includes an end limiting plate and two first lateral limiting plates, the end limiting plate is connected to an end of the bottom plate away from the opening space, and the two first lateral limiting plates are respectively connected to the end limiting plate and the opposite sides of the bottom plate.
6. The freeze-drying container moving device according to claim 5, characterized in that: The ends of the two first lateral limiting plates both extend out of one end of the bottom plate close to the open space.
7. The freeze-drying container moving device according to claim 5, characterized in that: The mounting member further comprises two handles, and the two handles are respectively fixed to two edges of the bottom plate connected to the first lateral limiting plate.
8. The freeze-drying container moving device according to claim 5, characterized in that: The limiting portion further includes two corner limiting members, and the two corner limiting members are respectively connected to the upper edges of the corners where the end limiting plate and the two first lateral limiting plates are connected.
9. The freeze-drying container moving device according to claim 5, characterized in that: The limiting portion further includes two second lateral limiting plates, the two second lateral limiting plates are respectively connected to the upper edges of the two first lateral limiting plates, and the positions of the two second lateral limiting plates correspond to each other.
10. The freeze-drying container moving device according to claim 5, characterized in that: A push-pull groove is provided in the middle of the upper edge of the end limiting plate, and the push-pull groove is used for the push-pull tool to enter and exit.