Magnetic particle chemiluminescence detection reagent storage box

Abstract

The utility model discloses a magnetic particle chemiluminescence detection reagent preservation box, which relates to the technical field of chemiluminescence detection, and comprises a box body, a bottle support, an upper cover and a uniform temperature fan device, a heat conduction partition plate is vertically arranged in the box body, the heat conduction partition plate divides the box body into an ice bag storage groove and a reagent storage groove, and the ice bag storage groove is used for storing an ice bag; the bottle support is arranged in the reagent storage tank and is used for placing a magnetic separation reagent bottle, a standard substance reagent bottle, an enzyme-labeled antibody solution reagent bottle, a luminous substrate solution reagent bottle, a sample diluent reagent bottle and a concentrated washing liquid reagent bottle; the upper cover is detachably connected to the upper end of the box body and used for sealing an opening in the upper end of the box body. The uniform-temperature fan device is connected to the inner bottom wall of the upper cover and is used for driving air in the reagent storage tank to circularly flow. According to the utility model, a low-temperature environment can be kept in the box body.

Description

Technical Field

[0001] The utility model relates to the technical field of chemiluminescence detection, in particular to a magnetic particle chemiluminescence detection reagent storage box. Background Art

[0002] In recent years, chemiluminescent immunoassay technology has developed rapidly, and its application in the fields of medicine and life sciences has been continuously expanded. Immunological detection is mainly a method of detection using the specific reaction of antigens and antibodies. Since it can use isotopes, enzymes, chemiluminescent substances, etc. to amplify and display the detection signal, it is often used to detect trace substances such as proteins and hormones. Magnetic particle chemiluminescent immunoassay is a new type of labeled immunoassay technology that combines chemiluminescent substrates with immune reactions and is used to detect trace antigens or antibodies. The principle of chemiluminescent reaction is to label the luminescent substance or enzyme on the antigen (or antibody), stimulate the luminescent substance to emit light by oxidizing the substrate, and then detect it by a chemiluminescent analyzer. At present, the magnetic particle chemiluminescent product kits are all liquid packaging. Since the core raw materials (antigens or antibodies) used in chemiluminescent products are biologically active substances, they are easy to lose biological activity at room temperature, so all liquid kits need cold chain transportation and low temperature storage. The temperature of existing kits is easy to rise rapidly after leaving the low temperature environment, causing the inactivation of the detection reagents. Utility Model Content

[0003] The utility model aims to solve at least one of the technical problems existing in the prior art. To this end, the utility model provides a magnetic particle chemiluminescence detection reagent storage box, which can keep a low temperature environment in the box body.

[0004] According to the first aspect of the utility model, a magnetic particle chemiluminescence detection reagent storage box includes: a box body, a bottle holder, an upper cover, and a temperature-averaging fan device. A heat-conducting partition is vertically provided in the box body, and the heat-conducting partition divides the box body into an ice bag storage slot and a reagent storage slot. The ice bag storage slot is used to store ice bags; the bottle holder is installed in the reagent storage slot, and the bottle holder is used to place magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles; the upper cover is detachably connected to the upper end of the box body, and the upper cover is used to close the opening at the upper end of the box body; the temperature-averaging fan device is connected to the inner bottom wall of the upper cover, and the temperature-averaging fan device is used to drive the air circulation in the reagent storage slot.

[0005] According to some embodiments of the utility model, two heat-conducting partitions are provided, and two ice bag storage slots are also provided, and the two ice bag storage slots are respectively located on the left and right sides of the reagent storage slot.

[0006] According to some embodiments of the present invention, a heat dissipation fin is provided on a side of the heat conductive partition close to the reagent storage tank.

[0007] According to some embodiments of the utility model, the temperature equalizing fan device is electrically connected to a temperature sensor, the temperature sensor extends out of the upper end of the upper cover, and the temperature equalizing fan device is started when the temperature sensor detects that the temperature is higher than a preset value.

[0008] According to some embodiments of the present invention, the temperature-averaging fan device is detachably connected to the upper cover.

[0009] According to some embodiments of the utility model, one side of the upper cover is hinged to the upper end of the box body, and the other end is connected to the upper end of the box body by a buckle.

[0010] According to some embodiments of the utility model, the bottle holder includes an upper plate, a lower plate and a plurality of columns, the upper plate and the lower plate are spaced apart from each other, the upper plate and the lower plate are connected through the columns, the lower end height of the columns is lower than the height of the lower plate, the lower end of the columns is connected to the bottom wall of the reagent storage slot, the upper plate is provided with a plurality of storage holes, the plurality of storage holes are respectively used to place magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles, and the lower plate is used to support magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles.

[0011] According to some embodiments of the utility model, a plurality of elastic limiting cylinders are connected to the bottom of the reagent storage tank, and the columns are respectively embedded in the corresponding elastic limiting cylinders.

[0012] According to some embodiments of the present invention, the box body is at least partially made of heat-insulating material.

[0013] According to some embodiments of the present invention, a sealing ring is provided on the upper edge of the box body to seal the gap between the box body and the upper cover.

[0014] A magnetic microparticle chemiluminescence detection reagent storage box according to an embodiment of the utility model has at least the following beneficial effects:

[0015] (1) After the box body leaves the low-temperature environment, the ice pack and the temperature-averaging fan device cool down the reagent storage tank to ensure that the detection reagent is not inactivated;

[0016] (2) The elastic limiting cylinder cushions the bottle holder during transportation, reducing losses during transportation;

[0017] (3) Bottle holders are provided to classify and place various test reagents for easy access.

[0018] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention is further described below with reference to the accompanying drawings and embodiments, wherein:

[0020] Figure 1 This is a schematic diagram of a closed upper cover of an embodiment of the utility model;

[0021] Figure 2 This is a schematic diagram of an embodiment of the utility model with the upper cover opened;

[0022] Figure 3 for Figure 2 The enlarged view of point A in the middle;

[0023] Figure 4 This is a schematic diagram of a box body according to an embodiment of the utility model;

[0024] Figure 5 This is a schematic diagram of a bottle holder according to an embodiment of the utility model;

[0025] Figure 6 It is a schematic diagram of an elastic limiting cylinder according to an embodiment of the utility model.

[0026] Figure Number:

[0027] Box body 100, heat-conducting baffle 101, heat-dissipating fins 102, ice pack storage slot 110, reagent storage slot 120, elastic limiting cylinder 130;

[0028] Bottle holder 200, upper plate 210, storage hole 211, lower plate 220, column 230;

[0029] Upper cover 300;

[0030] The temperature-averaging fan device 400 and the temperature sensor 410 . DETAILED DESCRIPTION

[0031] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0032] In the description of the present invention, it should be understood that the descriptions involving orientation, such as the orientation or positional relationship indicated as up, down, etc., are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0033] In the description of the present utility model, "a plurality" means more than two. If there is a description of "first" or "second", it is only for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0034] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0035] Reference Figures 1 to 6As shown, a magnetic particle chemiluminescence detection reagent storage box according to an embodiment of the utility model comprises: a box body 100, a bottle holder 200, an upper cover 300, a temperature-averaging fan device 400, the box body 100 is hollow inside and open at the upper end, the cross section of the box body 100 is rectangular, a heat-conducting baffle 101 is vertically arranged in the box body 100, and the heat-conducting baffle 101 is connected to the box body 100 by bolts or welding. The heat-conducting baffle 101 is made of a metal material with a high thermal conductivity, such as aluminum alloy. The heat-conducting baffle 101 divides the box body 100 into an ice bag storage slot 110 and a reagent storage slot 120. The size of the ice bag storage slot 110 matches the size of the ice bag used. The ice bag storage slot 110 is a rectangular parallelepiped, and the ice bag can just be loaded into the ice bag storage slot 110. The ice bag storage slot 110 is used to store the ice bag; the ice bag uses an ordinary medical ice bag. Compared with directly using ice cubes, using an ice bag can prevent the water after the ice cubes melt from contaminating the box body 100. The bottle holder 200 is detachably installed in the reagent storage tank 120, and the bottle holder 200 is used to place magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles; the bottle holder 200 plays a fixing role to prevent the above reagent bottles from shaking in the reagent storage tank 120, thereby reducing losses during transportation. The upper cover 300 is detachably connected to the upper end of the box body 100, and the size of the upper cover 300 matches the size of the opening above the box body 100. The upper cover 300 is used to close the opening at the upper end of the box body 100. The temperature-averaging fan device 400 is connected to the inner bottom wall of the upper cover 300, and the temperature-averaging fan device 400 is used to drive the air circulation in the reagent storage tank 120. The specific structure of the temperature-averaging fan device 400 is a prior art, which has been disclosed in the Chinese utility model patent with publication number CN201953688U, so it will not be described in detail. When the test kit is disposable, the battery used by the temperature-averaging fan device 400 contained therein is a non-rechargeable alkaline zinc-manganese dry cell. When the test kit needs to be reused, the battery used by the temperature-averaging fan device 400 contained therein is a rechargeable lithium polymer battery. The function of the temperature-averaging fan device 400 is to make the air flow in the reagent storage tank 120, the temperature distribution is uniform, and when the area of ​​the heat-conducting baffle 101 is limited, the temperature of all reagent bottles is kept consistent. When the box body 100 is out of the low-temperature environment, the heat-conducting baffle 101 absorbs the heat in the reagent storage tank 120 and transfers the heat to the ice bag, so that the temperature in the reagent storage tank 120 is always maintained at a low temperature to prevent the stored reagent from failing. Ensure the accuracy of the test results.

[0036] Reference Figures 1 to 6As shown, it is understandable that two heat-conducting baffles 101 are vertically arranged, and two ice bag storage slots 110 are correspondingly formed, and the two ice bag storage slots 110 are respectively located on the left and right sides of the reagent storage slot 120. The volume design is compact, and the space occupied by the box body 100 is saved while providing enough space to accommodate ice bags. It is convenient for transportation and storage.

[0037] Reference Figures 1 to 6 As shown, it can be understood that a heat dissipation fin 102 is provided on one side of the heat-conducting baffle 101 close to the reagent storage tank 120. The heat dissipation fin 102 can increase the heat exchange area between the heat-conducting baffle 101 and the reagent storage tank 120, and cooperate with the temperature-averaging fan device 400 to quickly transfer the heat of the air in the reagent storage tank 120 to the heat-conducting baffle 101. It can be foreseen that the size of the ice bag matches the ice bag storage tank 110 so that the ice bag directly contacts the heat-conducting baffle 101, and the ice bag directly absorbs the heat of the heat-conducting baffle 101 through heat conduction, which is conducive to improving the cooling effect.

[0038] Reference Figures 1 to 6 As shown, it can be understood that the temperature-averaging fan device 400 is electrically connected to a temperature sensor 410, and the temperature sensor 410 extends out of the upper end of the upper cover 300. The temperature sensor 410 is used to monitor the temperature outside the box body 100. When the box body 100 leaves the low-temperature environment, the temperature sensor 410 will detect a temperature rise, and the temperature-averaging fan device 400 is started when the temperature sensor 410 detects that the temperature is higher than a preset value. In order to save the power used by the temperature-averaging fan device 400, the temperature-averaging fan device 400 is not started in a low-temperature environment such as a cold storage. By setting the temperature sensor 410, the temperature-averaging fan device 400 is automatically turned on after leaving a low-temperature environment such as a cold storage to ensure that the reagent storage tank 120 is in a uniform low-temperature environment.

[0039] Reference Figures 1 to 6 As shown, it can be understood that the temperature-averaging fan device 400 is detachably connected to the upper cover 300. The temperature-averaging fan device 400 is connected to the upper cover 300 by bolts. In some other embodiments of the utility model, the temperature-averaging fan device 400 and the upper cover 300 can also be connected by snaps. Bolt connection is cheaper than snap connection and the connection is more stable, but it is more convenient to disassemble and assemble using snap connections than bolt connections. In order to reduce the cost of use, the temperature-averaging fan device 400 can be disassembled to replace the battery or charge. And when the box body 100 is disposable, the temperature-averaging fan device 400 can be removed and reused to achieve the purpose of saving use costs.

[0040] Reference Figures 1 to 6As shown, it can be understood that the rear side of the upper cover 300 is hinged to the upper end of the box body 100 through a hinge. In some other embodiments of the utility model, the upper cover 300 and the box body 100 are integrally formed plastic, and the connection between the upper cover 300 and the box body 100 is relatively thin to achieve hinge connection. The front side of the upper cover 300 is connected to the upper end of the box body 100 through a buckle. The specific structure of the buckle connection is prior art, so it will not be described in detail. The buckle connection is used to facilitate opening and closing the box body 100.

[0041] Reference Figures 1 to 6 As shown, it can be understood that the bottle holder 200 includes an upper plate 210, a lower plate 220 and a plurality of columns 230, the upper plate 210 and the lower plate 220 are arranged in parallel, and the upper plate 210 is located directly above the lower plate 220. The upper plate 210 and the lower plate 220 are arranged at intervals up and down, and the upper plate 210 and the lower plate 220 are connected by the columns 230, and there are four columns 230, and the four columns 230 symmetrically pass through the lower plate 220 and are welded with the lower plate 220, and the lower end height of the column 230 is lower than the lower plate 220. It can be foreseen that in some other embodiments of the utility model, in order to save costs, the upper plate 210, the lower plate 220, and the columns 230 are integrally formed plastic parts. Two handles are also symmetrically arranged on the upper end of the upper plate 210, and the bottle holder 200 can be conveniently taken out and placed in the reagent storage tank 120 as a whole by the handles. The lower end of the column 230 is connected to the bottom wall of the reagent storage tank 120, and the upper plate 210 is provided with a plurality of storage holes 211, and the plurality of storage holes 211 are respectively used to place magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles, and the sizes of the plurality of storage holes 211 are different to accommodate reagent bottles of different sizes. The lower plate 220 is used to support magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles. A plurality of positioning grooves are provided on the corresponding storage holes 211 on the lower plate 220. The positioning grooves are provided for the corresponding lower ends of the reagent bottles to be embedded for support and positioning.

[0042] Reference Figures 1 to 6As shown, it can be understood that a plurality of elastic limiting cylinders 130 are connected to the bottom of the reagent storage tank 120, a plurality of threaded holes are provided at the bottom of the reagent storage tank 120, the elastic limiting cylinder 130 is made of silicone, a mounting ring is formed integrally at the lower end of the elastic limiting cylinder 130, a gasket is provided on the gasket, a plurality of screws are provided, the screws pass through the mounting ring and are threadedly connected in the threaded hole, and since the elastic limiting cylinder 130 is made of silicone and is not convenient for installation, the elastic limiting cylinder 130 is fixed to the bottom of the reagent storage tank 120 by connecting the gasket and the screw. In addition to supporting the column 230, the elastic limiting cylinder 130 also plays a buffering role in the horizontal direction. The columns 230 are respectively embedded in the corresponding elastic limiting cylinders 130. When the bottle holder 200 receives a horizontal force, the elastic limiting cylinder plays a buffering role to reduce the shaking of the bottle holder 200.

[0043] Reference Figure 1 and Figure 2 As shown, it can be understood that at least part of the box body 100 is made of heat-insulating material. The outer layers of the box body 100 and the upper cover 300 are pasted with polyurethane foam material plates to play a heat-insulating role. The polyurethane foam material plates have a low thermal conductivity and can reduce the heat transfer between the box body 100 and the outside. It is foreseeable that other materials with low thermal conductivity can also be used as the heat-insulating material.

[0044] Reference Figure 1 and Figure 2 As shown, it is understandable that a sealing ring is provided at the upper edge of the box body 100 to seal the gap between the box body 100 and the upper cover 300. The sealing ring prevents the external hot air from entering the reagent storage tank 120 from the gap between the box body 100 and the upper cover 300.

[0045] Usage steps: open the buckle, flip the upper cover 300 and open the upper opening of the box body 100, take out the reagent bottle on the bottle holder 200 for use, and keep the upper cover 300 closed to close the upper opening of the box body 100 during use, except for taking and putting back the reagent bottle. The temperature-averaging fan device 400 circulates the air in the reagent storage tank 120, and the heat of the air is quickly transferred to the heat-conducting partition 101. The ice bag directly absorbs the heat of the heat-conducting partition 101 through heat conduction, so as to maintain a low temperature environment in the reagent storage tank 120.

[0046] The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of ordinary technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A magnetic microparticle chemiluminescence detection reagent storage box, characterized in that: include: A box body (100), wherein a heat-conducting partition (101) is vertically arranged in the box body (100), wherein the heat-conducting partition (101) divides the box body (100) into an ice pack storage slot (110) and a reagent storage slot (120), wherein the ice pack storage slot (110) is used to store ice packs; A bottle holder (200) is installed in the reagent storage tank (120), and the bottle holder (200) is used to place a magnetic separation reagent bottle, a standard reagent bottle, an enzyme-labeled antibody solution reagent bottle, a luminescent substrate solution reagent bottle, a sample diluent reagent bottle, and a concentrated washing solution reagent bottle; An upper cover (300), the upper cover (300) being detachably connected to the upper end of the box body (100), and the upper cover (300) being used to close the opening at the upper end of the box body (100); A temperature-averaging fan device (400) is connected to the inner bottom wall of the upper cover (300), and the temperature-averaging fan device (400) is used to drive the air circulation in the reagent storage tank (120).

2. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 1, characterized in that: Two heat-conducting baffles (101) are provided, and two ice bag storage slots (110) are also provided. The two ice bag storage slots (110) are respectively located on the left and right sides of the reagent storage slot (120).

3. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 2, characterized in that: A heat dissipation fin (102) is provided on one side of the heat-conducting baffle (101) close to the reagent storage tank (120).

4. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 1, characterized in that: The temperature-averaging fan device (400) is electrically connected to a temperature sensor (410), and the temperature sensor (410) extends out of the upper end of the upper cover (300). The temperature-averaging fan device (400) is activated when the temperature sensor (410) detects that the temperature is higher than a preset value.

5. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 4, characterized in that: The temperature-averaging fan device (400) is detachably connected to the upper cover (300).

6. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 5, characterized in that: One side of the upper cover (300) is hinged to the upper end of the box body (100), and the other end is connected to the upper end of the box body (100) via a buckle.

7. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 6, characterized in that: The bottle holder (200) comprises an upper plate (210), a lower plate (220) and a plurality of columns (230), wherein the upper plate (210) and the lower plate (220) are arranged with a vertical interval, the upper plate (210) and the lower plate (220) are connected via the columns (230), the lower end of the columns (230) is lower than the lower plate (220), and the lower end of the columns (230) is connected to the bottom wall of the reagent storage tank (120). The upper plate (210) is provided with a plurality of storage holes (211), and the plurality of storage holes (211) are respectively used to place magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles, and the lower plate (220) is used to support magnetic separation reagent bottles, standard reagent bottles, enzyme-labeled antibody solution reagent bottles, luminescent substrate solution reagent bottles, sample diluent reagent bottles and concentrated washing liquid reagent bottles.

8. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 7, characterized in that: A plurality of elastic limiting cylinders (130) are connected to the bottom of the reagent storage tank (120), and the upright posts (230) are respectively embedded in the corresponding elastic limiting cylinders (130).

9. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 1, characterized in that: The box body (100) is at least partially made of heat-insulating material.

10. The magnetic microparticle chemiluminescence detection reagent storage box according to claim 1, characterized in that: A sealing ring is provided on the upper edge of the box body (100) to seal the gap between the box body (100) and the upper cover (300).

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