Glaucoma drainage device

Abstract

The utility model provides a glaucoma drainage device, and relates to the technical field of medical instruments. The glaucoma drainage device comprises a base body, a first hydrophilic layer and a second hydrophilic layer, the base body is provided with a channel penetrating through the base body in the first preset direction. The base body is provided with a first end face and a second end face which are oppositely arranged in the first preset direction. The first hydrophilic layer covers the first end surface and the second end surface; the inner wall of the channel is at least partially covered by the second hydrophilic layer. According to the glaucoma drainage device, accumulation and adhesion of substances such as protein, cells and bacteria in aqueous humor at a channel opening and in a channel can be reduced, the blocking risk of the channel is reduced, the eye aqueous humor can be better led out, intraocular pressure is reduced, and the inflammatory response of eyes can be reduced.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular, to a glaucoma drainage device. Background Art

[0002] Glaucoma is a group of diseases characterized by optic disc atrophy and depression, visual field loss and decreased vision. Pathologically increased intraocular pressure and insufficient blood supply to the optic nerve are the primary risk factors for the onset of glaucoma.

[0003] At present, the treatment of glaucoma mainly involves lowering intraocular pressure, which is divided into two categories: drug therapy and surgical treatment. The principle is to establish a new dynamic balance of aqueous humor, or to reduce the amount of aqueous humor produced, or to increase the outflow of aqueous humor, so that the intraocular pressure drops to a safe range. Among them, drug therapy controls intraocular pressure by controlling the rate of aqueous humor production. It requires long-term use and may have side effects. For example, some patients may experience allergic reactions, headaches, eye pain and other adverse reactions. Surgical treatment generally includes trabecular meshwork resection, stent implantation and drainage device implantation. Its mechanism is mainly to control intraocular pressure by draining excess aqueous humor.

[0004] Drainage device implantation is the process of implanting a glaucoma drainage device into the eye to drain excess aqueous humor from the eye. However, proteins, cells, bacteria and other substances in the eye area and aqueous humor can easily block the aqueous humor drainage channel of the glaucoma drainage device, causing obstruction in the drainage of aqueous humor. Utility Model Content

[0005] The purpose of the present application is to provide a glaucoma drainage device, which aims to improve the technical problem that the existing glaucoma drainage device is prone to clogging.

[0006] The present application provides a glaucoma drainage device, which includes a substrate, a first hydrophilic layer and a second hydrophilic layer; the substrate has a channel penetrating the substrate along a first preset direction; the substrate has a first end face and a second end face arranged opposite to each other along the first preset direction; the first hydrophilic layer covers the first end face and the second end face; the inner wall of the channel is at least partially covered by the second hydrophilic layer.

[0007] The glaucoma drainage device provided in the present application is used to be implanted in the eye to drain the aqueous humor of the eye, thereby reducing the intraocular pressure; the substrate has a channel that penetrates the substrate along a first preset direction, and the channel provides space for draining the aqueous humor of the eye; the two end surfaces of the substrate that are relatively arranged along the first preset direction are covered with a first hydrophilic layer, which can reduce the accumulation and adhesion of proteins, cells, bacteria and other substances in the eye area at the channel mouth, reduce the risk of channel blockage, and help reduce the inflammatory response of the eye tissue in the area near the channel mouth; the inner wall of the channel is at least partially covered by the second hydrophilic layer, which can promote the spreading of aqueous humor on the inner wall of the channel, reduce the flow resistance of aqueous humor in the channel, and reduce the accumulation and adhesion of proteins, cells, bacteria and other substances in the aqueous humor in the channel, which can further reduce the risk of channel blockage.

[0008] In an optional embodiment of the present application, the inner wall of the channel is completely covered by the second hydrophilic layer.

[0009] In the above technical solution, the inner wall of the channel is completely covered by the second hydrophilic layer, which can further reduce the flow resistance of aqueous humor in the channel and further reduce the accumulation and adhesion of proteins, cells, bacteria and other substances in the aqueous humor in the channel, thereby helping to further reduce the risk of channel blockage.

[0010] In an optional embodiment of the present application, the two opposite ends of the substrate along a first preset direction are defined as a first end and a second end; the glaucoma drainage device also includes a third hydrophilic layer and a fourth hydrophilic layer, the third hydrophilic layer is arranged at the first end, the fourth hydrophilic layer is arranged at the second end, and the third hydrophilic layer and the fourth hydrophilic layer are both covered on the outer peripheral wall of the substrate.

[0011] In the above technical solution, the provision of the third hydrophilic layer and the fourth hydrophilic layer can further reduce the accumulation and adhesion of substances such as proteins, cells, and bacteria in the aqueous humor at the channel opening, thereby further reducing the risk of channel blockage and reducing inflammatory response.

[0012] In an optional embodiment of the present application, the glaucoma drainage device further includes a hydrophobic layer, which is disposed between the first end and the second end and covers the outer peripheral wall of the base.

[0013] In the above technical solution, the bonding force between the outer peripheral surface of the glaucoma drainage device and the eye tissue can be increased, which is beneficial to avoid displacement of the glaucoma drainage device after implantation in the eye.

[0014] In an optional embodiment of the present application, the glaucoma drainage device further comprises a bioadhesive layer, which is disposed between the first end and the second end and covers the outer peripheral wall of the substrate.

[0015] In the above technical solution, the bonding force between the outer peripheral surface of the glaucoma drainage device and the eye tissue can be increased, which is beneficial to avoid displacement of the glaucoma drainage device after implantation in the eye.

[0016] In an optional embodiment of the present application, the glaucoma drainage device has at least two channels.

[0017] In the above technical solution, the glaucoma drainage device has at least two channels, which is convenient for better draining the aqueous humor of the eye to reduce the intraocular pressure.

[0018] In an optional embodiment of the present application, the glaucoma drainage device has at least three channels, and the at least three channels are arranged at intervals along the second preset direction.

[0019] In the above technical solution, it is convenient to better draw out the aqueous humor of the eye to reduce the intraocular pressure.

[0020] In an optional embodiment of the present application, the glaucoma drainage device is a tubular structure.

[0021] In the above technical solution, it is convenient to implant the glaucoma drainage device into the eye.

[0022] In an optional embodiment of the present application, the outer peripheral surface of the glaucoma drainage device has a concave-convex structure.

[0023] In the above technical solution, the friction between the outer surface of the glaucoma drainage device and the eye tissue can be increased to increase the movement resistance of the glaucoma drainage device in the eye area, which is beneficial to avoid displacement of the glaucoma drainage device after implantation in the eye.

[0024] In an optional embodiment of the present application, a flap valve is installed in the channel.

[0025] The above technical solution can further play a role in controlling intraocular pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0027] Figure 1 A schematic structural diagram of a first example of a glaucoma drainage device provided in an embodiment of the present application.

[0028] Figure 2 A front view of a first example of a glaucoma drainage device provided in an embodiment of the present application.

[0029] Figure 3 for Figure 2 Cross-sectional view along the AA direction.

[0030] Figure 4 A schematic structural diagram of a second example of a glaucoma drainage device provided in an embodiment of the present application.

[0031] Figure 5 A front view of a second example of a glaucoma drainage device provided in an embodiment of the present application.

[0032] Figure 6 for Figure 5 Cross-sectional view along direction BB.

[0033] Icon: 100 - glaucoma drainage device; 101 - first preset direction; 110 - base; 111 - channel; 112 - first end surface; 113 - first end portion; 114 - second end portion. DETAILED DESCRIPTION

[0034] The following embodiments of the technical solution of the present application are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0035] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which this application belongs; the terms used herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" in the specification of this application and the above-mentioned drawings and any variations thereof are intended to cover non-exclusive inclusions.

[0036] In the description of the embodiments of the present application, the technical terms "first", "second", etc. are only used to distinguish different objects, and cannot be understood as indicating or implying relative importance or implicitly indicating the number, specific order or primary and secondary relationship of the indicated technical features. In the description of the embodiments of the present application, the meaning of "multiple" is more than two, unless otherwise clearly and specifically defined.

[0037] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0038] In the description of the embodiments of the present application, the orientations or positional relationships indicated by the technical terms "inside" and "outside" are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the embodiments of the present application and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the embodiments of the present application.

[0039] In the description of the embodiments of the present application, unless otherwise clearly specified and limited, technical terms such as "connection" and "fixation" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the embodiments of the present application can be understood according to specific circumstances.

[0040] The present embodiment provides a glaucoma drainage device 100, which is used to be implanted in the eye to drain the aqueous humor of the eye, thereby reducing the intraocular pressure.

[0041] Figure 1 This is a schematic structural diagram of a first example of a glaucoma drainage device 100 provided in an embodiment of the present application. Figure 2 A front view of a first example of a glaucoma drainage device 100 provided in an embodiment of the present application, Figure 3 for Figure 2 Cross-sectional view along AA direction, Figure 4 This is a schematic structural diagram of a second example of the glaucoma drainage device 100 provided in an embodiment of the present application. Figure 5 A front view of a second example of a glaucoma drainage device 100 provided in an embodiment of the present application, Figure 6 for Figure 5 Cross-sectional view along BB direction. Figures 1 to 6 , the glaucoma drainage device 100 includes a base 110 .

[0042] The base body 110 has a channel 111 penetrating the base body 110 along the first preset direction 101 , and the channel 111 provides a space for draining the aqueous humor of the eye.

[0043] See also Figure 1 and Figure 4 The base body 110 has a first end surface 112 and a second end surface (not shown in the figure) arranged opposite to each other along the first preset direction 101.

[0044] The glaucoma drainage device 100 further includes a first hydrophilic layer (not shown in the figure). The first hydrophilic layer covers the first end surface 112 and the second end surface. Due to the presence of proteins, cells, bacteria and other substances in the eye area and the aqueous humor, the above-mentioned arrangement can reduce the accumulation and adhesion of proteins, cells, bacteria and other substances in the eye area and the aqueous humor at the mouth of the channel 111, thereby reducing the risk of blockage of the channel 111; in addition, the reduction of the accumulation and adhesion of proteins, cells, bacteria and other substances at the mouth of the channel 111 is also conducive to reducing the inflammatory reaction of the eye tissue in the area near the mouth of the channel 111.

[0045] The glaucoma drainage device 100 further includes a second hydrophilic layer (not shown in the figure). The inner wall of the channel 111 is at least partially covered by the second hydrophilic layer; the second hydrophilic layer can promote the spreading of aqueous humor on the inner wall of the channel 111, reduce the flow resistance of aqueous humor in the channel 111, and reduce the accumulation and adhesion of substances such as proteins, cells, and bacteria in the aqueous humor in the channel 111, which can further reduce the risk of blockage of the channel 111.

[0046] In some optional embodiments of the present application, the inner wall of the channel 111 is completely covered by the second hydrophilic layer, which can further reduce the flow resistance of the aqueous humor in the channel 111 and further reduce the accumulation and adhesion of proteins, cells, bacteria and other substances in the aqueous humor in the channel 111, thereby helping to further reduce the risk of blockage of the channel 111.

[0047] In the present application, the first hydrophilic layer and the second hydrophilic layer refer to a layer structure made of a hydrophilic material, and the hydrophilic material refers to a material whose surface water contact angle is less than or equal to 90°. As an example, the hydrophilic material can be polyvinyl alcohol, polyethylene glycol, polyoxyethylene, poly-2-methacryloyloxyethyl phosphorylcholine, polyvinyl pyrrolidone, polyacrylic acid, hyaluronic acid, collagen, heparin, hydroxyethyl methacrylate or hirudin, etc.

[0048] In some optional embodiments of the present application, the radial shape of the channel 111 is circular; the above-mentioned arrangement can further reduce the flow resistance of the aqueous humor in the channel 111, and further reduce the accumulation and adhesion of proteins, cells, bacteria and other substances in the aqueous humor in the channel 111, thereby helping to further reduce the risk of blockage of the channel 111.

[0049] It should be noted that the present application does not limit the shape of the channel 111. For example, the radial shape of the channel 111 may be square or triangular.

[0050] In some optional embodiments of the present application, the material of the substrate 110 may be poly(styrene-isobutylene-styrene) triblock polymer.

[0051] In the present application, two opposite ends of the base body 110 along the first preset direction 101 are defined as a first end 113 and a second end 114 .

[0052] In some optional embodiments of the present application, the glaucoma drainage device 100 further includes a third hydrophilic layer (not shown in the figure) and a fourth hydrophilic layer (not shown in the figure), the third hydrophilic layer is disposed at the first end 113, the fourth hydrophilic layer is disposed at the second end 114, and the third hydrophilic layer and the fourth hydrophilic layer are both covered on the outer peripheral wall of the substrate 110. The provision of the third hydrophilic layer and the fourth hydrophilic layer can further reduce the accumulation and adhesion of substances such as proteins, cells, and bacteria in the aqueous humor at the mouth of the channel 111, thereby further reducing the risk of blockage of the channel 111 and reducing inflammatory reactions.

[0053] In the present application, the third hydrophilic layer and the fourth hydrophilic layer refer to a layer structure made of a hydrophilic material, and the hydrophilic material refers to a material with a surface water contact angle of less than or equal to 90°. As an example, the hydrophilic material can be polyvinyl alcohol, polyethylene glycol, polyoxyethylene, poly-2-methacryloyloxyethyl phosphorylcholine, polyvinyl pyrrolidone, polyacrylic acid, hyaluronic acid, collagen, heparin, hydroxyethyl methacrylate or hirudin, etc.

[0054] In some optional embodiments of the present application, the glaucoma drainage device 100 further includes a covering layer, which is disposed between the first end 113 and the second end 114 and covers the outer peripheral wall of the base 110 .

[0055] Furthermore, in some optional embodiments of the present application, the covering layer is a hydrophobic layer, which is arranged between the first end 113 and the second end 114 and covers the outer peripheral wall of the substrate 110; the provision of the hydrophobic layer can increase the bonding force between the outer peripheral surface of the glaucoma drainage device 100 and the eye tissue, thereby helping to avoid displacement of the glaucoma drainage device 100 after implantation in the eye.

[0056] In the present application, the hydrophobic layer refers to a layer structure made of a hydrophobic material, and the hydrophobic material refers to a material with a surface water contact angle greater than 90°. As an example, the hydrophobic material may be a poly(styrene-isobutylene-styrene) triblock polymer or the like.

[0057] In some optional embodiments of the present application, the covering layer is a bioadhesive layer, which is disposed between the first end 113 and the second end 114 and covers the outer peripheral wall of the substrate 110; the provision of the bioadhesive layer can increase the bonding force between the outer peripheral surface of the glaucoma drainage device 100 and the eye tissue, thereby helping to avoid displacement of the glaucoma drainage device 100 after implantation in the eye.

[0058] In the present application, the bioadhesive layer refers to a layer structure made of a material having bioadhesive properties. As an example, the material having bioadhesive properties is polydopamine or the like.

[0059] In some optional embodiments of the present application, the covering layer may be partially a hydrophobic layer and partially a bioadhesive layer.

[0060] like Figures 1 to 3 As shown, the glaucoma drainage device 100 has only one channel 111. In some optional embodiments of the present application, the glaucoma drainage device 100 has at least two channels 111, for example Figures 4 to 6 As shown, the glaucoma drainage device 100 has two channels 111 .

[0061] The glaucoma drainage device 100 has at least two channels 111 to better drain the aqueous humor from the eye to reduce intraocular pressure.

[0062] In some optional embodiments of the present application, the glaucoma drainage device 100 has at least three channels 111, and the at least three channels 111 are arranged at intervals along the second preset direction. The above arrangement facilitates better drainage of ocular aqueous humor to reduce intraocular pressure.

[0063] It should be noted that the present application does not limit the number of channels 111 in the glaucoma drainage device 100, and the number can be set according to actual conditions.

[0064] In some optional embodiments of the present application, the glaucoma drainage device 100 is a tubular structure. In the above configuration, the tubular structure is not easy to damage the eye tissue, which facilitates the implantation of the glaucoma drainage device 100 into the eye.

[0065] In some optional embodiments of the present application, the outer peripheral surface of the glaucoma drainage device 100 has a concave-convex structure. The above arrangement can increase the friction between the outer peripheral surface of the glaucoma drainage device 100 and the eye tissue, so as to increase the movement resistance of the glaucoma drainage device 100 in the eye area, thereby facilitating the prevention of displacement of the glaucoma drainage device 100 after implantation in the eye.

[0066] As an example, the outer surface of the glaucoma drainage device 100 has a concave-convex structure in the following manner, for example, a plurality of spaced protrusions are provided on the outer surface of the glaucoma drainage device 100, etc., which is not limited in the present application.

[0067] In some optional embodiments of the present application, a flap valve is installed in the channel 111. The provision of the flap valve can further play a role in controlling intraocular pressure.

[0068] The glaucoma drainage device 100 provided in the present application has at least the following advantages:

[0069] The glaucoma drainage device 100 provided in the present application is used to be implanted in the eye to drain the aqueous humor of the eye, thereby reducing the intraocular pressure; the substrate 110 has a channel 111 that penetrates the substrate 110 along a first preset direction 101, and the channel 111 provides a space for draining the aqueous humor of the eye; the two end surfaces of the substrate 110 that are relatively arranged along the first preset direction 101 are covered with a first hydrophilic layer, which can reduce the accumulation and adhesion of substances such as proteins, cells, bacteria, etc. in the eye area at the mouth of the channel 111, reduce the risk of blockage of the channel 111, and help reduce the inflammatory response of the eye tissue in the area near the mouth of the channel 111; the inner wall of the channel 111 is at least partially covered by the second hydrophilic layer, which can promote the spreading of aqueous humor on the inner wall of the channel 111, reduce the flow resistance of aqueous humor in the channel 111, and reduce the accumulation and adhesion of substances such as proteins, cells, bacteria, etc. in the aqueous humor in the channel 111, which can further reduce the risk of blockage of the channel 111.

[0070] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A glaucoma drainage device, characterized in that: include: A substrate, wherein the substrate has a channel penetrating the substrate along a first preset direction; The base body has a first end surface and a second end surface which are arranged opposite to each other along the first preset direction; a first hydrophilic layer, the first hydrophilic layer covering the first end surface and the second end surface; A second hydrophilic layer, wherein the inner wall of the channel is at least partially covered by the second hydrophilic layer.

2. The glaucoma drainage device according to claim 1, characterized in that: The inner wall of the channel is completely covered by the second hydrophilic layer.

3. The glaucoma drainage device according to claim 1, characterized in that: defining two opposite ends of the substrate along the first preset direction as a first end and a second end; The glaucoma drainage device further comprises a third hydrophilic layer and a fourth hydrophilic layer, wherein the third hydrophilic layer is arranged at the first end portion, and the fourth hydrophilic layer is arranged at the second end portion, and both the third hydrophilic layer and the fourth hydrophilic layer cover the outer peripheral wall of the substrate.

4. The glaucoma drainage device according to claim 3, characterized in that: The glaucoma drainage device further includes a hydrophobic layer, which is disposed between the first end and the second end and covers the outer peripheral wall of the base.

5. The glaucoma drainage device according to claim 3, characterized in that: The glaucoma drainage device further comprises a bioadhesive layer, which is disposed between the first end and the second end and covers the outer peripheral wall of the substrate.

6. The glaucoma drainage device according to any one of claims 1 to 5, characterized in that: The glaucoma drainage device has at least two of the channels.

7. The glaucoma drainage device according to claim 6, characterized in that: The glaucoma drainage device has at least three channels, and at least three channels are arranged at intervals along a second preset direction.

8. The glaucoma drainage device according to any one of claims 1 to 5, characterized in that: The glaucoma drainage device is a tubular structure.

9. The glaucoma drainage device according to any one of claims 1 to 5, characterized in that: The outer peripheral surface of the glaucoma drainage device has a concave-convex structure.

10. The glaucoma drainage device according to any one of claims 1 to 5, characterized in that: A flap valve is installed in the passage.

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