Heterogeneous reaction kettle for drug intermediates

Abstract

The utility model discloses a drug intermediate heterogeneous reaction kettle which comprises a kettle body, a stirring device is mounted in the kettle body, an emulsifying device parallel to the stirring device is further mounted in the kettle body, and a baffling device is mounted on the inner wall of one side, opposite to the emulsifying device, of the kettle body; an air inlet is formed in the bottom of the kettle body and is connected with an air inlet valve. Through the design of the stirring device, the emulsifying device, the baffling device and the air inlet, heterogeneous materials in the reaction kettle can be subjected to four-stage stirring and multi-directional mixing, so that the heterogeneous materials can be fully and comprehensively mixed within limited time, the mixing effect and the mixing efficiency are improved, and the production cost is reduced. The device can be used for large-scale heterogeneous reaction and is high in practicability.

Description

Technical Field

[0001] The utility model relates to the field of chemical reaction equipment, in particular to a drug intermediate heterogeneous reaction kettle. Background Art

[0002] Gas-liquid, liquid-liquid, and solid-liquid heterogeneous reactions are common reactions in organic chemistry and are widely used in the production of APIs. A typical reaction type is the heterogeneous oxidation of alcohol compounds to aldehydes or carboxylic acids in water and organic solvents under NaClO / TEMPO conditions. The reaction effect of this type of heterogeneous reaction is easily affected by the production scale. The larger the scale, the worse the stirring effect, which is less conducive to large-scale commercial production.

[0003] Therefore, for heterogeneous reactions, the stirring effect seriously affects the reaction results, especially for large-scale heterogeneous reactions. Traditional paddle and propeller stirring methods cannot meet the mixing requirements of heterogeneous reactions, and the industry urgently needs to develop a reactor suitable for heterogeneous reactions. Utility Model Content

[0004] The utility model provides a drug intermediate heterogeneous reaction kettle, which can solve the problem of poor stirring effect and influence on reaction effect in the heterogeneous reaction in the prior art.

[0005] In order to solve the above technical problems, the utility model provides a drug intermediate heterogeneous reaction kettle, including a kettle body, a stirring device is installed in the kettle body, an emulsifying device arranged parallel to the stirring device is also installed in the kettle body, and a deflection device is installed on the inner wall of the kettle body on the side opposite to the emulsifying device; an air inlet is opened at the bottom of the kettle body, and the air inlet is connected to an air inlet valve.

[0006] In a preferred embodiment of the present invention, the air inlet is located at the bottom center of the kettle body and is in a straight line with the stirring device.

[0007] In a preferred embodiment of the utility model, an exhaust port is provided on the top of the kettle body, a one-way valve is connected to the exhaust port, and the one-way valve is connected to the tail gas absorption device through a pipeline.

[0008] In a preferred embodiment of the utility model, the baffle device includes a baffle plate, which is arranged along the radial direction of the kettle body and the outer side of the baffle plate is fixed to the inner wall of the kettle body through a connecting rod.

[0009] In a preferred embodiment of the present invention, the cross section of the baffle is an isosceles triangle, the plate surface where the base of the isosceles triangle is located faces the wall surface of the kettle body and is connected to the connecting rod.

[0010] In a preferred embodiment of the present invention, the cross section of the baffle is an isosceles trapezoid, the plate surface where the long bottom side of the isosceles trapezoid is located faces the wall surface of the kettle body and is connected to the connecting rod.

[0011] In a preferred embodiment of the utility model, the cross section of the baffle is fan-shaped, and the plate surface where the arc-shaped edge of the fan faces the wall surface of the kettle body and is connected to the connecting rod.

[0012] In a preferred embodiment of the utility model, the emulsifying device includes an emulsifying machine, a reducer and an emulsifying motor; the emulsifying machine is built in the kettle body, and the top end of the emulsifying machine is connected to the emulsifying motor through the reducer.

[0013] In a preferred embodiment of the present invention, the distance between the bottom end of the stirring device and the air inlet is 1 / 5 to 1 / 3 of the height of the kettle body.

[0014] In a preferred embodiment of the present invention, the stirring device includes a stirring shaft and a stirring motor. The stirring shaft is built into the kettle body, and the top end of the stirring shaft is connected to the stirring motor.

[0015] The beneficial effects of the utility model are as follows: the utility model is a pharmaceutical intermediate heterogeneous reaction kettle, which can provide a four-stage stirring effect and a multi-directional mixing effect for the heterogeneous materials in the reaction kettle body through the design of a stirring device, an emulsifying device, a baffle device and an air inlet, so that the heterogeneous materials can be fully and comprehensively mixed within a limited time, thereby improving the mixing effect and mixing efficiency, and can be used for large-scale heterogeneous reactions, with strong practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a three-dimensional structural schematic diagram of a preferred embodiment of a heterogeneous reaction kettle for drug intermediates of the utility model;

[0017] Figure 2 It is a schematic diagram of the cross-sectional structure of the baffle plate in a preferred embodiment 1 of a heterogeneous reaction kettle for pharmaceutical intermediates of the utility model and its connection relationship with the inner wall of the kettle body;

[0018] Figure 3 It is a schematic diagram of the cross-sectional structure of the baffle plate in a preferred embodiment 2 of a heterogeneous reaction kettle for pharmaceutical intermediates of the utility model and its connection relationship with the inner wall of the kettle body;

[0019] Figure 4 It is a schematic diagram of the cross-sectional structure of the baffle plate in a preferred embodiment 3 of a heterogeneous reaction kettle for pharmaceutical intermediates of the utility model and its connection relationship with the inner wall of the kettle body;

[0020] Figure 5 is a schematic diagram of the material flow direction in the emulsifier;

[0021] The markings of the components in the accompanying drawings are as follows:

[0022] 100. kettle body, 110. jacket, 120. stirring motor, 130. stirring shaft, 140. emulsifying motor, 150. reducer, 160. emulsifying machine, 161. shearing head, 170. baffle, 180. connecting rod, 190. air inlet, 191. air inlet valve, 200. exhaust port, 210. one-way valve, 300. tail gas absorption device. DETAILED DESCRIPTION

[0023] The preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, thereby making a clearer and more definite definition of the protection scope of the present invention.

[0024] The utility model embodiment includes:

[0025] Example 1

[0026] like Figure 1 and 2 As shown, the utility model discloses a drug intermediate heterogeneous reaction kettle, comprising a kettle body 100, wherein the exterior of the kettle body 100 is provided with a jacket 110 for introducing a heat source or a cold source to heat or cool the reaction kettle.

[0027] A stirring device is installed in the kettle body 100 along the direction of its central axis. The stirring device includes a stirring motor 120 located outside the kettle body and a stirring shaft 130 located inside the kettle body. The stirring shaft 130 is vertically suspended in the kettle body 100, and its top end is drivingly connected to the stirring motor 120, and its bottom end does not contact the inner wall surface of the kettle body. The stirring device provides a primary stirring function.

[0028] An emulsifying device arranged in parallel with the stirring device is also installed on any side of the kettle body 100. The emulsifying device includes an emulsifying motor 140, a reducer 150 and an emulsifying machine 160. The emulsifying machine 160 is vertically suspended in the kettle body 100, and its top end extends out of the kettle body and is connected to the emulsifying motor 140 through the reducer 150. The bottom end of the emulsifying machine 160 is provided with a shearing head 161. During high-speed rotation, the shearing head 161 can absorb the material and throw the material out from the top of the shearing head under the action of centrifugal force, thereby accelerating the mixing between the heterogeneous materials and providing a secondary stirring effect.

[0029] The working principle of the emulsifier 160 is to shear, disperse and impact the material through high-speed rotation to make the material more delicate. Different materials require different shear heads 161.

[0030] A baffle device is installed on the inner wall of the kettle body 100 opposite to the emulsifying device. The baffle device includes a baffle plate 170 and a connecting rod 180. The baffle plate 170 is arranged along the radial direction of the kettle body 100, and its outer side is fixed to the inner wall of the kettle body 100 through the connecting rod 180.

[0031] Specifically, the baffle plate 170 is a special-shaped structure, and its cross section is an isosceles triangle. The plate surface where the base of the isosceles triangle is located faces the wall surface of the kettle body 100 and is connected to the connecting rod 180 .

[0032] Under the stirring action of the stirring device, whether it is rotating forward or reverse, part of the heterogeneous materials being stirred and mixed will collide with the isosceles surface of the baffle 170, thereby changing the flow direction and increasing the mixing effect. Therefore, the baffle device can provide a three-level stirring action.

[0033] The bottom center of the kettle body 100 is also provided with an air inlet 190, and the air inlet 190 is connected to an air inlet valve 191, and the air inlet 190 is connected to an air source storage tank (not shown) through the air inlet valve 191, and the air source in the air source storage tank can be nitrogen or compressed air. By introducing nitrogen or compressed air into the kettle body 100 through the air inlet, the solid phase material or high specific gravity material deposited in the kettle body due to gravity can be blown upward into the mixing system again for stirring and mixing, thereby improving the mixing effect of the heterogeneous material, and thus playing the role of four-stage stirring.

[0034] In addition, the distance between the stirring shaft 130 and the air inlet 190 is 1 / 5 to 1 / 3 of the height of the reactor body, preferably 1 / 4. By controlling this distance, the blades on the stirring shaft can be prevented from being blocked, so that the solid phase or high specific gravity phase can be effectively returned to the mixing system under the action of air blowing, ensuring the best air blowing mixing effect.

[0035] Furthermore, the top of the kettle body 100 is provided with an exhaust port 200, and the exhaust port 200 is connected with a one-way valve 210, and the one-way valve 210 is connected to the tail gas absorption device 300 through a pipeline. Through the design of the exhaust port 200 and the one-way valve 210, on the one hand, the gas blown into the kettle body through the air inlet 190 can be discharged in time to ensure the stability of the air pressure in the kettle body, and on the other hand, the waste gas generated during the stirring process or the gas generated by the reaction can also be discharged in time to avoid directly entering the atmosphere to pollute the environment.

[0036] Example 2

[0037] like Figure 3As shown, the difference from Example 1 is that a baffle device is installed on the inner wall of the kettle body 100 opposite to the emulsifying device. The baffle device includes a baffle plate 170 and a connecting rod 180. The baffle plate 170 is arranged along the radial direction of the kettle body 100, and its outer side is fixed to the inner wall of the kettle body 100 through the connecting rod 180.

[0038] Specifically, the baffle 170 is a special-shaped structure, and its cross section is an isosceles trapezoid. The plate surface where the long bottom side of the isosceles trapezoid is located faces the wall surface of the kettle body 100 and is connected to the connecting rod 180 .

[0039] Under the stirring action of the stirring device, whether it is rotating forward or reverse, part of the heterogeneous materials being stirred and mixed will collide with the isosceles surface of the baffle 170, thereby changing the flow direction and increasing the mixing effect. Therefore, the baffle device can provide a three-level stirring action.

[0040] Example 3

[0041] like Figure 4 As shown, the difference from Example 1 is that a baffle device is installed on the inner wall of the kettle body 100 opposite to the emulsifying device. The baffle device includes a baffle plate 170 and a connecting rod 180. The baffle plate 170 is arranged along the radial direction of the kettle body 100, and its outer side is fixed to the inner wall of the kettle body 100 through the connecting rod 180.

[0042] Specifically, the baffle 170 is a special-shaped structure, and its cross section is fan-shaped. The arc-shaped plate surface where the arc-shaped edge of the fan is located faces the wall surface of the kettle body 100 and is connected to the connecting rod 180 .

[0043] Under the stirring action of the stirring device, whether it is rotating forward or reverse, part of the heterogeneous materials being stirred and mixed will collide with the symmetrical inclined surfaces on both sides of the baffle 170, thereby changing the flow direction and increasing the mixing effect. Therefore, the baffle device can provide a three-level stirring action.

[0044] The utility model discloses a drug intermediate heterogeneous reaction kettle, which can provide multi-stage stirring action for heterogeneous materials through the design of a stirring device, an emulsifying device, a baffle device and an air inlet, improves the mixing effect in all directions, is suitable for large-scale heterogeneous reactions, and has strong practicability.

[0045] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A pharmaceutical intermediate heterogeneous reaction kettle, characterized in that: It comprises a kettle body, in which a stirring device is installed, and an emulsifying device arranged in parallel with the stirring device is also installed in the kettle body, and a deflection device is installed on the inner wall of the kettle body on the side opposite to the emulsifying device; an air inlet is opened at the bottom of the kettle body, and the air inlet is connected to an air inlet valve.

2. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 1, characterized in that: The air inlet is located at the bottom center of the kettle body and is in a straight line with the stirring device.

3. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 2, characterized in that: An exhaust port is provided on the top of the kettle body, and a one-way valve is connected to the exhaust port. The one-way valve is connected to the tail gas absorption device through a pipeline.

4. A pharmaceutical intermediate heterogeneous reaction kettle according to any one of claims 1 to 3, characterized in that: The baffle device comprises a baffle plate, which is arranged along the radial direction of the kettle body and whose outer side is fixed to the inner wall of the kettle body through a connecting rod.

5. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 4, characterized in that: The cross section of the baffle is an isosceles triangle, the plate surface where the base of the isosceles triangle is located faces the wall surface of the kettle body and is connected to the connecting rod.

6. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 4, characterized in that: The cross section of the baffle is an isosceles trapezoid, the plate surface where the long bottom side of the isosceles trapezoid is located faces the wall surface of the kettle body and is connected to the connecting rod.

7. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 4, characterized in that: The cross section of the baffle is fan-shaped, and the plate surface where the arc edge of the fan is located faces the wall surface of the kettle body and is connected to the connecting rod.

8. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 4, characterized in that: The emulsifying device comprises an emulsifying machine, a reducer and an emulsifying motor; the emulsifying machine is built in the kettle body, and the top end of the emulsifying machine is connected to the emulsifying motor through the reducer.

9. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 4, characterized in that: The distance between the bottom end of the stirring device and the air inlet is 1 / 5 to 1 / 3 of the height of the kettle body.

10. A pharmaceutical intermediate heterogeneous reaction kettle according to claim 4, characterized in that: The stirring device comprises a stirring shaft and a stirring motor. The stirring shaft is built in the kettle body, and the top end of the stirring shaft is connected to the stirring motor.

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