Liquid supplementing structure of dissolution tester
By integrating a water bath system for uniform heating, the device ensures consistent liquid temperatures between cups, thereby stabilizing experimental conditions and improving the accuracy of solvent extraction processes.
Patent Information
- Application Number
- CN202422027247.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-21
- Publication Date
- 2025-07-15
- Estimated Expiration
- 2034-08-21
AI Technical Summary
During the liquid replenishment process of the existing dissolution instrument, the liquid temperature in the liquid replenishment cup is different from the liquid temperature in the dissolution cup, resulting in unstable experimental results.
The water bath is used to fix both the dissolution cup and the replenishing cup inside. The water in the water bath is heated evenly through the heating plate to make the liquid in the dissolution cup and the replenishing cup the same temperature, and heat loss is reduced through the insulation tube, vibration is absorbed using a shock absorbing mechanism, and the intestinal peristalsis environment is simulated to improve the accuracy of the experiment.
It effectively reduces the temperature difference and vibration influence during the fluid replenishment process, and improves the accuracy and accuracy of experimental results.
Smart Images
Figure CN223107786U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of dissolution testers, in particular to a liquid supplementing structure of a dissolution tester. Background Technique
[0002] A dissolution tester is an important experimental instrument widely used in the fields of drug research and development, quality control, etc. The dissolution tester is mainly used to detect the dissolution rate and degree of drugs from preparations under specific conditions. It evaluates the performance of drug preparations by simulating the environment of the human gastrointestinal tract, such as temperature, stirring speed, pH value of the medium, etc.
[0003] The existing Chinese patent with the publication number CN108956913A discloses a dissolution tester with controllable temperature and real-time liquid supplementing. A liquid supplementing pump (14) is arranged outside the dissolution cup (2). The dissolution cup (2) is connected to the liquid supplementing pump (14) through a conduit (15). One end of the liquid supplementing pump (14) is arranged inside the liquid supplementing cup (3). When the sampling volume is too large, in order to ensure the accuracy of data, the liquid supplementing pump can be turned on to supplement a specified volume of dissolution medium into the dissolution cup. However, when this device is supplementing liquid, it cannot ensure that the liquid temperature in the liquid supplementing cup (3) is the same as the liquid temperature in the dissolution cup (2), thus forming an unstable factor during the experiment and affecting the experimental results. Content of the Utility Model
[0004] The purpose of the utility model is to provide a liquid supplementing structure of a dissolution tester. By using this device for work, the problem that the liquid temperature in the liquid supplementing cup is different from the liquid temperature in the dissolution cup, thus affecting the experiment, is solved.
[0005] To achieve the above object, the present utility model provides the following technical solution: A liquid replenishing structure for a dissolution tester, comprising a water bath tank. On one side inside the water bath tank, there is a dissolution cup, and inside the dissolution cup, there is a stirring mechanism. On the other side inside the water bath tank, there is a liquid replenishing cup. At the upper end of the liquid replenishing cup, there is a shock absorption mechanism. Inside the liquid replenishing cup, there is a liquid replenishing mechanism. At the upper end of the water bath tank, there is a fixed water inlet. Inside the water bath tank, there is a fixed heating plate. On the outer side of the dissolution cup, there is a fixed connecting piece one, and the connecting piece one is fixedly connected to the inner wall surface of the water bath tank. On the outer side of the liquid replenishing cup, there is a fixed connecting piece two, and the connecting piece two is fixedly connected to the inner wall surface of the water bath tank. Through the connecting piece one and the connecting piece two, both the dissolution cup and the liquid replenishing cup are fixed inside the water bath tank. First, the required amount of water is transported into the water bath tank from the water inlet, and then the water in the water bath tank is evenly heated by the heating plate to reach the specified temperature required for the experiment and maintain a constant temperature. Since both the dissolution cup and the liquid replenishing cup are located inside the water bath tank, the temperature conduction of the water in the water bath tank to the liquid inside itself is the same, so that the liquid temperatures in the dissolution cup and the liquid replenishing cup are the same. When the liquid replenishing mechanism transports the liquid in the liquid replenishing cup into the dissolution cup, the formed temperature difference is relatively small, greatly reducing the impact on the experimental process and results.
[0006] Preferably, a connecting pipe opening is fixedly installed at the upper end of the dissolution cup. A liquid extraction pipe is installed through the inside of the liquid replenishing cup. At the upper end of the liquid extraction pipe, there is a fixed small liquid replenishing pump. At the output end of the small liquid replenishing pump, there is a fixed liquid replenishing pipe. The other end of the liquid replenishing pipe is matched with the connecting pipe opening and is fixedly connected. A heat preservation pipe is sleeved outside the liquid replenishing pipe. When liquid replenishment is required, the small liquid replenishing pump extracts the replenishing liquid in the liquid replenishing cup from the lower port of the liquid extraction pipe and transports it into the dissolution cup through the liquid replenishing pipe. When the replenishing liquid is being transported, heat loss will occur. By sleeving a heat preservation pipe outside the liquid replenishing pipe, the speed of heat loss is greatly reduced, further reducing the temperature difference when the replenishing liquid contacts the inside of the dissolution cup and improving the accuracy of the experimental results.
[0007] Preferably, a box body is fixedly installed at the lower end of the small liquid replenishing pump. At the four corners of the lower end of the box body, there are fixed springs. At the lower end of the springs, there is a fixed rubber plate. The lower surface of the rubber plate is fixedly connected to the liquid replenishing cup. Through holes are respectively and penetratingly opened inside the box body and the rubber plate. The liquid extraction pipe penetrates through the through holes and is communicated with the small liquid replenishing pump inside the box body. When the small liquid replenishing pump is working, vibrations will be generated, and after being transmitted, they will affect the experiment inside the dissolution cup. The setting of multiple springs and the rubber plate effectively absorbs the vibrations generated when the small liquid replenishing pump is working, reducing the impact of the vibrations on the experiment.
[0008] Preferably, a stirring shaft is installed through the inside of the dissolution cup. A servo motor is fixedly installed at the driving end of the stirring shaft. A fixing member is fixedly installed on one side of the servo motor, and the fixing member is fixedly connected to the upper surface of the dissolution cup. A stirring fan is fixedly installed at the lower end of the stirring shaft. The servo motor drives the stirring shaft to rotate and drives the stirring fan to rotate, stirring the liquid inside the dissolution cup to simulate the intestinal peristalsis environment in the human body and improve the accuracy of the experiment.
[0009] Preferably, a liquid replenishing port is fixedly installed at the upper end of the liquid replenishing cup. A liquid inlet pipe is installed through the inside of the liquid replenishing cup. A rubber pipe is fixedly installed at the upper end of the liquid replenishing cup. The other end of the rubber pipe is fixedly installed with a pipe cap, and the pipe cap is matched with the liquid inlet pipe. When liquid replenishment is required, just unfasten the pipe cap. When the device is idle, fasten the pipe cap between the pipe cap and the liquid inlet pipe to prevent foreign impurities from entering, which is convenient for next use.
[0010] Preferably, a feeding port is fixedly installed on one side of the upper end of the dissolution cup, and a sampling port is fixedly installed on the other side of the upper end of the dissolution cup. The feeding port and the sampling port have exactly the same structure as the liquid replenishing port. The setting of the feeding port facilitates putting the medicine into the dissolution cup for experiments, and the setting of the sampling port facilitates sampling the samples after the experiment is completed, improving the practicability of the device.
[0011] Compared with the prior art, the beneficial effects of the present utility model are as follows:
[0012] For a liquid replenishing structure of a dissolution instrument proposed by the present utility model, first, the required amount of water is transported into the water bath box from the water inlet, and then the water in the water bath box is evenly heated by the heating plate to reach the specified temperature required for the experiment and keep it constant. Since the dissolution cup and the liquid replenishing cup are both inside the water bath box, the water in the water bath box conducts heat to the liquid inside itself in the same way, so that the liquid temperatures in the dissolution cup and the liquid replenishing cup are the same. When the liquid replenishing mechanism transports the liquid in the liquid replenishing cup into the dissolution cup, the temperature difference formed is relatively small, greatly reducing the influence on the experimental process and results. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 is the overall structure schematic diagram of the present utility model;
[0014] Figure 2 is the water bath box structure schematic diagram of the present utility model;
[0015] Figure 3 is the dissolution cup and liquid replenishing cup structure schematic diagram of the present utility model;
[0016] Figure 4 is the stirring mechanism structure schematic diagram of the present utility model;
[0017] Figure 5 is the liquid replenishing mechanism structure schematic diagram of the present utility model;
[0018] Figure 6 This is a schematic structural diagram of the shock absorption mechanism of the present utility model.
[0019] In the figure: 1. Water bath box; 11. Heating plate; 12. Water inlet; 2. Dissolution cup; 21. First connecting piece; 22. Sampling port; 23. Feeding port; 24. Connecting pipe orifice; 3. Stirring mechanism; 31. Stirring shaft; 32. Servo motor; 33. Fixing piece; 34. Stirring fan; 4. Supplementary liquid cup; 41. Second connecting piece; 42. Supplementary liquid port; 421. Liquid inlet pipe; 422. Rubber pipe; 423. Pipe cover; 5. Supplementary liquid mechanism; 51. Liquid extraction pipe; 52. Small supplementary liquid pump; 53. Supplementary liquid pipe; 54. Heat preservation pipe; 6. Shock absorption mechanism; 61. Box body; 62. Spring; 63. Through hole; 64. Rubber plate. Specific embodiments
[0020] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.
[0021] To further understand the content of the present utility model, the present utility model will be described in detail in conjunction with the accompanying drawings.
[0022] Combined with Figures 1-3 , a supplementary liquid structure of a dissolution tester, including a water bath box 1, a dissolution cup 2 is arranged on one side inside the water bath box 1, a stirring mechanism 3 is arranged inside the dissolution cup 2, a supplementary liquid cup 4 is arranged on the other side inside the water bath box 1, a shock absorption mechanism 6 is arranged at the upper end of the supplementary liquid cup 4, a supplementary liquid mechanism 5 is arranged inside the supplementary liquid cup 4, a water inlet 12 is fixedly installed at the upper end of the water bath box 1, a heating plate 11 is fixedly installed inside the water bath box 1, a first connecting piece 21 is fixedly installed on the outer side of the dissolution cup 2, the first connecting piece 21 is fixedly connected to the inner wall surface of the water bath box 1, a second connecting piece 41 is fixedly installed on the outer side of the supplementary liquid cup 4, the second connecting piece 41 is fixedly connected to the inner wall surface of the water bath box 1. Through the first connecting piece 21 and the second connecting piece 41, both the dissolution cup 2 and the supplementary liquid cup 4 are fixed inside the water bath box 1. First, the required amount of water is conveyed into the water bath box 1 from the water inlet 12, and then the water in the water bath box 1 is evenly heated by the heating plate 11 to reach the specified temperature required for the experiment and keep it constant. Since both the dissolution cup 2 and the supplementary liquid cup 4 are located inside the water bath box 1, the temperature conduction of the water in the water bath box 1 to the liquid inside itself is the same, so that the liquid temperatures in the dissolution cup 2 and the supplementary liquid cup 4 are the same. When the supplementary liquid mechanism 5 conveys the liquid in the supplementary liquid cup 4 into the dissolution cup 2, the formed temperature difference is smaller, greatly reducing the influence on the experimental process and results.
[0023] Combined with Figure 3 and Figure 5 At the upper end of the dissolution cup 2, a connecting pipe orifice 24 is fixedly installed. Inside the replenishing liquid cup 4, a liquid extraction pipe 51 is installed through. At the upper end of the liquid extraction pipe 51, a small replenishing liquid pump 52 is fixedly installed. At the output end of the small replenishing liquid pump 52, a replenishing liquid pipe 53 is fixedly installed. The other end of the replenishing liquid pipe 53 is matched with the connecting pipe orifice 24 and is fixedly connected. A heat preservation pipe 54 is sleeved outside the replenishing liquid pipe 53. When replenishing liquid is needed, the small replenishing liquid pump 52 extracts the replenishing liquid in the replenishing liquid cup 4 from the lower port of the liquid extraction pipe 51 and transports it into the dissolution cup 2 through the replenishing liquid pipe 53. When the replenishing liquid is being transported, heat loss will occur. By sleeving the heat preservation pipe 54 outside the replenishing liquid pipe 53, the speed of heat loss is greatly reduced, and the temperature difference when the replenishing liquid contacts the inside of the dissolution cup 2 is further reduced, improving the accuracy of the experimental results.
[0024] Combined with Figures 5-6 At the lower end of the small replenishing liquid pump 52, a box body 61 is fixedly installed. At the four corners of the lower end of the box body 61, springs 62 are fixedly installed. At the lower end of the springs 62, a rubber plate 64 is fixedly installed. The lower surface of the rubber plate 64 is fixedly connected to the replenishing liquid cup 4. Through holes 63 are respectively and penetratingly opened inside the box body 61 and the rubber plate 64. The liquid extraction pipe 51 penetrates through the through holes 63 and is communicated with the small replenishing liquid pump 52 inside the box body 61. When the small replenishing liquid pump 52 is working, vibrations will be generated, and after being transmitted, they will affect the experiment inside the dissolution cup 2. The setting of multiple springs 62 and the rubber plate 64 effectively absorbs the vibrations generated when the small replenishing liquid pump 52 is working and reduces the influence of the vibrations on the experiment.
[0025] Combined with Figure 4 Inside the dissolution cup 2, a stirring shaft 31 is installed through. At the driving end of the stirring shaft 31, a servo motor 32 is fixedly installed. On one side of the servo motor 32, a fixing member 33 is fixedly installed. The fixing member 33 is fixedly connected to the upper surface of the dissolution cup 2. At the lower end of the stirring shaft 31, a stirring fan 34 is fixedly installed. The servo motor 32 drives the stirring shaft 31 to rotate and drives the stirring fan 34 to rotate, stirring the liquid inside the dissolution cup 2 to simulate the intestinal peristalsis environment in the human body and improving the accuracy of the experiment.
[0026] Combined with Figure 3 At the upper end of the replenishing liquid cup 4, a replenishing liquid port 42 is fixedly installed. Inside the replenishing liquid cup 4, a liquid inlet pipe 421 is installed through. At the upper end of the replenishing liquid cup 4, a rubber pipe 422 is fixedly installed. The other end of the rubber pipe 422 is fixedly installed with a pipe cap 423. The pipe cap 423 is matched with the liquid inlet pipe 421. When replenishing liquid is needed, just unfasten the pipe cap 423. When the device is idle, fasten the pipe cap 423 to the liquid inlet pipe 421 to prevent foreign impurities from entering, facilitating the next use.
[0027] Combined withFigure 3 , on one side of the upper end of the dissolution cup 2, a feed port 23 is fixedly installed, and on the other side of the upper end of the dissolution cup 2, a sampling port 22 is fixedly installed. The feed port 23 and the sampling port 22 have exactly the same structural composition as the liquid supplement port 42. The setting of the feed port 23 facilitates the putting of drugs into the dissolution cup 2 for experiments, and the setting of the sampling port 22 facilitates the sampling of samples after the experiment is completed, improving the practicability of the device.
[0028] The specific working process and principle of the present utility model: First, the required amount of water is conveyed into the water bath tank 1 from the water inlet 12, and then the water in the water bath tank 1 is evenly heated by the heating plate 11. Then, the required liquid is heated in the dissolution cup 2 and the liquid supplement cup 4. After the temperature is constant, the feed port 23 is opened to put the drug in. Then, the servo motor 32 drives the stirring shaft 31 to rotate and drives the stirring fan 34 to rotate to stir the liquid inside the dissolution cup 2 to simulate the intestinal peristalsis environment in the human body. During this period, when liquid supplement is needed, the small liquid supplement pump 52 is started to pump out the liquid supplement in the liquid supplement cup 4 from the lower port of the liquid extraction pipe 51 and convey it into the dissolution cup 2 through the liquid supplement pipe 53 for liquid supplement. After the experiment is completed, sampling is carried out from the sampling port 22.
[0029] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.
[0030] Although the embodiments of the present utility model have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present utility model. The scope of the present utility model is defined by the appended claims and their equivalents.
Claims
1. A liquid replenishing structure of a dissolution tester, comprising a water bath tank (1), a dissolution cup (2) is arranged on one side inside the water bath tank (1), a stirring mechanism (3) is arranged inside the dissolution cup (2), a liquid replenishing cup (4) is arranged on the other side inside the water bath tank (1), a shock absorption mechanism (6) is arranged at the upper end of the liquid replenishing cup (4), and a liquid replenishing mechanism (5) is arranged inside the liquid replenishing cup (4), characterized in that: The upper end of the water bath box (1) is fixedly installed with a water inlet (12). Inside the water bath box (1), a heating plate (11) is fixedly installed. On the outer side of the dissolution cup (2), a first connecting piece (21) is fixedly installed, and the first connecting piece (21) is fixedly connected to the inner wall surface of the water bath box (1). On the outer side of the liquid replenishing cup (4), a second connecting piece (41) is fixedly installed, and the second connecting piece (41) is fixedly connected to the inner wall surface of the water bath box (1).
2. The liquid replenishing structure of a dissolution tester according to claim 1, wherein: The upper end of the dissolution cup (2) is fixedly installed with a connecting pipe orifice (24). Inside the liquid replenishing cup (4), a liquid extraction pipe (51) is installed through it. The upper end of the liquid extraction pipe (51) is fixedly installed with a small liquid replenishing pump (52). The output end of the small liquid replenishing pump (52) is fixedly installed with a liquid replenishing pipe (53). The other end of the liquid replenishing pipe (53) is matched with the connecting pipe orifice (24) and is fixedly connected. A heat preservation pipe (54) is sleeved on the outer side of the liquid replenishing pipe (53).
3. The liquid replenishing structure of a dissolution tester according to claim 2, characterized in that: The lower end of the small liquid replenishing pump (52) is fixedly installed with a box body (61). At the four corners of the lower end of the box body (61), springs (62) are fixedly installed. The lower ends of the springs (62) are fixedly installed with rubber plates (64). The lower surface of the rubber plate (64) is fixedly connected to the liquid replenishing cup (4). Through holes (63) are respectively formed through the box body (61) and the rubber plate (64). The liquid extraction pipe (51) passes through the through holes (63) and is communicated with the small liquid replenishing pump (52) inside the box body (61).
4. The liquid replenishment structure of a dissolution tester according to claim 1, characterized in that: Inside the dissolution cup (2), a stirring shaft (31) is installed through it. The driving end of the stirring shaft (31) is fixedly installed with a servo motor (32). On one side of the servo motor (32), a fixing piece (33) is fixedly installed. The fixing piece (33) is fixedly connected to the upper surface of the dissolution cup (2). The lower end of the stirring shaft (31) is fixedly installed with a stirring fan (34).
5. The liquid supplement structure of a dissolution tester according to claim 1, wherein: The upper end of the liquid replenishing cup (4) is fixedly installed with a liquid replenishing port (42). Inside the liquid replenishing cup (4), a liquid inlet pipe (421) is installed through it. The upper end of the liquid replenishing cup (4) is fixedly installed with a rubber pipe (422). The other end of the rubber pipe (422) is fixedly installed with a pipe cap (423). The pipe cap (423) is matched with the liquid inlet pipe (421).
6. The liquid replenishment structure of a dissolution tester according to claim 1, characterized in that: On one side of the upper end of the dissolution cup (2), a feeding port (23) is fixedly installed. On the other side of the upper end of the dissolution cup (2), a sampling port (22) is fixedly installed. The feeding port (23) and the sampling port (22) have exactly the same structural composition as the liquid replenishing port (42).
Citation Information
Patent Citations
Real-time fluid infusion dissolving out instrument capable of controlling temperature
CN108956913A