Extraction device for preparing monoclonal antibody

Abstract

The utility model relates to an extraction device for preparing monoclonal antibodies, which comprises a mounting box, butt joint rods and fixing sleeves, a protective cover is movably mounted on the top of the mounting box, the butt joint rods are fixedly mounted on two sides of the protective cover, and the mounting sleeves matched with the butt joint rods are fixedly mounted on two sides of the mounting box. A fixing sleeve is fixedly mounted in the mounting box, a rotating seat is rotatably mounted at the top of the fixing sleeve, a test tube is movably mounted on the rotating seat, and a clamping piece is mounted in the rotating seat in a threaded manner. Through mutual cooperation of a clamping piece, a threaded rod, a test tube and a transmission belt, the transmission belt can conveniently and synchronously drive a rotating seat to rotate through rotation of the output end of a motor, so that the rotating seat rotates synchronously, and meanwhile, the test tube in a mounting limiting hole is convenient to mount. The clamping pieces can be attached to the surfaces of the test tubes by rotating the threaded rods, so that the test tubes are limited, and the collision condition is effectively prevented in the rotating process of the rotating seat.

Description

Technical Field

[0001] The utility model relates to the technical field of bioengineering, and particularly relates to an extraction device for preparing monoclonal antibodies. Background Technique

[0002] Monoclonal antibodies are highly homogeneous antibodies produced by cloning a single B cell and targeting only a specific antigen epitope. They are usually prepared by hybridoma technology. The hybridoma antibody technology is based on cell fusion technology, which fuses sensitized B cells with the ability to secrete specific antibodies and myeloma cells with the ability to reproduce infinitely into B cell hybridomas.

[0003] Among them, the "extraction device for preparing monoclonal antibodies" disclosed in the patent application number "CN212864615U" records that the utility model discloses an extraction device for preparing monoclonal antibodies, including a liquid inlet pipe. One end of the liquid inlet pipe is communicated with a buffer tank. One end of the buffer tank is fixedly connected with a liquid outlet pipe. One end of the liquid outlet pipe is provided with a pump body. One side of the pump body is fixedly connected with a main pipe. There are multiple branch pipes on one side of the main pipe. One end of each branch pipe is fixedly connected with a filter. The filter includes an upper shell and a lower shell. A partition is fixedly connected to the inner cavity of the lower shell. A first connecting pipe is fixedly connected to the top of the partition. A filter element is sleeved on the outer periphery of the first connecting pipe. The bottom ends of the filters are all fixedly connected with second connecting pipes. A confluence box is arranged below the filters. One end of each second connecting pipe is communicated with the confluence box. There are multiple shunt pipes at the bottom of the confluence box. This kind of extraction device for preparing monoclonal antibodies has a simple structure, can automatically extract and package, and is convenient for replacing the internal filter element, and is easy to use. However, in actual use, an extraction device for preparing monoclonal antibodies with a similar structure still has many defects. For example, the current extraction device for monoclonal antibodies is a centrifuge tube. Existing centrifuges cannot limit the test tubes during use, so they are prone to collision during rotation and are prone to breakage. Therefore, it is necessary to design an extraction device for preparing monoclonal antibodies to solve the problems raised in the above background technique. Summary of the Utility Model

[0004] The purpose of the utility model is to provide an extraction device for preparing monoclonal antibodies to solve the problems raised in the above background technique.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: an extraction device for preparing monoclonal antibodies, comprising an installation box, a docking rod and a fixed sleeve, a protective cover movably installed on the top of the installation box, docking rods fixedly installed on both sides of the protective cover, installation sleeves matched with the docking rods fixedly installed on both sides of the installation box, a fixed sleeve fixedly installed inside the installation box, a rotating seat rotatably installed on the top of the fixed sleeve, a test tube movably installed on the rotating seat, and a clamping piece installed on the internal thread of the rotating seat. The rotation of the output end of the motor enables the transmission belt to synchronously drive the rotating seat to rotate, so that the rotating seat rotates synchronously, and at the same time, the test tube inside the installation limit hole can be fitted with the clamping piece on the surface of the test tube by rotating the threaded rod.

[0006] Preferably, the clamping piece is threadedly mounted on the rotating seat via a threaded rod, and the clamping piece fits the test tube. The threaded rod can be rotated to fit the clamping piece on the surface of the test tube, thereby limiting the position of the test tube and effectively preventing collision during the rotation of the rotating seat.

[0007] Preferably, a limiting hole is provided on the rotating seat to match the test tube, the test tube passes through the limiting hole, and a limiting block is provided on the test tube. The test tube can be conveniently installed and limited through the limiting hole, and can be effectively fixed with the limiting block.

[0008] Preferably, a motor is fixedly installed inside the installation box, and the output end of the motor is connected to the bottom of the rotating seat through a transmission belt. Under the action of the rotation of the motor output end, the transmission belt can be used to synchronously drive the rotating seat to rotate, which is more convenient when used.

[0009] Preferably, the installation sleeve and the docking rod are fixed by a fixed knob, and a docking hole matching the fixed knob is provided on the docking rod. The fixed knob is rotated to dock the fixed knob with the docking hole, so that the protective cover and the installation box can be fitted and limited.

[0010] Preferably, a support column is fixedly installed at the bottom of the installation box, and an observation window is provided on the protective cover. The support column can support the device, making the device more stable when in use, and the observation window can facilitate observation of the interior of the installation box.

[0011] In summary, this application includes the following beneficial technical effects:

[0012] 1. The utility model can conveniently drive the rotating seat to rotate synchronously through the rotation of the output end of the motor by the mutual cooperation among the clamping piece, the threaded rod, the test tube and the transmission belt. Thus, the rotating seat rotates synchronously. Meanwhile, for the test tube installed inside the installation limit hole, the clamping piece can be made to fit the surface of the test tube by rotating the threaded rod, thereby limiting the test tube and effectively preventing collision during the rotation of the rotating seat.

[0013] 2. The utility model can conveniently fit the protective cover and the installation box through the mutual cooperation among the docking rod, the docking hole, the installation sleeve and the fixing knob, so that the bottom of the docking rod can extend into the interior of the installation sleeve. By rotating the fixing knob to dock the fixing knob with the docking hole, the protective cover and the installation box can be fitted and limited. Meanwhile, the interior can be directly observed through the observation window, and the operation is convenient and fast. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 is the first three-dimensional structure schematic diagram of the utility model;

[0015] Figure 2 is the second three-dimensional structure schematic diagram of the utility model;

[0016] Figure 3 is the three-dimensional structure schematic diagram of the interior of the installation box of the utility model;

[0017] Figure 4 is the three-dimensional partial structure schematic diagram of the test tube installation of the utility model.

[0018] In the figure: 1. Installation box; 101. Support column; 102. Protective cover; 103. Observation window; 2. Docking rod; 201. Docking hole; 202. Installation sleeve; 203. Fixing knob; 3. Fixed sleeve; 301. Rotating seat; 302. Motor; 303. Transmission belt; 304. Limit hole; 305. Test tube; 306. Clamping piece; 307. Threaded rod. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] The following detailed description is provided to assist the reader in obtaining a comprehensive understanding of the methods, devices, and / or systems described herein. However, various changes, modifications, and equivalents of the methods, devices, and / or systems described herein will be apparent after understanding the disclosure of this application. For example, the order of the operations described herein is merely exemplary and is not limited to the order set forth herein. Rather, changes that will be apparent after understanding the disclosure of this application can be made, except for operations that must occur in a specific order. Additionally, descriptions of features known in the art may be omitted for the sake of clarity and brevity.

[0020] The features described herein can be implemented in various forms and should not be construed as limited to the examples described herein. Rather, the examples described herein are provided only to illustrate some of the many possible ways of implementing the methods, devices, and / or systems described herein that will be apparent after understanding the disclosure of the present application.

[0021] Throughout the specification, when an element (such as, a layer, region, or substrate) is described as being “on” another element, “connected to” another element, “coupled to” another element, “above” another element, or “covering” another element, it can be directly “on” another element, “connected to” another element, “coupled to” another element, “above” another element, or “covering” another element, or there can be one or more other elements intervening therebetween. In contrast, when an element is described as being “directly on” another element, “directly connected to” another element, “directly coupled to” another element, “directly above” another element, or “directly covering” another element, there can be no other elements intervening therebetween.

[0022] As used herein, the term “and / or” includes any one of the listed related items and any combination of any two or more of them.

[0023] Although terms such as “first,” “second,” and “third” may be used herein to describe various components, elements, regions, layers, or sections, these components, elements, regions, layers, or sections are not limited by these terms. Rather, these terms are only used to distinguish one component, element, region, layer, or section from another. Thus, a first component, element, region, layer, or section described in the examples herein may also be referred to as a second component, element, region, layer, or section without departing from the teachings of the examples.

[0024] For ease of description, spatial relationship terms such as “above,” “upper,” “below,” and “lower” may be used herein to describe the relationship of one element to another as shown in the figures. Such spatial relationship terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, an element described as “above” or “upper” relative to another element will then be “below” or “lower” relative to the other element.

[0025] Accordingly, the term "above" includes both the orientations of "above" and "below" depending on the spatial orientation of the device. The device may also be positioned in other ways (e.g., rotated 90 degrees or in other orientations), and the spatial relationship terms used herein will be interpreted accordingly.

[0026] The terms used herein are for the purpose of describing various examples only and are not intended to limit the present disclosure. Unless the context clearly dictates otherwise, the singular forms are also intended to include the plural forms. The terms "comprises", "comprising", and "having" list the stated features, quantities, operations, components, elements, and / or combinations thereof that exist, but do not preclude the existence or addition of one or more other features, quantities, operations, components, elements, and / or combinations thereof.

[0027] Due to manufacturing techniques and / or tolerances, variations in the shapes shown in the drawings may occur. Accordingly, the examples described herein are not limited to the specific shapes shown in the drawings, but include changes in shape that occur during manufacturing.

[0028] The features of the examples described herein can be combined in various ways that will be apparent after understanding the disclosure of the present application. In addition, although the examples described herein have various configurations, other configurations are possible, as will be apparent after understanding the disclosure of the present application.

[0029] The technical solution of the present utility model will be further described below in conjunction with the drawings and specific embodiments.

[0030] Embodiment 1

[0031] As Figure 1 , Figure 2 , Figure 3 and Figure 4 shown, an extraction device for preparing monoclonal antibodies proposed by the present utility model includes an installation box 1, a docking rod 2, and a fixing sleeve 3. A protective cover 102 is movably installed on the top of the installation box 1. Docking rods 2 are fixedly installed on both sides of the protective cover 102. Installation sleeves 202 cooperating with the docking rods 2 are fixedly installed on both sides of the installation box 1. A fixing sleeve 3 is fixedly installed inside the installation box 1. A rotating seat 301 is rotatably installed on the top of the fixing sleeve 3. A test tube 305 is movably installed on the rotating seat 301. A clamping piece 306 is threadedly installed inside the rotating seat 301. The clamping piece 306 and the rotating seat 301 are threadedly installed through a threaded rod 307. The clamping piece 306 is in contact with the test tube 305. A limiting hole 304 cooperating with the test tube 305 is formed on the rotating seat 301. The test tube 305 passes through the inside of the limiting hole 304. A limiting block is provided on the test tube 305.

[0032] The working principle of an extraction device for preparing monoclonal antibodies based on Embodiment 1 is as follows: The rotation of the output end of the motor 302 enables the drive belt 303 to synchronously drive the rotating seat 301 to rotate, so that the rotating seat 301 rotates synchronously. At the same time, for the test tube 305 inside the installation limit hole 304, the clamping piece 306 can be made to fit the surface of the test tube 305 by rotating the threaded rod 307, thereby limiting the test tube 305. During the rotation of the rotating seat 301, the situation of collision can be effectively prevented. It is convenient for the protective cover 102 to fit with the installation box 1, so that the bottom of the docking rod 2 can extend into the installation sleeve 202. By rotating the fixing knob 203 to dock the fixing knob 203 with the docking hole 201, the protective cover 102 can be fitted and limited with the installation box 1. At the same time, the inside can be directly observed through the observation window 103, and the operation is convenient and fast.

[0033] Embodiment 2

[0034] As Figure 1 、 Figure 2 and Figure 3 shown, an extraction device for preparing monoclonal antibodies proposed by the present utility model, compared with Embodiment 1, this embodiment further includes: A motor 302 is fixedly installed inside the installation box 1, and the output end of the motor 302 is in transmission connection with the bottom of the rotating seat 301 through a drive belt 303. The installation sleeve 202 and the docking rod 2 are limited and fixed through a fixing knob 203. A docking hole 201 cooperating with the fixing knob 203 is provided on the docking rod 2. A support column 101 is fixedly installed at the bottom of the installation box 1, and an observation window 103 is provided on the protective cover 102.

[0035] In this embodiment, as Figure 3 shown, under the action of the rotation of the output end of the motor 302, the drive belt 303 can be used to synchronously drive the rotating seat 301 to rotate, which is more convenient in use; as Figure 2 shown, by rotating the fixing knob 203 to dock the fixing knob 203 with the docking hole 201, the protective cover 102 can be fitted and limited with the installation box 1; as Figure 1 shown, the device can be supported by the support column 101, making the device more stable in use. At the same time, the inside of the installation box 1 can be conveniently observed through the observation window 103.

[0036] The above specific embodiments are only several preferred embodiments of the present utility model. Based on the technical solution of the present utility model and the relevant revelations of the above embodiments, those skilled in the art can make various alternative improvements and combinations to the above specific embodiments.

Claims

1. An extraction device for preparing monoclonal antibodies, comprising a mounting box (1), a docking rod (2) and a fixing sleeve (3), characterized in that: A protective cover (102) is movably installed on the top of the installation box (1). Docking rods (2) are fixedly installed on both sides of the protective cover (102). Installation sleeves (202) that cooperate with the docking rods (2) are fixedly installed on both sides of the installation box (1). A fixed sleeve (3) is fixedly installed inside the installation box (1). A rotating seat (301) is rotatably installed on the top of the fixed sleeve (3). A test tube (305) is movably installed on the rotating seat (301). A clamping piece (306) is threadedly installed inside the rotating seat (301).

2. The extraction device for preparing monoclonal antibodies according to claim 1, wherein: The clamping piece (306) is threadedly installed with the rotating seat (301) through a threaded rod (307), and the clamping piece (306) is in contact with the test tube (305).

3. The extraction device for preparing monoclonal antibodies according to claim 1, wherein: A limiting hole (304) that cooperates with the test tube (305) is formed in the rotating seat (301). The test tube (305) passes through the inside of the limiting hole (304), and a limiting block is provided on the test tube (305).

4. An extraction device for preparing monoclonal antibodies according to claim 1, characterized in that: A motor (302) is fixedly installed inside the installation box (1). The output end of the motor (302) is drivingly connected to the bottom of the rotating seat (301) through a transmission belt (303).

5. An extraction device for preparing monoclonal antibodies according to claim 1, characterized in that: The installation sleeve (202) and the docking rod (2) are limited and fixed through a fixing knob (203). A docking hole (201) that cooperates with the fixing knob (203) is formed in the docking rod (2).

6. The extraction device for preparing monoclonal antibodies according to claim 1, characterized in that: Support columns (101) are fixedly installed at the bottom of the installation box (1). An observation window (103) is provided on the protective cover (102).

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