Semi-permeable membrane fixing device and colloid osmotic pressure tester

Abstract

The utility model discloses a semipermeable membrane fixing device which comprises a reference chamber container and a measuring chamber container, a reference cavity is arranged in the reference chamber container, a measuring cavity and a liquid pipeline communicated with the measuring cavity are arranged in the measuring chamber container, the reference chamber container is installed below the measuring chamber container, and the upper end of the reference cavity is communicated with the lower end of the measuring cavity. A supporting sieve plate is mounted at the upper end of the reference cavity, a semipermeable membrane covers the supporting sieve plate, and a connecting structure used for being detachably connected with a reference chamber working hole of the colloid osmotic pressure tester is arranged on the periphery of the reference chamber container. The semi-permeable membrane and the installation container are combined into a whole to form a fixing device, the fixing device and the semi-permeable membrane are disassembled and installed together when the semi-permeable membrane needs to be replaced, the installation process is simplified, manual operation is reduced, the failure rate is reduced, and the working efficiency is improved. The utility model further discloses a colloid osmotic pressure tester comprising the semipermeable membrane fixing device.

Description

Technical Field

[0001] The utility model relates to the field of medical equipment, in particular to a semipermeable membrane fixing device. In addition, the utility model also relates to a colloid osmotic pressure measuring instrument comprising the semipermeable membrane fixing device. Background Art

[0002] The colloid osmotic pressure meter is a widely used medical device used to detect the osmotic pressure of colloids. The semipermeable membrane is an important component to achieve the above function. The protein in the sample cannot pass through the semipermeable membrane. Therefore, in the process of measuring the colloid osmotic pressure value of the sample, due to the existence of the colloid osmotic pressure, the sample will absorb ions and small molecules on the other side of the semipermeable membrane to offset the colloid osmotic pressure value. Therefore, the semipermeable membrane must be replaced when it reaches the end of its service life.

[0003] In the prior art, the method for replacing the semipermeable membrane is: first soak the semipermeable membrane until it is completely wet, then manually unscrew the screw cap above the semipermeable membrane, remove the sealing ring and the old semipermeable membrane, clean the cavity below the semipermeable membrane, and inject reference solution, then install the new semipermeable membrane, install the sealing ring, and then tighten the screw cap.

[0004] The above-mentioned semipermeable membrane replacement method makes the process of replacing the semipermeable membrane complicated, has a high failure rate caused by excessive human operations, and takes a long time to replace.

[0005] Therefore, how to provide a semipermeable membrane fixing device that can quickly and efficiently replace the semipermeable membrane is a technical problem that those skilled in the art currently need to solve. Utility Model Content

[0006] The purpose of the present invention is to provide a semipermeable membrane fixing device, which can be installed in a container and removed and installed together with the fixing device when the semipermeable membrane needs to be replaced, thereby simplifying the installation process and improving work efficiency. Another purpose of the present invention is to provide a colloidal osmotic pressure measuring instrument including the semipermeable membrane fixing device.

[0007] In order to solve the above technical problems, the utility model provides a semipermeable membrane fixing device, including a reference chamber container and a measuring chamber container, wherein a reference chamber is provided in the reference chamber container, a measuring chamber and a liquid pipeline connected to the measuring chamber are provided in the measuring chamber container, the reference chamber container is installed below the measuring chamber container, and the upper end of the reference chamber is connected to the lower end of the measuring chamber, a supporting sieve plate is installed at the upper end of the reference chamber, and the supporting sieve plate is covered with a semipermeable membrane, and a connecting structure for detachably connecting the reference chamber working hole of a colloid osmotic pressure measuring instrument is provided on the outer periphery of the reference chamber container.

[0008] Preferably, the reference chamber container is a vertically arranged cylindrical structure, and a stepped through hole running through the middle of the reference chamber container is provided to form the reference cavity.

[0009] Preferably, the stepped through hole is, from top to bottom, an upper sealing section, a sieve plate mounting section, an upper conical transition section, an intermediate section, a lower conical transition section and a lower sealing section. The supporting sieve plate is inserted into the sieve plate mounting section. The upper sealing ring is installed in the upper sealing section and presses the semipermeable membrane and the supporting sieve plate. A lower sealing ring is installed in the lower sealing section for sealing and connecting the detection sensor.

[0010] Preferably, the connection structure is an annular groove surrounding the outer circumference of the reference chamber container, and the inner wall of the reference chamber working hole is provided with a matching annular protrusion.

[0011] Preferably, the bottom surface of the reference chamber container is provided with a plurality of positioning pits.

[0012] Preferably, a mounting hole is provided at the lower end of the measuring chamber container, the upper end of the reference chamber container is inserted into the mounting hole, a straight hole running through the upper and lower parts is provided in the middle of the measuring chamber container to form the measuring cavity, the measuring cavity and the mounting hole are coaxially arranged, and a connecting plate for supporting the reference chamber container is provided below the measuring chamber container.

[0013] Preferably, a plurality of process holes surrounding the measuring cavity are provided in the measuring chamber container, the upper end openings of the process holes are connected to the measuring cavity, and the lower end openings of the process holes are located at the lower end surface of the lower end boss of the measuring chamber container.

[0014] Preferably, a conduit and a silicone tube are installed in the lower opening of the process hole.

[0015] Preferably, the supporting sieve plate is an upwardly arched arc-shaped plate, and a plurality of sieve holes are arranged in an array on the supporting sieve plate.

[0016] The utility model provides a colloid osmotic pressure measuring instrument, comprising any one of the above-mentioned semipermeable membrane fixing devices.

[0017] The utility model provides a semipermeable membrane fixing device, comprising a reference chamber container and a measuring chamber container, wherein a reference cavity is arranged in the reference chamber container, a measuring cavity and a liquid pipeline connected with the measuring cavity are arranged in the measuring chamber container, the reference chamber container is installed below the measuring chamber container, and the upper end of the reference cavity is connected with the lower end of the measuring cavity, a supporting sieve plate is installed at the upper end of the reference cavity, the supporting sieve plate is covered with a semipermeable membrane, and a connecting structure for detachably connecting to a reference chamber working hole of a colloid osmotic pressure measuring instrument is arranged on the outer periphery of the reference chamber container.

[0018] The semipermeable membrane and the installation container are combined into a whole to form a fixing device. When the semipermeable membrane needs to be replaced, it can be disassembled and installed together with the fixing device, which simplifies the installation process, reduces manual operations, reduces failure rate, and improves work efficiency.

[0019] The present invention also provides a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane fixing device. Since the above-mentioned semipermeable membrane fixing device has the above-mentioned technical effects, the above-mentioned colloid osmotic pressure measuring instrument should also have the same technical effects, which will not be described in detail here. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A schematic diagram of the internal structure of a specific embodiment of the semipermeable membrane fixing device provided by the present invention;

[0021] Figure 2 A schematic diagram of the external structure of a specific embodiment of the semipermeable membrane fixing device provided by the present invention;

[0022] Figure 3 This is a cross-sectional schematic diagram of a reference chamber container in a specific embodiment of the semipermeable membrane fixing device provided by the present invention;

[0023] Figure 4 This is a cross-sectional schematic diagram of a measuring chamber container in a specific embodiment of the semipermeable membrane fixing device provided by the present invention;

[0024] Figure 5 This is a schematic top view of a supporting sieve plate in a specific embodiment of the semipermeable membrane fixing device provided by the present invention.

[0025] Among them, the reference chamber container 1, the upper sealing section 11, the sieve plate mounting section 12, the upper conical transition section 13, the middle section 14, the lower conical transition section 15, the lower sealing section 16, the annular groove 17, the limiting step 18, the measuring chamber container 2, the measuring cavity 21, the mounting hole 22, the process hole 23, the boss 24, the supporting sieve plate 3, the sieve hole 31, the semipermeable membrane 4, the upper sealing ring 5, the plug 6, the connecting plate 7, the catheter 8, and the silicone tube 9. DETAILED DESCRIPTION

[0026] The core of the present invention is to provide a semipermeable membrane fixing device, which is used to install the semipermeable membrane in a container. When the semipermeable membrane needs to be replaced, it can be removed and installed together with the fixing device, thus simplifying the installation process and improving work efficiency. Another core of the present invention is to provide a colloidal osmotic pressure measuring instrument including the semipermeable membrane fixing device.

[0027] In order to enable those skilled in the art to better understand the present invention, the present invention will be described in further detail below with reference to the accompanying drawings and specific implementation methods.

[0028] Please refer to Figure 1 and Figure 2 , Figure 1 A schematic diagram of the internal structure of a specific embodiment of the semipermeable membrane fixing device provided by the present invention; Figure 2This is a schematic diagram of the external structure of a specific embodiment of the semipermeable membrane fixing device provided by the present invention.

[0029] The specific embodiment of the present invention provides a semipermeable membrane fixing device, including a reference chamber container 1 and a measuring chamber container 2, wherein a reference chamber is provided in the reference chamber container 1, a measuring chamber 21 and a liquid pipeline connected to the measuring chamber 21 are provided in the measuring chamber container 2, the reference chamber container 1 is installed below the measuring chamber container 2, and the upper end of the reference chamber is connected to the lower end of the measuring chamber 21, a supporting sieve plate 3 is installed at the upper end of the reference chamber, and the supporting sieve plate 3 is covered with a semipermeable membrane 4, that is, the reference chamber container 1 and the measuring chamber container 2 are combined to form a fixing device, and a cavity is provided inside the reference chamber container 1 and the measuring chamber container 2 for detection work, and a semipermeable membrane 4 is installed in the cavity, and the reference chamber container 1 and the measuring chamber container 2 and the semipermeable membrane 4 are regarded as an integral component. When the semipermeable membrane 4 needs to be replaced, the fixing device is replaced as a whole. Since the semipermeable membrane 4 is in a ready state in the fixing device, no manual preparation work is required, which greatly reduces human interference and reduces the failure rate. At the same time, the reference chamber container 1 is provided with a connection structure on its outer periphery, which realizes the detachable connection between the semipermeable membrane fixing device and the reference chamber working hole at the corresponding position of the colloidal osmotic pressure measuring instrument. The replacement work can be completed by simply plugging and unplugging, further improving work efficiency.

[0030] Preferably, cylindrical protrusion structures can be provided on both sides of the lower end of the measuring chamber container 2 and inserted into corresponding positioning holes during installation to achieve guidance and positioning during installation.

[0031] Preparatory work before operation: at first the liquid in the measuring cavity 21 insides must be drained, by the colloid osmotic pressure measuring instrument, the semipermeable membrane fixture that reaches the service life inside the colloid osmotic pressure measuring instrument is pulled out and gets final product.Subsequent operation is to replace a new semipermeable membrane fixture.The film below the new semipermeable membrane fixture reference chamber container 1 is torn off, the cylindrical protrusion structures on both sides below the semipermeable membrane fixture are aligned with the corresponding reference chamber working hole position on the colloid osmotic pressure measuring instrument, and press down, when pressed to the bottom, realize sealing between the lower sealing ring below the reference chamber container 1 and the sensor fixture inside the colloid osmotic pressure measuring instrument, the switch inside the colloid osmotic pressure measuring instrument can be squeezed below the reference chamber container 1, determine with this whether the new semipermeable membrane fixture is installed in place, it is adjusted to level after the new semipermeable membrane fixture is installed in place and gets final product, so far new semipermeable membrane fixture, replacement ends, can carry out new test.

[0032] The semipermeable membrane 4 and the installation container are combined into a whole to form a fixing device. When the semipermeable membrane 4 needs to be replaced, it is disassembled and installed together with the fixing device, which simplifies the installation process, reduces manual operations, reduces failure rate, and improves work efficiency.

[0033] Please refer to Figures 3 to 5, Figure 3 This is a cross-sectional schematic diagram of a reference chamber container in a specific embodiment of the semipermeable membrane fixing device provided by the present invention; Figure 4 This is a cross-sectional schematic diagram of a measuring chamber container in a specific embodiment of the semipermeable membrane fixing device provided by the present invention; Figure 5 This is a schematic top view of a supporting sieve plate in a specific embodiment of the semipermeable membrane fixing device provided by the present invention.

[0034] Specifically, the reference chamber container 1 is a vertically arranged cylindrical structure, and a stepped through hole is provided in the middle of the reference chamber container 1, which runs through the upper and lower parts to form a reference cavity. Furthermore, the stepped through hole is composed of an upper sealing section 11, a sieve plate mounting section 12, an upper conical transition section 13, an intermediate section 14, a lower conical transition section 15, and a lower sealing section 16 from top to bottom. The diameters of the upper sealing section 11, the sieve plate mounting section 12, the upper conical transition section 13, the intermediate section 14, and the lower conical transition section 15 decrease in sequence, and the diameter of the lower sealing section 16 is larger than that of the intermediate section 14. Through the above-mentioned size setting, the supporting sieve plate 3 is inserted into the sieve plate mounting section 12, the upper sealing ring 5 is installed in the upper sealing section 11 and presses the semipermeable membrane 4 and the supporting sieve plate 3, and the lower sealing ring is installed in the lower sealing section 16 for sealing and connecting the detection sensor.

[0035] The bottom of the reference chamber container 1 is in contact with the sensor to transmit the pressure changes inside the measuring cavity 21. The reference liquid is stored in the reference cavity. When there is colloidal osmotic pressure, it will exchange ions and small molecules with the sample. When equilibrium is reached, there will be a certain pressure in the reference cavity. The semipermeable membrane 4 is a thin film that is selective for the passage of different particles. It is a membrane structure that only allows ions and small molecules to pass freely. Biological macromolecules cannot pass through the semipermeable membrane freely. The reason is that the pore size of the semipermeable membrane is larger than that of ions and small molecules but smaller than biological macromolecules such as proteins and starch.

[0036] To ensure quick disassembly and connection, the connection structure comprises an annular groove 17 surrounding the outer circumference of the reference chamber container 1, and a matching annular protrusion is provided on the inner wall of the reference chamber working hole. During installation, the two snap together. Of course, other connection and positioning methods, such as axially extending guide grooves, are also possible and fall within the scope of this utility model. Multiple positioning pits can also be provided on the bottom surface of the reference chamber container 1. These multiple positioning pits are arranged around the reference chamber to provide radial positioning after installation, ensuring smooth insertion of the sensor into the lower end of the reference chamber.

[0037] Furthermore, a mounting hole 22 is provided at the lower end of the measuring chamber container 2, and the upper end of the reference chamber container 1 is inserted into the mounting hole 22. A straight hole running through the middle of the measuring chamber container 2 is provided to form a measuring cavity 21. The measuring cavity 21 and the mounting hole 22 are coaxially arranged. A connecting plate 7 for supporting the reference chamber container 1 is provided below the measuring chamber container 2. Specifically, a hole is provided in the middle of the connecting plate 7 for the lower end of the reference chamber container 1 to pass through. At the same time, a limiting step 18 is provided at a corresponding position on the outer circumference of the reference chamber container 1. After the connecting plate 7 is connected to the lower end of the measuring chamber container 2 by bolts or other means, the inner ring of the connecting plate 7 abuts against the limiting step 18, thereby supporting and fixing the reference chamber container 1. Of course, other connection methods can also be used, such as providing a snap fastener, or threading the upper end of the reference chamber container 1 to the mounting hole 22, etc., which are all within the scope of protection of the present utility model.

[0038] In the semipermeable membrane fixing device provided in a specific embodiment of the present invention, a plurality of process holes 23 are provided in the measuring chamber container 2, surrounding the measuring cavity 21. The process holes 23 in multiple directions are interconnected to form a liquid pipeline. The openings of the process holes 23 located on the outer surface of the measuring chamber container 2 are sealed with plugs 6. After the process holes 23 are connected, the upper end opening of the liquid pipeline is connected to the measuring cavity 21, and the lower end opening of the liquid pipeline is located at the lower end surface of the boss 24 at the lower end of the measuring chamber container 2. Furthermore, a guide tube 8 and a silicone tube 9 are installed in the lower end opening of the process holes 23.

[0039] On the basis of the semipermeable membrane fixing device provided in each of the above-mentioned specific embodiments, the supporting sieve plate 3 is an upwardly arched arc-shaped plate, and a plurality of sieve holes 31 are arranged in an array on the supporting sieve plate 3. This not only increases the strength of the support, but also increases the contact area between the semipermeable membrane 4 and the sample and reference liquid; the semipermeable membrane 4 is placed above the supporting sieve plate 3 to block the protein in the sample and realize the measurement of the colloidal osmotic pressure; the measuring cavity 21 is installed above the reference cavity, and the axial hole is matched to ensure that the measuring cavity 21 and the reference cavity are concentric, and there is a raised structure below the measuring cavity 21 to squeeze the upper sealing ring 5 to achieve sealing. There are two bosses 24 below the measuring chamber container 2, and the catheter 8 and the silicone tube 9 are arranged in the bosses 24. The catheter 8 is connected to the liquid pipeline inside the measuring chamber container 2 to realize the liquid inlet and outlet of the measuring cavity 21.

[0040] In addition to the above-mentioned semipermeable membrane fixing device, the specific embodiment of the present invention also provides a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane fixing device. For the structures of other parts of the colloid osmotic pressure measuring instrument, please refer to the existing technology and will not be described in detail herein.

[0041] The above is a detailed introduction to the semipermeable membrane fixing device and colloid osmotic pressure measuring instrument provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only intended to help understand the method and core concept of the present invention. It should be pointed out that, for those skilled in the art, without departing from the principles of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A semipermeable membrane fixing device, characterized in that: The invention comprises a reference chamber container (1) and a measuring chamber container (2), wherein the reference chamber container (1) is provided with a reference cavity, the measuring chamber container (2) is provided with a measuring cavity (21) and a liquid pipeline communicating with the measuring cavity (21), the reference chamber container (1) is installed below the measuring chamber container (2), and the upper end of the reference cavity is communicated with the lower end of the measuring cavity (21), the upper end of the reference cavity is provided with a supporting sieve plate (3), the supporting sieve plate (3) is covered with a semipermeable membrane (4), and the outer periphery of the reference chamber container (1) is provided with a connection structure for detachably connecting to the reference chamber working hole of a colloid osmotic pressure measuring instrument.

2. The semipermeable membrane fixing device according to claim 1, characterized in that: The reference chamber container (1) is a vertically arranged cylindrical structure, and a stepped through hole penetrating vertically is provided in the middle of the reference chamber container (1) to form the reference cavity.

3. The semipermeable membrane fixing device according to claim 2, characterized in that: The stepped through hole comprises, from top to bottom, an upper sealing section (11), a sieve plate mounting section (12), an upper conical transition section (13), an intermediate section (14), a lower conical transition section (15) and a lower sealing section (16); the supporting sieve plate (3) is inserted into the sieve plate mounting section (12); an upper sealing ring (5) is mounted on the upper sealing section (11) and presses the semipermeable membrane (4) and the supporting sieve plate (3); and a lower sealing ring is mounted in the lower sealing section (16) for sealing and connecting a detection sensor.

4. The semipermeable membrane fixing device according to claim 3, characterized in that: The connection structure is an annular groove (17) surrounding the outer periphery of the reference chamber container (1), and a matching annular protrusion is provided on the inner wall of the reference chamber working hole.

5. The semipermeable membrane fixing device according to claim 4, characterized in that: The bottom surface of the reference chamber container (1) is provided with a plurality of positioning pits.

6. The semipermeable membrane fixing device according to claim 2, characterized in that: The lower end of the measuring chamber container (2) is provided with a mounting hole (22), the upper end of the reference chamber container (1) is inserted into the mounting hole (22), and a straight hole running through the middle of the measuring chamber container (2) is provided to form the measuring cavity (21), the measuring cavity (21) and the mounting hole (22) are coaxially arranged, and a connecting plate (7) for supporting the reference chamber container (1) is provided below the measuring chamber container (2).

7. The semipermeable membrane fixing device according to claim 6, characterized in that: A plurality of process holes (23) surrounding the measuring cavity (21) are provided in the measuring chamber container (2); the upper end openings of the process holes (23) are connected to the measuring cavity (21); and the lower end openings of the process holes (23) are located at the lower end surface of the lower end boss (24) of the measuring chamber container (2).

8. The semipermeable membrane fixing device according to claim 7, characterized in that: A conduit (8) and a silicone tube (9) are installed in the lower opening of the process hole (23).

9. The semipermeable membrane fixing device according to any one of claims 1 to 8, characterized in that: The supporting sieve plate (3) is an upwardly arched arc-shaped plate, and a plurality of sieve holes (31) are arranged in an array on the supporting sieve plate (3).

10. A colloid osmotic pressure measuring instrument, characterized in that: The device comprises a semipermeable membrane fixing device according to any one of claims 1 to 9.

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