Filtering and drying device for tauroursodeoxycholic acid production

Abstract

The utility model discloses a filtering and drying device for tauroursodeoxycholic acid production, and belongs to the technical field of tauroursodeoxycholic acid synthesis. Comprising a filter box and a drying box, a filter cartridge is detachably arranged in the filter box, a plurality of filter holes are formed in the bottom wall of the filter cartridge, and two pull rods are arranged at the top end of the filter cartridge; a heating device, a plurality of placing plates arranged from top to bottom, and a mounting frame arranged above each placing plate are arranged in the drying oven; each placing plate can vertically slide on the inner wall of the drying oven; a placing hole for placing a filter cartridge is formed in the top end of each placing plate, a scraping device is arranged right above each placing hole, and the scraping devices are mounted on the mounting rack; and a plurality of air holes are vertically formed in each placing plate and each placing hole in a penetrating manner. The filter paper can be conveniently taken out from the filter box, materials can be scraped to be scattered in the drying process, and the drying efficiency is effectively improved.

Description

Technical Field

[0001] The utility model relates to the technical field of tauroursodeoxycholic acid production, in particular to a filtering and drying device for tauroursodeoxycholic acid production. Background Art

[0002] Tauroursodeoxycholic acid (TUDCA), a taurine conjugate of ursodeoxycholic acid (UDCA), is the primary bile acid component in bear bile and is present in trace amounts in human bile. Modern medical research shows that TUDCA not only plays an important role in dissolving gallstones and protecting the liver, but also plays a crucial physiological and pathological role in neuroprotection, immune regulation, oxidative stress, and metabolism.

[0003] Patent application number CN202210211489.1 discloses an industrial preparation method of tauroursodeoxycholic acid. Specifically, 20.0 kg of UDCA, 180 kg of n-propanol and 8 kg of triethylamine are added to a 1000 L reactor, stirred, and cooled to Slowly add 7kg of propyl chloroformate dropwise. The temperature must not exceed -5℃ during the addition process. After the addition is complete, control the temperature not to exceed -10℃ and track the completion of the UDCA reaction. Maintain the temperature and add pre-cooled taurine sodium hydroxide aqueous solution (containing 7.5kg of taurine, 2.6kg of NaOH, and 80kg of water). After the addition is complete, raise the temperature to 20-25℃ and continue the reaction until the mixed anhydride disappears. Raise the temperature to 50℃ and distill under reduced pressure to obtain TUDCA oil. Cool to 20℃ (±2℃), add 80kg of pure water, stir to dissolve, add concentrated hydrochloric acid dropwise to adjust the pH to 1, cool to 10℃, continue stirring for more than 1h, the product crystallizes, filter and dry to obtain 26kg of crude TUDCA.

[0004] During the above-mentioned process of preparing crude TUDCA, the crystallized product needs to be filtered and dried. In the prior art, the filter screen in the filtration device is often fixed. After filtration, the staff removes the filter paper and the crystals on the filter paper from the filter screen and places them in an oven for drying. However, during actual removal, the filter paper itself is wet and has a large amount of crystals attached to it, so it is easily damaged during removal. Furthermore, because the edge of the filter paper is not enclosed, static drying is the only option during drying. This results in a slow internal drying speed, seriously affecting drying efficiency. Utility Model Content

[0005] The purpose of the utility model is to provide a filtering and drying device for the production of tauroursodeoxycholic acid, which is not only convenient for taking out the filter paper from the filter box, but also can scrape the material during the drying process, thereby effectively improving the drying efficiency.

[0006] The purpose of this utility model is achieved through the following technical solutions:

[0007] A filtering and drying device for producing tauroursodeoxycholic acid, comprising a filter box and an oven, wherein a filter cartridge is detachably provided in the filter box, a bottom wall of the filter cartridge is provided with a plurality of filter holes, and a top end of the filter cartridge is provided with two pull rods;

[0008] The oven is provided with a heating device, a plurality of placement plates arranged from top to bottom, and a mounting rack arranged above each placement plate; each placement plate can slide vertically on the inner wall of the oven; a placement hole for placing a filter cartridge is provided at the top of each placement plate, and a scraping device is provided directly above each placement hole, and the scraping device is installed on the mounting rack; a plurality of air holes are vertically penetrated on each placement plate and each placement hole.

[0009] Preferably, the pull rod is a telescopic rod.

[0010] Preferably, the inner wall of the filter box is provided with a support ring for placing the filter cartridge.

[0011] Preferably, a vacuum pump is provided on the side wall of the filter box, and an air inlet pipe of the vacuum pump is connected to the interior of the filter box.

[0012] Preferably, the breaking up device includes a motor arranged on the mounting frame, a rotating rod arranged at the output end of the motor, and a scraper arranged at the bottom end of the rotating rod, wherein the scraper is provided with a plurality of rake teeth.

[0013] Preferably, a limiting groove is provided on the edge of each placement hole; and a limiting strip adapted to the limiting groove is hinged on the side wall of the filter cartridge.

[0014] Preferably, sliders are provided on both sides of each placement plate, and the inner wall of the oven is provided with vertical slide grooves that slide with the sliders, and the number of the vertical slide grooves is the same as the number of the placement plates; a fixed plate is provided at the bottom end of each placement plate, and slots are provided on both sides of the fixed plate close to the vertical slide groove, and a limit plate is slidably provided in each of the slots.

[0015] Preferably, a plurality of holes are provided on the limiting plate.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0017] By arranging a detachable filter cartridge in the filter box and two pull rods at the top of the filter cartridge, after the filtration is completed, the filter cartridge can be taken out of the filter box by pulling the two pull rods upward, and then the filter paper and crystals placed in the filter cartridge and the filter cartridge can be placed in an oven for drying. Compared with the prior art, the filter net is fixedly arranged in the filter box, which means that the filter paper must be taken out separately, resulting in a technical problem that the filter paper is easily damaged.

[0018] By installing multiple placement plates within the oven, multi-layer drying is possible, improving drying efficiency. By providing placement holes for filter cartridges at the top of each placement plate, the filter cartridges can be placed within the placement holes to limit their position. By installing a scraping device directly above each placement hole, and because the edges of the filter cartridges are inherently protected, the scraping device can be used to scrape away crystals within the filter cartridges without leaking out of the edges. Scraping drying allows for dynamic drying of the crystals during drying, thereby improving drying uniformity both inside and outside the crystals and, consequently, improving drying efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the cross-sectional structure of the filter box in the front view direction;

[0020] Figure 2 for Figure 1 Schematic diagram of the structure from a top-down perspective;

[0021] Figure 3 This is a schematic diagram of the cross-sectional structure of the oven when it is working;

[0022] Figure 4 It is a schematic diagram of the cross-sectional structure in the oven when the scraping device is not working;

[0023] Figure 5 for Figure 3 Schematic diagram of the structure when the plate is placed in the middle;

[0024] In the figure: 1-filter box, 2-drying oven, 3-filter cartridge, 4-pull rod, 5-placement plate, 6-mounting frame, 7-heating device, 8-placement hole, 9-support ring, 10-vacuum pump, 11-motor, 12-rotating rod, 13-scraper, 14-limiting groove, 15-limiting bar, 16-slider, 17-vertical slide, 18-fixed plate, 19-limiting plate. DETAILED DESCRIPTION

[0025] Example 1

[0026] A filtering and drying device for producing tauroursodeoxycholic acid, comprising a filter box 1 (such as Figure 1 and Figure 2 As shown) and oven 2 (as Figure 3-5 As shown), Figure 1-2 As shown, a filter cartridge 3 is detachably provided in the filter box 1, and a plurality of filter holes are provided on the bottom wall of the filter cartridge 3 (not shown in the prior art). Two pull rods 4 are provided on the top of the filter cartridge 3. The pull rods 4 are telescopic rods, so that the pull rods 4 can be retracted to the shortest state when not in use and during subsequent drying to reduce space occupation; Figure 1-2 As shown, the inner wall of the filter box 1 is provided with a support ring 9 for placing the filter cartridge 3. Figure 1 As shown, a vacuum pump 10 is provided on the side wall of the filter box 1 , and an air inlet pipe of the vacuum pump 10 is connected to the interior of the filter box 1 .

[0027] like Figure 3-5 As shown, the oven 2 is provided with a heating device 7 (such as Figure 3-5 As shown, the heating device 7 is a plurality of heating tubes. In actual use, hot air heating can also be provided. The heating device 7 is not limited here. A plurality of placement plates 5 are provided from top to bottom in the oven 2, and a mounting rack 6 is provided above each of the placement plates 5. The mounting rack 6 in this embodiment is essentially a crossbar. Each of the placement plates 5 can slide vertically on the inner wall of the oven 2. Specifically, Figure 3-5 As shown, each of the placement plates 5 is provided with sliders 16 on both sides, and the inner wall of the oven 2 is provided with vertical slides 17 that slidably engage with the sliders 16. The number of the vertical slides 17 is the same as the number of the placement plates 5. The top wall of the oven 2 is also provided with exhaust holes (not shown in the figure, according to the prior art).

[0028] like Figure 3-5 As shown, the top of each placement plate 5 is provided with a placement hole 8 for placing the filter cartridge 3. A scraping device is provided directly above each placement hole 8 and is mounted on the mounting frame 6. Each placement plate 5 and each placement hole 8 are vertically perforated with a plurality of air holes (not shown in the prior art to facilitate the passage of hot air from the oven 2). Furthermore, the scattering device includes a motor 11 mounted on the mounting frame 6, a rotating rod 12 disposed at the output end of the motor 11, and a scraper 13 disposed at the bottom end of the rotating rod 12. The scraper 13 is provided with a plurality of rake teeth.

[0029] Working principle: First, place a piece of filter paper on the top of the filter cartridge 3, then pour the solid and liquid materials containing crystallized products produced during the preparation of TUDCA crude product into the filter cartridge 3. Under the action of the vacuum pump 10, a negative pressure is formed under the filter cartridge 3, thereby achieving the purpose of filtration. After the filtration is completed, pull the two pull rods 4 upward to remove the filter cartridge 3 from the filter box 1. Then, place the filter cartridge 3 together with the filter paper and crystals in it into the placement hole 8 in the drying oven 2 (as shown in the figure). Figure 4 As shown), thereafter, the placement plate 5 on which the filter cartridge 3 is placed is lifted upwards. At this time, the sliders 16 on both sides of the placement plate 5 slide upwards in the vertical chute 17 until they stop sliding just above the vertical chute 17. At this time, there is a slight gap between the scraping device just above the placement hole 8 and the bottom wall of the filter cartridge 3 (as shown). Figure 3 As shown). Thereafter, the oven door 2 is closed (not shown in the prior art) and the heating device 7 is turned on. The motor 11 is then started, causing the rotating rod 12 to rotate the scraper 13 and rake teeth, thereby scraping away the crystals to achieve dynamic drying and improve drying efficiency. After drying is completed, the filter cartridge 3 is removed and the dried material is poured out. It is worth noting that the filter box 1 is equipped with multiple filter cartridges 3, so that while one filter cartridge 3 is drying, filtration is performed through other filter cartridges 3.

[0030] Example 2

[0031] On the basis of Example 1, Figure 3 and Figure 4 As shown, each of the placement plates 5 is provided with a fixing plate 18 at the bottom end, and the fixing plate 18 is provided with slots on both sides of the vertical slide 17, and a limit plate 19 is slidably provided in each of the slots. Furthermore, the limit plate 19 is provided with a plurality of holes (not shown in the prior art to facilitate the passage of hot air in the oven 2). Figure 3-5 As shown, each edge of the placement hole 8 is provided with a limiting groove 14; Figure 1-5 As shown, the side wall of the filter cartridge 3 is hinged with a limiting strip 15 adapted to the limiting groove 14. When not in use, the limiting strip 15 is in a vertical state (such as Figure 1-2 When in use, it is in a horizontal position (as shown in Figure 3-5 shown).

[0032] Working principle: When the slider 16 slides to the top of the vertical chute 17, the two limit plates 19 slide toward the vertical chute 17 respectively until they slide into the vertical chute 17. Figure 3As shown, at this time, the top of the limit plate 19 just contacts the bottom of the slider 16, and the bottom just contacts the bottom of the vertical slot 17. By moving the two limit plates 19 into the two vertical slots 17, the slider 16 can be limited, preventing the slider 16 from moving downward under the action of gravity, which would make it difficult for the scraping device to operate.

[0033] When the filter cartridge 3 is initially placed in the placement hole 8, the two limit bars 15 are rotated to a horizontal state and respectively inserted into the two limit grooves 14. In this way, the filter cartridge 3 can be further limited to ensure that the filter cartridge 3 will not rotate during the subsequent scraping operation, thereby ensuring that the scraping operation proceeds smoothly.

Claims

1. A filtering and drying device for producing tauroursodeoxycholic acid, comprising a filtering box (1) and a drying oven (2); characterized in that: A filter cartridge (3) is detachably provided in the filter box (1), a bottom wall of the filter cartridge (3) is provided with a plurality of filter holes, and a top end of the filter cartridge (3) is provided with two pull rods (4); The oven (2) is provided with a heating device (7), a plurality of placement plates (5) arranged from top to bottom, and a mounting frame (6) arranged above each placement plate (5); each placement plate (5) is capable of sliding vertically on the inner wall of the oven (2); A placement hole (8) for placing the filter cartridge (3) is provided at the top of each placement plate (5), and a scraping device is provided directly above each placement hole (8), and the scraping device is installed on the mounting frame (6); and a plurality of air holes are vertically provided on each placement plate (5) and each placement hole (8).

2. A filtration and drying device for producing tauroursodeoxycholic acid according to claim 1, characterized in that: The pull rod (4) is a telescopic rod.

3. A filtration and drying device for producing tauroursodeoxycholic acid according to claim 1, characterized in that: The inner wall of the filter box (1) is provided with a support ring (9) for placing the filter cartridge (3).

4. A filtration and drying device for producing tauroursodeoxycholic acid according to claim 1, characterized in that: A vacuum pump (10) is provided on the side wall of the filter box (1), and an air inlet pipe of the vacuum pump (10) is in communication with the interior of the filter box (1).

5. A filtration and drying device for producing tauroursodeoxycholic acid according to claim 1, characterized in that: The scattering device comprises a motor (11) arranged on the mounting frame (6), a rotating rod (12) arranged at the output end of the motor (11), and a scraper (13) arranged at the bottom end of the rotating rod (12), wherein the scraper (13) is provided with a plurality of rake teeth.

6. A filtration and drying device for producing tauroursodeoxycholic acid according to claim 1, characterized in that: A limiting groove (14) is provided on the edge of each placement hole (8); and a limiting strip (15) adapted to the limiting groove (14) is hingedly connected to the side wall of the filter cartridge (3).

7. A filtration and drying device for producing tauroursodeoxycholic acid according to claim 1, characterized in that: Each of the placement plates (5) is provided with sliders (16) on both sides, and the inner wall of the oven (2) is provided with vertical slide grooves (17) that slide with the sliders (16), and the number of the vertical slide grooves (17) is the same as the number of the placement plates (5); a fixed plate (18) is provided at the bottom end of each of the placement plates (5), and slots are provided on both sides of the fixed plate (18) close to the vertical slide groove (17), and a limit plate (19) is slidably provided in each of the slots.

8. A filtering and drying device for producing tauroursodeoxycholic acid according to claim 7, characterized in that: The limiting plate (19) is provided with a plurality of holes.

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