Body fixing device of mouse brain stereotaxic apparatus

Abstract

The utility model discloses a mouse brain stereotaxic instrument body fixing device, and relates to the technical field of brain stereotaxic instruments, the mouse brain stereotaxic instrument body fixing device comprises a plate body, a brain stereotaxic instrument body is fixedly installed on one side of the top end of the plate body, a square hole is formed in the bottom end of the plate body, and a supporting mechanism is fixedly installed in the square hole; the top end of the plate body is fixedly provided with an experiment plate, the top end of the experiment plate is rotatably connected with a retaining ring, one side of the experiment plate is fixedly provided with a locking device, the supporting mechanism is arranged, a two-way threaded rod in the supporting mechanism drives a sliding block and a connecting rod to jack up the experiment plate, the height can be adjusted, and the body of a mouse is not suspended in the air in the experiment process; according to the mouse experiment board, the body of the mouse can not droop on one side without perception by arranging the fastening device, the body temperature of the mouse can be kept constant in the experiment process through the temperature adjusting module in the experiment board, and the reliability of research results and data is guaranteed.

Description

Technical Field

[0001] This application relates to the field of stereotaxic imaging technology, and in particular to a body fixation device for a mouse stereotaxic imaging system. Background Technology

[0002] A stereotaxic device, also known as a brain fixation device, uses a three-dimensional coordinate system defined by landmarks or other reference points outside the skull to determine the location of certain subcortical neural structures, so as to conduct targeted stimulation, destruction, drug injection, and potential guidance studies on them without direct visual exposure.

[0003] According to announcement number CN210384105U, a stereotactic instrument for flexibly fixing the brains of mice and rats is disclosed. This technology discloses "including an optical plate, an operating arm, and a fixing device. The optical plate has multiple threaded holes, the operating arm is fixedly mounted on the optical plate, and several fixing devices for fixing the mouse brain are provided on the outside of the operating arm. The fixing devices are connected to the threaded holes by bolts." This technology has the advantages of allowing simultaneous experiments on multiple mice and rats, flexible assembly, improved utilization of the operating arm, greatly improved experimental efficiency, and reduced experimental costs.

[0004] Regarding the aforementioned technologies, the inventors believe that the device still has the following problems.

[0005] First, the device uses a nose clip and ear rod to fix the experimental mice. If the device cannot fix the mouse's body, even if the mouse has been anesthetized before the experiment, the mouse's body is likely to be damaged or die during the experiment if it is not supported.

[0006] Secondly, the device does not include any protective measures for the mice, which may cause the mice to lose body temperature during the experiment, affecting the experimental results or even causing them to die, thus reducing the practical effectiveness of the device. Utility Model Content

[0007] The purpose of this application is to provide a mouse stereotaxic device for body immobilization, in order to improve the problems of not being able to support the mouse body and not being able to maintain the mouse body temperature.

[0008] The mouse stereotaxic apparatus body fixation device provided in this application adopts the following technical solution:

[0009] A mouse stereotaxic apparatus body fixation device includes a plate, characterized in that: a stereotaxic apparatus body is fixedly installed on one side of the top of the plate; a square hole is opened at the bottom of the plate, and a support mechanism is fixedly installed inside the square hole; an experimental plate is fixedly installed at the top of the plate; a buckle is rotatably connected to the top of the experimental plate; a locking device is fixedly installed on one side of the experimental plate; the support mechanism includes a fixed plate; a rotating shaft is movably inserted in the middle of the fixed plate; a first knob is fixedly installed at one end of the rotating shaft; a bracket is rotatably connected to the end of the rotating shaft away from the fixed plate; a first gear is fixedly inserted in the middle of the rotating shaft; a second gear is meshed with the outer surface of the first gear; a bidirectional threaded rod is movably inserted in the middle of the second gear; sliders are threadedly fitted at different thread directions on the outer surface of the bidirectional threaded rod; round rods are fixedly connected to both sides of the two sliders; connecting rods are rotatably connected to the outer surfaces of the four round rods; and the tops of the four connecting rods are rotatably connected to the experimental plate.

[0010] By adopting the above technical solution, the first gear and the second gear are driven by the rotating shaft to rotate the bidirectional threaded rod. The bidirectional threaded rod drives the experimental plate to rise through the slider, which can support the mouse's body.

[0011] Optionally, the locking device includes a first disc, a second disc rotatably connected to the top of the first disc, a lead screw rotatably connected to the top of the second disc, a pressure plate threaded onto the middle of the lead screw, one bottom end of the pressure plate abutting against one side of the buckle, a slide rod provided on the side of the pressure plate away from the buckle, limit rings installed at both ends of the slide rod, and a limit groove for cooperating with the slide rod fixedly installed on one side of the second disc.

[0012] By adopting the above technical solution, the mouse's body can be fixed on the experimental board by using a lead screw to drive the pressure plate to press the buckle.

[0013] Optionally, the experimental board is equipped with a heating coil inside, a temperature controller is inserted into one side of the experimental board, and a thermal pad is fixedly installed on the top of the experimental board.

[0014] By employing the above technical solution, the body temperature of mice can be maintained through the heating coil.

[0015] Optionally, the two ends of the bidirectional threaded rod are rotatably connected to the inner walls of the two sides of the square hole.

[0016] By adopting the above technical solution, the bidirectional threaded rod will not fall off or shift.

[0017] Optionally, two buckles and two locking devices are provided.

[0018] By adopting the above technical solution, the two can better fix the mouse's body.

[0019] Optionally, the two ends of the bracket are fixedly connected to the bottom end of the plate.

[0020] By adopting the above technical solution, the first gear can be fixed in place by a bracket to prevent it from falling off.

[0021] Optionally, a second knob is fixedly installed at the top of the lead screw.

[0022] By adopting the above technical solution, the lead screw can be turned more effectively using the second knob.

[0023] Optionally, four anti-slip legs arranged in a rectangular array are installed at the bottom of the plate.

[0024] By adopting the above technical solution, the movement of the plate can be prevented during the experiment.

[0025] In summary, this application includes at least one of the following beneficial technical effects:

[0026] 1. This utility model, by setting up a support mechanism, in which a bidirectional threaded rod drives a slider and a connecting rod to lift the experimental plate, can adjust the height, so that the mouse's body does not suspend in the air during the experiment, reducing the risk of injury or even death to the mouse.

[0027] 2. By setting a fastening device, this utility model can prevent the mouse's body from drooping to one side without the mouse being aware of it. By using the temperature adjustment module in the experimental board, the mouse's body temperature can be kept constant during the experiment, ensuring the reliability of the research results and data. Attached Figure Description

[0028] Figure 1 This is a schematic diagram of the structure of this utility model.

[0029] Figure 2 This is a schematic diagram of the structure of this utility model from another perspective.

[0030] Figure 3 This is a schematic diagram of the fastening device structure of this utility model.

[0031] Figure 4 This is a schematic diagram of the support mechanism structure of this utility model.

[0032] Figure 5 This is a schematic diagram of the internal structure of the experimental board of this utility model.

[0033] In the diagram, 1. Plate; 2. Stereoscopic instrument body; 3. Locking device; 4. Experimental plate; 5. Square hole; 6. Support mechanism; 7. Anti-slip leg; 8. Buckle; 301. Lead screw; 302. Pressure plate; 303. Second disc; 304. First disc; 305. Limiting ring; 306. Limiting groove; 307. Slide rod; 308. Second knob; 402. Temperature controller; 403. Heating coil; 404. Thermal pad; 601. First knob; 602. Fixing plate; 603. Bracket; 604. Slider; 605. Round rod; 606. Bidirectional threaded rod; 607. Connecting rod; 608. Second gear; 610. First gear; 611. Rotating shaft. Detailed Implementation

[0034] The following is in conjunction with the appendix Figure 1 -Appendix Figure 5 This application will be described in further detail below.

[0035] Example

[0036] A mouse stereotaxic apparatus for body immobilization, as described in the following description. Figure 1 The device includes a plate 1, a stereotaxic instrument body 2 mounted on one side of the top of the plate 1, an experimental plate 4 mounted on the top of the plate 1, a locking device 3 fixedly mounted on one side of the experimental plate 4, a heating coil 403 inside the experimental plate 4, a thermostat 402 inserted on one side of the experimental plate 4, both the heating coil 403 and the thermostat 402 are installed on the device using existing technology, a heat-conducting pad 404 fixedly mounted on the top of the experimental plate 4, the thermostat 402 can adjust the temperature of the heating coil 403, and the heat-conducting pad 404 can transfer heat to the mouse on the heat-conducting pad 404.

[0037] The locking device 3 includes a pressure plate 302, a lead screw 301, a second disc 303, and a first disc 304. The top of the heat-conducting pad 404 has a latch 8 connected by a hinge. The top of the side of the latch 8 without the hinge is in contact with the pressure plate 302. The lead screw 301 is threaded into the middle of the pressure plate 302. The top of the lead screw 301 is fixedly connected to a second knob 308. The bottom of the lead screw 301 is rotatably connected to the second disc 303. The bottom of the second disc 303 is rotatably connected to the first disc 304. Turning the second disc 303 can adjust the direction of the entire locking device 3. Adjust the pressure plate 302 to the top of the latch 8, and then turn the second knob 308. The second knob 308 can drive the lead screw 301 to rotate, and the lead screw 301 drives the pressure plate 302 to move downward.

[0038] The other end of the pressure plate 302 is horizontally inserted with a slide rod 307. The two ends of the slide rod 307 are fixedly connected with limit rings 305. The slide rod 307 slides in the groove of the limit groove 306. The bottom of the limit groove 306 is fixedly connected to the second disc 303. The limit groove 306 and the slide rod 307 cooperate to prevent the pressure plate 302 from shifting direction.

[0039] A support mechanism 6 is installed at the bottom of the plate 1. The support mechanism 6 includes a fixed plate 602 and a bracket 603. A rotating shaft 611 is inserted in the middle of the fixed plate 602. One end of the rotating shaft 611 is rotatably connected to the middle of the bracket 603. The other end of the rotating shaft 611 is fixedly connected to a first knob 601. A first gear 610 is fixedly sleeved in the middle of the rotating shaft 611. When the first knob 601 is turned, the first knob 601 drives the first gear 610 to rotate through the rotating shaft 611.

[0040] A square hole 5 is provided in the middle of the plate 1. A bidirectional threaded rod 606 is rotatably installed between the inner walls of the two sides of the square hole 5. A slider 604 is threaded onto the outer surface of the bidirectional threaded rod 606 at each of the threaded directions. A round rod 605 is rotatably installed on both sides of the slider 604. A connecting rod 607 is rotatably connected to the outer surface of the round rod 605. The top end of the connecting rod 607 is rotatably connected to the experimental plate 4. A second gear 608 is fixedly provided on one side of the bidirectional threaded rod 606. The outer surface of the second gear 608 meshes with a first gear 610. When the first gear 610 rotates, it can drive the second gear 608 and the bidirectional threaded rod 606 to rotate. The bidirectional threaded rod 606 drives the connecting rod 607 to move through the slider 604. The connecting rod 607 drives the experimental plate 4 to rise.

[0041] Four anti-slip legs 7 are installed at the bottom of the plate 1. The anti-slip legs 7 can prevent the support mechanism 6 from contacting the table and getting stuck, and can also prevent the device from shifting during the experiment.

[0042] The implementation principle of this application embodiment is as follows: First, after anesthetizing the mouse, it is placed on the experimental plate 4. Then, the mouse's body is fixed with the buckle 8. Next, the second disc 303 is rotated to align the pressure plate 302 with one side of the buckle 8. The second knob 308 is turned, which drives the lead screw 301 to rotate. The lead screw 301 drives the pressure plate 302 to descend. The slide bar 307 can slide in the limiting groove 306 to prevent the pressure plate 302 from shifting. After the buckle 8 is fixed to a suitable tightness with the pressure plate 302, the heating coil 403 is started. The temperature is then adjusted by the thermostat 402 until it is conducted through the heat-conducting pad 404 without feeling hot.

[0043] Then, turn the first knob 601. The first knob 601 drives the rotating shaft 611 to rotate. The rotating shaft 611 drives the first gear 610 to rotate. The first gear 610 drives the second gear 608 to rotate. The second gear 608 drives the bidirectional threaded rod 606 to rotate in the square hole 5 on the plate 1. The bidirectional threaded rod 606 drives the two sliders 604 to move to both sides. The two sliders 604 drive the four connecting rods 607 to move through the round rods 605 on both sides. The connecting rods 607 push the experimental plate 4 upward and adjust it to a suitable height. Then, the stereotaxic instrument body 2 can be used to study the mice on the experimental plate 4.

[0044] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Identical components are represented by the same reference numerals. Therefore, all equivalent changes made to the structure, shape, and principle of this application should be included within the scope of protection of this application.

Claims

1. A mouse stereotaxic apparatus for body immobilization, comprising a plate (1), characterized in that: The top side of the plate (1) is fixedly installed with the body (2) of the stereotaxic instrument. The bottom end of the plate (1) is provided with a square hole (5). A support mechanism (6) is fixedly installed inside the square hole (5). The top end of the plate (1) is fixedly installed with an experimental plate (4). The top end of the experimental plate (4) is rotatably connected with a buckle (8). A locking device (3) is fixedly installed on one side of the experimental plate (4). The support mechanism (6) includes a fixed plate (602), a rotating shaft (611) is movably inserted in the middle of the fixed plate (602), a first knob (601) is fixedly installed at one end of the rotating shaft (611), a bracket (603) is rotatably connected to the end of the rotating shaft (611) away from the fixed plate (602), a first gear (610) is fixedly inserted in the middle of the rotating shaft (611), a second gear (608) is meshed with the outer surface of the first gear (610), a bidirectional threaded rod (606) is movably inserted in the middle of the second gear (608), a slider (604) is threadedly fitted at the different thread directions on the outer surface of the bidirectional threaded rod (606), round rods (605) are fixedly connected to both sides of the two sliders (604), and connecting rods (607) are rotatably connected to the outer surfaces of the four round rods (605), and the top ends of the four connecting rods (607) are rotatably connected to the experimental plate (4).

2. The mouse brain stereotaxic apparatus body fixation device according to claim 1, characterized in that: The locking device (3) includes a first disc (304), a second disc (303) is rotatably connected to the top of the first disc (304), a lead screw (301) is rotatably connected to the top of the second disc (303), a pressure plate (302) is threadedly fitted in the middle of the lead screw (301), one bottom end of the pressure plate (302) is in contact with one side of the buckle (8), a slide rod (307) is provided on the side of the pressure plate (302) away from the buckle (8), limit rings (305) are installed at both ends of the slide rod (307), and a limit groove (306) that cooperates with the slide rod (307) is fixedly installed on one side of the second disc (303).

3. The mouse brain stereotaxic apparatus body fixation device according to claim 1, characterized in that: The experimental plate (4) is equipped with a heating coil (403) inside, a thermostat (402) is inserted on one side of the experimental plate (4), and a heat-conducting pad (404) is fixedly installed on the top of the experimental plate (4).

4. The mouse brain stereotaxic apparatus body fixation device according to claim 1, characterized in that: The two ends of the bidirectional threaded rod (606) are rotatably connected to the inner walls of the square hole (5) on both sides.

5. The mouse brain stereotaxic apparatus body fixation device according to claim 1, characterized in that: Both the buckle (8) and the locking device (3) are provided in twos.

6. The mouse brain stereotaxic apparatus body fixation device according to claim 1, characterized in that: The two ends of the bracket (603) are fixedly connected to the bottom end of the plate (1).

7. The mouse brain stereotaxic apparatus body fixation device according to claim 2, characterized in that: A second knob (308) is fixedly installed at the top of the lead screw (301).

8. The mouse brain stereotaxic apparatus body fixation device according to claim 1, characterized in that: The bottom of the plate (1) is equipped with four anti-slip legs (7) arranged in a rectangular array.

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