Precise injection mechanism for nasal cavity administration and nasal spray device thereof

Abstract

The utility model discloses a precise injection mechanism for nasal cavity administration and a nasal spray device thereof. The precise injection mechanism comprises a stepping motor, a cam, a roller, a push rod spring, a push rod, a push rod shell, a piston rod spring, a piston rod and a medicine storage bin. The medicine storage bin is sealed through a piston, and the piston is connected with a piston rod spring and coaxially connected with a push rod. The contour surface of the cam is connected with the roller which is vertically connected with the center shaft of the push rod. By the adoption of the precise injection mechanism, the constant amount of liquid medicine can be delivered to the atomization device each time, precise dosage of medicine administration each time is achieved, and parallelism of medicine administration and safety of medicine administration are guaranteed.

Description

Technical Field

[0001] This patent application relates to the field of medical device technology, specifically to a precise injection mechanism for nasal drug delivery and its nasal spray. Background Technology

[0002] Conventional drug administration methods include oral and injection. However, in cases of brain disease, the blood-brain barrier protects the brain, requiring higher doses to achieve sufficient concentrations in the brain. This higher dose can lead to absorption by other organs, resulting in significant side effects. Nasal administration, on the other hand, bypasses the blood-brain barrier and delivers drugs directly to the brain, reducing side effects even after reaching the desired concentration. Nasal drug delivery is increasingly attracting attention from research institutions and pharmaceutical companies.

[0003] Commercially available nasal nebulizers employ several nebulization methods, including pressurized canister nebulization, Venturi principle nebulization, metered pump nebulization, and micro-mesh ultrasonic nebulization. However, these methods have limitations that restrict their application in intranasal drug delivery. Pressurized canister nebulization requires pre-dose medication, necessitating switching between solutions when dual nasal administration is needed. Furthermore, the pressurized canister poses transportation risks and cannot achieve precise single-spray delivery of multiple doses. Venturi principle nebulization requires a larger initial dose, relying on negative pressure from the nozzle to draw the medication in, but its dosage is not precise. Metered pump nebulization, while capable of metering and pumping, relies on external force to atomize the medication, making it susceptible to variations in particle size and delivery to the olfactory region. Micro-mesh ultrasonic nebulization, while capable of metering and creating a constant particle size, uses a larger atomizing disc that may not penetrate the nasal cavity or deliver the medication precisely to the olfactory region.

[0004] In view of this, a new precision injection mechanism and nasal spray for nasal drug delivery have been developed, which can deliver the drug solution to the nebulizer at a constant rate each time, achieving precise dosage for each administration and ensuring the consistency and safety of drug administration. Utility Model Content

[0005] The first objective of this patent application is to provide a novel precise nasal delivery mechanism that can deliver a constant amount of medication to the nebulizer each time, thereby ensuring the consistency of medication administration and the safety of the medication.

[0006] This patent application is achieved through the following technical solution: This patent application provides a new precise injection mechanism for nasal drug delivery, comprising:

[0007] A motion mechanism assembly includes a stepper motor, a cam, a roller, a push rod spring, a push rod, a push rod housing, a piston rod spring, a piston rod, and a drug storage chamber; the drug storage chamber is sealed by a piston, the piston is connected to the piston rod spring and coaxially connected to the push rod; the cam profile surface is connected to the roller, and the roller is perpendicularly connected to the central axis of the push rod.

[0008] A second objective of this patent application is to provide a nasal spray employing the aforementioned precision injection mechanism, including the aforementioned motion mechanism assembly, and further comprising:

[0009] Atomizing mechanism includes a nozzle housing and a nozzle inner housing. When the nozzle inner housing and the nozzle housing are fitted together, they form a sandwich layer through which airflow can pass. The lower end of the sandwich layer is connected to an air inlet channel, and the upper end of the sandwich layer is provided with multiple spiral rotating ribs to form a spiral airflow. The nozzle inner housing is a hollow liquid passage, and the top ends of the nozzle inner housing and the nozzle housing are provided with spray holes that communicate with the liquid passage.

[0010] And / or, the valve body assembly includes a medicine bottle, a first one-way valve plug, a first one-way valve spring, a second one-way valve plug, a second one-way valve spring, a second one-way valve housing, a connecting pipe, and a valve body housing; the first one-way valve housing and the medicine storage chamber are connected together to form the valve body housing. The first one-way valve and the second one-way valve are connected in series by the connecting pipe, the second one-way valve housing is installed on the connecting pipe, and the medicine storage chamber is located in the middle of the two one-way valves. The first one-way valve plug and the first one-way valve spring are installed inside the first one-way valve housing; the second one-way valve plug and the second one-way valve spring are installed inside the second one-way valve housing.

[0011] And / or, control circuit: The control circuit is connected to the stepper motor of the motion mechanism assembly and provides the required motion signals.

[0012] And / or, provide gas components, such as an air pump, which is connected to the air intake passage.

[0013] Preferably, the roller and the cam can have rolling friction, or the roller and the cam can have sliding friction. The roller is cylindrical, parallel to the axis of motion of the cam, and perpendicular to the axis of motion of the push rod.

[0014] Preferably, the roller is cylindrical.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] 1. Atomizing mechanism: By setting up a spiral airflow to drive the liquid medicine, a uniform atomization spray is formed;

[0017] 2. By using a fixed long and short shaft of a cam, the piston is displaced at a fixed position during rotation, allowing for precise extraction of the same dose of medication. This ensures the accuracy of each dose, guarantees the parallelism of medication administration, and safeguards the safety of medication use.

[0018] 3. By utilizing the one-way opening and closing characteristic of the one-way valve in the valve body assembly, the liquid medicine can be drawn into the medicine tank, and the liquid medicine drawn into the medicine tank in a metered manner can be delivered to the atomizing mechanism.

[0019] 4. The structure of this utility model can achieve precise quantitative atomization of the medicine. Attached Figure Description

[0020] Other features, objects, and advantages of this invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0021] Figure 1 This is a schematic diagram of the motion mechanism component of this utility model;

[0022] Figure 2 This is an exploded view of the atomizing mechanism of this utility model;

[0023] Figure 3 This is a structural schematic diagram of the valve body assembly;

[0024] Figure 4 This is a schematic diagram of the assembled motion mechanism component and valve body component of this utility model;

[0025] Figure 5 This is a schematic diagram of the internal structure of the nasal spray device of this utility model. Detailed Implementation

[0026] The present technical solution will be described in detail below with reference to specific embodiments. The following embodiments are exemplary and will help those skilled in the art to further understand the present invention, but do not limit the present invention in any way. It should be noted that those skilled in the art can make several changes and improvements without departing from the inventive concept of the present invention. These all fall within the protection scope of this utility model.

[0027] In the description of this application, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0028] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0029] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0030] In this application, unless otherwise expressly specified and limited, "above" or "below" a second feature can mean that the first and second features are in direct contact, or that they are in indirect contact through an intermediate medium. Furthermore, "above," "over," and "on top" of a second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" a second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature. It should be noted that when an element is referred to as "fixed to" or "set on" another element, it can be directly on the other element or there may be an intermediate element present. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element present. The terms "vertical," "horizontal," "above," "below," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible embodiments.

[0031] Terminology Explanation:

[0032] Cam: A wheel with rotational characteristics, having only one longest and one shortest side from the center of rotation.

[0033] Push rod: A rigid round rod that drives the medicine tank push rod and can be separated from the medicine tank push rod.

[0034] Roller: moves along the cam track to realize the up and down movement of the push rod.

[0035] One-way valve: A valve that allows one-way passage with a piston and a spring.

[0036] Medicine chamber: It has a smooth inner wall and a circular barrel-shaped structure with two outlets. The medicine pumped in is stored in the medicine chamber, and the medicine is accurately pushed out through the fixed injection distance by the push rod.

[0037] This patent application provides a novel nasal drug delivery device, such as Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 As shown, it includes:

[0038] The motion mechanism assembly 1 includes a stepper motor (not shown in the figure), a cam 11, a roller 12, a push rod 13, a push rod spring 14, a piston 15, a piston rod 16, a piston rod spring 17, and a drug storage chamber 18. The drug storage chamber 18 is closed by the piston 15, which is connected to the piston rod spring 17 and coaxially connected to the push rod 13. The contour surface of the cam 11 is connected to the roller 12, and the roller 12 is perpendicularly connected to the central axis of the push rod 13.

[0039] Atomizing mechanism 2 includes an inner nozzle shell 2-1 and an outer nozzle shell 2-2. When the inner nozzle shell 2-1 and the outer nozzle shell 2-2 are fitted together, they form a sandwich layer that can be used for airflow. The lower end of the sandwich layer is connected to an air inlet channel 2-12, and the upper end of the sandwich layer is provided with multiple spiral rotating ribs 2-11 to form a spiral airflow. The inner nozzle shell 2-1 is a hollow liquid passage, and the top ends of the inner nozzle shell 2-1 and the outer nozzle shell 2-2 are provided with spray holes that communicate with the liquid passage.

[0040] The valve body assembly 3 includes a medicine bottle 3-1, a first one-way valve plug 3-2, a first one-way valve spring 3-3, a second one-way valve plug 3-4, a second one-way valve spring 3-5, and a connecting pipe 3-6. The first one-way valve 3-2 and the second one-way valve 3-4 are connected in series by the connecting pipe 3-6, and the second one-way valve 3-4 is installed on the connecting pipe 3-6. The medicine storage chamber 18 is located between these two one-way valves. The first one-way valve 3-2 and the first one-way valve spring 3-3 are jointly installed inside the first one-way valve housing (housing not shown); the second one-way valve plug 3-4 and the second one-way valve spring 3-5 are jointly installed inside the second one-way valve housing (housing not shown).

[0041] The gas supply component includes an air pump 4, which is connected to one end of the air intake passage 2-12 to supply gas.

[0042] Control circuit: The control circuit is connected to the stepper motor of motion mechanism component 1 and provides the required motion signals.

[0043] In one specific embodiment, the motion mechanism assembly, wherein the roller 12 and the cam 11 undergo rolling friction or sliding friction, thereby reducing wear and increasing durability.

[0044] The working process and principle of this patent application are based on the atomization principle:

[0045] 1: By utilizing the switching characteristics of the series-connected double check valves 3-2 and 3-4, the liquid in the medicine bottle is extracted and placed in the medicine storage chamber 18;

[0046] 2. When it is necessary to draw the medicine, cam 11 first rotates 180°, and push rod 13 moves upward with the rotation of cam 11, creating positive pressure in the medicine storage chamber 18, and air is discharged through the second one-way valve 3-4. Push rod 13 stops when it reaches the highest point of cam 11. As cam 11 continues to rotate 180°, push rod 13 moves downward due to the spring's rebound, creating negative pressure in the medicine storage chamber 18. At this time, the first one-way valve 3-2 opens, drawing the medicine from the medicine bottle 3-1 into the medicine storage chamber 18.

[0047] 3. When the liquid medicine needs to be pushed, the cam 11 continues to rotate 180°, and the push rod 13 moves upward with the rotation of the cam 11. At this time, the medicine storage chamber 18 is under positive pressure, and the liquid medicine is discharged from the second one-way valve 3-4 to the atomizing mechanism 2. Since the major and minor diameters of the cam 11 do not change during liquid suction and discharge, the liquid medicine sucked in is equal to the liquid medicine pushed out, thus achieving the purpose of precise pushing.

[0048] 4: When the nozzle needs to atomize the drug solution, compressed gas is added to the ventilation pipe 2-12 of the outer shell 2-2. At the same time, the piston in the liquid suction chamber pushes the drug in, and the second one-way valve 3-4 at the proximal end of the inner shell 2-1 opens the drug and enters the through hole of the inner shell. When the drug and airflow reach the front end of the nozzle at the same time, the multiple gas channels divided by the rib drive the gas to rotate and generate a rotating airflow, which drives the drug to be sprayed out from the nozzle hole, forming a rotating aerosol and producing a spray atomization dispersion angle of 10 to 30°, thus completing one atomized drug delivery.

[0049] In the description of this application, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0050] The specific embodiments of this utility model have been described above. It should be understood that this utility model is not limited to the specific embodiments described above, and those skilled in the art can make various changes or modifications within the scope of the claims, which do not affect the substantive content of this utility model. Unless otherwise specified, the embodiments and features described in this application can be arbitrarily combined with each other.

Claims

1. A precise injection mechanism for nasal drug delivery, characterized in that, include: A motion mechanism assembly includes a stepper motor, a cam, a roller, a push rod spring, a push rod, a push rod housing, a piston rod spring, a piston rod, and a drug storage chamber; the drug storage chamber is sealed by a piston, the piston is connected to the piston rod spring and coaxially connected to the push rod; the cam profile surface is connected to the roller, and the roller is perpendicularly connected to the central axis of the push rod.

2. The precision injection mechanism according to claim 1, characterized in that, The roller and the cam can have rolling friction or sliding friction.

3. The precision injection mechanism according to claim 1, characterized in that, The roller is cylindrical.

4. A nasal spray for intranasal drug delivery, comprising the motion mechanism assembly as described in any one of claims 1 to 3, characterized in that, Also includes: Atomizing mechanism; The atomizing mechanism includes a nozzle outer shell and a nozzle inner shell. When the nozzle inner shell and the nozzle outer shell are fitted together, they form a sandwich layer that can be used for airflow. The lower end of the sandwich layer is connected to an air inlet channel, and the upper end of the sandwich layer is provided with multiple spiral rotating ribs to form a spiral airflow. The nozzle inner shell is a hollow liquid passage, and the top of the nozzle inner shell and the nozzle outer shell are provided with spray holes that communicate with the liquid passage.

5. The nasal spray device according to claim 4, characterized in that, It also includes the valve body assembly, The valve body assembly includes a medicine bottle, a first one-way valve plug, a first one-way valve spring, a second one-way valve plug, a second one-way valve spring, a second one-way valve housing, a connecting pipe, and a valve body housing. The first one-way valve housing and the medicine storage chamber are connected together to form the valve body housing. The first one-way valve and the second one-way valve are connected in series by the connecting pipe, the second one-way valve housing is installed on the connecting pipe, and the medicine storage chamber is located in the middle of the two one-way valves. The first one-way valve plug and the first one-way valve spring are installed inside the first one-way valve housing. The second one-way valve plug and the second one-way valve spring are installed inside the second one-way valve housing.

6. The nasal spray according to claim 5, characterized in that, It also includes components for providing gas, such as an air pump connected to an air intake passage.

7. The nasal spray according to claim 5, characterized in that, It also includes control circuitry. The control circuit is connected to the stepper motor of the motion mechanism assembly, providing the required motion signals.

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