Annular hemostatic clip capable of carrying radioactive particles

Abstract

The utility model relates to the technical field of medical instruments, in particular to an annular hemostatic clip capable of carrying radioactive particles, which is made of titanium-nickel-based shape memory alloy materials and comprises a plurality of outer arc sections and inner arc sections, the outer arc sections and the inner arc sections are arranged in a staggered manner and are connected through fillets, and the integral connecting structure is in central symmetry. An inner tooth is arranged in the middle of each inner arc section, the free end of each inner tooth points to the center of the annular hemostatic clip, placing grooves are formed in the outer arc sections, the inner arc sections, the round corners and the inner teeth, and radioactive particles are embedded in the placing grooves; according to the shape memory characteristic and the superelasticity of the titanium-nickel memory alloy, the annular hemostatic clip can be turned over to be cylindrical, and when the annular hemostatic clip is released at a focus, the annular hemostatic clip contracts inwards and continuously applies pressure to tissues, so that a wound is closed, and further carried radioactive particles start to play a role to continuously carry out close-range irradiation treatment on tumors; and a new solution is provided for the field of tumor treatment.

Description

TECHNICAL FIELD

[0001] The utility model relates to medical equipment technical field especially relates to a ring shape hemostatic clamp that can carry radioactive particle. BACKGROUND

[0002] Radioactive particle interventional therapy is a treatment method for destroying tumors by implanting radioactive sources in the tumor. However, it is difficult to completely remove tumor cells during the operation, which easily leads to the recurrence and metastasis of malignant tumors, affecting the prognosis. In order to solve this problem, radioactive particle implantation has become an effective treatment option, which has a wide range of indications, continuously releases low-dose gamma rays, has a short irradiation distance, reduces damage to normal tissues, and has little impact on medical staff and the environment.

[0003] Esophageal cancer is one of the common malignant tumors in clinical practice. Surgical resection is the most important means of radical treatment for esophageal cancer. However, postoperative complications such as pulmonary infection, anastomotic fistula, and atelectasis easily occur, which seriously affect the prognosis of patients and reduce the quality of life of patients. Anastomotic fistula is the most serious complication after esophageal cancer surgery, with an incidence of 5% to 40% and a mortality rate of 11% to 35.7%.

[0004] With the development of endoscopic minimally invasive technology, endoscopic anastomotic clips (OTSC) have good closure effect on postoperative hemostasis, fistula, and perforation. After the release of the clip, it is left in the body, and after the wound tissue is repaired, the tissue in the closed part is necrotic and falls off due to the clamping force, and the clip is discharged out of the body with the falling tissue. A number of clinical studies have shown that for postoperative wounds with a length of 1 to 3 cm, OTSC can achieve the closure of full-thickness defects in a relatively short time through a relatively simple operation process, with a closure success rate of 100% and a lower incidence of complications. However, the existing anastomotic clips only have a closure effect and cannot further perform close-range irradiation therapy on tumors.

[0005] Therefore, there is an urgent need to design a ring-shaped hemostatic clamp that can carry radioactive particles. By combining radioactive particles with the hemostatic clamp, the anastomotic fistula can be quickly closed with high stability, and the close-range treatment of tumor cells can also be achieved to solve the above problems. UTILITY MODEL CONTENTS

[0006] The utility model aims at providing a ring-shaped hemostatic clamp that can carry radioactive particles. The clamp is made of titanium-nickel memory alloy material, which utilizes its unique shape memory effect and super-elasticity characteristics to quickly and stably close the anastomotic fistula. In addition, the ring-shaped hemostatic clamp also carries radioactive particles, which can accurately perform close-range radiotherapy on tumors, improve the treatment effect, and reduce the risk of complications.

[0007] To achieve this purpose, the utility model adopts the following scheme:

[0008] The application discloses a ring-shaped hemostatic clamp capable of carrying radioactive particles, which is made of a titanium-nickel shape memory alloy material and comprises outer arc segments, inner arc segments, round corners, inner teeth, placing grooves and radioactive particles.

[0009] As an option, the placing grooves are rectangular grooves, cylindrical grooves or trapezoidal grooves, and the groove depth is smaller than the thickness of the outer arc segments, the inner arc segments, the round corners and the inner teeth.

[0010] Further, the placing grooves can be through communication grooves.

[0011] As an option, the radioactive particles are externally sleeved with particle sleeves, the particle sleeves are made of degradable materials, and the particle sleeves contain radiosensitizing materials.

[0012] As an option, the number of the outer arc segments is 3-8.

[0013] Further, the plurality of outer arc segments form a discontinuous circle or polygon.

[0014] As an option, the inner teeth are rectangular teeth or trapezoidal teeth with thick fixed ends and thin free ends.

[0015] Further, the inner teeth are externally convex at least one tine on both sides.

[0016] As an option, the inner teeth can be outwardly turned from the symmetric center, so that the ring-shaped hemostatic clamp has a cylindrical structure.

[0017] The application has the following beneficial effects:

[0018] The utility model provides a kind of annular hemostat of portable radioactive particle, titanium nickel memory alloy is made, can be folded into cylindrical, embedded radioactive particle releases after annular hemostat at focus, the superelasticity of alloy makes it can automatically contract inward, it is continuously pressed to surrounding tissue, effectively closes wound, realizes the repair of full layer defect;Annular hemostat's inner tooth is designed with tines, can be in-depth inside tissue, further fixed additional tissue, simultaneously, annular hemostat carried radioactive particle starts to play its therapeutic effect, continuously near distance irradiation therapy is carried out to tumor;Particle is fixed on annular hemostat, unnecessary movement in body is avoided, the accuracy and safety of treatment are ensured, these radioactive particles have high energy and long half-life, can efficiently exterminate tumor cell;In addition, according to the specific condition of patient and treatment situation, the position and quantity of radioactive particle can be flexibly adjusted, to realize the best therapeutic effect. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is the structure schematic view of the annular hemostat provided by the utility model;

[0020] Figure 2 It is the structure schematic view of the annular hemostat of the utility model and releases state;

[0021] Figure 3 It is the structure schematic view of the annular hemostat of the utility model and releases state of radioactive particle;

[0022] Figure 4 It is the structure schematic view of the annular hemostat of the utility model and releases state of radioactive particle;

[0023] Figure 5 It is the structure schematic view of the annular hemostat of the utility model and releases state of radioactive particle;

[0024] In the drawing:

[0025] 1, outer arc segment, 2, inner arc segment, 3, round angle, 4, inner tooth, 41, tine, 5, placement slot, 6, radioactive particle. DETAILED DESCRIPTION

[0026] The technical scheme of the utility model is further illustrated below by combining with the drawings and through specific embodiment.

[0027] The utility model discloses some orientation words, under the condition of not making opposite statement, the orientation words such as " upper " " lower " " left " " right " " internal " " external " used are for the convenience of understanding and thus do not constitute the limitation of the protection scope of the utility model.

[0028] In the utility model, unless another definite provision and limitation, the first feature is " on " or " under " the second feature can include that the first and second features are directly contacted, also can include that the first and second features are not directly contacted but are contacted through the additional feature between them.

[0029] In the description of the utility model, unless another definite provision and limitation, the term " is connected " " is connected " " is fixed " should be broad sense understanding, for example, can be fixed connection, also can be detachable connection, or is integrated;Can be mechanical connection, also can be electrical connection;Can be directly connected, also can be indirectly connected through intermediate medium, can be the intercommunication of two elements or the interaction of two elements.For the ordinary skilled person in the art, the specific meaning of the above-mentioned terms in the utility model can be understood according to the specific circumstances.

[0030] As shown in Figure 1 The utility model provides a ring shape hemostat of carrying radioactive particle, is made of titanium nickel shape memory alloy material, including outer arc section 1, inner arc section 2, round angle 3, internal tooth 4, deposit groove 5 and radioactive particle 6, outer arc section 1 and inner arc section 2 staggered arrangement, outer arc section 1 and inner arc section 2 are connected through round angle 3, and the whole connection structure is central symmetry, and each inner arc section 2 middle part is provided with internal tooth 4, and the free end of internal tooth 4 all points to the center of ring shape hemostat, is set with deposit groove 5 on outer arc section 1, inner arc section 2, round angle 3 and internal tooth 4, and radioactive particle 6 is clamped in deposit groove 5, and ring shape hemostat utilizes its unique structure design, realizes the accurate closure of focus tissue and radiotherapy.

[0031] Specifically, ring shape hemostat adopts titanium nickel shape memory alloy material, and the material can restore to preset shape under specific temperature, utilizes its shape memory characteristic and superelasticity, ensures that ring shape hemostat can automatically clamp tissue after releasing, reaches the purpose of closing wound, and simultaneously, the radioactive particle 6 carried by ring shape hemostat carries out radiotherapy to tumor cell at close range and continuously.

[0032] The shape of the placement groove 5 is designed in various ways, which can be a rectangular groove, a cylindrical groove or a trapezoidal groove, to accommodate particles of different shapes and ensure their stable placement. In addition, the number and position of radioactive particles 6 can also be flexibly adjusted according to the patient's condition and treatment situation. The depth of the placement groove 5 is less than the thickness of each component of the annular hemostat, further ensuring the fixation of the particles during the operation. The placement groove 5 can also be designed as a through communication groove, which is particularly suitable for the treatment of large area tumors, providing a wider radiation coverage area and improving the efficiency of particle replacement.

[0033] By precisely controlling the size and shape of the placement groove 5, precise control of the radiation dose and distribution is achieved, protecting the surrounding healthy tissues while maximizing the killing effect on tumor cells. The flexibility of this design provides doctors with the option of personalized treatment plans, improving treatment effectiveness and patient recovery speed.

[0034] The radioactive particles 6 are externally sleeved with a particle sleeve made of biodegradable materials such as poly (lactic-co-glycolic acid) (PLGA), polycaprolactone (PCL), and controlled rapid degradation of magnesium and magnesium alloys, which can be safely degraded in the body within a short period of time (1 week to 1 month). In addition, the particle sleeve also integrates radioactive sensitizing materials such as gadolinium (Gd)-based nanomaterials, which can increase the sensitivity of tumor cells to radiation, allowing effective treatment at lower doses of radiation. In addition to gadolinium, other radiosensitizing materials include gold nanoparticles (AuNPs), ferrocene derivatives, copper nanoparticles, silver nanoparticles, bismuth oxide nanoparticles, etc. These sensitizing materials can enhance the effectiveness of radiotherapy through various mechanisms, such as increasing oxidative stress in tumor cells, interfering with DNA damage repair processes, changing cell cycle distribution, or enhancing X-ray physical interactions through their high atomic number. Through this design, the radioactive particles 6 can stably exert radiation pressure on the tumor tissue during treatment, while the biodegradable particle sleeve and sensitizing materials ensure the safety and effectiveness of the treatment. After the radioactive particles 6 complete their treatment task, these materials can be safely degraded in the body, reducing the long-term impact on the patient's health.

[0035] Further, the number of outer arc segments 1 is 3-8, which can be adjusted according to the operation requirements. Multiple outer arc segments 1 form a discontinuous circle or polygon to adapt to different surgical scenarios and tissue characteristics.

[0036] Preferably, the design of the inner teeth 4 is a key factor in improving the fixation effect of the annular hemostat. The inner teeth 4 can be designed as rectangular teeth or trapezoidal teeth with different thicknesses, with the fixed end being thicker and the free end being thinner. This design allows the inner teeth 4 to better adapt to and grasp the tissue, providing stable clamping force.

[0037] To further enhance the fixation effect of the ring-shaped hemostatic clip, the inner teeth 4 are particularly designed with an outward protruding tine 41 on both sides. This tine 41 design allows it to slightly penetrate into the tissue, providing additional grip and stability without causing excessive damage. This design is particularly suitable for surgical situations that require precise fixation and maintenance of position, such as tissue closure after tumor resection. In addition, the presence of the tine 41 not only improves the fixation ability of the ring-shaped hemostatic clip, but also helps to reduce tissue sliding during surgery, ensuring that the therapeutic effect of the radioactive particles 6 can accurately act on the target area.

[0038] Further, the outer turning of the inner teeth 4 from the center of symmetry of the ring-shaped hemostatic clip allows it to deform into a cylindrical structure, which enhances its adaptability and ease of operation in surgery.

[0039] To facilitate the assembly of the ring-shaped hemostatic clip into the release device, when the ring-shaped hemostatic clip is in a cylindrical structure, its outer diameter is designed to be greater than or equal to the diameter of the outer arc segment 1 in the natural state. Such design ensures the stability of the ring-shaped hemostatic clip during assembly, avoiding assembly difficulties or equipment damage due to size mismatch. In addition, this design also allows the ring-shaped hemostatic clip to maintain a proper gap within the release device, facilitating the precise positioning and release of the operator during surgery.

[0040] In actual surgery, the cylindrical structure design of the ring-shaped hemostatic clip provides significant advantages, including improved surgical flexibility, reduced damage to surrounding tissues, and simplified operation process, thereby improving surgical efficiency. In addition, this structure allows customization of the outer diameter and inner teeth 4 shape according to specific surgical needs to ensure optimal adaptability and operability while minimizing tissue damage.

Claims

1. A ring-shaped hemostatic clip capable of carrying radioactive particles, made of a titanium-nickel shape memory alloy material, characterized in that, The application relates to a ring-shaped hemostat, which comprises an outer arc segment (1), an inner arc segment (2), a round corner (3), inner teeth (4), a placing groove (5) and radioactive particles (6), the outer arc segment (1) and the inner arc segment (2) are staggered, the outer arc segment (1) and the inner arc segment (2) are connected through the round corner (3), the whole connecting structure is centrally symmetric, the inner teeth (4) are arranged in the middle of each inner arc segment (2), the free ends of the inner teeth (4) all point to the center of the ring-shaped hemostat, the placing groove (5) is arranged on the outer arc segment (1), the inner arc segment (2), the round corner (3) and the inner teeth (4), and the radioactive particles (6) are clamped in the placing groove (5).

2. The annular hemostatic clip of claim 1, wherein, The placing groove (5) is a rectangular groove, a cylindrical groove or a trapezoidal groove, and the groove depth is smaller than the thickness of the outer arc segment (1), the inner arc segment (2), the round corner (3) and the inner teeth (4).

3. A ring-shaped hemostatic clip capable of carrying radioactive seeds according to claim 2, wherein, The placing groove (5) can be a through communication groove.

4. The annular hemostatic clip of claim 1, wherein the annular hemostatic clip is configured to carry radioactive seeds. The radioactive particles (6) are externally sleeved with particle sleeves made of degradable materials, and the particle sleeves contain radioactive sensitizing materials.

5. The annular hemostatic clip of claim 1, wherein the annular hemostatic clip is configured to carry radioactive seeds. The number of the outer arc segments (1) is 3-8.

6. A ring-shaped hemostatic clip capable of carrying radioactive seeds according to claim 5, wherein, A plurality of the outer arc segments (1) form a discontinuous circle or polygon.

7. The annular hemostatic clip of claim 1, wherein the annular hemostatic clip is configured to carry radioactive seeds. The inner teeth (4) are rectangular teeth or trapezoidal teeth with thick fixed ends and thin free ends.

8. The annular hemostatic clip of claim 1, wherein, At least one sharp tooth (41) is arranged on the outer side of the inner teeth (4).

9. The annular hemostatic clip of claim 1, wherein, The inner teeth (4) can be turned outwards from the symmetric center, so that the ring-shaped hemostat has a cylindrical structure.

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