High-flux reactor for BSA (Bovine Serum Albumin) coupling antigen
By designing a modular, high-throughput reactor and employing limiting components and a heat exchange system, the problem of existing devices being unable to adapt to the number of reaction tanks and the accuracy of temperature control has been solved. This has enabled flexible adaptation of the number of reaction tanks and improved the accuracy of temperature control, thereby enhancing the flexibility and accuracy of BSA-conjugated antigen experiments.
Patent Information
- Application Number
- CN202422485762.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-15
- Publication Date
- 2025-12-09
- Estimated Expiration
- 2034-10-15
AI Technical Summary
Existing high-throughput bioreactors are monolithic and cannot accommodate different numbers of reaction tanks. The temperature control accuracy of the reaction tanks is poor, which affects the flexibility and accuracy of BSA-conjugated antigen experiments.
A modular high-throughput reactor was designed, which achieves flexible adaptation of the number of reaction tanks and precise temperature control through limiting components and heat exchange system. Magnetic connection and heat exchange ring plate structure are adopted to improve the stability and heat exchange efficiency of the reaction tank.
It achieves flexible adaptation of the number of reaction tanks and precise temperature control, improving the flexibility of BSA-conjugated antigen experiments and the accuracy of reaction temperature control.
Smart Images
Figure CN223650550U_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of high-throughput reactor technology, specifically a high-throughput reactor for BSA-conjugated antigens. Background Technology
[0002] BSA-conjugated antigens refer to a complex formed by conjugating a target antigen to BSA using bovine serum albumin as a carrier through specific chemical or biological methods. In BSA-conjugated antigen experiments, high-throughput reactors are used for material synthesis. High-throughput reactors are a type of equipment used in scientific research, drug development, and material synthesis.
[0003] Chinese patent discloses a high-throughput bioreactor (authorization announcement number CN218811697U). This patented technology can provide sufficient oxygen during the cultivation and screening of aerobic microorganisms, increasing the mixing and oxygen transfer performance during cultivation and improving the applicability of the device. However, the aforementioned high-throughput bioreactor is a single-unit structure with fixed reaction tank data, which cannot be adapted to the required number of reaction tanks for BSA-coupled antigen experiments, thus limiting its flexibility. Furthermore, temperature control is required during the reaction process, but the heat exchange between the reaction tank and the external air is generally poor, hindering the accuracy of temperature control. Therefore, those skilled in the art have provided a high-throughput reactor for BSA-coupled antigens to address the problems mentioned in the background section. Utility Model Content
[0004] The purpose of this invention is to provide a high-throughput reactor for BSA-conjugated antigens to solve the problems mentioned in the background art.
[0005] To achieve the above objectives, this utility model provides the following technical solution:
[0006] A high-throughput reactor for BSA-conjugated antigens includes a support member, a reaction member, and a limiting member. The reaction member is located inside the support member, and the limiting member is located on one side of the reaction member. The support member includes a tray with an adjustment groove on its upper side and a heat exchange strip on its outer side. The reaction member includes a reaction box with a reaction tank tube inside. A heat exchange ring is located outside the reaction tank tube, and a heat exchange plate is located outside the heat exchange ring. A magnetic block is installed on the outer side of the reaction box, and an adjustment block is located on the lower side of the reaction box.
[0007] As a further embodiment of this utility model: Slide grooves are provided on both sides of the tray; the limiting component includes a push plate; slide rods are provided at both ends of the push plate; a pressure plate is provided on one side of the slide rod; a first spring is provided on the outer side of the slide rod at the corresponding side of the push plate and the pressure plate; threaded rods are provided at both ends of the push plate; a turntable is provided on the outer side of the threaded rod; a pressure ring is provided at the inner end of the outer side of the threaded rod; and a second spring is provided on the outer side of the threaded rod at the corresponding side of the turntable and the pressure ring.
[0008] As a further improvement of this utility model: the heat exchange plate and the heat exchange strip are positioned correspondingly, and the reaction box slides on the inner side of the tray.
[0009] As a further embodiment of this utility model: the position of the adjusting block corresponds to the position of the adjusting groove, and the adjusting block slides inside the adjusting groove.
[0010] As a further embodiment of this utility model: one end of the slide rod slides inside the push plate, and the pressure plate slides to one side of the push plate via the slide rod.
[0011] As a further embodiment of this utility model: the threaded rod corresponds to the position of the slide groove, the threaded rod slides inside the slide groove, the pressure ring is located outside the tray, the inner end of the threaded rod rotates inside the push plate, the push plate and the pressure plate both slide inside the tray, and the pressure plate is located on one side of the reaction box.
[0012] Compared with the prior art, the beneficial effects of this utility model are:
[0013] 1. This utility model discloses a high-throughput reactor for BSA-coupled antigens. By assembling reaction components, it adapts to the required number of reaction tanks for BSA-coupled antigen experiments, which is beneficial to the flexibility of use. The reaction components are limited by the limiting components, which improves the stability of the reaction components.
[0014] 2. By using heat exchange bars, heat exchange plates, and heat exchange rings to exchange temperatures between the reaction tank tubes and the outside environment, the heat exchange rate of the materials inside the reaction tank tubes is increased, thereby improving the accuracy of reaction temperature control. Attached Figure Description
[0015] Figure 1 This is a schematic diagram of a high-throughput reactor for BSA-conjugated antigens.
[0016] Figure 2 This is a schematic diagram of a support structure in a high-throughput reactor used for BSA-conjugated antigens.
[0017] Figure 3A perspective view of a reaction component in a high-throughput reactor for BSA-conjugated antigens;
[0018] Figure 4 This is a schematic diagram of a confinement component in a high-throughput reactor for BSA-conjugated antigens.
[0019] Figure 5 A high-throughput reactor for BSA-conjugated antigens Figure 4 A schematic diagram of the structure of part A.
[0020] In the diagram: 1. Bearing component; 2. Reaction component; 3. Limiting component; 4. Tray; 5. Adjusting groove; 6. Heat exchange bar; 7. Reaction box; 8. Reaction tank tube; 9. Adjusting block; 10. Heat exchange ring; 11. Heat exchange plate; 12. Magnetic block; 13. Slide groove; 14. Push plate; 15. Slide rod; 16. Pressure plate; 17. First spring; 18. Threaded rod; 19. Turntable; 20. Pressure ring; 21. Second spring. Detailed Implementation
[0021] Please see Figures 1-5 In this embodiment of the invention, a high-throughput reactor for BSA-conjugated antigens includes a support member 1, a reaction member 2, and a limiting member 3. The reaction member 2 is located inside the support member 1, and the limiting member 3 is located on one side of the reaction member 2. The support member 1 includes a tray 4, with an adjustment groove 5 on its upper side and a heat exchange strip 6 on its outer side. The reaction member 2 includes a reaction box 7, with a reaction tank tube 8 inside the reaction box 7. A heat exchange ring 10 is located outside the reaction tank tube 8, and a heat exchange plate 11 is located outside the heat exchange ring 10. A magnetic block 12 is installed on the outer side of the reaction box 7, and an adjustment block 9 is located on the lower side of the reaction box 7. The heat exchange plate 11 corresponds to the position of the heat exchange strip 6, and the reaction box 7 slides inside the tray 4. The position of the adjusting block 9 corresponds to that of the adjusting groove 5. The adjusting block 9 slides inside the adjusting groove 5. First, a high-throughput reactor for BSA-coupled antigen is brought to the place of use. According to the requirements of the BSA-coupled antigen experiment, the corresponding number of reaction components 2 are installed inside the supporting component 1. During the installation process, the adjusting block 9 slides into the inside of the adjusting groove 5, the reaction box 7 slides into the inside of the tray 4, the outer side of the heat exchange plate 11 is attached to the inner side of the heat exchange strip 6, and the adjacent reaction boxes 7 are connected by magnetic attraction block 12. Then, the limiting component 3 slides into the inside of the tray 4 to limit the reaction component 2. Finally, the BSA-coupled antigen experiment begins. The external temperature is conducted to the inside of the heat exchange ring 10 through the heat exchange plate 11, and the heat exchange ring 10 replaces the heat of the reaction tank tube 8.
[0022] exist Figure 1 , 2In sections 4 and 5: Slide grooves 13 are provided on both sides of tray 4. The limiting component 3 includes a push plate 14. Slide rods 15 are provided at both ends of the push plate 14. A pressure plate 16 is provided on one side of each slide rod 15. A first spring 17 is provided on the outer side of the slide rod 15 at the corresponding side of the push plate 14 and pressure plate 16. Threaded rods 18 are provided at both ends of the push plate 14. A turntable 19 is provided on the outer side of each threaded rod 18. A pressure ring 20 is provided at the inner end of the outer side of each threaded rod 18. A second spring 21 is provided on the outer side of each threaded rod 18 at the corresponding side of the turntable 19 and pressure ring 20. One end of the slide rod 15 slides within the push plate 14. The pressure plate 16 slides on one side of the push plate 14 via the slide rod 15. The threaded rod 18 corresponds to the position of the slide groove 13. The threaded rod 18 slides... Inside the chute 13, the pressure ring 20 is located outside the tray 4. The inner end of the threaded rod 18 rotates inside the push plate 14. The push plate 14 and the pressure plate 16 slide inside the tray 4. The pressure plate 16 is located on one side of the reaction box 7. The threaded rod 18 slides into the chute 13. The pressure ring 20 is located outside the tray 4. The push plate 14 and the pressure plate 16 slide into the inside of the tray 4. The pressure plate 16 presses against one side of the reaction box 7. The first spring 17 contracts. One end of the slide rod 15 slides outside the push plate 14, pressing the pressure plate 16 against one side of the reaction box 7, limiting the reaction component 2. The hand-held turntable 19 rotates the threaded rod 18. The threaded rod 18 rotates inside the push plate 14. The second spring 21 extends, pressing the pressure ring 20 against the outside of the tray 4, fixing the push plate 14 inside the tray 4.
[0023] The working principle of this invention is as follows: First, a high-throughput reactor for BSA-conjugated antigens is brought to the application location. Based on the requirements of the BSA-conjugated antigen experiment, a corresponding number of reaction components 2 are installed inside the supporting component 1. During installation, the adjusting block 9 slides into the adjusting groove 5, the reaction box 7 slides into the inner side of the tray 4, the outer side of the heat exchange plate 11 is attached to the inner side of the heat exchange strip 6, and adjacent reaction boxes 7 are connected by magnetic attraction blocks 12. Then, the threaded rod 18 slides into the sliding groove 13, the pressure ring 20 is located on the outer side of the tray 4, and the push plate 14 and pressure plate 16 slide into... Inside the tray 4, the pressure plate 16 presses against one side of the reaction box 7, the first spring 17 contracts, one end of the slide rod 15 slides on the outer end of the push plate 14, pressing the pressure plate 16 against one side of the reaction box 7, limiting the reaction component 2. The hand-held turntable 19 rotates the threaded rod 18, the threaded rod 18 rotates inside the push plate 14, the second spring 21 extends and presses the pressure ring 20 against the outside of the tray 4, fixing the push plate 14 inside the tray 4. Finally, the BSA conjugated antigen experiment begins. The external temperature is conducted to the inside of the heat exchange ring 10 through the heat exchange plate 11, and the heat exchange ring 10 displaces the heat of the reaction tank tube 8.
[0024] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.
Claims
1. A high-throughput reactor for BSA-conjugated antigens, comprising a support member (1), a reaction member (2), and a limiting member (3), wherein the reaction member (2) is located inside the support member (1), and the limiting member (3) is located on one side of the reaction member (2), characterized in that, The supporting component (1) includes a tray (4), an adjustment groove (5) is provided on the upper side of the tray (4), and a heat exchange strip (6) is provided on the outer side of the tray (4). The reaction component (2) includes a reaction box (7), a reaction tank tube (8) is provided inside the reaction box (7), a heat exchange ring (10) is provided on the outer side of the reaction tank tube (8), a heat exchange plate (11) is provided on the outer side of the heat exchange ring (10), a magnetic block (12) is installed on the outer side of the reaction box (7), and an adjustment block (9) is provided on the lower side of the reaction box (7).
2. A high-throughput reactor for BSA-conjugated antigens according to claim 1, characterized in that, The tray (4) has sliding grooves (13) on both sides. The limiting member (3) includes a push plate (14). The push plate (14) has sliding rods (15) at both ends. The sliding rods (15) have pressure plates (16) on one side. The sliding rods (15) have first springs (17) on the outer side of the sliding rods (15) at the corresponding side of the push plate (14) and pressure plates (16). The push plate (14) has threaded rods (18) at both ends. The threaded rods (18) have turntables (19) on the outer side of the threaded rods (18). The threaded rods (18) have pressure rings (20) at the inner end of the outer side of the threaded rods (18). The threaded rods (18) have second springs (21) on the outer side of the threaded rods (18) at the corresponding side of the turntables (19) and pressure rings (20).
3. A high-throughput reactor for BSA-conjugated antigens according to claim 1, characterized in that, The heat exchange plate (11) is positioned corresponding to the heat exchange strip (6), and the reaction box (7) slides on the inner side of the tray (4).
4. A high-throughput reactor for BSA-conjugated antigens according to claim 1, characterized in that, The position of the adjusting block (9) corresponds to that of the adjusting groove (5), and the adjusting block (9) slides inside the adjusting groove (5).
5. A high-throughput reactor for BSA-conjugated antigens according to claim 2, characterized in that, One end of the slide rod (15) slides inside the push plate (14), and the pressure plate (16) slides on one side of the push plate (14) via the slide rod (15).
6. A high-throughput reactor for BSA-conjugated antigens according to claim 2, characterized in that, The threaded rod (18) is positioned corresponding to the slide groove (13). The threaded rod (18) slides inside the slide groove (13). The pressure ring (20) is located outside the tray (4). The inner end of the threaded rod (18) rotates inside the push plate (14). The push plate (14) and the pressure plate (16) both slide inside the tray (4). The pressure plate (16) is located on one side of the reaction box (7).