Device for fixing body position of rat / mouse and assisting in stress application of rat / mouse living body

Abstract

The utility model discloses a device for fixing the body position of a rat / mouse and assisting in stress application of a rat / mouse living body, and relates to the technical field of biomedicine, the device for fixing the body position of the rat / mouse and assisting in stress application of the rat / mouse living body comprises an upper stress application module and a lower stress application module, a lower stress application column is arranged at the top of the lower stress application module, and the lower stress application column and the upper stress application column are opposite in position to clamp and measure the mechanical performance of the animal stress application bone; the telescopic supporting module is arranged at the top of the lower stress application module and used for supporting the trunk of the animal; the anesthesia cabin is arranged on the telescopic supporting module, anesthetic is contained in the anesthesia cabin, and an opening is formed in one side of the anesthesia cabin so that the head of the animal can penetrate through the opening. According to the technical scheme provided by the utility model, the body position fixation, the body temperature maintenance and the auxiliary living body stress application experiment of a rat / mouse in an anesthesia state are realized, and meanwhile, the measurement of the bone mechanical property is completed.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of biomedical technology, especially a mouse body position fixing device which can be used for assisting mouse live body force loading. BACKGROUND

[0002] In the field of medical experiments, the tibia or ulna of a mouse is often subjected to force loading experiments by mechanical loading to evaluate bone development, fracture healing and osteoporosis, etc. However, multiple devices are required to complete the steps of mouse anesthesia and experiments during the experiment, which is complicated and inconvenient to use. UTILITY MODEL CONTENT

[0003] The utility model aims to provide a mouse body position fixing device which can be used for assisting mouse live body force loading, so as to improve the convenience of mouse live body force loading experiment operation, the success rate and repeatability of force loading experiments.

[0004] To achieve the above-mentioned purpose, the utility model provides a mouse body position fixing device which can be used for assisting mouse live body force loading, comprising:

[0005] An upper force loading module is provided at the bottom of the device.

[0006] A lower force loading module is provided at the top of the device, and the lower force loading module and the upper force loading module are oppositely arranged to clamp and measure the limbs of an animal.

[0007] A telescopic support module is provided at the top of the lower force loading module, and the telescopic support module is used to support the torso of the animal.

[0008] A support plate is provided at the top of the lower force loading module to support the torso.

[0009] A heating element is provided on the support plate to heat the support plate.

[0010] A lifting assembly is provided on the lower force loading module and is drivingly connected to the support plate, and the lifting assembly is used to adjust the height of the support plate.

[0011] An anesthesia cabin is provided on the telescopic support module, and the anesthesia cabin contains anesthetic, and one side of the anesthesia cabin is provided with an opening for the head of the animal to pass through.

[0012] In an embodiment, two support plates are provided, and each support plate is provided with one lifting assembly.

[0013] In an embodiment, the lifting assembly is configured as a scissor lift; and / or, the heating element is configured as an electric heating wire, which is evenly distributed on the support plate.

[0014] In an embodiment, the telescopic support module further comprises a clamp, which is arranged on the top of the support plate to fix the limbs of the animal.

[0015] In an embodiment, the clamp and the anesthesia chamber are detachably connected with the support plate, respectively.

[0016] In an embodiment, the support plate is an iron plate, and at least one of the clamp and the anesthesia chamber is magnetically connected with the support plate.

[0017] In an embodiment, a sealing ring is arranged on the periphery of the opening of the anesthesia chamber to sealingly cooperate with the head.

[0018] In an embodiment, a groove is arranged at the bottom end of the upper force applying column to limit the limbs; and / or, a groove is arranged at the top end of the lower force applying column to limit the limbs.

[0019] In the technical scheme of the utility model, the device for fixing the body position of a mouse or a rat and assisting the force application on the mouse or rat in vivo comprises an upper force applying module and a lower force applying module, the upper force applying module is arranged above the lower force applying module, the bottom of the upper force applying module is provided with an upper force applying column, the top of the lower force applying module is provided with a lower force applying column, the upper force applying column and the lower force applying column are opposite to each other, when measuring, the upper force applying column and the lower force applying column clamp the bones of the limbs of the animal and apply force, and the key parameters such as the force value and the deformation amount are recorded through the upper force applying module and the lower force applying module, so that the measurement of the mechanical properties of the bones is realized; in addition, the telescopic support module is further arranged on the lower force applying module to support the torso of the animal, so as to ensure the stability of the position of the animal during the measurement and guarantee the accuracy of the measurement results; in addition, the anesthesia chamber is further arranged on the telescopic support module, and the head of the animal can be put into the anesthesia chamber to be anesthetized; when measuring, the animal is first anesthetized by using the anesthesia chamber, and then the bones of the animal are placed between the upper force applying column and the lower force applying column to be measured; through the integration of the anesthesia operation and the measurement operation on one device, the test process can be simplified, and the convenience of use is improved. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or the prior art, the drawings needed to be used in the following embodiment or prior art description will be briefly introduced, and obviously, the drawings in the following description are only some embodiments of the utility model, and for those skilled in the art, other drawings can be obtained from the structures shown in these drawings without creating labor.

[0021] Figure 1 The utility model provides a mouse body position fixed, can be used for the structure schematic view of the device of assisting mouse live force adding,

[0022] Figure 2 For Figure 1 The partial close -up view of A in the middle.

[0023] Explanation of the attached drawing:

[0024] 100, upper force adding module, 110, upper force adding column, 200, lower force adding module, 210, lower force adding column, 300, telescopic support module, 310, support plate, 320, lifting assembly, 330, clamp, 400, anesthesia cabin.

[0025] The utility model purposes realization, functional characteristics and advantages will combine embodiment, refer to the further illustration of the attached drawing. Specific implementation

[0026] The technical scheme in the utility model embodiment will be clearly and completely described below in combination with the drawings in the utility model embodiment, and obviously, the described embodiment is only a part of the embodiment of the utility model, not all the embodiment. Based on the embodiment in the utility model, all other embodiments obtained by the ordinary skill in the art without making creative labor belong to the range of protection of the utility model.

[0027] It should be noted that if the embodiment of the utility model has the directionality indication (such as up, down, left, right, front, back......), the directionality indication is only used to explain the relative position relationship, movement condition and the like between the components in a certain specific posture, if the specific posture changes, then the directionality indication also changes accordingly.

[0028] In addition, if the embodiment of the utility model has the description of "first", "second" and the like, the description of "first", "second" and the like is only for the description purpose, and can not be understood as indicating or suggesting the relative importance or implicitly indicating the number of the indicated technical features. Therefore, the feature with "first", "second" can explicitly or implicitly include at least one feature. In addition, if "and / or" or "and / or" appears in the whole text, its meaning includes three parallel schemes, for example, "A and / or B", including A scheme, or B scheme, or A and B simultaneously satisfy the scheme. In addition, the technical scheme of each embodiment can be combined with each other, but it must be based on the realization of the ordinary skill in the art, when the combination of technical schemes appears contradictory or unachievable, it should be considered that the combination of technical schemes does not exist, also not in the protection range required by the utility model.

[0029] In order to realize the bone mechanical property measurement of big / small mice and facilitate the test operation, the technical scheme provides a device for fixing the body position of big / small mice and assisting the in-vivo force of big / small mice, which comprises: an upper force applying module 100, a bottom of which is provided with an upper force applying column 110; a lower force applying module 200, a top of which is provided with a lower force applying column 210, the lower force applying column 210 and the upper force applying column 110 are opposite to each other to clamp and measure the bones of the limbs of the animals; a telescopic supporting module 300, which is arranged on the top of the lower force applying module 200, and is used to support the torso of the animals; and a narcosis cabin 400, which is arranged on the telescopic supporting module 300, and is provided with an opening on one side to allow the head of the animals to enter.

[0030] In the technical scheme of the utility model, the device for fixing the body position of big / small mice and assisting the in-vivo force of big / small mice comprises the upper force applying module 100 and the lower force applying module 200, the upper force applying module 100 is arranged above the lower force applying module 200, the bottom of the upper force applying module 100 is provided with the upper force applying column 110, the top of the lower force applying module 200 is provided with the lower force applying column 210, the upper force applying column 110 and the lower force applying column 210 are opposite to each other, when measuring, the upper force applying column 110 and the lower force applying column 210 clamp the bones of the limbs of the animals and apply the force, the force value and the deformation amount and other key parameters are recorded through the upper force applying module 100 and the lower force applying module 200, so that the measurement of the bone mechanical property is realized; in addition, the telescopic supporting module 300 is further arranged on the lower force applying module 200 to support the torso of the animals to ensure the position stability of the animals during the measurement process and guarantee the accuracy of the measurement results; in addition, the narcosis cabin 400 is further arranged on the telescopic supporting module 300, the head of the animals can enter the narcosis cabin 400 to be narcotized; when measuring, the animals are narcotized by using the narcosis cabin 400 first, and then the bones of the animals are placed between the upper force applying column 110 and the lower force applying column 210 to be measured, the narcotization operation and the measurement operation are integrated on one device, so that the test process can be simplified and the convenience of use can be improved.

[0031] As Figure 1 and Figure 2In an embodiment of the utility model, upper force adding module 100 is located at the top of whole device, adopts hydraulic rod drive to lift, the bottom of upper force adding module 100 is provided with upper force adding column 110, is used for clamping and exerting the downward force to the four limbs skeleton of animal, upper force adding column 110 can adopt high strength, corrosion -resistant metal material (such as stainless steel etc.), to ensure the stability and durability of long -term use, high -precision pressure sensor is arranged between upper force adding module 100 and upper force adding column 110, for real -time monitoring and record the applied force, lower force adding module 200 is a platform, is located below upper force adding module 100, the top of lower force adding module 200 is provided with lower force adding column 210, lower force adding column 210 and upper force adding column 110 position opposite, jointly in vertical direction clamps the tibia or ulna of animal, lower force adding column 210 also adopts high strength, corrosion -resistant metal material, displacement sensor and force sensor are arranged between lower force adding module 200 and lower force adding column 210, for recording the deformation of skeleton and applied force. In addition, telescopic support module 300 is located at the top of lower force adding module 200, to support the torso of animal, to ensure the position stability of animal during the experiment, prevent moving and lead to inaccurate data, the top of telescopic support module 300 is provided with soft and stable material, such as silica gel pad, to improve the comfort of animal. In addition, anesthetic cabin 400 is provided at the top of telescopic support module 300, the inside of anesthetic cabin 400 contains isoflurane etc. narcotic drug, one side of anesthetic cabin 400 is provided with opening, for the head of animal to enter and anesthetize, ensure that animal is in painless state during the experiment, one side of anesthetic cabin 400 can be provided with regulating valve and gas anesthesia machine connection, user can adjust regulating valve to adjust narcotic concentration, anesthetic cabin 400 can adopt transparent material such as acrylic, to facilitate monitoring the state of animal. In addition, to improve test efficiency, the upper force adding column 110 and lower force adding column 210 can be provided with multiple groups, when testing, the multiple skeletons of animal can be tested simultaneously, in addition, the shape and size of upper force adding column 110 and lower force adding column 210 of each group can be designed differently, to meet the test requirements of different parts of skeleton of animal ulna, tibia etc., improve the versatility and applicability of the device for assisting mouse body position fixation, can be used for the live force of big / small mouse.

[0032] The use of the mouse body position fixing device for assisting in the loading of a mouse in vivo will be described below. First, place the mouse on the telescopic support module 300 so that its head enters the anesthesia cabin 400. Then, use the gas anesthesia machine to deliver anesthetic into the anesthesia cabin 400 until the mouse is completely anesthetized. After the mouse is completely anesthetized, adjust its position so that the target bone (such as the tibia or ulna) is vertically placed between the upper loading column 110 and the lower loading column 210. Then, start the loading program through the computer. The upper loading module 100 drives the upper loading column 110 to move downward through the hydraulic rod, clamps the bone together with the lower loading column 210, and applies a predetermined force. The force sensor between the upper loading module 100 and the upper loading column 110 monitors and records the applied force in real time. The displacement sensor and the force sensor between the lower loading module 200 and the lower loading column 210 record the deformation of the bone and the applied force. Then, store the measurement data and transmit it to the computer for further analysis. The mouse body position fixing device for assisting in the loading of a mouse in vivo of the present scheme integrates anesthesia, fixation, and loading functions in one, simplifies the experimental process, and improves the operation convenience. The use of sensors to record data in real time during the loading process ensures the accuracy of the test results.

[0033] As Figure 2 In an embodiment of the present application, the telescopic support module 300 includes a support plate 310 arranged on the top of the lower loading module 200 to support the torso and a heating element arranged on the support plate 310 to heat the support plate 310. The telescopic support module 300 includes a support plate 310 for supporting the torso of a mouse, and the support plate 310 is horizontally placed. The torso of the mouse can be placed on the support plate 310 and adjusted at will. The support plate 310 ensures the stability of the position of the mouse during the experiment, preventing movement that can lead to inaccurate data. The support plate 310 can be made of soft and durable materials such as silicone pads or medical-grade foam to improve the comfort of the mouse and the service life of the support plate 310. The heating element can be an embedded heating element or an external heating element such as a hot air blower. By heating the support plate 310, the body temperature of the mouse is maintained within an appropriate range, which is particularly helpful in maintaining the stability of its physiological state under anesthesia. In addition, the heating element can be equipped with an overheating protection module to prevent injury to the mouse caused by excessive temperature.

[0034] As Figure 2In an embodiment of the utility model, telescopic support module 300 still includes lifting assembly 320, lifting assembly 320 is located in lower force adding module 200 and is driven to be connected with support plate 310, lifting assembly 320 is used to adjust the height of support plate 310, lifting assembly 320 can adopt electric push rod, pneumatic cylinder or hydraulic cylinder driving mode, lifting assembly 320 has fixed end and telescopic end moving along vertical direction relative to fixed end, fixed end is fixed with the top of lower force adding module 200, lifting end is connected with the bottom of support plate 310, the height of support plate 310 is adjusted by controlling the work of lifting assembly 320 by electric control mode to adjust the height of mouse to suitable height according to different experimental requirements and the size of mouse, the versatility and applicability of the mouse body position fixing device for assisting mouse live body force adding are improved.

[0035] As Figure 2 In an embodiment of the utility model, two support plates 310 are arranged, two support plates 310 are arranged on the two sides of lower force adding column 210 respectively, and one lifting assembly 320 is arranged corresponding to each support plate 310, the height of two support plates 310 can be adjusted respectively, the height of upper part of trunk and lower part of trunk of animal is adjusted to adjust the height of tibia or ulna of animal to meet the height of test requirement, the flexibility of the mouse body position fixing device for assisting mouse live body force adding is improved.

[0036] In an embodiment of the utility model, lifting assembly 320 is configured as scissor type lifting platform, and / or heating element is configured as electric heating wire, and the electric heating wire is uniformly distributed on support plate 310. In an embodiment of the utility model, lifting assembly 320 can adopt scissor type lifting platform structure, specifically, scissor type lifting platform adjusts the height of support plate 310 stably and accurately through the telescopic of multiple groups of cross arms, ensures the stability of support plate 310 on the top during lifting, and the scissor type lifting platform can be selected in conventional model size on the market according to requirements. In addition, in another embodiment of the utility model, heating element is configured as electric heating wire, and the electric heating wire can be attached to the bottom surface of support plate 310, and the electric heating wire can be selected in conventional model on the market, in order to ensure the uniformity of heating, the electric heating wire can extend along S shape and be uniformly distributed on support plate 310, ensure that the temperature of entire support plate 310 is uniform, and prevent the harm to mouse caused by too high or too low temperature.

[0037] As Figure 2In an embodiment of the present application, the telescopic supporting module further comprises a clamp 330, which is arranged on the top of the supporting plate 310 to fix the limbs of the animal. Specifically, the clamp 330 is arranged on the top of the supporting plate 310 to fix the limbs of the animal. The clamp 330 is arranged on each supporting plate 310, which can be an elastic band or an elastic buckle, etc., to ensure that the limbs are not damaged when fixed. In addition, the position and angle of the clamp 330 can be adjusted to meet the fixation of the mouse in different body positions. By arranging the clamp 330, the stability of the mouse during the experiment is improved, the inaccuracy of the data caused by movement is reduced, and the safety and repeatability of the experiment are further enhanced.

[0038] In an embodiment of the present application, the clamp 330 and the anesthesia cabin 400 are detachably connected with the supporting plate 310. The specific disassembly mode can be clamping or screwing, for example, a plurality of point positions for fixing the clamp 330 and a plurality of point positions for fixing the anesthesia cabin 400 can be arranged on the supporting plate 310, and the user can install or disassemble the clamp 330 and the anesthesia cabin 400 according to the needs, so that the flexibility of the device in use can be improved.

[0039] In an embodiment of the present application, the supporting plate 310 is made of iron, and at least one of the clamp 330 and the anesthesia cabin 400 is magnetically connected with the supporting plate 310. The supporting plate 310 is an iron plate, and the supporting plate 310 can be fixed on the lifting assembly 320 below through four studs. The bottom of the clamp 330 can be provided with a magnet, and the clamp 330 is magnetically attracted to the supporting plate 310. In this way, the clamp 330 can be conveniently disassembled and adjusted in position on the supporting plate 310, further improving the flexibility of use. Similarly, the anesthesia cabin 400 can also be magnetically fixed with the supporting plate 310, and the anesthesia cabin 400 can also be conveniently disassembled and adjusted in position.

[0040] In an embodiment of the present application, a sealing ring is arranged around the opening of the anesthesia cabin 400 to seal with the head. When the head of the animal is inserted into the anesthesia cabin 400, the sealing ring is sleeved on the head, so that the leakage of the anesthetic in the anesthesia cabin 400 is prevented, and the safety of the test is improved.

[0041] In an embodiment of the present application, a groove is arranged at the bottom end of the upper force column 110 to limit the limbs, and / or a groove is arranged at the top end of the lower force column 210 to limit the limbs. During the test, the end of the tibia or ulna of the mouse can be inserted into the groove and limited, so as to ensure the stability of the bone position during the test and ensure the accuracy of the test.

[0042] The above are only exemplary embodiments of the present application, and do not limit the patent scope of the present application, and any equivalent structural transformation made by using the content of the present application specification and drawings, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present application.

Claims

1. A device for fixing the position of a mouse / rat, which can be used to assist in the live force of a mouse / rat, characterized in that, The utility model relates to a four-limb animal body measurement device, comprising: an upper force application module provided with an upper force application column at the bottom; a lower force application module provided below the upper force application module, the top of the lower force application module being provided with a lower force application column, the lower force application column and the upper force application column being opposite to each other to clamp and measure the bones of the limbs of an animal; a telescopic support module provided at the top of the lower force application module, the telescopic support module being used to support the torso of the animal, the telescopic support module comprising: a support plate provided at the top of the lower force application module to support the torso; a heating element provided on the support plate to heat the support plate; a lifting assembly provided in the lower force application module and drivingly connected with the support plate, the lifting assembly being used to adjust the height of the support plate; a narcosis cabin provided in the telescopic support module, the narcosis cabin containing anesthetic, one side of the narcosis cabin being provided with an opening for the head of the animal to pass through.

2. The device for fixing the position of a mouse / rat, which can be used to assist in the force exerted on a mouse / rat in vivo according to claim 1, characterized in that, The support plate is provided with two support plates, the two support plates being respectively provided on the two sides of the lower force application column, and each support plate is provided with one lifting assembly.

3. The device for fixing the position of a mouse for assisting in the live force exertion on a mouse according to claim 1, wherein, The lifting assembly is configured as a scissor-type lifting table; and / or the heating element is configured as an electric heating wire, the electric heating wire being uniformly distributed on the support plate.

4. The device for fixing the position of a mouse for assisting in the live force application of a mouse according to claim 1, wherein, The telescopic support module further comprises a clamp provided at the top of the support plate to fix the limbs of the animal.

5. The device for fixing the position of a mouse / rat, which can be used to assist in the force exerted on a mouse / rat in vivo according to claim 4, characterized in that, The clamp and the narcosis cabin are respectively detachably connected with the support plate.

6. The device for fixing the position of a mouse / rat, which can be used to assist in the force exerted on a mouse / rat in vivo according to claim 5, characterized in that, The support plate is configured as an iron plate, and at least one of the clamp and the narcosis cabin is magnetically connected with the support plate.

7. The device for fixing the position of a mouse for assisting in the live force exertion on a mouse according to claim 1, wherein, The opening of the narcosis cabin is provided with a sealing ring to sealingly cooperate with the head.

8. The device for fixing the position of a mouse for assisting in the live force application of a mouse according to claim 1, wherein, The bottom end of the upper force application column is provided with a groove to limit the limbs; and / or the top end of the lower force application column is provided with a groove to limit the limbs.

9. The device for assisting in the force application to a live mouse / dog according to claim 1, wherein, The narcosis cabin is transparently provided.

Images