Filtering and sterilizing device for botulinum toxin

Abstract

The utility model discloses a filtering and sterilizing device for botulinum toxin, which relates to the technical field of botulinum toxin sterilizing and filtering and comprises a storage bottle, a liquid pump, a pressure valve, a membrane filter, a breaker, two liquid stopping clamps, three hoses and a collecting bottle. The three hoses are respectively a hose I, a hose II and a hose III, the hose I is connected between the output end of the storage bottle and the input end of the liquid pump, the hose II is connected between the output end of the liquid pump and the input end of the membrane filter, and the hose III is connected between the output end of the membrane filter and the input end of the collection bottle. In the process of filtering the botulinum toxin solution, the botulinum toxin solution can be in a closed environment in the whole process, and the risk that clostridium botulinum aerosol in the air pollutes the filtered solution in the thallus separation process can be effectively avoided, so that the condition that viable bacteria in the process of the section enter the process of the next section is effectively prevented, and the quality of the botulinum toxin solution is improved. The biological safety risk is reduced.

Description

TECHNICAL FIELD

[0001] The utility model relates to botulinum toxin degerming filter technical field especially relates to a filter degerming device for botulinum toxin. BACKGROUND

[0002] According to the classification of "Catalogue of Pathogenic Microorganisms for Human Transmission" and "Chinese Pharmacopoeia", the type A Clostridium botulinum belongs to three categories of pathogenic microorganisms, and the separation of the fragmented bacterial body and the toxin protein secreted by the bacteria after Clostridium botulinum culture, i.e. degerming filtration, provides a process basis for the subsequent purification of toxin protein.

[0003] The current separation process is to degerm filter from an open large bucket to a large vertical bottle covered by a sub-packaging cover and then transfer to an open large bucket for subsequent process operation. In this process, Clostridium botulinum aerosol in the air will re-enter the open large bucket and then bring the live bacteria into the next process. Therefore, in order to solve the aforementioned problems, we propose a filter degerming device for botulinum toxin. SUMMARY

[0004] The utility model aims at solving the defects existing in the prior art and proposes a filter degerming device for botulinum toxin.

[0005] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme:

[0006] A filter degerming device for botulinum toxin, comprising a storage bottle, a liquid pump, a pressure valve, a membrane filter, a disconnector, two liquid-stopping clamps, three hoses and a collection bottle;

[0007] The three hoses are hose one, hose two and hose three, the output end of the storage bottle is connected with the input end of the liquid pump through the hose one, the output end of the liquid pump is connected with the input end of the membrane filter through the hose two, and the output end of the membrane filter is connected with the input end of the collection bottle through the hose three;

[0008] The pressure valve is fixedly installed in the inside of the hose one, the disconnector and the two liquid-stopping clamps are sleeved on the outer surface of the hose three, and the two liquid-stopping clamps are located on the two sides of the disconnector respectively;

[0009] The disconnector comprises a box body, a pressing assembly is installed on the upper side in the box body, a fixed block is fixedly installed on the lower side in the box body, a pipe groove is formed in the top of the fixed block, the hose three penetrates through the box body and the pipe groove, a cutting assembly is slidably installed on the top of the box body, and the bottom of the cutting assembly extends into the inside of the box body.

[0010] Further, the lower pressing assembly comprises a mounting plate, four springs, four top ends of the four springs are fixedly installed on the top of the mounting plate, top ends of the four springs are fixedly installed on the top of the inside of the box body, the bottom of the mounting plate is fixedly installed with a pressing block, and the pressing block is matched with the pipe groove.

[0011] Further, four ends of the inside of the fixing block are all installed with push rods, top ends of the four push rods extend to the top of the fixing block and are all fixedly installed with limiting blocks, and bottom ends of the four push rods extend to the bottom of the box body and are fixedly installed with jacking plates.

[0012] Further, the left and right sides of the box body are all provided with through grooves, and the left and right sides of the box body are fixedly installed with clamps, bottom ends of the two clamps can penetrate through the corresponding through grooves and extend to the bottom of the mounting plate.

[0013] Further, the cutting assembly comprises a cutter, the top of the box body, the inside of the mounting plate, the pressing block and the fixing block are all provided with cutter grooves for penetrating through the cutter, and the top of the cutter is fixedly installed with a push plate.

[0014] Further, the left and right sides of the inside of the cutter groove of the top of the box body are all fixedly installed with limiting protrusions, and the left and right sides of the cutter are all provided with limiting grooves matched with the limiting protrusions.

[0015] Compared with the prior art, the beneficial effects of the utility model lie in:

[0016] In the process of filtering the botulinum toxin solution, the botulinum toxin solution is in a closed environment all the time, the risk that the botulinum toxin aerosol in the air contaminates the filtered solution in the separation process can be effectively avoided, the situation that the live bacteria in this process enter the next process is effectively blocked, and the biological safety risk is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0017] The drawings are used to provide a further understanding of the utility model, and constitute a part of the specification, are used together with the embodiments of the utility model to explain the utility model, and do not constitute the limitation on the utility model.

[0018] Figure 1 It is the overall structure schematic view of the utility model;

[0019] Figure 2 It is the perspective view of the disconnecting device of the utility model;

[0020] Figure 3 It is the sectional view of the disconnecting device of the utility model;

[0021] Figure 4Part structure diagram of the disconnector of the utility model;

[0022] Figure 5 The utility model discloses a box body's perspective view.

[0023] In the drawing: 1, storage bottle; 2, liquid pump; 3, pressure valve; 4, membrane filter; 5, disconnector; 6, liquid stop clamp; 7, hose; 8, collection bottle; 9, box body; 10, clamp; 11, cutter; 12, limiting groove; 13, push plate; 14, jacking plate; 15, push rod; 16, fixed block; 17, pipe groove; 18, pressing block; 19, mounting plate; 20, cutter groove; 21, spring; 22, limiting protrusion; 23, through groove. DETAILED DESCRIPTION

[0024] The technical scheme in the embodiments of the utility model will be described clearly and completely below with reference to the drawings in the embodiments of the utility model;

[0025] Refer to Figures 1-5 A filter and bacteria removing device for botulinum toxin, including storage bottle 1, liquid pump 2, pressure valve 3, membrane filter 4, disconnector 5, two liquid stop clamps 6, three hoses 7 and collection bottle 8, three hoses 7 are hose one, hose two, hose three respectively, and the output end of storage bottle 1 is connected with the input end of liquid pump 2 with hose one, and the output end of liquid pump 2 is connected with the input end of membrane filter 4 with hose two, and the output end of membrane filter 4 is connected with the input end of collection bottle 8 with hose three, pressure valve 3 is fixedly installed in the inside of hose one, and disconnector 5 and two liquid stop clamps 6 are all set on the outer surface of hose three, and two liquid stop clamps 6 are located at the two sides of disconnector 5 respectively,

[0026] The storage bottle 1 can store the botulinum toxin solution that needs to be filtered, and the solution in the storage bottle 1 can be delivered to the membrane filter 4 by starting the liquid pump 2, the botulinum toxin solution filtered and sterilized by the membrane filter 4 will directly enter the collection bottle 8 through the hose three to be collected, avoiding secondary pollution. Pressure valve 3 is used for detecting the working pressure of membrane filter 4, if the working pressure is abnormal, the staff can close liquid pump 2 in time to stop the filtering work.

[0027] The disconnector 5 comprises a box body 9, a pressing assembly is mounted on the upper side of the inside of the box body 9, a fixed block 16 is fixedly mounted on the lower side of the inside of the box body 9, a pipe groove 17 is formed in the top of the fixed block 16, the three hoses penetrate through the box body 9 and the pipe groove 17, a cutting assembly is slidably mounted on the top of the box body 9 and extends into the inside of the box body 9. The pressing assembly comprises a mounting plate 19 and four springs 21, the four springs 21 are fixedly mounted at the four ends of the top of the mounting plate 19, the top ends of the four springs 21 are fixedly mounted on the top of the inside of the box body 9, a pressing block 18 is fixedly mounted on the bottom of the mounting plate 19 and is matched with the pipe groove 17. The left and right sides of the box body 9 are provided with through grooves 23, and clamps 10 are fixedly mounted on the left and right sides of the box body 9, the bottom ends of the two clamps 10 can penetrate through the corresponding through grooves 23 and extend to the bottom of the mounting plate 19.

[0028] When the filtered botulinum toxin solution is collected in the collection bottle 8 and the three hoses need to be disconnected, the liquid pump 2 is first turned off, then the two clamps 10 are pressed to move the bottom ends of the clamps 10 out of the through grooves 23, at this time, the mounting plate 19 is lowered under the action of the springs 21 and presses the three hoses in the pipe groove 17 through the pressing block 18, then the two liquid-stopping clamps 6 are used to clamp the three hoses on the two sides of the disconnector 5, and finally the cutting assembly is used to cut the three hoses.

[0029] The four ends of the inside of the fixed block 16 are penetrated by push rods 15, the top ends of the four push rods 15 extend to the top of the fixed block 16 and are fixedly mounted with limit blocks, and the bottom ends of the four push rods 15 extend to the bottom of the box body 9 and are fixedly mounted with a jacking plate 14.

[0030] When the three hoses in the disconnector 5 need to be taken out, the jacking plate 14 is pushed upward, the jacking plate 14 pushes the mounting plate 19 upward through the push rods 15, so that the pressing block 18 no longer presses the three hoses, at this time, the three hoses can be pulled out of the disconnector 5.

[0031] The cutting assembly comprises a cutter 11, the top of the box body 9, the inside of the mounting plate 19, the pressing block 18 and the fixed block 16 are all provided with a knife groove 20 for penetrating through the cutter 11, and the top of the cutter 11 is fixedly mounted with a push plate 13. The left and right sides of the inside of the knife groove 20 of the top of the box body 9 are fixedly mounted with limit protrusions 22, the left and right sides of the cutter 11 are provided with limit grooves 12 matched with the limit protrusions 22.

[0032] The user can push the cutter 11 downward through the push plate 13, so that the cutter 11 cuts the three hoses through the knife groove 20, and the limit protrusions 22 and the limit grooves 12 can make the cutter 11 be in a vertical and stable state during cutting.

Claims

1. A filtering and sterilizing device for botulinum toxin, comprising a storage bottle (1), a liquid pump (2), a pressure valve (3), a membrane filter (4), a disconnector (5), two liquid stop clamps (6), three hoses (7) and a collection bottle (8). The three hoses (7) are hose one, hose two and hose three, respectively, the output end of the storage bottle (1) is connected with the input end of the liquid pump (2) through the hose one, the output end of the liquid pump (2) is connected with the input end of the membrane filter (4) through the hose two, and the output end of the membrane filter (4) is connected with the input end of the collection bottle (8) through the hose three. The pressure valve (3) is fixedly installed in the hose one, the disconnector (5) and the two liquid stop clamps (6) are sleeved on the outer surface of the hose three, and the two liquid stop clamps (6) are located on the two sides of the disconnector (5), respectively. characterized in that The disconnector (5) comprises a box body (9), a pressing assembly is installed on the upper side in the box body (9), a fixed block (16) is fixedly installed on the lower side in the box body (9), a pipe groove (17) is formed in the top of the fixed block (16), the hose three penetrates through the box body (9) and the pipe groove (17), a cutting assembly is slidably installed on the top of the box body (9), and the bottom of the cutting assembly extends into the box body (9).

2. The filter-sterilization device for botulinum toxin according to claim 1, characterized by, The pressing assembly comprises an installation plate (19) and four springs (21), the four springs (21) are fixedly installed at the four ends of the top of the installation plate (19), the top ends of the four springs (21) are fixedly installed on the top of the inner side of the box body (9), and the bottom of the installation plate (19) is fixedly installed with a pressing block (18) matched with the pipe groove (17).

3. The filter-sterilization device for botulinum toxin according to claim 2, characterized by Four push rods (15) are installed at the four ends in the fixed block (16), the top ends of the four push rods (15) extend to the top of the fixed block (16) and are fixedly installed with limiting blocks, and the bottom ends of the four push rods (15) extend to the bottom of the box body (9) and are fixedly installed with a jacking plate (14).

4. The filter-sterilization device for botulinum toxin according to claim 3, characterized by Tunnels (23) are formed in the left and right sides of the box body (9), clamps (10) are fixedly installed on the left and right sides of the box body (9), the bottoms of the two clamps (10) can penetrate through the corresponding tunnels (23) and extend to the bottom of the installation plate (19).

5. The filter-sterilization device for botulinum toxin according to claim 4, characterized by The cutting assembly comprises a cutter (11), cutter grooves (20) for penetrating the cutter (11) are formed in the interiors of the top of the box body (9), the installation plate (19), the pressing block (18) and the fixed block (16), and the top of the cutter (11) is fixedly installed with a push plate (13).

6. The filter-sterilization device for botulinum toxin according to claim 5, characterized by Limiting protrusions (22) are fixedly installed on the left and right sides in the cutter groove (20) of the top of the box body (9), and limiting grooves (12) are formed in the left and right sides of the cutter (11) and matched with the limiting protrusions (22).

Images