Fixing clamp holder for supine position of rat

Abstract

The utility model provides a fixing clamp holder for the supine position of a rat, and belongs to the technical field of instruments for supporting or binding animals for the purpose of surgery, the fixing clamp holder comprises a base plate, a neck exposing assembly and a fixing band, the base plate is provided with a ridge limiting groove, the neck exposing assembly comprises a traction piece and a binding rope, the traction piece is arranged on the base plate, and the binding rope is arranged on the base plate. The end part of one end of the binding rope is bound on the traction piece, and the fixing band is detachably arranged on the base plate and is used for fixing the limbs of a rat. The spine limiting groove is formed in the base plate, the rat is placed in the spine limiting groove, meanwhile, the fixing band is used for fixing the limbs of the rat, the rat is kept in the supine position for a long time, the traction piece is used for pulling the binding rope, the binding rope is in a tightened state, the effect of pulling the head of the rat is achieved, the neck of the rat is exposed in a large area, and therefore the rat can be prevented from falling off. The method is convenient for a suture to enter the common carotid artery and the internal carotid artery in a subsequent experiment, improves the research accuracy of the rat MCAO model, and can shorten the research time.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of the instrument for supporting or binding animals for the purpose of operation, particularly relates to a fixed clamping device for rat prone position. BACKGROUND

[0002] SD rats are a strain of rats, and their fur color is white. They are widely used in pharmacology, toxicology, drug efficacy and GLP experiments. In the research of medical rat MCAO model, 1-2 month old SD rats weighing about 250g are selected. Before the experiment, 7% chloral hydrate (0.5mI / 100g) is injected intraperitoneally for anesthesia, the front part of the neck is prepared and disinfected, a median incision of the neck is made, the right subcutaneous tissue and muscle are bluntly separated to expose the common carotid artery, the vagus nerve and the perianal mucosa tissue accompanying the common carotid artery are carefully separated with an ophthalmic clamp, the common carotid artery is separated for about 1cm, a "V" shaped incision is cut at the proximal end of the common carotid artery, the plug line is clamped with the ophthalmic clamp and inserted into the internal carotid artery from the common carotid artery, when the special plug line black mark reaches the vicinity of the Y-shaped bifurcation, the plug line has entered the middle cerebral artery and cannot continue to move forward. After the plug line is inserted, the reserved ligation line is tightened and fixed. However, since the rat cannot maintain a fixed prone position, the plug line is difficult to enter, which is time-consuming.

[0003] As the utility model of patent number CN201620043881.X discloses a rat acupuncture fixer, including bottom disc, two supports, body fixing cylinder, rear limb fixing fork, forelimb fixing fork and two neck fixing rods, two supports are fixed on the bottom disc and parallel to each other, the body fixing cylinder is placed horizontally on the two supports, the body fixing cylinder is a net-shaped cylindrical shape, when the rat is placed in the body fixing cylinder and the four limbs of the rat stretch out from the mesh hole of the body fixing cylinder, the rear limb fixing fork passes through the tail of the body fixing cylinder from top to bottom and the plane where the rear limb fixing fork is located intersects with the axis of the body fixing cylinder, the forelimb fixing fork passes through the body fixing cylinder vertically downward and the plane where the forelimb fixing fork is located is parallel to the axis of the body fixing cylinder, the two neck fixing rods cross through the body fixing cylinder along the cross section direction of the body fixing cylinder, and the intersection point is in the body fixing cylinder, so as to fix the head of the rat through the cooperation of the body fixing cylinder and the neck fixing rod.

[0004] As the utility model for patent No. CN202321424217.6, a kind of rat fixator, including placement plate, the bottom of placement plate is provided with for extending the extension assembly of binding length, extension assembly includes extension plate, the top of placement plate and extension plate one side is provided with for fixedly binding rope first limit piece and second limit piece;The utility model utilizes the design of placement plate, second groove, first recess, adjusting bolt, extension assembly, first limit piece and second limit piece, by rotating loosening adjusting bolt, pull extension plate, adjust the distance between first limit piece and second limit piece, to bind the limbs of rat according to the length of rat, by first binding band and second binding band are fixed in the first limit block and second limit block of different position, it can make first fixed block and second fixed block be in different position in first slot and second slot respectively, so that the limbs of different body type rats can be completely pulled apart, more convenient experimental operation.

[0005] However, the above two patents cannot make the rat achieve the prone position, even if the rat achieves the prone position, but lack of device for completely exposing the neck of rat, cannot make the neck of rat expose in large area, it is difficult for the thread to enter the common carotid artery and internal carotid artery, and the experimental research takes a long time. Utility model content

[0006] Therefore, the utility model provides a kind of rat prone position fixed holder to solve the technical problems in prior art, existing device cannot make the rat achieve the prone position, even if the rat achieves the prone position, but lack of device for completely exposing the neck of rat, cannot make the neck of rat expose in large area, it is difficult for the thread to enter the common carotid artery and internal carotid artery, and the experimental research takes a long time.

[0007] The technical scheme for solving the above technical problems is as follows:

[0008] A kind of rat prone position fixed holder, including base plate, neck exposure assembly and fixing band, the dorsal limiting slot is formed in the base plate, the neck exposure assembly includes traction member and binding rope, the traction member is arranged on the base plate, one end of the binding rope is bound to the traction member, the fixing band is detachably arranged on the base plate, for fixing the limbs of rat.

[0009] Preferably, the dorsal limiting slot includes mouse head placement slot, arc-shaped mouse body placement slot and strip-shaped mouse tail placement slot in sequence.

[0010] Preferably, the traction member includes electric push rod and telescopic sleeve, the electric push rod is vertically arranged on the base plate, and is arranged on the side close to the mouse head placement slot, the telescopic sleeve is arranged on the upper end of the electric push rod, and the telescopic sleeve is connected with one end of the binding rope, the telescopic sleeve can be extended or contracted.

[0011] Preferably, one end of the binding rope is provided with a thimble, which is located away from one end of the telescopic sleeve, and the thimble is sleeved on the incisor of the rat.

[0012] Preferably, the other end of the binding rope is provided with a rope collecting ring, which is arranged at the end of the telescopic sleeve, and a cavity is formed in the rope collecting ring for accommodating the binding rope.

[0013] Preferably, the fixing belt comprises a first belt body and a second belt body, the first belt body is detachably arranged on one side close to the arc-shaped rat body placing groove, and the second belt body is detachably arranged on one side close to the strip-shaped rat tail placing groove.

[0014] Preferably, the first belt body is an inflatable flexible belt.

[0015] Preferably, the base plate is further provided with a cotton swab placing cylinder and a cotton placing cylinder.

[0016] Preferably, the base plate is rotatably provided with an illuminating lamp, and the illuminating lamp can be rotated to be directly above the binding rope.

[0017] Compared with the prior art, the utility model has at least the following advantages:

[0018] By opening the dorsal limiting groove on the base plate, the rat is placed in the dorsal limiting groove, and the rat limbs are fixed by using the fixing belt, so that the rat can keep the prone position for a long time, the binding rope is in a taut state by using the traction member to pull the binding rope, the head of the rat is pulled, the neck of the rat is exposed in a large area, the thread can enter the common carotid artery and the internal carotid artery in the subsequent experiment, the precision of the rat MCAO model research is improved, and the research time is shortened. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is a rat prone position fixing clamp isometric view.

[0020] Figure 2 It is a rat prone position fixing clamp front view.

[0021] Figure 3 It is a rat prone position fixing clamp left view.

[0022] Figure 4 It is a rat prone position fixing clamp embodiment 1 plan view.

[0023] Figure 5 It is Figure 4 A partial enlarged view of the A in the figure.

[0024] Figure 6Figure 2 is a top view of an embodiment 2 of a fixing holder for a rat in a supine position.

[0025] Figure 7 Figure 2 is a top view of an embodiment 2 of a fixing holder for a rat in a supine position. Figure 6 Figure 2 is a top view of an embodiment 2 of a fixing holder for a rat in a supine position.

[0026] Figure 2 is a top view of an embodiment 2 of a fixing holder for a rat in a supine position. DETAILED DESCRIPTION

[0027] It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict. The technical solutions of the present application will be further described below with reference to the drawings of the embodiments of the present application. The present application is not limited to the following specific embodiments.

[0028] It should be understood that the same or similar reference numerals in the drawings of the embodiments correspond to the same or similar components. In the description of the present application, it should be understood that the orientations or positional relationships indicated by the terms "upper", "lower", "front", "back", "left", "right", "top" and "bottom" are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore, the terms describing the positional relationship in the drawings are only used for exemplary illustration, and cannot be understood as a limitation of the present patent, for those skilled in the art, the specific meanings of the above terms can be understood according to the specific circumstances.

[0029] Please refer to Figures 1 to 7 A fixing holder for a rat in a supine position, comprising a base plate 100, a neck exposure assembly 200 and a fixing belt 300.

[0030] Among them, after intraperitoneal injection of rats, the rats need to be in a supine position during the experiment. In the existing experiment, after the rats are turned to a supine position, they are prone to lateral turning, which requires the experimenter to turn the rats to a supine position again, therefore, a dorsal limiting groove 110 is formed on the base plate 100, the dorsal limiting groove 110 is a groove, the rat is placed in a supine position in the dorsal limiting groove 110, and the rat will not turn laterally, which is convenient for the experimenter to conduct the experiment.

[0031] In order to expose the neck of the supine rat, the neck exposure assembly 200 includes a traction member 210 and a binding rope 220, the traction member 210 is arranged on the base plate 100, the traction member 210 plays a traction role, one end of the binding rope 220 is bound to the traction member 210, and the other end is bound to the rat's incisors (since most rodents have long and strong incisors, the SD rat also has long incisors), by using the traction member 210, the binding rope 220 is pulled and tightened, when the binding rope 220 is tightened, it will pull the rat's head slightly backward, exposing the rat's neck, and facilitating the subsequent use of an ophthalmic clamp to hold the thread from the common carotid artery into the internal carotid artery.

[0032] The fixing belt 300 is detachably arranged on the base plate 100, the fixing belt 300 is an elastic belt, which is detached from the base plate 100 when not in use, when the rat is placed in the dorsal limiting groove 110, the rat's limbs are fixed by the fixing belt 300, and at the same time, the traction member 210 can also prevent the rat from moving on the base plate 100 when the binding rope 220 is pulled.

[0033] By opening the dorsal limiting groove 110 on the base plate 100, the rat is placed in the dorsal limiting groove 110, and the rat's limbs are fixed by the fixing belt 300, so that the rat can maintain a supine position for a long time, and the binding rope 220 is pulled by the traction member 210, so that the binding rope 220 is in a tightened state, achieving the effect of pulling the rat's head, exposing the rat's neck, facilitating the subsequent experiment of the thread into the common carotid artery and internal carotid artery, improving the precision of the rat MCAO model research, and shortening the research time.

[0034] Further, referring to Figure 4 , the dorsal limiting groove 110 includes a rat head placing groove 111, an arc-shaped rat body placing groove 112 and a strip-shaped rat tail placing groove 113 which are sequentially communicated. The rat head placing groove 111 is shallow in depth but large in bottom area, which is convenient for experimenters to conduct experiments. The arc-shaped rat body placing groove 112 is an arc-shaped groove which can fit the rat's back and limit the rat to prevent the rat from turning over during the experiment. The strip-shaped rat tail placing groove 113 is narrow in width and is used to clamp the rat tail. By arranging the rat head placing groove 111, the arc-shaped rat body placing groove 112 and the strip-shaped rat tail placing groove 113 which are sequentially communicated, the rat is limited to maintain a supine position for a long time, which is convenient for experiments.

[0035] Still further, referring to Figure 1 and Figure 2, part of the rat volume, size, the substrate 100 can not be placed in different rats, in order to make the rat to keep supine position, and the neck of a large area of naked, therefore, the traction member 210 includes electric push rod 211, the electric push rod 211 is vertically arranged on the substrate 100, and is located close to the mouse head placement groove 111 side setting, the electric push rod 211 is used for vertical upward push, specifically, the electric push rod 211 is detachably connected with the substrate 100 through bolts. The traction member 210 further includes telescopic sleeve 212, the telescopic sleeve 212 is arranged on the electric push rod 211 upper end, and the telescopic sleeve 212 is connected with one end of the binding rope 220, the telescopic sleeve 212 can be stretched or can be contracted. For the volume of the rat, through the electric push rod 211 upward movement, push high telescopic sleeve 212, using the binding rope 220 binding in the rat's incisors, for the volume of the rat, the telescopic sleeve 212 is stretched out shorter (i.e. contraction is longer), adjust the telescopic sleeve 212, make the telescopic sleeve 212 contract, tighten the binding rope 220, make the rat head to lean back, the rat neck in turn a large area of naked, is favorable for subsequent experimental research.

[0036] Specifically, the telescopic sleeve 212 is provided with a scale line, which is used for observing the contraction or extension size.

[0037] In a possible embodiment 1, referring to Figure 4 and Figure 5 , one end of the binding rope 220 is provided with a sleeve ring 221, the sleeve ring 221 is located away from the telescopic sleeve 212, the sleeve ring 221 is sleeved on the rat's incisors, which avoids fixing the binding rope 220 on the rat's incisors by binding, only needs to be sleeved on the rat's incisors through the sleeve ring 221, and since the rat is in supine position, the sleeve ring 221 is sleeved on the rat's incisors and will not fall off from the rat's incisors, at the same time, the sleeve ring 221 is a flexible sleeve ring 221, which changes from a circular shape to an oval shape under stress, further preventing the sleeve ring 221 from falling off from the rat's incisors.

[0038] Specifically, the other end of the binding rope 220 is provided with a rope collecting ring 222, the rope collecting ring 222 is arranged on the end of the telescopic sleeve 212, a cavity is formed in the rope collecting ring 222, and the binding rope 220 is accommodated in the cavity. Since the binding rope 220 is wound in the rope collecting ring 222 for several turns, by placing rats with different volumes on the substrate 100, the binding rope 220 in the rope collecting ring 222 can be stretched to an appropriate length, and the remaining binding rope 220 is fixed in the rope collecting ring 222, and then the telescopic sleeve 212 is fine adjusted, so that the binding rope 220 is in a taut state.

[0039] In a possible embodiment 2, referring toFigure 6 And Figure 7 For part of the rat incisor damaged or need to be in the rat neck lateral arterial experimental study, can not use the binding rope 220. The traction member 210 also includes a clamping member 230 and a rotating disc 231, the clamping member 230 is used for clamping the rat mouth, one end of the rotating member is connected with the clamping member 230, used for driving the clamping member 230 to rotate, the other end is connected with the telescopic sleeve 212. By the clamping member 230 clamping the rat mouth, through the telescopic sleeve 212 contraction, make the rat head back, achieve the rat neck large area exposed. When the experimental study needs to be carried out in the rat neck lateral arterial, through the clamping member 230 clamping the rat mouth, through rotating the rotating disc 231, drive the clamping member 230 to rotate, and then make the rat neck rotate, expose the rat lateral arterial.

[0040] As preferred, the fixing belt 300 includes a first belt body 310 and a second belt body 320, the first belt body 310 is detachably arranged on one side close to the arc-shaped mouse body placing groove 112, and the second belt body 320 is detachably arranged on one side close to the strip-shaped mouse tail placing groove 113. The first belt body 310 is used for fixing the forelimbs and mouse body of the rat, and the second belt body 320 is used for fixing the hind limbs of the rat, so that the rat is fixed in the dorsal limiting groove 110 and the rat is prevented from shaking.

[0041] Specifically, the first belt body 310 is a flexible inflatable belt. The inflatable belt is inflated to expand the belt body, so that the hands of the experimenter can be supported and the stability of the hands is improved when the experimenter performs thread puncture to the common carotid artery.

[0042] Further, the substrate 100 is also provided with a cotton swab placing cylinder 120 and a cotton placing cylinder 130. The cotton swab placing cylinder 120 and the cotton placing cylinder 130 are used for cleaning blood when the neck of the rat is cut.

[0043] Still further, the substrate 100 is rotatably provided with an illuminating lamp 400, and the illuminating lamp 400 can be rotated to be directly above the binding rope 220. When the illuminating lamp 400 is used, the illuminating lamp 400 is rotated to one side of the substrate 100. When the rat is fixed, the illuminating lamp 400 is rotated to be directly above the binding rope 220 (i.e. directly above the head of the rat), so that light source is provided.

[0044] The working principle of the utility model is as follows:

[0045] In use, 6-8 years old SD rats are selected, 7% chloral hydrate (0.5mI / 100g) is injected into the abdominal cavity for anesthesia, the substrate 100 is placed horizontally, the first belt 310 and the second belt 320 are disassembled, and the rat is placed in the dorsal limiting groove 110, wherein the rat head is placed in the rat head placing groove 111, the rat back is placed and limited in the arc-shaped rat body placing groove 112, and the rat tail is placed and limited in the strip-shaped rat tail placing groove 113, so that the rat is kept in a supine position with the belly upwards.

[0046] Then, the first belt 310 is used to fix the forelimbs and body of the rat, air is filled into the first belt 310, the first belt 310 is inflated and extruded to fix the forelimbs and body of the rat, and the second belt 320 is used to fix the hind limbs of the rat.

[0047] Subsequently, according to the size of the rat, the height of the electric push rod 211 is adjusted, the binding rope 220 is pulled out from the rope collecting ring 222, the binding rope 220 with an appropriate length is pulled out, the thimble 221 is sleeved on the rat's incisors, the telescopic sleeve 212 is retracted, the binding rope 220 is gradually tightened, the rat's head is pulled to a backward state, the neck of the rat is exposed in a large area, the telescopic sleeve 212 stops retracting and remains stationary.

[0048] Finally, the illuminating lamp 400 is rotated and turned on, the front part of the rat's neck is skinned and disinfected, a median incision of the neck is made, and the experiment is performed.

[0049] Obviously, the above embodiments of the utility model are only examples for clearly illustrating the utility model, and are not a limitation on the embodiments of the utility model. For ordinary skilled in the art, other different forms of changes or variations can be made on the basis of the above description. Here, all the embodiments are not enumerated. Any modification, equivalent replacement and improvement made within the spirit and principle of the utility model should be included in the protection scope of the utility model.

Claims

1. A fixing holder for a rat in a supine position, characterized by, Including substrate, neck bare components and fixed band, the substrate is provided with dorsal position slot, the neck bare components includes traction and binding rope, the traction is arranged on the substrate, one end of the binding rope is bound on the traction, the fixed band is detachably arranged on the substrate, and is used for fixing rat limbs.

2. The fixation holder for a rat prone position according to claim 1, characterized in that, The dorsal position slot includes mouse head placing groove, arc-shaped mouse body placing groove and strip-shaped mouse tail placing groove which are communicated in sequence.

3. The fixation holder for a rat prone position according to claim 2, characterized in that The traction includes electric push rod and telescopic sleeve, the electric push rod is vertically arranged on the substrate and located on the side close to the mouse head placing groove, the telescopic sleeve is arranged on the upper end of the electric push rod, and the telescopic sleeve is connected with one end of the binding rope, and the telescopic sleeve can be stretched out or contracted.

4. The fixation holder for a rat prone position according to claim 3, characterized in that, One end of the binding rope is provided with a sleeve ring, the sleeve ring is located away from the telescopic sleeve, and the sleeve ring is sleeved on the rat's incisor.

5. The fixation holder for a rat prone position according to claim 4, characterized in that, The other end of the binding rope is provided with a rope collecting ring, the rope collecting ring is arranged on the end of the telescopic sleeve, a cavity is formed in the rope collecting ring, and the binding rope is accommodated in the cavity.

6. The fixation holder for a rat prone position according to claim 2, wherein The fixed band includes first band body and second band body, the first band body is detachably arranged on the side close to the arc-shaped mouse body placing groove, and the second band body is detachably arranged on the side close to the strip-shaped mouse tail placing groove.

7. The fixation holder for a rat prone position according to claim 6, characterized in that The first band body is a flexible inflatable band.

8. The fixation holder for a rat prone position according to claim 1, characterized in that, The substrate is further provided with cotton swab placing cylinder and cotton placing cylinder.

9. The fixation holder for a rat prone position according to claim 1, characterized in that, The substrate is rotatably provided with an illuminating lamp, and the illuminating lamp can be rotated to be directly above the binding rope.

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