Thread bolt auxiliary device for rat MCAO model

Abstract

The utility model provides a suture auxiliary device for a rat MCAO model, which belongs to the technical field of surgical instruments for veterinarians and comprises a guide tube, a smooth inner cavity is arranged in the guide tube, a suture is driven to slide in the smooth inner cavity, one end of the guide tube is provided with an acupuncture tip, the guide tube is further provided with a guide rod, and the guide rod is connected with the suture. The guide rod is positioned on one side far away from the acupuncture tip; and the clamping piece is connected to the guide rod in a sliding and sleeving manner, and the clamping piece is used for clamping a wire bolt. The suture auxiliary device is easy to use, experimental operation steps are simplified, the suture can be conveniently fed into the internal carotid artery of the rat, a guide tube cannot be reserved in the internal carotid artery of the rat, the accuracy of a simulation experiment can be greatly improved, and damage of the experiment to the internal carotid artery of the rat is reduced.

Description

TECHNICAL FIELD

[0001] The utility model belongs to the technical field of veterinary surgical instruments, and particularly relates to a thread plug auxiliary device for a rat MCAO model. BACKGROUND

[0002] The rat middle cerebral artery occlusion (MCAO) model is an important tool for studying the mechanism of ischemic brain injury and its treatment methods. The MCAO thread plug method simulates the pathological process of human cerebral apoplexy by blocking the blood flow of the middle cerebral artery, causing local cerebral ischemia. However, due to the complexity of the operation and the high sensitivity of the model, the establishment of the MCAO model needs to be optimized to improve its stability, reproducibility and reliability of experimental results. The MCAO thread plug method inserts a specially designed nylon thread plug into the rat internal carotid artery until the front end blocks the starting position of the middle cerebral artery, thereby inducing cerebral ischemia. The advantage of this method is that it can control the area and time of ischemia, and can induce reperfusion injury, suitable for various ischemic encephalopathy research.

[0003] The existing method is for the experimenter to hold the thread plug with tweezers after opening the rat's internal carotid artery, and insert the thread plug into the rat's internal carotid artery. However, due to the relatively thin rat internal carotid artery and the softness of the thread plug, the thread plug is not easy to enter the internal carotid artery, resulting in an increase in experimental time and easy damage to the rat's internal carotid artery.

[0004] For example, the utility model patent with patent number CN202322649846.5 discloses a rat middle cerebral artery thread plug device, which includes a catheter and a thread plug. The catheter is a Y-shaped structure, including a main pipe and a branch pipe communicating with the main pipe. The thread plug enters the main pipe from the branch pipe. The rat middle cerebral artery thread plug device of the utility model has simple structure and is convenient to operate. During use, it does not need to cut the external carotid artery and its branches, reducing surgical damage and making the embolism closer to the real state, while reducing the experience and skill requirements for the operator's ligation and surgery.

[0005] However, during use of the device, the catheter and thread plug are buried in the rat's internal carotid artery as a whole. In subsequent simulation experiments, since the catheter is not removed from the rat's internal carotid artery, and the overall volume of the catheter is relatively large, it will seriously affect the accuracy of the simulation experiment. UTILITY MODEL CONTENT

[0006] Therefore, the utility model provides a thread plug auxiliary device for a rat MCAO model to simplify the experimental operation steps, improve the accuracy of the simulation experiment, and reduce the damage to the rat's internal carotid artery.

[0007] The technical solution of the utility model to solve the above technical problems is as follows:

[0008] A wire plug auxiliary device for a rat MCAO model, comprising

[0009] A guide tube, the guide tube has a smooth inner cavity inside, the wire plug is driven to slide in the smooth inner cavity, one end of the guide tube is provided with a needle tip, and a guide rod is further arranged on the guide tube and located on the side away from the needle tip; and

[0010] A clamping piece, the clamping piece is slidably sleeved on the guide rod, and the clamping piece is used for clamping the wire plug.

[0011] Preferably, the guide tube comprises a puncture part and a guide part, the puncture part and the guide part are arranged at a preset included angle alpha, the needle tip is located at one end of the puncture part, and the guide rod is located at one end of the guide part.

[0012] Preferably, the preset included angle alpha is 150°≤alpha≤180°.

[0013] Preferably, the guide part port is a trumpet mouth, and the guide rod is arranged on the trumpet mouth.

[0014] Preferably, a pushing handle is further arranged on the guide tube, and the pushing handle is arranged on the guide part.

[0015] Preferably, the clamping piece comprises a fixed clamp and a sliding sleeve, the fixed clamp is used for clamping the wire plug, the sliding sleeve is arranged on the fixed clamp, and the sliding sleeve is slidably sleeved on the guide rod.

[0016] Compared with the prior art, the wire plug auxiliary device has at least the following advantages:

[0017] The wire plug auxiliary device is simple to use, simplifies the experimental operation steps, facilitates the wire plug to be sent into the internal carotid artery of a rat, does not remain the guide tube in the internal carotid artery of the rat, can greatly improve the precision of simulation experiments, and reduces the damage of experiments to the internal carotid artery of the rat. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a perspective view of the wire plug auxiliary device for the rat MCAO model.

[0019] Figure 2 It is a front view of the wire plug auxiliary device for the rat MCAO model.

[0020] Figure 3 It is a top view of the wire plug auxiliary device for the rat MCAO model.

[0021] Figure 4 It is a perspective view of the clamping piece.

[0022] In the figure: guide tube 100, piercing part 110, needle piercing tip 111, lead-in part 120, guide rod 121, trumpet mouth 122, push handle 130, clamping piece 200, fixed clamp 210, sliding sleeve 220, wire plug 300. DETAILED DESCRIPTION

[0023] It should be noted that the embodiments in the utility model and the features in the embodiments can be combined with each other without conflict. The technical solutions of the utility model will be further described below in combination with the drawings of the utility model embodiments. The utility model is not limited to the following specific embodiments.

[0024] It should be understood that the same or similar reference numerals in the drawings of the embodiments correspond to the same or similar components. In the description of the utility model, it should be understood that the orientation or position relationship indicated by the terms ''upper'', ''lower'', ''front'', ''rear'', ''left'', ''right'', ''top'', ''bottom'' and the like is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore, the terms describing the position relationship in the drawings are only used for exemplary illustration, and cannot be understood as a limitation on the patent. For ordinary skilled persons in the art, the specific meanings of the above terms can be understood according to the specific circumstances.

[0025] Please refer to Figure 1 and Figure 4 A wire plug auxiliary device for a rat MCAO model, comprising a guide tube 100, the guide tube 100 has a smooth inner cavity, a wire plug 300 is driven to slide in the smooth inner cavity, so that after the wire plug 300 is stretched into the guide tube 100, the wire plug 300 can slide in the smooth inner cavity without obstruction, one end of the guide tube 100 is provided with a needle piercing tip 111, the needle piercing tip 111 is similar to an existing syringe needle, which is convenient for piercing the internal carotid artery of a rat, the guide tube 100 is also provided with a guide rod 121, the guide rod 121 is located away from the needle piercing tip 111, the guide rod 121 has a guiding effect, that is, the extension direction of the guide rod 121 is consistent with the opening direction of the guide tube 100; and a clamping piece 200, the clamping piece 200 is slidably sleeved on the guide rod 121, the clamping piece 200 is used for clamping the wire plug 300, when the wire plug 300 is stretched into the smooth inner cavity, the clamping piece 200 is opened, the clamping piece 200 clamps the wire plug 300, since the clamping piece 200 is slidably sleeved on the guide rod 121, the clamping piece 200 is slightly pushed, so that the clamping piece 200 slowly moves towards the side close to the guide tube 100, thereby driving the wire plug 300 to slowly move in the smooth inner cavity.

[0026] The suture 300 is an existing medical suture embolism, mainly used in rat MCAO suture embolism simulation experiments. The suture 300 enters from the internal carotid artery of the rat and extends to the middle cerebral artery of the rat.

[0027] The specific usage method is as follows:

[0028] 1. The preliminary preparation work is the same as the traditional rat MCAO suture occlusion simulation method. After bluntly separating the rat's neck and exposing the rat's internal carotid artery, if the rat is small and the rat's internal carotid artery is relatively thin, a small incision is cut in the rat's internal carotid artery, and the needle tip 111 of the guide tube 100 is inserted into the rat's internal carotid artery through the small incision and extended to an appropriate length. If the rat is large and the rat's internal carotid artery is relatively thick, the needle tip 111 of the guide tube 100 is directly inserted into the rat's internal carotid artery.

[0029] 2. Since a suture 300 has been pre-inserted into the cannula 100, the clamping member 200 moves along the guide rod 121 to gradually insert the suture 300 into the rat's internal carotid artery, and gradually moves from the rat's internal carotid artery toward the rat's middle cerebral artery; after extending a predetermined distance, the clamping member 200 is separated from the suture 300, that is, the suture 300 is no longer clamped, the clamping member 200 slides off the guide rod 121, and clamps the clamping member 200 on the surface of the rat's internal carotid artery. Because the rat's internal carotid artery has the suture 300, the clamping member 200 will connect the rat's internal carotid artery with the suture 300. The suture thrombus 300 simultaneously clamps (the clamping part does not have the guide tube 100) and withdraws the guide tube 100 from the rat's internal carotid artery. The function of the clamping member 200 in clamping the rat's internal carotid artery and the suture thrombus 300 is to keep the suture thrombus in the rat's internal carotid artery from moving and to prevent damage to the rat's internal carotid artery and middle cerebral artery. If the clamping member 200 does not clamp the rat's internal carotid artery and the suture thrombus 300, since there is part of the suture thrombus 300 in the guide tube 100, during the withdrawal of the guide tube 100 from the rat's internal carotid artery, the pre-inserted suture thrombus 300 may be brought out from the rat's internal carotid artery, requiring a second introduction of the suture thrombus 300.

[0030] 3. After the cannula 100 is withdrawn from the rat's internal carotid artery, the clamping member 200 is released from the clamping part of the rat's internal carotid artery, and the clamping member 200 is re-clamped onto the suture 300. The suture 300 is moved by fine adjustment so that it is in the predetermined area of ​​the rat's middle cerebral artery. The excess suture 300 is cut off to allow the rat's internal carotid artery and other blood vessels to supply blood normally. The suture is then closed. Once the animal wakes up after the modeling process, it will show obvious hemiplegic symptoms, tilt its body, and crawl and rotate, which is considered a successful modeling.

[0031] The wire plug 300 auxiliary device is simple to use, simplifies the experimental operation steps, facilitates the wire plug 300 to be sent into the internal carotid artery of the rat, and does not leave the guide tube 100 in the internal carotid artery of the rat, so that the precision of the simulation experiment can be greatly improved, and the damage to the internal carotid artery of the rat in the experiment is reduced.

[0032] In a possible embodiment, the guide tube 100 includes a piercing part 110 and a leading part 120, the piercing part 110 and the leading part 120 are arranged at a preset included angle α, the needle tip 111 is located at one end of the piercing part 110, and the guide rod 121 is located at one end of the leading part 120. The piercing part 110 is mainly used for piercing the internal carotid artery of the rat due to the needle tip 111 at the front end, and the leading part 120 is located outside the internal carotid artery of the rat, used for guiding the wire plug 300 into the leading part 120, and then into the piercing part 110 by the leading part 120. Generally, the length of the piercing part 110 is 1-3 cm, and the inner diameter is 1.5-1.8 mm, the length of the leading part 120 is 1-2 cm, and the inner diameter is 1.5-1.8 mm, and the connection between the piercing part 110 and the leading part 120 is smoothly connected by a round corner, so as to prevent the corner between the piercing part 110 and the leading part 120 from hindering the movement of the wire plug 300 when the wire plug 300 moves in the guide tube 100.

[0033] Specifically, the preset included angle α is 150°≤α≤180°. When the wire plug 300 moves from the leading part 120 into the piercing part 110, the wire plug 300 moves more smoothly in the guide tube 100, preventing the wire plug 300 from being hindered. If the preset included angle α is less than 150°, when the wire plug 300 moves to the corner between the piercing part 110 and the leading part 120, the corner hinders the movement of the wire plug 300, resulting in a decrease in the precision of the wire plug 300 entering the middle cerebral artery of the rat.

[0034] Specifically, referring to Figure 2 and Figure 3 , the port of the leading part 120 is a horn mouth 122, and the guide rod 121 is arranged on the horn mouth 122. The horn mouth 122 facilitates the wire plug 300 to enter the leading part 120, avoiding the difficulty of guiding the wire plug 300 into the guide tube 100 due to the small inner diameter of the guide tube 100; in addition, the connection between the horn mouth 122 and the leading part 120 is smoothly connected by a round corner, preventing the wire plug 300 from being stuck.

[0035] In a possible embodiment, the guide tube 100 is further provided with a pushing handle 130, which is arranged on the guide part 120. The pushing handle 130 is arranged to facilitate pushing the guide tube 100 into the internal carotid artery of a rat. Specifically, the pushing handle 130 can be in the form of a pushing plate or a pushing rod.

[0036] In a possible embodiment, referring to Figure 4 The clamping member 200 comprises a fixed clamp 210 and a sliding sleeve 220. The fixed clamp 210 is used to clamp the wire plug 300, and the sliding sleeve 220 is arranged on the fixed clamp 210 and is sleeved on the guide rod 121. The fixed clamp 210 is small in size and can clamp the wire plug 300. The fixed clamp 210 and the sliding sleeve 220 can be connected by bolts or welding. The inner diameter of the sliding sleeve 220 is slightly larger than the diameter of the guide rod 121, so that the sliding sleeve 220 can move on the guide rod 121 and be easily removed from the guide rod 121.

[0037] Obviously, the above embodiments of the utility model are only examples for clearly illustrating the utility model, and are not a limitation on the embodiments of the utility model. For ordinary skilled in the art, other different forms of changes or variations can be made on the basis of the above description. Here, all the embodiments are not required to be exhausted. Any modification, equivalent replacement and improvement within the spirit and principle of the utility model should be included in the protection scope of the utility model.

Claims

1. A suture assisted device for a rat MCAO model, characterized in that, The application relates to a needle tube and a clamping piece. The needle tube has a smooth inner cavity, a wire plug is driven to slide in the smooth inner cavity, one end of the needle tube is provided with a needle tip, and a guide rod is further arranged on the needle tube and located on the side far from the needle tip. The clamping piece is slidably sleeved on the guide rod and used for clamping the wire plug.

2. The suture-assisted device for a rat MCAO model according to claim 1, wherein, The needle tube comprises a penetrating part and a leading-in part, the penetrating part and the leading-in part are arranged at a preset included angle alpha, the needle tip is located at one end of the penetrating part, and the guide rod is located at one end of the leading-in part.

3. The suture-assisted device for a rat MCAO model according to claim 2, wherein, The preset included angle alpha is 150 DEG <= alpha <= 180 DEG.

4. The suture-assisted device for a rat MCAO model according to claim 2, wherein, The leading-in part port is a horn mouth, and the guide rod is arranged on the horn mouth.

5. The suture-assisted device for a rat MCAO model according to claim 2, wherein, A pushing handle is further arranged on the needle tube and located on the leading-in part.

6. The suture-assisted device for a rat MCAO model according to claim 1, wherein, The clamping piece comprises a fixed clamp used for clamping the wire plug and a sliding sleeve pipe arranged on the fixed clamp and slidably sleeved on the guide rod.

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