Microneedle patch

Abstract

The utility model belongs to the technical field of microneedle patches, and particularly relates to a microneedle patch which comprises a soluble microneedle, the soluble microneedle is composed of a base plate and a plurality of microneedles formed at the bottom of the base plate, the edge of the base plate is adhered to one side of a waterproof film layer, the waterproof film layer is adhered to a hard base layer, and the hard base layer is adhered to the bottom of the base plate. The soluble microneedles are arranged in a cavity formed by the hard base layer and the waterproof membrane layer in a supporting mode, a cavity of a medicine storage cavity used for containing active medicine components is formed between the waterproof membrane layer and the soluble microneedles, the breathable surface layer is bonded to the other side of the waterproof membrane layer, and one end of the breathable surface layer is connected with the hard base layer in a bonded mode. A superficial layer microneedle puncture method is adopted, injection is carried out through a channel which is filled in a medicine storage cavity and formed through microneedle puncture after soluble microneedles are dissolved, the medicine storage amount of the patch is increased, the dosage can be accurately controlled through a microneedle percutaneous mode, the absorption and utilization degree of medicine is increased, and the first pass effect of the liver is reduced.

Description

Technical Field

[0001] This utility model belongs to the field of microneedle patch technology, and specifically relates to a microneedle patch. Background Technology

[0002] Poria cocos polysaccharides possess antioxidant and anti-aging functions. Currently, the market primarily offers oral solutions containing Poria cocos polysaccharides. However, excessive use of these oral solutions may lead to gastrointestinal discomfort, liver and kidney damage, electrolyte imbalances, blood sugar fluctuations, and neurotoxicity. Furthermore, the bioactivity of Poria cocos polysaccharides exhibits a certain linear relationship with dosage (concentration); both excessively high and low dosages reduce its bioactivity.

[0003] In recent years, microneedling technology has become increasingly popular. This technology can break through the barrier of the stratum corneum with relatively low pain, creating hundreds of micron-sized pores, which greatly promotes drug penetration, improves drug absorption and utilization, allows for precise control of drug dosage, and can avoid the severe first-pass effect in the liver that exists with some oral medications. Therefore, combining Poria cocos polysaccharides with microneedling technology has high practical value.

[0004] However, traditional microneedle patches can only inject a small amount of drug, which is insufficient to meet the effective dosage of Poria cocos polysaccharide. While injecting multiple microneedle patches can meet the effective dosage of Poria cocos polysaccharide, it consumes a large number of microneedle patches and causes more damage to the skin surface. Utility Model Content

[0005] To address the above problems, the purpose of this utility model is to provide a microneedle patch that solves the problem that existing microneedle patches cannot meet the effective dosage of Poria cocos polysaccharide due to the small amount of drug injected.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a microneedle patch comprising soluble microneedles, wherein the soluble microneedles are composed of a substrate and a plurality of microneedles formed on the bottom of the substrate, the edge of the substrate is bonded to one side of a waterproof membrane layer, the waterproof membrane layer is bonded to a rigid substrate, the soluble microneedles are disposed in a cavity formed by the rigid substrate and the waterproof membrane layer, and a cavity for filling active drug components is formed between the waterproof membrane layer and the soluble microneedles, wherein a breathable surface layer is bonded to the other side of the waterproof membrane layer, and one end of the breathable surface layer is bonded to the rigid substrate.

[0007] The beneficial effects of this invention are as follows: by using a shallow microneedle puncture method, the drug is injected through the channel formed by the microneedle puncture after the soluble microneedles are dissolved in the drug storage cavity, thereby increasing the drug storage capacity of the patch. Moreover, the percutaneous microneedle method can precisely control the dosage, improve the absorption and utilization of the drug, and reduce the first-pass effect of the liver.

[0008] To effectively protect the microneedles;

[0009] As a further improvement to the above technical solution: a groove with a depth not less than the height of the microneedle is formed on the rigid base layer.

[0010] The beneficial effects of this improvement are: the grooves formed by the sinking of the rigid base layer can provide isolation space for the microneedles, effectively isolating and protecting them.

[0011] To effectively prevent leakage from the drug storage chamber;

[0012] As a further improvement to the above technical solution: the waterproof membrane layer is an e-PTFE waterproof and breathable membrane.

[0013] The beneficial effects of this improvement are: the waterproof membrane layer, together with the soluble microneedles, can provide a sealed cavity isolated from the outside world for the drug storage chamber, preventing leakage from the drug storage chamber.

[0014] To make it easier to peel off the waterproof membrane layer;

[0015] As a further improvement to the above technical solution: the waterproof membrane layer is coated with adhesive on one side, and one end of the waterproof membrane layer is located on the outside of the breathable surface layer.

[0016] The beneficial effect of this improvement is that the operator can pinch one end of the waterproof membrane and drag it outward, thereby quickly separating the waterproof membrane from the breathable surface layer and the skin.

[0017] To ensure the effectiveness of drug injection into the reservoir;

[0018] As a further improvement to the above technical solution: the height of the microneedle is 380 micrometers, and the soluble microneedle includes a soluble gel and an active pharmaceutical ingredient, wherein the active pharmaceutical ingredient is Poria cocos polysaccharide.

[0019] The beneficial effects of this improvement are: compared with oral administration of Poria cocos polysaccharide, microneedle injection of Poria cocos polysaccharide can precisely control the dosage, greatly improve the absorption and utilization of the drug, and also avoid the obvious first-pass effect of the liver present in oral Poria cocos polysaccharide.

[0020] To improve the user comfort of this microneedle patch;

[0021] As a further improvement to the above technical solution: the interior of the breathable surface layer is filled with a buffer layer, which is positioned directly above the soluble microneedles.

[0022] The beneficial effects of this improvement are: the buffer layer provides a buffering and protective function, protecting the wound formed after soluble microneedle puncture.

[0023] The parts of the device not covered herein are the same as or can be implemented using existing technologies. Attached Figure Description

[0024] Figure 1 This is a cross-sectional view of the present invention;

[0025] Figure 2 This is a schematic diagram of the structure of this utility model after the hard base layer has been removed;

[0026] Figure 3 This is a schematic diagram of the structure of the soluble microneedles after dissolution in this utility model;

[0027] Figure 4 This is a schematic diagram of the structure of this utility model after the waterproof membrane layer has been removed;

[0028] In the diagram: 1. Rigid substrate; 2. Waterproof membrane; 3. Breathable surface layer; 4. Buffer layer; 5. Soluble microneedles; 51. Substrate; 52. Microneedles; 6. Drug storage chamber. Detailed Implementation

[0029] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be described in detail below with reference to the accompanying drawings. The description in this part is only exemplary and explanatory, and should not be used to limit the scope of protection of the present invention in any way.

[0030] Example 1:

[0031] like Figure 1As shown in Figure 4: A microneedle patch includes soluble microneedles 5. The soluble microneedles 5 are composed of a substrate 51 and a plurality of microneedles 52 formed on the bottom of the substrate 51. The edge of the substrate 51 is bonded to one side of a waterproof membrane layer 2. The waterproof membrane layer 2 is bonded to a rigid base layer 1. The soluble microneedles 5 are disposed in a cavity formed by the rigid base layer 1 and the waterproof membrane layer 2. A drug storage cavity 6 for filling active drug components is formed between the waterproof membrane layer 2 and the soluble microneedles 5. The other side of the waterproof membrane layer 2 is bonded to... The patch has a breathable surface layer 3, one end of which is bonded to a rigid base layer 1. Using a shallow microneedle puncture method, the drug is injected through channels formed by the microneedles 52 after dissolving in the soluble microneedles 52, which are filled in the drug storage cavity 6. This increases the drug storage capacity of the patch, and the percutaneous microneedle approach allows for precise dosage control, improving drug absorption and utilization, and reducing the first-pass effect in the liver. The rigid base layer 1 has grooves with a depth not less than the height of the microneedles 52. These grooves provide isolation space for the microneedles 52. The microneedles 52 are effectively isolated and protected. The waterproof membrane layer 2 is an e-PTFE waterproof and breathable membrane. The waterproof membrane layer 2, together with the soluble microneedles 5, provides a sealed cavity for the drug storage chamber 6, isolating it from the outside world and preventing leakage. The waterproof membrane layer 2 is coated with adhesive on one side, and one end of the waterproof membrane layer 2 is located outside the breathable surface layer 3. The operator can pinch one end of the waterproof membrane layer 2 and drag it outward, thereby quickly separating the waterproof membrane layer 2 from the breathable surface layer 3 and the skin. The height of the microneedles 52 is 380 micrometers. The soluble microneedle 5 includes a soluble gel and an active pharmaceutical ingredient, namely Poria cocos polysaccharide. Compared with oral administration of Poria cocos polysaccharide, microneedle injection of Poria cocos polysaccharide can precisely control the dosage, greatly improve the absorption and utilization of the drug, and avoid the obvious first-pass effect of the liver present in oral administration of Poria cocos polysaccharide. The breathable surface layer 3 is filled with a buffer layer 4, which is located directly above the soluble microneedle 5. The buffer layer 4 plays a buffering and protective role to protect the wound formed after puncture of the soluble microneedle 5.

[0032] The working principle of this technical solution is as follows: When using this patch, firstly, the rigid base layer 1 is peeled off from the waterproof membrane layer 2 and the breathable surface layer 3. Then, the soluble microneedles 5 are facing the skin, and the patch is applied to the skin. At this time, one end of the breathable surface layer 3 and the waterproof membrane layer 2 are adhered to the skin, allowing the microneedles 52 to stably penetrate into the skin. Pressing the breathable surface layer 3 makes the substrate 51 adhere tightly to the skin surface. After the substrate 51 and microneedles 52 dissolve rapidly upon contact with water or interdermal fluid, the user presses the buffer layer 4 located above the drug storage cavity 6, allowing the drug storage cavity 6 to be directly guided to the epidermis or upper dermis through the channel formed by the microneedles 52. After the drug injection is completed, the user peels off the waterproof membrane layer 2 and then presses the breathable surface layer 3, making the other end of the breathable surface layer 3 adhere to the skin surface as well, thus achieving breathable protection of the injection site.

[0033] It should be noted that, in this document, the terms “comprising,” “including,” or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0034] This article uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only for the purpose of helping to understand the method and core ideas of the present invention. The above descriptions are only preferred embodiments of the present invention. It should be noted that due to the limitations of textual expression, there are objectively infinite specific structures. For those skilled in the art, several improvements, modifications, or changes can be made without departing from the principles of the present invention, and the above technical features can also be combined in an appropriate manner. These improvements, modifications, changes, or combinations, or the direct application of the inventive concept and technical solution to other situations without modification, should all be considered within the scope of protection of the present invention.

Claims

1. A microneedle patch, characterized by: The application relates to a dissolvable microneedle (5) which is composed of a substrate (51) and a plurality of microneedles (52) formed at the bottom of the substrate (51), the edge of the substrate (51) is bonded to one side of a waterproof film layer (2), the waterproof film layer (2) is bonded to a hard base layer (1), the dissolvable microneedle (5) is arranged in a cavity formed by the hard base layer (1) and the waterproof film layer (2), a cavity for filling an active pharmaceutical ingredient storage cavity (6) is formed between the waterproof film layer (2) and the dissolvable microneedle (5), and the other side of the waterproof film layer (2) is bonded to a breathable surface layer (3), one end of the breathable surface layer (3) is bonded to the hard base layer (1).

2. The microneedle patch of claim 1, wherein: The hard base layer (1) is formed with a sink groove with a depth not less than the height of the microneedle (52).

3. The microneedle patch of claim 1, wherein: The waterproof film layer (2) is an e-PTFE waterproof breathable film.

4. The microneedle patch of claim 1, wherein: The waterproof film layer (2) is coated on one side, and one end of the waterproof film layer (2) is located outside the breathable surface layer (3).

5. The microneedle patch of claim 1, wherein: The height of the microneedle (52) is 380 microns.

6. The microneedle patch of claim 1, wherein: The breathable surface layer (3) is filled with a buffer layer (4) arranged directly above the dissolvable microneedle (5).

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