Sterilizing device for mitoxantrone hydrochloride process preparation

Abstract

The utility model discloses a degerming device for mitoxantrone hydrochloride process preparation, and relates to the technical field of pharmaceutical preparations. The top surface of the base is fixedly connected with an infrared heating cylinder, a threaded cylinder is arranged in the infrared heating cylinder, a cavity is arranged in the base, a motor is arranged in the cavity, the output shaft end of the motor is fixedly connected with a screw rod, the screw rod is located in the infrared heating cylinder, and the screw rod is matched with the threaded cylinder; a convex cylinder is fixedly connected to the outer side wall of the threaded cylinder and comprises a cylinder opening, a convex column is detachably arranged in the cylinder opening, and a bearing frame is arranged on one side of the convex column; according to the utility model, the storage tank filled with the medicament can be in a high-temperature environment, so that the medicament in the storage tank can be sterilized to achieve the required sterilization effect, and after the sterilization operation is completed, the storage tank filled with the medicament is convenient to take and place.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of pharmaceutical preparations, in particular to a mitoxantrone hydrochloride process preparation is with sterilizing device. BACKGROUND

[0002] Mitoxantrone hydrochloride is a drug for treating cancer, when preparing the liquid preparation of mitoxantrone hydrochloride, the raw materials need to be mixed first, then pH adjustment is carried out, and then filtering and sterilizing, the existing mitoxantrone hydrochloride process preparation is with sterilizing device when using, the sterilization effect is not good, and after completing the sterilization operation, it is inconvenient to take and place the storage tank containing the medicament, in view of the above problems, the inventor proposes a kind of mitoxantrone hydrochloride process preparation is with sterilizing device for solving the above problems. SUMMARY

[0003] In order to solve the problem that the existing mitoxantrone hydrochloride process preparation is with sterilizing device when using, the sterilization effect is not good, and after completing the sterilization operation, the medicament storage tank is inconvenient to take and place; The purpose of the present utility model is to provide a kind of mitoxantrone hydrochloride process preparation is with sterilizing device.

[0004] To solve the above technical problems, the utility model adopts the following technical scheme: a kind of mitoxantrone hydrochloride process preparation is with sterilizing device, including base, the top surface of the base is fixedly connected with infrared heating cylinder, the inside of the infrared heating cylinder is provided with threaded cylinder, the inside of the base is provided with chamber, the inside of the chamber is provided with motor, the output shaft end of the motor is fixedly connected with screw rod, the screw rod is located in infrared heating cylinder, and the screw rod is matched with threaded cylinder, the outer lateral wall of the threaded cylinder is fixedly connected with convex cylinder, the convex cylinder includes cylinder mouth, the cylinder mouth is detachably provided with convex column, the side of the convex column is provided with support frame.

[0005] Preferably, the side wall of the motor is provided with a base, the base is fixedly connected with the inner wall of the chamber, the output shaft of the motor penetrates the infrared heating cylinder, and the output shaft of the motor is rotatably connected with the infrared heating cylinder, the motor is installed through the base, the motor is started, and the screw rod can rotate under the action of the output shaft of the motor, the side wall of the base is provided with air hole, and one end of the air hole extends into the chamber, the air hole is used for circulating air inside and outside the chamber to cool the motor.

[0006] Preferably, the bottom surface of the threaded cylinder is fixedly connected with a sealing sleeve, the middle of the inner bottom wall of the infrared heating cylinder is provided with a notch, the sealing sleeve corresponds to and matches the notch, the inner bottom wall of the infrared heating cylinder is fixedly connected with a guide plate, the outer side wall of the threaded cylinder is provided with a guide groove, the guide plate corresponds to and is slidingly connected with the guide groove, when the motor is started, the screw rod can rotate under the action of the motor output shaft, through the cooperation of the screw rod and the threaded cylinder and the cooperation of the guide plate and the guide groove, the threaded cylinder can be lifted, thereby the supporting frame can be moved out of the infrared heating cylinder, so that the storage tank on the supporting frame can be taken and placed, when preparing the mitoxantrone hydrochloride liquid preparation, the raw materials need to be mixed first, then pH adjustment is carried out, and then filtration and sterilization are carried out, this preparation process is completely described in the "CN114601791A" one kind of mitoxantrone hydrochloride liquid preparation and its preparation method, and too much repetition is not performed here, the storage tank is used for storing the filtered medicament, the top surface of the supporting frame is provided with a stepped groove in penetration, the storage tank can be placed in the stepped groove, and then the medicament in the storage tank can be high-temperature sterilized through the infrared heating cylinder, the infrared heating cylinder is a mature product, and its principle is to work in a radiation heat transfer mode, when far infrared rays irradiate the heated object, part of the rays is reflected back, and part of the rays is penetrated, when the wavelength of the emitted far infrared rays and the absorption wavelength of the heated object are consistent, the heated object absorbs the far infrared rays, the molecules and atoms in the object resonate, strong vibration and rotation are generated, so that the temperature of the object is increased, and the purpose of heating is achieved, the medicament in the storage tank needs to be sterilized at 110-130 DEG C for 5-15 minutes to achieve the required sterilization effect.

[0007] Preferably, the side wall of the convex cylinder is provided with a threaded hole in penetration, one end of the threaded hole extends into the cylinder opening, one side of the convex cylinder is provided with a fastening knob, the rod part of the fastening knob is threadedly connected with the threaded hole, the end surface of the supporting frame is fixedly connected with a limiting disc, one side of the limiting disc away from the supporting frame is fixedly connected with the end surface of the convex column, the rod end of the fastening knob is separated from the convex column by screwing the fastening knob, so that the supporting frame can be removed, and the supporting frame can be overhauled or replaced, when the supporting frame needs to be installed, only reverse operation is needed.

[0008] Compared with the prior art, the utility model has the advantages that:

[0009] The utility model discloses, in the preparation of mitoxantrone hydrochloride liquid preparation, through infrared heating cylinder can make the storage tank that is equipped with medicament be in high temperature environment, to the medicament in the storage tank is sterilized, thereby reach the required sterilization effect.

[0010] This invention facilitates the placement and removal of storage tanks containing medicines after sterilization. Through the cooperation of the screw and the threaded cylinder, and the cooperation of the guide plate and the guide groove, the threaded cylinder can be raised, thereby allowing the support frame to be moved out of the infrared heating cylinder, so that the storage tanks on the support frame can be placed and removed. Attached Figure Description

[0011] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0012] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0013] Figure 2 This is a schematic diagram of the internal structure of the infrared heating cylinder of this utility model.

[0014] Figure 3 This is a schematic diagram of the threaded cylinder structure of this utility model.

[0015] Figure 4 This is an enlarged view of section A of this utility model.

[0016] Figure 5 This is an enlarged view of section B of this utility model.

[0017] In the diagram: 1. Base; 2. Infrared heating cylinder; 3. Cylinder cover; 4. Handle; 5. Chamber; 6. Air vent; 7. Motor; 8. Base; 9. Screw; 10. Threaded cylinder; 11. Sealing sleeve; 12. Guide plate; 13. Guide groove; 14. Protruding cylinder; 15. Cylinder opening; 16. Threaded hole; 17. Support bracket; 18. Limiting plate; 19. Protruding column; 20. Fastening knob; 21. Storage tank. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Example: Figures 1-5As shown, this utility model provides a sterilization device for the preparation of mitoxantrone hydrochloride, including a base 1, an infrared heating cylinder 2 fixedly connected to the top surface of the base 1, a threaded cylinder 10 disposed inside the infrared heating cylinder 2, a chamber 5 disposed inside the base 1, a motor 7 disposed inside the chamber 5, a screw 9 fixedly connected to the output shaft end of the motor 7, the screw 9 being located inside the infrared heating cylinder 2 and cooperating with the threaded cylinder 10, a protruding cylinder 14 fixedly connected to the outer wall of the threaded cylinder 10, the protruding cylinder 14 including a cylinder opening 15, a protruding post 19 detachably disposed inside the cylinder opening 15, and a support frame 17 disposed on one side of the protruding post 19.

[0020] A base 8 is provided on the side wall of the motor 7. The base 8 is fixedly connected to the inner wall of the chamber 5. The output shaft end of the motor 7 passes through the infrared heating cylinder 2, and the output shaft of the motor 7 is rotatably connected to the infrared heating cylinder 2.

[0021] By adopting the above technical solution, the motor 7 is installed on the base 8. When the motor 7 is started, the screw 9 can rotate under the action of the output shaft of the motor 7.

[0022] The side wall of the base 1 is provided with an air hole 6, and one end of the air hole 6 extends into the chamber 5.

[0023] By adopting the above technical solution, the air hole 6 is used to allow air to circulate inside and outside the chamber 5 in order to dissipate heat from the motor 7.

[0024] A sealing sleeve 11 is fixedly connected to the bottom surface of the threaded cylinder 10. A notch is provided in the middle of the inner bottom wall of the infrared heating cylinder 2. The sealing sleeve 11 corresponds to and fits with the notch. A guide plate 12 is fixedly connected to the inner bottom wall of the infrared heating cylinder 2. A guide groove 13 is provided on the outer side wall of the threaded cylinder 10. The guide plate 12 corresponds to and slides with the guide groove 13.

[0025] By adopting the above technical solution, when the motor 7 is started, the screw 9 can rotate under the action of the output shaft of the motor 7. Through the mutual cooperation between the screw 9 and the threaded cylinder 10, and the cooperation between the guide plate 12 and the guide groove 13, the threaded cylinder 10 can be raised, thereby moving the support frame 17 out of the infrared heating cylinder 2, so as to pick up and put down the storage tank 21 on the support frame 17. When preparing mitoxantrone hydrochloride liquid preparation, the raw materials need to be mixed first, then the pH is adjusted, and then filtered and sterilized. This preparation process is fully described in the publication "Mitoxantrone Hydrochloride Liquid Preparation and Preparation Method Thereof" with publication number "CN114601791A", and will not be elaborated further here. The storage tank 21 is used to store the filtered drug. The storage tank 21 is placed in a stepped groove on the top surface of the support frame 17. The agent in the storage tank 21 can then be sterilized at high temperature by the infrared heating cylinder 2. The infrared heating cylinder 2 is an existing mature product. Its principle is to work by radiation heat transfer. When far-infrared rays irradiate the object being heated, some rays are reflected back and some are penetrated. When the wavelength of the emitted far-infrared rays is consistent with the absorption wavelength of the object being heated, the object absorbs the far-infrared rays. The molecules and atoms inside the object resonate, producing strong vibration and rotation, thereby raising the temperature of the object and achieving the purpose of heating. The agent in the storage tank 21 needs to be sterilized at 110-130℃ for 5-15 minutes to achieve the required sterilization effect.

[0026] A threaded hole 16 is provided through the side wall of the protruding cylinder 14. One end of the threaded hole 16 extends into the cylinder opening 15. A fastening knob 20 is provided on one side of the protruding cylinder 14. The rod of the fastening knob 20 is threadedly connected to the threaded hole 16. A limiting plate 18 is fixedly connected to the end face of the support frame 17. The side of the limiting plate 18 facing away from the support frame 17 is fixedly connected to the end face of the protruding column 19.

[0027] By adopting the above technical solution, the fastening knob 20 is turned so that the rod end of the fastening knob 20 is separated from the protrusion 19, and the support bracket 17 can be removed for inspection or replacement. When the support bracket 17 needs to be installed, the operation can be reversed.

[0028] Working principle: When using this utility model to prepare mitoxantrone hydrochloride liquid preparation, the raw materials need to be mixed first, then the pH is adjusted, and then the solution is filtered and sterilized. The filtered medicine can be stored in the storage tank 21. The storage tank 21 can be placed in the support frame 17. After placing the storage tank 21, the lid 3 is closed by the handle 4.

[0029] Next, the infrared heating cylinder 2 is controlled to heat the agent in the storage tank 21 to a temperature of 110-130°C, and sterilization is required for 5-15 minutes to achieve the desired sterilization effect.

[0030] After the sterilization process is completed, when the cylinder cover 3 is opened and the motor 7 is started, the screw 9 can rotate under the action of the output shaft of the motor 7. Through the cooperation between the screw 9 and the threaded cylinder 10, and the cooperation between the guide plate 12 and the guide groove 13, the threaded cylinder 10 can be raised, thereby allowing the support frame 17 to be moved out of the infrared heating cylinder 2, so that the storage tank 21 on the support frame 17 can be picked up and put on.

[0031] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A sterilization device for the preparation of mitoxantrone hydrochloride, comprising a base (1), characterized in that: An infrared heating cylinder (2) is fixedly connected to the top surface of the base (1). A threaded cylinder (10) is provided inside the infrared heating cylinder (2). A chamber (5) is provided inside the base (1). A motor (7) is provided inside the chamber (5). A screw (9) is fixedly connected to the output shaft end of the motor (7). The screw (9) is located inside the infrared heating cylinder (2) and the screw (9) cooperates with the threaded cylinder (10). A protruding cylinder (14) is fixedly connected to the outer wall of the threaded cylinder (10). The protruding cylinder (14) includes a cylinder opening (15). A protruding post (19) is detachably provided inside the cylinder opening (15). A support frame (17) is provided on one side of the protruding post (19).

2. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, The motor (7) has a base (8) on its side wall, and the base (8) is fixedly connected to the inner wall of the chamber (5).

3. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, The side wall of the base (1) is provided with an air hole (6), and one end of the air hole (6) extends into the chamber (5).

4. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, The output shaft of the motor (7) passes through the infrared heating cylinder (2), and the output shaft of the motor (7) is rotatably connected to the infrared heating cylinder (2).

5. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, A sealing sleeve (11) is fixedly connected to the bottom surface of the threaded cylinder (10), and a notch is provided in the middle of the inner bottom wall of the infrared heating cylinder (2). The sealing sleeve (11) corresponds to and cooperates with the notch.

6. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, The inner bottom wall of the infrared heating cylinder (2) is fixedly connected to a guide plate (12), and the outer side wall of the threaded cylinder (10) is provided with a guide groove (13). The guide plate (12) and the guide groove (13) correspond to each other and are slidably connected.

7. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, The side wall of the protruding cylinder (14) is provided with a threaded hole (16), one end of which extends into the cylinder opening (15). A fastening knob (20) is provided on one side of the protruding cylinder (14), and the rod of the fastening knob (20) is threadedly connected to the threaded hole (16).

8. The sterilization device for the preparation of mitoxantrone hydrochloride as described in claim 1, characterized in that, The end face of the support frame (17) is fixedly connected to the limiting plate (18), and the side of the limiting plate (18) facing away from the support frame (17) is fixedly connected to the end face of the protrusion (19).

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