Glaucoma spinning drainage tube and preparation device thereof

Abstract

The utility model discloses a glaucoma spinning drainage tube and a preparation device thereof, which can improve the in-situ property of the drainage tube and reduce the occurrence of complications such as retraction of the drainage tube into a tunnel or separation of the drainage tube from an anterior chamber. The glaucoma spinning drainage tube comprises a drainage tube body and a spinning layer arranged on the outer surface of the drainage tube body, and the spinning layer is of a net-shaped structure. The preparation device comprises a base, vertical plates are arranged on the two sides of the base, one vertical plate is provided with a fixed seat and a sliding seat which are used for clamping the conductive receiving tube, and the other vertical plate is provided with a spinning device which can slide up and down. With the adoption of the glaucoma spinning drainage tube, fibrosis after the drainage tube is implanted can be reduced, so that the functional life of the drainage tube after the drainage tube is implanted is prolonged; by adopting the glaucoma spinning drainage tube preparation device disclosed by the utility model, the control can be simplified; and the spinning receiving pipes with different lengths can be conveniently mounted.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of medical devices, especially a glaucoma spinning drainage tube and its preparation device. BACKGROUND

[0002] Glaucoma is a kind of optic nerve pathological disease, often caused by intraocular pressure rise, has become the second largest blind cause in the world. Traditional glaucoma filtration surgery includes trabeculectomy and glaucoma drainage device implantation, and the two surgeries are based on the same principle: creating another drainage pathway, making aqueous humor escape from the anterior chamber of the eye, draining to the subconjunctival / sub-Tenon space, forming a liquid reservoir called filtering bleb.

[0003] Glaucoma is a chronic, progressive optic nerve degenerative disease, and it is the first irreversible blindness in the world. Elevated intraocular pressure is the most important and only controllable risk factor for glaucoma. Surgery is an important treatment for glaucoma, and traditional glaucoma filtration surgery includes trabeculectomy and glaucoma drainage device implantation. The principle is to establish a new aqueous humor dynamic balance, or reduce the amount of aqueous humor, or increase the outflow of aqueous humor, so that the intraocular pressure is reduced to a safe range. Glaucoma drainage tube in glaucoma drainage device has the characteristics of significant and continuous reduction of intraocular pressure, minimally invasive approach, good biocompatibility, etc.

[0004] Glaucoma drainage tube is a minimally invasive implant device, and its surgical process is convenient and fast, and it provides a new treatment approach for refractory glaucoma patients and doctors. However, the current glaucoma drainage tube implantation to reduce intraocular pressure still leads to postoperative complications, such as drainage tube retraction into the tunnel or prolapse into the anterior chamber, Tenon fiber encapsulating cyst, etc., which greatly reduces the success rate of glaucoma drainage tube surgery.

[0005] Therefore, the utility model provides a kind of glaucoma spinning drainage tube;Through electrospinning technology, a layer of spinning coating is covered on glaucoma drainage tube, to solve the complications existing after glaucoma drainage tube implantation.

[0006] However, the existing glaucoma drainage tube spinning device will cause the conductive silk collection tube to bend under the action of gravity during the spinning process to the conductive silk collection tube due to the thin conductive wire in the drainage tube, thereby affecting the spinning effect of the drainage tube and causing the spinning layer on the surface of the drainage tube to be not uniform. UTILITY MODEL CONTENT

[0007] The technical problem to be solved by the utility model is to provide a glaucoma spinning drainage tube capable of improving the in-situ property of the drainage tube and reducing the occurrence of complications such as drainage tube retraction into the tunnel or prolapse into the anterior chamber.

[0008] The utility model discloses a glaucoma spinning drainage tube, including drainage tube body and the spinning layer of drainage tube body outer surface arrangement, the spinning layer is the network structure.

[0009] Further, the drainage tube body and the spinning layer are made of biological material; the biological material is polyisobutylene-based thermoplastic elastomer or styrene-based thermoplastic elastomer;

[0010] Specifically, the polyisobutylene-based thermoplastic elastomer uses SIBS; the SIBS refers to polystyrene-b-isobutylene-b-styrene three-block copolymer.

[0011] Further, the thickness of the spinning layer is 0.01-0.03 mm.

[0012] Further, the inner diameter of the glaucoma spinning drainage tube is 0.07 mm.

[0013] Further, the outer diameter of the glaucoma spinning drainage tube is 0.23-0.27 mm.

[0014] The utility model discloses still provided a kind of preparation device of the glaucoma spinning drainage tube, including base;The base one end is provided with first vertical plate, the other end is provided with second vertical plate;

[0015] The first vertical plate is provided with vertical guide rail;The first vertical plate lower end is provided with fixed base;The fixed base one end is fixedly connected with the first vertical plate, and the other end is provided with the first vertical pivot that penetrates the one end of fixed base;Vertical guide rail on the first vertical plate is installed with sliding seat;The one end of sliding seat is slidably connected with vertical guide rail;The other end is provided with the second vertical pivot that penetrates the one end of sliding seat;The first vertical pivot is coaxial with the second vertical pivot;The first vertical plate is provided with the first linear drive device of driving sliding seat to move up and down;

[0016] The fixed base below is provided with drive motor;Driving motor is connected with driving shaft;The driving shaft one end is drivingly connected with the shaft of drive motor, and the other end is spline shaft;

[0017] The driving shaft one end passes through fixed base, sliding seat in proper order;The driving shaft is provided with first transmission wheel;Sliding seat is provided with annular connecting boss;The annular connecting boss is connected with second transmission wheel;

[0018] The second transmission wheel has the center spline hole matched with spline shaft;The second transmission wheel one end is provided with connecting sleeve;The connecting sleeve is sleeved on annular connecting boss, and is rotationally connected with annular connecting boss through bearing;The spline shaft passes through center spline hole, and is matched with center spline hole.

[0019] The first vertical rotating shaft is provided with a first driven wheel at one end and a first rotary chuck at the other end; and the second vertical rotating shaft is provided with a second driven wheel at one end and a second rotary chuck at the other end.

[0020] The first driven wheel corresponds to and is in transmission connection with a first transmission wheel; and the second driven wheel corresponds to and is in transmission connection with a second transmission wheel.

[0021] A conductive receiving pipe is arranged between the first rotary chuck and the second rotary chuck; a sliding plate that can move up and down is arranged on the second vertical plate; a second linear driving device that drives the sliding plate to move up and down is arranged on the second vertical plate; and a spinning device is arranged on the sliding plate.

[0022] Specifically, the first linear driving device comprises a first vertical screw rod; the first vertical screw rod is located on one side of the first vertical plate; a first support plate is arranged at the top end of the first vertical plate; a first driving motor that drives the first vertical screw rod to rotate is arranged on the first support plate; and the first vertical screw rod passes through the sliding seat and is in threaded cooperation with the sliding seat.

[0023] Specifically, the second linear driving device comprises a second vertical screw rod; the second vertical screw rod is located on one side of the second vertical plate; a second driving motor that drives the second vertical screw rod to rotate is arranged at the lower end of the second vertical screw rod; and the second vertical screw rod passes through the sliding plate and is in threaded cooperation with the sliding plate.

[0024] Specifically, the first driven wheel and the first transmission wheel and the second driven wheel and the second transmission wheel are all in belt transmission connection.

[0025] The green light spinning drainage tube has the following advantages:

[0026] 1. The surface spinning layer of the green light spinning drainage tube can be used as an extracellular matrix (ECM) simulation support (mesh structure), which can reproduce the morphology of protein fibers, and at the same time, a loose microenvironment is utilized to promote cell adhesion, migration, growth and differentiation.

[0027] 2. The surface spinning fiber layer of the green light spinning drainage tube can create a suitable environment for cell migration, thereby guiding tissue to grow into the spinning coating layer, improving the in-situ property of the drainage tube, and reducing the occurrence of complications such as the drainage tube retracting into the tunnel or falling out of the anterior chamber.

[0028] 3. The glaucoma spun fiber drainage tube of this utility model retains the surface spun fiber layer structure after implantation, and the cells are integrated within the surface nanofiber layer. There is no obvious protein deposition or implant encapsulation on the surface, which minimizes fibrosis after drainage tube implantation and thus prolongs the functional lifespan of the drainage tube after implantation.

[0029] The glaucoma spinning drainage tube preparation device described in this utility model has the following advantages:

[0030] 1. By setting the device vertically, the downward bending of the diversion tube during the spinning process can be avoided due to gravity;

[0031] 2. By driving the spindle through the fixed seat and the sliding seat, the rotating shafts on both the fixed seat and the sliding seat use the same rotation drive device, thus facilitating the synchronous rotation of the two rotating chucks and simplifying control.

[0032] 3. The distance between the two rotating clamps can be adjusted by sliding the sliding seat, thus facilitating the installation of spinning receiving tubes of different lengths. Attached Figure Description

[0033] Figure 1 This is a schematic diagram of the structure of the glaucoma spinning tube in an embodiment of this utility model;

[0034] Figure 2 This is a physical image of the glaucoma spinning tube in an embodiment of this utility model;

[0035] Figure 3 This is a schematic diagram of the spinning layer on the glaucoma spinning tube in an embodiment of this utility model;

[0036] Figure 4 This is a schematic diagram of the glaucoma spinning tube preparation device in an embodiment of this utility model;

[0037] Figure 5 This is a schematic diagram of the installation structure of the second transmission wheel in an embodiment of this utility model;

[0038] Figure 6 This is a schematic diagram showing the position of the glaucoma spinning drainage tube implanted in the rabbit's eye in an embodiment of this utility model;

[0039] Figure 7 These are in-situ diagrams of the glaucoma drainage tubes after implantation in embodiments of this utility model, including both spun and unspun tubes.

[0040] The diagram shows: 1-drainage tube body, 2-spinning layer, 100-base, 200-fixed seat, 300-sliding seat, 400-drive motor, 500-first drive motor, 600-sliding plate, 700-second drive motor, 800-spinning device, 900-conductive receiving tube. DETAILED DESCRIPTION

[0041] The utility model is further explained below in connection with the drawings and examples.

[0042] As Figures 1 to 3 The glaucoma filament drainage tube of the utility model, including drainage tube body 1 and the filament layer 2 of drainage tube body 1 outer surface setting, the filament layer 2 is the network structure.

[0043] The drainage tube body 1 and filament layer 2 all adopt biological material to make, the biological material is polyisobutylene-based thermoplastic elastomer or styrene-based thermoplastic elastomer,

[0044] Specifically, the biological material polyisobutylene-based thermoplastic elastomer, and polyisobutylene-based thermoplastic elastomer adopts SIBS, and SIBS is poly (styrene-b-isobutylene-b-styrene) tri-block copolymer.

[0045] The thickness of the filament layer is 0.01-0.03 mm. The inner diameter of the glaucoma filament drainage tube is 0.07 mm. The outer diameter of the glaucoma filament drainage tube is 0.23-0.27 mm.

[0046] The glaucoma filament drainage tube of the utility model, its surface filament layer 2 can be used as extracellular matrix (ECM) simulation support (network structure), can reproduce the morphology of protein fiber, and a loose microenvironment is utilized to promote cell adhesion, migration, growth and differentiation. Secondly, as Figure 3 The surface filament fiber layer of filament layer 2 can create a suitable environment for cell migration, thereby guiding tissue to grow into the filament coating and improving the in-situ property of the drainage tube and reducing the occurrence of complications such as drainage tube retraction into the tunnel or expulsion from the anterior chamber.

[0047] Thirdly, the glaucoma filament drainage tube of the utility model, after implantation, the surface filament fiber layer structure is retained, and the cells are integrated in the surface nanofiber layer, and there is no obvious protein deposition or implant encapsulation on the surface, which maximally reduces the fibrosis after implantation of the drainage tube, thereby prolonging the functional life after implantation of the drainage tube.

[0048] The utility model further provides a kind of device for preparing above-mentioned glaucoma filament drainage tube, as Figure 4 And 5 The preparation device of glaucoma filament drainage tube includes base 100, one end of the base 100 is provided with first vertical plate 110, and the other end is provided with second vertical plate 120.

[0049] The first vertical plate 110 is provided with a vertical guide rail 130; the lower end of the first vertical plate 110 is provided with a fixed seat 200; one end of the fixed seat 200 is fixedly connected with the first vertical plate 110, and the other end is provided with a first vertical rotating shaft 210 penetrating through one end of the fixed seat 200; the vertical guide rail 130 of the first vertical plate 110 is installed with a sliding seat 300; one end of the sliding seat 300 is in sliding fit with the vertical guide rail 130; the other end is provided with a second vertical rotating shaft 310 penetrating through one end of the sliding seat 300; the first vertical rotating shaft 210 is coaxial with the second vertical rotating shaft 310; the first vertical plate 110 is provided with a first linear drive device for driving the sliding seat 300 to move up and down;

[0050] The fixed seat 200 is provided below with a driving motor 400; the driving motor 400 is connected with a driving transmission shaft 410; one end of the driving transmission shaft 410 is in transmission connection with the rotating shaft of the driving motor 400, and the other end is a spline shaft 420;

[0051] One end of the driving transmission shaft 410 penetrates through the fixed seat 200 and the sliding seat 300 in sequence; the driving transmission shaft 410 is provided with a first transmission wheel 430; the sliding seat 300 is provided with an annular connecting boss 340; the annular connecting boss 340 is connected with a second transmission wheel 350;

[0052] The second transmission wheel 350 has a central spline hole 351 matched with the spline shaft 420; the second transmission wheel 350 is provided at one end with a connecting sleeve 353; the connecting sleeve 353 is sleeved on the annular connecting boss 340 and is in rotary fit with the annular connecting boss 340 through a bearing 360; the spline shaft 420 penetrates through and cooperates with the central spline hole 351;

[0053] One end of the first vertical rotating shaft 210 is provided with a first driven wheel 220, and the other end is provided with a first rotary chuck 230; one end of the second vertical rotating shaft 310 is provided with a second driven wheel 320, and the other end is provided with a second rotary chuck 330;

[0054] The first driven wheel 220 corresponds to and is in transmission connection with the first transmission wheel 430; the second driven wheel 320 corresponds to and is in transmission connection with the second transmission wheel 350;

[0055] The first rotary chuck 230 and the second rotary chuck 330 are provided with a conductive receiving pipe 900 therebetween; the second vertical plate 120 is provided with a sliding plate 600 which can move up and down; the second vertical plate 120 is provided with a second linear drive device for driving the sliding plate 600 to move up and down; the sliding plate 600 is provided with a spinning device 800.

[0056] Specifically in the application process:

[0057] Firstly, the first linear driving device is started to move the sliding seat 300 to the upper end of the first vertical plate 110, then one end of the conductive receiving tube 900 is installed on the first rotating chuck 230 on the fixed seat 200, then the first linear driving device is started to make the sliding seat 300 slide downward, so that the second rotating chuck 330 clamps the other end of the conductive receiving tube 900.

[0058] In the process of collecting the wire of the conductive receiving tube 900, the driving motor 400 drives the driving shaft 410 to rotate; the driving shaft 410 drives the first transmission wheel 430 to rotate, thereby driving the first driven wheel 220 to rotate; and the driving shaft 410 drives the second transmission wheel 350 to rotate, thereby driving the second driven wheel 320 to rotate; so as to ensure that the first vertical rotating shaft 210 and the second vertical rotating shaft 310 rotate synchronously; and simplify the synchronous control.

[0059] In the process of spinning, the second linear driving device is started to move the sliding plate 600 up and down, so that the spinning device 800 can move up and down; so as to realize spinning and ensure that the full length of the conductive receiving tube 900 can realize spinning.

[0060] Specifically, the spinning device 800 includes a spinning head and a syringe pump; the spinning solution is pressurized by the syringe pump, and the spinning solution is sprayed out through the spinning head.

[0061] Specifically, the conductive receiving tube 900 is a glaucoma drainage tube wrapped with a stainless steel wire; the stainless steel wire is fixed on the electrospinning negative electrode; the stainless steel wire is wrapped inside the glaucoma drainage tube to ensure that the drainage tube is a hollow tube with an inner diameter of 0.07mm.

[0062] In a feasible embodiment, in order to facilitate control, simplify the structure, and have a guiding effect, the first linear driving device includes a first vertical screw rod 510; the first vertical screw rod 510 is located on one side of the first vertical plate 110; the first vertical plate 110 is provided with a first support plate 150 at the top end; the first support plate 150 is provided with a first driving motor 500 for driving the first vertical screw rod 510 to rotate; one end of the first vertical screw rod 510 penetrates through the sliding seat 300 and is threadedly matched with the sliding seat 300. The second linear driving device includes a second vertical screw rod 710; the second vertical screw rod 710 is located on one side of the second vertical plate 120; the second vertical screw rod 710 is provided with a second driving motor 700 at the lower end for driving the second vertical screw rod 710 to rotate; the second vertical screw rod 710 penetrates through the sliding plate 600 and is threadedly matched with the sliding plate 600.

[0063] In a feasible embodiment, in order to facilitate the implementation of the transmission connection and the installation and maintenance of the transmission connection, the first driven wheel 220 and the first transmission wheel 430, as well as the second driven wheel 320 and the second transmission wheel 350, are all connected by belt drive.

[0064] The process of fabricating a glaucoma spinning drainage tube using the above-mentioned glaucoma spinning drainage tube preparation device includes the following steps:

[0065] 1. The drainage tube body is prepared using an extrusion process.

[0066] 2. An electrospinning method is used to prepare a spinning layer on the body of the drainage tube.

[0067] The glaucoma drainage tube is fixed to the negative electrode of the electrospinning machine, such as... Figure 4 The conductive receiving tube 900 shown serves as an electrospun fiber collector. Using electrospun technology, the spinning liquid is sprayed into oriented fibers through the spinning device 800 under the action of an electric field. The translation speed of the injection pump of the spinning device 800, the tilt angle and rotation speed of the conductive receiving tube 900 are adjusted to make the oriented fibers adhere to the outer wall of the glaucoma drainage tube and be evenly cross-wound, thereby forming a spinning coating with a mesh fiber structure.

[0068] Specifically, the glaucoma drainage tube is fixed to the electrospinning negative electrode with stainless steel wire, and the stainless steel wire is wrapped inside the glaucoma drainage tube to ensure that the drainage tube is a hollow tube with an inner diameter of 0.07mm.

[0069] The spinning solution is a SIBS spinning solution; the spinning solution includes SIBS polymer, tetrahydrofuran (THF), and N,N-dimethylformamide (DMF); the ratio of THF to DMF is 90:10. The concentration of the SIBS spinning solution is 13%-15%; preferably, the concentration of the SIBS spinning solution is 14%.

[0070] 3. Place the glaucoma spinning tube obtained in step 2 into a vacuum oven at 60-75℃ for drying and heating.

[0071] Specifically, after the glaucoma spinning drainage tube is formed, it is dried in a vacuum oven at 60-75℃ for 12 hours. Drying in a vacuum oven at 60-75℃ for 12 hours does not affect the physicochemical properties of the glaucoma spinning drainage tube and can remove excess organic reagent residues from the spinning coating.

[0072] The glaucoma spinning drainage tube prepared by the above method has a large specific surface area of ​​the spinning coating fiber and exhibits a fibrous structure similar to the extracellular matrix, which simulates the network structure of the natural extracellular matrix and can provide a good microenvironment for cell adhesion and proliferation on the glaucoma spinning drainage tube.

[0073] The orientation of the spun coating fiber can create a suitable environment for cell migration, guide tissue to grow into the spun coating, increase the bonding force between the glaucoma filament drainage tube and the tissue, reduce the displacement of the glaucoma filament drainage tube after being implanted into the eye, and thus improve the in-situ property of the glaucoma filament drainage tube.

[0074] Example 1 of preparing a glaucoma filament drainage tube

[0075] The glaucoma drainage tube (conductive receiving tube 900) is fixed on the electrospinning negative electrode as the electrospinning collector. 1.4 g of SIBS polymer is dissolved in 10 ml of THE / DMF (90:10) mixed solution, magnetically stirred for more than 2 h, and left to remove bubbles to obtain a SIBS spinning solution. The SIBS spinning solution is electrospun at room temperature, the injection rate of the injection pump of the spinning device 800 is set to 1.5 mm / min, the spinning working voltage is adjusted to 17 kv, the distance between the spinning device 800 and the conductive receiving tube 900 is 10 cm, and the rotation rate of the collector (conductive receiving tube 900) is 50 rpm / min to prepare a glaucoma filament drainage tube. Under the rotation of the collector, the spun filaments ejected by the strong electric field rotate uniformly to the outer wall of the drainage tube, the spinning device 800 is moved up and down, a mesh-like spun coating with a fiber diameter of 1-3 μm and a thickness of 0.01-0.015 mm is formed on the surface, and the drainage tube is taken out and dried in a vacuum oven at 60°C to obtain a glaucoma filament drainage tube, as shown in Figure 2 .

[0076] Example 2:

[0077] The glaucoma drainage tube (conductive receiving tube 900) is fixed on the electrospinning negative electrode as the electrospinning collector. 1.4 g of SIBS polymer is dissolved in 10 ml of THE / DMF (90:10) mixed solution, magnetically stirred for more than 2 h, and left to remove bubbles to obtain a SIBS spinning solution. The SIBS spinning solution is electrospun at room temperature, the injection rate of the injection pump of the spinning device 800 is set to 1.5 mm / min, the spinning working voltage is adjusted to 17 kv, the distance between the spinning device 800 and the conductive receiving tube 900 is 10 cm, and the rotation rate of the collector (conductive receiving tube 900) is 50 rpm / min to prepare a glaucoma filament drainage tube. Under the rotation of the collector, the spun filaments ejected by the strong electric field rotate uniformly to the outer wall of the drainage tube, the spinning device 800 is moved up and down, a mesh-like spun coating with a fiber diameter of 1-3 μm and a thickness of 0.01-0.015 mm is formed on the surface, and the drainage tube is taken out and dried in a vacuum oven at 60°C to obtain a glaucoma filament drainage tube, as shown in Figure 3 .

[0078] Example 3:

[0079] The glaucoma drainage tube (conductive receiving tube 900) is fixed on the electrostatic spinning negative electrode as the electrostatic spinning collector; 1.4 g of SIBS polymer is dissolved in 10 ml of THE / DMF (90:10) mixed solution, and is magnetically stirred for 2 h or more, and is left to remove bubbles, to obtain a SIBS spinning solution; the SIBS spinning solution is electrospun at room temperature, the injection pump of the spinning device 800 is set to an injection rate of 2 mm / min, the spinning working voltage is adjusted to 15 kv, the spinning machine receiving distance is 10 cm, and the conductive receiving tube 900 is rotated at a speed of 50 rpm / min, to prepare a glaucoma spinning drainage tube; under the rotating action of the collector, the spinning ejected by the strong electric field rotates uniformly to the outer wall of the drainage tube, the spinning device 800 is moved up and down, a spinning coating with a fiber diameter of 1-3 μm and a thickness of 0.02-0.03 mm is formed on the surface of the drainage tube, and the drainage tube is taken out and dried in a vacuum oven at 60°C to obtain a glaucoma spinning drainage tube.

[0080] Application example of glaucoma spinning drainage tube

[0081] The glaucoma spinning drainage tube is cut into a size of 7 mm / rod, and then the spinning drainage tube is loaded into a disposable glaucoma drainage tube implantation system, so as to facilitate the ophthalmologist to manually inject and deliver the drainage tube to the predetermined position. The glaucoma spinning drainage tube is implanted into the eye through the angle of the scleral puncture, and a permanent channel is established through the sclera, so that the aqueous humor flows from the anterior chamber into the subconjunctival space. (A total of 17 cases were implanted). As shown in the small frame in Figure 6 The spinning coating drainage tube is easily observed in the angle of the anterior chamber. After different time of implantation in the experimental eye, the in-situ property is calculated by the forward moving distance of the drainage tube, and the result is shown in Figure 7 The glaucoma spinning drainage tube basically has no obvious displacement and has good in-situ property. After two months, the glaucoma spinning drainage tube still maintains the flow, and there is no phenomenon of tissue fiber wrapping the tube port to block the drainage tube; and when the spinning drainage tube is pulled out, obvious resistance can be felt, while the coating drainage tube can be easily taken out, which is obviously compared.

[0082] Application comparative example of glaucoma drainage tube:

[0083] The glaucoma drainage tube is cut into a size of 7 mm / rod by a tool, and then the drainage tube is loaded into a glaucoma drainage tube implantation system. The glaucoma drainage tube is implanted into the eye through the angle of the scleral puncture by using the glaucoma drainage tube implantation system, so that the aqueous humor can be smoothly drained to the subconjunctival space (a total of 17 cases were implanted). As shown in the large frame in Figure 6 The glaucoma drainage tube is not easily observed in the angle of the anterior chamber. After different time of implantation in the experimental eye, the in-situ property is calculated by the forward moving distance of the drainage tube, and the result is shown in Figure 7As shown, the drainage tube has a large displacement with the extension of the implantation time, and has a poor position. After two months, the drainage tube is easily removed when pulled out, and no obvious resistance is felt, which is obviously different from the spinning drainage tube.

[0084] The above is only the preferred embodiment of the present application, but the protection scope of the present application is not limited to this. Any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A glaucoma drainage device characterized by: The drainage tube body (1) and the spinning layer (2) are made of a biomaterial.

2. The glaucoma drainage device of claim 1, wherein: The biomaterial is a polyisobutylene-based thermoplastic elastomer or a styrene-based thermoplastic elastomer. The polyisobutylene-based thermoplastic elastomer is SIBS, and SIBS refers to a polystyrene-b-isobutylene-b-styrene triblock copolymer.

3. The glaucoma drainage device of claim 1, wherein: The thickness of the spinning layer is 0.01-0.03 mm.

4. The glaucoma drainage device of claim 3, wherein: The inner diameter of the glaucoma spinning drainage tube is 0.07 mm.

5. The glaucoma drainage device of claim 4, wherein: The outer diameter of the glaucoma spinning drainage tube is 0.23-0.27 mm.

6. A device for the production of a glaucoma drainage filament according to any one of claims 1 to 5, characterized in that: The base (100) is provided with a first vertical plate (110) at one end and a second vertical plate (120) at the other end. The first vertical plate (110) is provided with a vertical guide rail (130); the lower end of the first vertical plate (110) is provided with a fixing seat (200); one end of the fixing seat (200) is fixedly connected with the first vertical plate (110), and the other end is provided with a first vertical rotating shaft (210) penetrating one end of the fixing seat (200); the vertical guide rail (130) of the first vertical plate (110) is installed with a sliding seat (300); one end of the sliding seat (300) is in sliding fit with the vertical guide rail (130); the other end is provided with a second vertical rotating shaft (310) penetrating one end of the sliding seat (300); the first vertical rotating shaft (210) is coaxial with the second vertical rotating shaft (310); the first vertical plate (110) is provided with a first linear driving device for driving the sliding seat (300) to move up and down. A driving motor (400) is arranged below the fixing seat (200); the driving motor (400) is connected with a driving transmission shaft (410); one end of the driving transmission shaft (410) is in transmission connection with the rotating shaft of the driving motor (400), and the other end is a spline shaft (420); One end of the driving transmission shaft (410) penetrates the fixing seat (200) and the sliding seat (300) in sequence; the driving transmission shaft (410) is provided with a first transmission wheel (430); the sliding seat (300) is provided with an annular connecting boss (340); the annular connecting boss (340) is connected with a second transmission wheel (350); The second transmission wheel (350) has a center spline hole (351) matched with the spline shaft (420); the second transmission wheel (350) is provided with a connecting sleeve (353) at one end; the connecting sleeve (353) is sleeved on the annular connecting boss (340) and is in rotary fit with the annular connecting boss (340) through a bearing (360); the spline shaft (420) penetrates the center spline hole (351) and cooperates with the center spline hole (351); The first vertical rotating shaft (210) is provided with a first driven wheel (220) at one end and a first rotary chuck (230) at the other end; the second vertical rotating shaft (310) is provided with a second driven wheel (320) at one end and a second rotary chuck (330) at the other end; The first driven wheel (220) corresponds to the first transmission wheel (430) and is in transmission connection; the second driven wheel (320) corresponds to the second transmission wheel (350) and is in transmission connection; The first rotary chuck (230) and the second rotary chuck (330) are provided with a conductive receiving pipe (900) therebetween; the second vertical plate (120) is provided with a sliding plate (600) that can move up and down; the second vertical plate (120) is provided with a second linear driving device that drives the sliding plate (600) to move up and down; the sliding plate (600) is provided with a spinning device (800).

7. The glaucoma drainage device of claim 6, wherein: The first linear driving device comprises a first vertical screw rod (510); the first vertical screw rod (510) is located at one side of the first vertical plate (110); the first vertical plate (110) is provided at the top end with a first support plate (150); the first support plate (150) is provided with a first driving motor (500) that drives the first vertical screw rod (510) to rotate; one end of the first vertical screw rod (510) passes through the sliding seat (300) and is in threaded cooperation with the sliding seat (300).

8. The glaucoma drainage device of claim 6, wherein: The second linear driving device comprises a second vertical screw rod (710); the second vertical screw rod (710) is located at one side of the second vertical plate (120); the lower end of the second vertical screw rod (710) is provided with a second driving motor (700) that drives the second vertical screw rod (710) to rotate; the second vertical screw rod (710) passes through the sliding plate (600) and is in threaded cooperation with the sliding plate (600).

9. The glaucoma drainage device of claim 6, wherein: The first driven wheel (220) and the first transmission wheel (430) and the second driven wheel (320) and the second transmission wheel (350) are all in belt transmission connection.

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