Mouse dosing device

Abstract

The utility model discloses a mouse drug delivery device, and belongs to the technical field of animal experiments. The device comprises a dosing box and a plurality of atomizers fixed on the dosing box, and further comprises a plurality of atomization cavities and a standing chamber which are formed in the dosing box, the atomization cavities correspond to the atomizers in position, the standing chamber is correspondingly located below the atomization cavities, and an isolation assembly is movably arranged between the atomization cavities in a penetrating mode. A glass plate and a timer are arranged on two sides of the dosing box; the isolation component is used for isolating and cooperating with a plurality of atomizers for drug administration, and atomized drugs with different concentrations are provided to act on mice in different standing chambers, so that the mice in the standing chambers have a good contrast effect, and the experimental result is more accurate and more scientific; continuous administration of a single atomizer is matched with fixed-point isolation through the isolation assembly, and the administration time of the standing chambers on the two sides can be controlled; therefore, experimenters can better understand the action mechanism of the medicine under different conditions, and the experiment accuracy is improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of animal experiment technology, specifically to a mouse dosing device. BACKGROUND

[0002] A mouse dosing device is a device used to provide drugs or other compounds to mice, usually laboratory mice, in experimental research. These devices ensure accurate dosing, administration method, and timing of the drug, so that researchers can effectively evaluate the efficacy and safety of the drug. The common administration methods include injection, oral administration, inhalation, and skin administration. Among them, the inhalation administration method often uses an aerosol device to cooperate to achieve corresponding dose administration; this method can directly send the drug into the respiratory tract and lungs, so that the drug is rapidly absorbed into the blood, thereby increasing the effective concentration of the drug; and this method can be designed for continuous or intermittent administration, so that researchers can simulate the effect of long-term treatment.

[0003] In the prior art, for example, a patent with application number CN202022058604.8 discloses a "mouse dosing device. The device includes an aerosol main machine and an aerosol container, the aerosol main machine is connected to the aerosol container through a pipeline; wherein the end of the pipeline extending into the aerosol container is equipped with a breathing mask, the aerosol container is equipped with a heating device and a temperature sensor, and the side wall of the aerosol container is equipped with a positioning device. The mouse dosing device in the utility model can control the temperature in the aerosol container through the heating device and the temperature controller, prevent the influence of low temperature on the experimental mice, fix the experimental mice through the breathing mask and the positioning device, ensure the stable inhalation amount of the experimental mice, and provide reliable and stable experimental results."

[0004] Although this device can use an aerosol container to achieve the purpose of dosing mice, it only sets up a single dosing device for dosing, and does not set up multiple combined dosing devices; compared with a single dosing device, multiple dosing devices have the advantages of: comparing the effects of different treatment groups in the same experiment, thereby improving the reliability and comparability of the results, and helping researchers better understand the mechanism of action of drugs under different conditions, thereby providing more information for subsequent research. In view of the above, a new mouse dosing device needs to be designed to solve the above problems.

[0005] The information disclosed in this BACKGROUND section is only for the purpose of enriching the understanding of the background of the present disclosure and should not be regarded as acknowledging or implying in any form that this information constitutes prior art known to those skilled in the art. UTILITY MODEL CONTENT

[0006] This disclosure provides a mouse drug delivery device designed to address the problems existing in the prior art.

[0007] According to one aspect of this disclosure, a mouse drug delivery device is provided, including a drug delivery box, a plurality of nebulizers fixed on the drug delivery box, and a plurality of nebulization chambers and a settling chamber opened in the drug delivery box. The positions of the nebulization chambers correspond to the positions of the nebulizers, and the settling chamber is located below the nebulization chambers. An isolation component is also movably disposed between the nebulization chambers. A glass plate and a timer are also provided on both sides of the drug delivery box. The nebulizers output nebulized drugs, and the drugs can be administered to mice in the settling chambers through the nebulization chambers.

[0008] Furthermore, the drug delivery box also includes an atomizing port located between the atomizing chamber and the settling chamber, a horizontal partition installed horizontally within the settling chamber, and vertical partitions installed at equal intervals within the settling chamber. The horizontal and vertical partitions divide the settling chamber into settling compartments of equal size, and a partition opening is provided at the top of the horizontal partition. The use of horizontal and vertical partitions can effectively isolate each experimental mouse, making it easier for researchers to conduct experimental observations.

[0009] Furthermore, the drug delivery box also includes a sealing groove between the atomizing chambers and an abutment plate fixed downwards to the top of the atomizing chambers, the abutment plate being attached to the left side of the isolation component; by using the sealing groove to engage with the isolation component, the atomizing chambers can be effectively isolated.

[0010] Furthermore, the isolation assembly includes a main body block that is locked between the atomizing chambers, a limiting block located at the upper end of the main body block, a protrusion located at the lower end of the main body block, and a push handle installed at the upper end of the limiting block. The protrusion is locked in the sealing groove, and the limiting block is locked outside the drug delivery box and fits against the drug delivery box. The limiting block and the protrusion can ensure the sealing of the atomizing chamber.

[0011] Furthermore, a movable sealing component is also installed on the top of the atomizing chamber, which abuts against the right side of the isolation component; the sealing component ensures that the device remains sealed when the isolation component is removed.

[0012] Furthermore, the sealing assembly includes a positioning plate fixed on the atomizing chamber, connecting slots fixed on both sides of the positioning plate, multiple movable columns movably passing through the positioning plate, and a sealing block fixed on the left end of the movable columns. The sealing block is attached to the surface of the atomizing chamber, and a spring is also sleeved on the movable column between the positioning plate and the sealing block.

[0013] Furthermore, the sealing block includes an inclined plate extending to its left side and snap-fit ​​protrusions extending to its front and rear sides. The end of the inclined plate abuts against the isolation component, and the snap-fit ​​protrusions are movably engaged in the connection slot. The inclined plate and the abutment plate cooperate with each other to achieve a sealing effect.

[0014] Further, the outer side of the dosing box is also provided with a clamping plate groove corresponding to the outer side of the static chamber, and the glass plate is movably clamped in the clamping plate groove; the glass plate helps the experimenter to observe the activity of the mice in the static chamber.

[0015] Further, the atomizer is also connected with an input pipeline, the end of the input pipeline is communicated with the atomization cavity, and the lower end of the input pipeline at the middle position of the dosing box is also provided with a three-way spray head which is extendedly arranged in the atomization cavity; the three-way spray head can uniformly provide the atomized medicine to each static chamber.

[0016] The one or more technical solutions provided in the embodiments of the application have at least the following technical effects or advantages:

[0017] 1. The device of the application uses the isolation assembly to isolate and cooperate with multiple atomizers for dosing, can control the dose of medicine of each static chamber, uses the isolation assembly to be arranged between the atomization cavities, forms an independent space for each atomization cavity and the static chamber, and then uses the atomizer to provide atomized medicine with different concentrations to act on the mice in different static chambers, so that the mice in the static chambers can play a good control role, and the experimental results are more accurate and scientific.

[0018] 2. The device of the application uses the continuous dosing of a single atomizer and the point isolation by using the isolation assembly, can realize the control of the dosing time of different static chambers, uses the atomizer at the middle position and uniformly doses multiple atomization cavities through the three-way spray head, so that the waste of atomized medicine can be avoided, and the consistency of the dosing amount can be ensured; during the continuous dosing, the dosing time of the static chambers on both sides can be controlled by using the isolation assembly; different dosing times can effectively play a control role, and at the same time, help the experimenter to better understand the mechanism of the medicine under different conditions, and improve the accuracy of the experiment. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is a structure schematic view of the dosing device in the utility model;

[0020] Figure 2 It is a front view of the dosing device in the utility model;

[0021] Figure 3 It is Figure 2 It is an enlarged schematic view of A part in the utility model;

[0022] Figure 4 It is a structure schematic view of the dosing device in the utility model;

[0023] Figure 5 It is a structure schematic view of the isolation assembly in the utility model;

[0024] Figure 6 It is a structure schematic view of the sealing assembly in the utility model.

[0025] In the above figures, 1, the administration box; 11, atomization cavity; 111, atomization port; 12, static chamber; 121, vertical partition; 13, clamping groove; 15, sealing groove; 16, abutment plate; 17, horizontal partition; 171, partition port; 2, atomizer; 21, input pipeline; 22, three-way spray head; 3, glass plate; 4, isolation assembly; 41, main body block; 411, protruding block; 42, limiting block; 43, push handle; 5, timer; 6, sealing assembly; 61, positioning plate; 62, movable column; 63, sealing block; 631, inclined plate; 632, clamping protrusion; 64, spring; 65, connecting bayonet. DETAILED DESCRIPTION

[0026] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inner", "outer", "vertical", "horizontal", "clockwise", "counterclockwise" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. The "first", "second" and the like involved in the present application are used to distinguish the described objects, and do not have any order or technical meaning. The "connection", "coupling" involved in the present application includes direct and indirect connection (coupling) unless otherwise specified.

[0027] The mouse administration device provided by the embodiments of the present application solves the problem that the mouse administration device in the prior art can only administer drugs individually and cannot administer drugs for comparison. In order to better understand the technical solutions of the present application, the above technical solutions will be described in detail below in combination with the drawings of the specification and specific embodiments.

[0028] The present example discloses a mouse administration device, referring to Figures 1-6The device comprises a drug delivery box 1, a plurality of atomizers 2 fixed on the drug delivery box 1, a plurality of atomizing cavities 11 and a static chamber 12 opened in the drug delivery box 1, the atomizing cavities 11 correspond to the positions of the atomizers 2, the static chamber 12 is correspondingly located below the atomizing cavities 11, a separation assembly 4 is movably arranged between the atomizing cavities 11, and glass plates 3 and a timer 5 are arranged on both sides of the drug delivery box 1; the atomizers 2 output atomized drugs, and the atomizing cavities 11 can be used to deliver drugs to mice in the static chamber 12. The drug delivery box 1 further comprises an atomizing opening 111 opened between the atomizing cavities 11 and the static chamber 12, a horizontal partition plate 17 horizontally arranged in the static chamber 12, and vertical partition plates 121 vertically arranged in the static chamber 12 at equal intervals, the horizontal partition plate 17 and the vertical partition plates 121 divide the static chamber 12 into static sub-chambers of equal size, and a partition plate opening 171 is further opened in the top of the horizontal partition plate 17; the horizontal partition plate 17 and the vertical partition plates 121 can effectively isolate each experimental mouse, facilitating better observation by the experimental personnel. The drug delivery box 1 further comprises a sealing groove 15 arranged between the atomizing cavities 11 and an abutting plate 16 fixed downward on the top of the atomizing cavities 11, the abutting plate 16 is attached to the left side of the separation assembly 4; the sealing groove 15 cooperates with the separation assembly 4 to be connected, which can effectively isolate the atomizing cavities 11.

[0029] The separation assembly 4 comprises a main block 41 clamped between the atomizing cavities 11, a limiting block 42 arranged on the upper end of the main block 41, a protruding block 411 arranged on the lower end of the main block 41, and a pushing handle 43 mounted on the upper end of the limiting block 42, the protruding block 411 is clamped in the sealing groove 15, and the limiting block 42 is clamped outside the drug delivery box 1 and attached to the drug delivery box 1; the limiting block 42 and the protruding block 411 can ensure the sealing of the atomizing cavities 11.

[0030] A movable sealing assembly 6 is further mounted on the top of the atomizing cavities 11, and the sealing assembly 6 abuts the right side of the separation assembly 4; the sealing assembly 6 can ensure that the device is still in a sealed state when the separation assembly 4 is removed. The sealing assembly 6 comprises a positioning plate 61 fixed on the atomizing cavities 11, connecting sockets 65 fixed on both sides of the positioning plate 61, a plurality of movable columns 62 movably arranged on the positioning plate 61, and sealing blocks 63 fixed on the left end of the movable columns 62, the sealing blocks 63 are attached to the surface of the atomizing cavities 11, and springs 64 are sleeved on the movable columns 62 between the positioning plate 61 and the sealing blocks 63. The sealing block 63 comprises an inclined plate 631 extending on the left side thereof and clamping protrusions 632 extending on the front and rear sides thereof, the end of the inclined plate 631 abuts on the separation assembly 4, and the clamping protrusions 632 are movably clamped in the connecting sockets 65, the inclined plate 631 cooperates with the abutting plate 16 to achieve a sealing effect.

[0031] The outer side of the administration box 1 is also provided with a clamping plate groove 13 corresponding to the outer side of the static chamber 12, and the glass plate 3 is movably clamped in the clamping plate groove 13. The glass plate 3 helps the experimenter to observe the activity of the mice in the static chamber 12.

[0032] The atomizer 2 is also connected with an input pipeline 21, the end of which is communicated with the atomization cavity 11, and the lower end of the input pipeline 21 at the middle position of the administration box 1 is also provided with a three-way spray head 22 which is extendedly arranged in the atomization cavity 11. The three-way spray head 22 can uniformly provide the atomized medicine to each static chamber 12.

[0033] In the implementation of the device, first open the glass plate 3, and place the experimental mouse to be administered in the static compartment, and ensure that one mouse in one compartment, then close the glass plate 3, and start the corresponding atomizer 2 to atomize the mouse in the administration box 1. In the atomization administration of the device, the atomizer 2 cooperates with the isolation assembly 4 to realize the control of the administration time and the administration dose in different static compartments 12; when the administration dose is the experimental variable, the respective static compartments 12 need to be administered separately; in this process, first ensure that the isolation assembly 4 is arranged between the atomization cavities 11, so that each atomization cavity 11 and the static compartment 12 are independent spaces, and then start the atomizer 2 to spray the corresponding static compartment 12; since each static compartment 12 is provided with an independent atomizer 2, different concentrations of atomized drugs can be provided to the respective static compartments 12, so as to realize the control of the administration dose; the use of different doses of drugs on mice in different areas can play a good control effect, and synchronous administration can ensure the consistency of the administration environment, so that the influence of the external environment on the experimental results can be avoided, and the experimental results are more accurate and scientific; when the administration time is the experimental variable, pull out the isolation assembly 4, at this time the atomization cavities 11 are interconnected; at the same time, the inclined plate 631 is attached to the abutment plate 16 under the elastic force of the spring 64, and seals the corresponding position of the gap, so as to avoid the overflow of the atomized drug; then start the atomizer 2 in the middle position, the atomizer 2 inputs the atomized drug from the input pipeline 21 into the atomization cavity 11, and sprays to the left and right and downward through the three-way spray head 22, the atomized drug sprayed to the left and right enters the corresponding atomization cavity 11, and enters the static compartment 12 through the corresponding atomization port 111 to administer the mouse; the use of the same atomizer 2 for synchronous administration of multiple static compartments 12 can not only avoid the waste of atomized drugs, but also ensure the consistency of the administration dose; during continuous administration, the administration time can be judged according to the timer 5, and at the same time the administration time of the static compartments 12 on both sides is controlled by the isolation assembly 4; when the isolation assembly 4 is used for isolation, the protruding block 411 enters the corresponding gap and displaces, when it displaces downward, the protruding block 411 continuously pushes the inclined plate 631 to move to the right side, until the protruding block 411 is clamped into the sealing groove 15, and then the isolation of the corresponding atomization cavity 11 is completed, the isolated atomization cavity 11 and the static compartment 12 are cut off from the atomization administration and form an independent space, so as to realize the control of the administration time in the corresponding area; the use of different administration times on mice in different static compartments 12 can effectively play a control effect, and at the same time, it is also helpful for the experimental personnel to better understand the mechanism of the drug under different conditions, and improves the accuracy of the experiment. In addition, the atomizer 2 used in the device is a prior art, and the specific working principle is not described herein.

[0034] While several preferred embodiments of the present application have been described, one skilled in the art will readily recognize that other modifications and variations can be made thereto without departing from the spirit and scope of the application. Accordingly, it is intended that there be included within the scope of the application whatever modifications and variations are resorted to by those skilled in the art in light of the above teachings. The claims should therefore be construed to cover any such modifications and variations.

[0035] It will be apparent to those skilled in the art that various modifications and variations can be made to the present application without departing from the spirit or scope of the application. Thus, it is intended that the present application cover modifications and variations of this application provided they come within the scope of the appended claims and their equivalents.

Claims

1. A mouse drug delivery device, comprising a drug delivery box (1) and a plurality of nebulizers (2) fixed on the drug delivery box (1), characterized in that, It also includes multiple nebulizing chambers (11) and a settling chamber (12) opened in the drug delivery box (1). The nebulizing chambers (11) correspond to the positions of the nebulizer (2), and the settling chamber (12) is located below the nebulizing chambers (11). An isolation component (4) is also movably installed between the nebulizing chambers (11). A glass plate (3) and a timer (5) are also provided on both sides of the drug delivery box (1).

2. The mouse drug delivery device according to claim 1, characterized in that, The drug delivery box (1) also includes an atomizing port (111) opened between the atomizing chamber (11) and the settling chamber (12), a horizontal partition (17) horizontally arranged in the settling chamber (12), and vertical partitions (121) equidistantly arranged in the settling chamber (12). The horizontal partition (17) and the vertical partition (121) divide the settling chamber (12) into settling compartments of equal size. A partition opening (171) is also opened at the top of the horizontal partition (17).

3. The mouse drug delivery device according to claim 2, characterized in that, The drug delivery box (1) also includes a sealing groove (15) between the atomizing chambers (11) and an abutment plate (16) fixed downward on the top of the atomizing chambers (11), the abutment plate (16) being attached to the left side of the isolation assembly (4).

4. The mouse drug delivery device according to claim 3, characterized in that, The isolation component (4) includes a main body block (41) that is locked between the atomizing chambers (11), a limiting block (42) located at the upper end of the main body block (41), a protrusion block (411) located at the lower end of the main body block (41), and a push handle (43) installed at the upper end of the limiting block (42). The protrusion block (411) is locked in the sealing groove (15), and the limiting block (42) is locked outside the drug delivery box (1) and fits against the drug delivery box (1).

5. The mouse drug delivery device according to claim 3, characterized in that, A movable sealing component (6) is also installed on the top of the atomizing chamber (11), and the sealing component (6) abuts against the right side of the isolation component (4).

6. The mouse drug delivery device according to claim 5, characterized in that, The sealing assembly (6) includes a positioning plate (61) fixed on the atomizing chamber (11), connecting slots (65) fixed on both sides of the positioning plate (61), multiple movable columns (62) movably passing through the positioning plate (61), and a sealing block (63) fixed on the left end of the movable column (62). The sealing block (63) fits against the surface of the atomizing chamber (11), and a spring (64) is also sleeved on the movable column (62) between the positioning plate (61) and the sealing block (63).

7. The mouse drug delivery device according to claim 6, characterized in that, The sealing block (63) includes an inclined plate (631) extending on its left side and snap-fit ​​protrusions (632) extending on its front and rear sides. The end of the inclined plate (631) abuts against the isolation component (4), and the snap-fit ​​protrusions (632) are movably snapped into the connection slot (65).

8. The mouse drug delivery device according to claim 1, characterized in that, The outside of the drug delivery box (1) is also provided with a card slot (13), which corresponds to the outside of the settling chamber (12), and the glass plate (3) is movably locked in the card slot (13).

9. The mouse drug delivery device according to claim 1, characterized in that, The atomizer (2) is also connected to an input pipe (21), the end of which is connected to the atomizing chamber (11). A three-way nozzle (22) is also provided at the lower end of the input pipe (21) in the middle of the dosing box (1), and the three-way nozzle (22) extends into the atomizing chamber (11).

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