Nasal cavity administration atomization device

Abstract

A nasal cavity administration atomization device comprises a piston assembly and an atomizing pump assembly, gas in a cavity I enters a cavity II through one compression stroke or expansion stroke of an initial section of the piston assembly, and liquid or a gas-liquid mixture in the cavity II enters and fills the cavity I through the other corresponding stroke and negative pressure of the cavity II; liquid or a gas-liquid mixture in the cavity I is atomized by the nozzle through a continuous compression stroke or an expansion stroke after the initial section of the piston assembly; a positioning part is arranged in the liquid output assembly and used for abutting against the first reset assembly, and the first reset assembly is used for being matched with the piston assembly to reset. A reset assembly II is arranged on the outlet side of the liquid output assembly and used for being matched with the one-way valve assembly to reset.

Description

Technical Field

[0001] This utility model belongs to the field of nasal spray drug delivery technology, specifically relating to a nasal atomizing device for drug delivery. Background Technology

[0002] Currently, the medication delivery device used for nasal administration is usually a spray pump structure. The liquid medication is drawn into the internal channel of the spray pump by pressing the nozzle, and finally sprayed out from the nozzle at the top of the spray pump. In order to facilitate the use of medication by patients, portable medicine bottles are generally used, and patients compress the liquid themselves to form a spray and introduce it into the nasal cavity.

[0003] In existing technology, spray pumps have a normally closed nozzle structure, with a movable sub-column at the nozzle and a spring acting on the sub-column. The sub-column and spring work together to act as a one-way valve; for example, a medicinal antibacterial nasal spray applicator disclosed in Chinese Utility Model Application No. 202322795129.3. When the spray pump is not in use, the sub-column is tightly fitted to the nozzle under the action of the spring, preventing both internal liquid leakage and external air entry. When the spray pump is in use, pressing the nozzle draws the liquid into the internal channel of the spray pump and acts on the sub-column. Under the action of liquid pressure, the sub-column moves away from the nozzle, allowing the liquid to be sprayed out through the nozzle. After one spray is completed, the liquid pressure disappears, and the sub-column returns to its original position under the action of the spring, quickly closing the nozzle.

[0004] The piston structure of the aforementioned spray pump includes two pistons: a main piston fixed inside the nozzle and capable of moving up and down with the nozzle, and a secondary piston fixed to the pump body. However, the main piston in this structure is relatively complex, comprising a piston body, an inner piston sleeve located on the inner circumference of the piston body, a piston core located on the inner circumference of the inner piston sleeve, and a piston outlet groove formed within the inner piston sleeve. The piston body is quite long, with its lower end extending into the pump body, while the lower end of the piston core extends into the secondary piston. Furthermore, to ensure sealing, sealing flanges are required at the lower end of the piston core of the main piston and the upper end of the outer circumference of the secondary piston. Ultimately, this results in a complex structure for both the main and secondary pistons. Since both the main and secondary pistons are injection-molded products, the structure of the injection molds used to produce them is also complex, leading to significant deformation during production and compromising the reliable performance of the piston structure.

[0005] The device has the following problems: the pressure required for nasal drug delivery is too high, making operation inconvenient. At the same time, production costs need to be considered to further reduce the economic cost of the product. In addition, the range of elastic force is difficult to adjust, so improvements are needed. Utility Model Content

[0006] The purpose of this utility model is to provide a nasal drug delivery nebulizer, including a piston assembly and a spray pump assembly. The piston assembly and the spray pump assembly are used to draw in and atomize the drug. The piston assembly includes piston I, piston II, and piston III. The spray pump assembly includes a main column, a secondary column, a reset assembly II, a pressing cover, a reset assembly I, a drug delivery pressurization device, a sealing cover, a sealing gasket, and a container.

[0007] In the initial stage of the piston assembly, a compression or expansion stroke allows gas from chamber I to enter chamber II. In the next corresponding stroke, chamber II is under negative pressure, allowing liquid or gas-liquid mixture in chamber II to enter and fill chamber I. The continuous compression or expansion stroke following the initial stage of the piston assembly atomizes the liquid or gas-liquid mixture in chamber I through the nozzle. The continuous compression or expansion stroke following the initial stage of the piston assembly unlocks the one-way valve assembly. A one-way valve assembly is installed before the nozzle. During the continuous compression or expansion stroke following the initial stage of the piston assembly, the liquid or gas-liquid mixture in chamber I opens the one-way valve assembly.

[0008] The liquid output assembly has an internal positioning part for contacting the reset assembly I, which is used to reset the piston assembly; the liquid output assembly has a reset assembly II on the outlet side, which is used to reset the check valve assembly.

[0009] The reset assembly I includes a first support ring I and a first support ring II. A first main helical spring I and a first main helical spring II are disposed between the first support ring I and the first support ring II, and the first main helical spring I and the first main helical spring II are rotated out of position. A first auxiliary helical spring I and a first auxiliary helical spring II are disposed between the first main helical spring I and the first main helical spring II, and the first auxiliary helical spring I and the first auxiliary helical spring II are rotated out of position.

[0010] The technical solution provided in this application also has the following technical features:

[0011] Preferably, in one embodiment of this application, the cross-section of the helical springs of reset component I and reset component II is not circular, but a polygon with a variable of four or more.

[0012] Preferably, in one embodiment of this application, the inner diameter of the first support ring I and the first support ring II is greater than twice the width of the first main helical spring I and the first main helical spring II; the dimensions of the first main helical spring I and the first main helical spring II are greater than the dimensions of the first auxiliary helical spring I and the first auxiliary helical spring II; the reset assembly II includes a second support ring I and a second support ring II, with the second helical spring I and the second helical spring II disposed between the second support ring I and the second support ring II, and the second helical spring I and the second helical spring II are offset and rotated; the inner diameter of the second support ring I and the second support ring II is less than four times the width of the second helical spring I and the second helical spring II.

[0013] Preferably, in one embodiment of this application, the liquid output component is equipped with a protective cover; the outer surface of the middle part of the protective cover is provided with an anti-slip part; the lower end of the protective cover has a notch at the fastening edge, the notch is used for venting air from the inside of the protective cover when it is fastened and for drawing air from the inside of the protective cover when it is pulled out; two notches are symmetrically arranged; the inside of the protective cover is provided with a sealing contact part, which is used to abut against the nozzle of the liquid output component to isolate air pollution; a reinforcing rib I is provided around the sealing contact part to strengthen the structural strength of the protective cover; a reinforcing rib II is provided on the side of the protective cover near the notch to strengthen the structural strength of the protective cover; the protective cover locks with the liquid output component through the reinforcing rib II, and the locking mechanism is formed by limiting the movement through friction and elasticity.

[0014] Preferably, in one embodiment of this application, the reset component II and / or the reset component I are metal parts.

[0015] Preferably, in one embodiment of this application, the side surface of the container is provided with sealing protrusion I and sealing protrusion II, and the inner surface of the sealing cap is provided with at least two annular grooves. The container forms a seal by embedding the sealing protrusion I and sealing protrusion II into the annular grooves of the sealing cap.

[0016] The upper surface of the container is provided with a sealing protrusion I, and a sealing gasket is provided between the upper surface of the container and the sealing cap. The lower surface of the sealing gasket is provided with a sealing groove, which is embedded in the sealing protrusion I to form a mating seal.

[0017] Preferably, in one embodiment of this application, a gas compensation channel is provided between the cavity containing the drug and the outside to eliminate the negative pressure formed in the cavity after continuous drug output; the gas compensation channel includes a sealing cap, a through hole at the gap between the drug delivery pressurizing device and the sealing cap, and the through hole connects to the cavity where the reset component I is located; the gas compensation channel includes a gap between the sealing cap and the pressing cap, a gap between the sealing cap and the liquid output component, and a gap between the drug delivery pressurizing device and the liquid output component; the liquid output component is provided with an air inlet groove, and the drug delivery pressurizing device is provided with an air inlet groove; the gas compensation channel is provided with a filter device, which includes a filter sleeve, a filter membrane, and a filter membrane inner core.

[0018] Preferably, in one embodiment of this application, the spray pump assembly includes a sealing cap mounted on the upper end of the container, a drug delivery pressurization device fixed inside the sealing cap, a liquid output assembly movable up and down mounted on the drug delivery pressurization device, a piston assembly fixed inside the liquid output assembly, and a one-way valve assembly, with an output port provided at the top of the liquid output assembly.

[0019] Preferably, in one embodiment of this application, the piston assembly includes piston I, piston II, and piston III; piston I includes a pressure-bearing sealing part sealed and fixed within the liquid output assembly, a cavity column I fixed on the inner periphery of the pressure-bearing sealing part, a liquid storage tank connected between the pressure-bearing sealing part and the cavity column I, and a through hole opened on the liquid storage tank; piston II is a cylindrical structure and is sealed and fixed on the outer periphery of the cavity column I, and a through part II is opened between piston II and the cavity column I; piston III is sealed and fixed at the lower end of the cavity column I and / or piston II, and a through part III is opened between piston II and piston III; a one-way valve assembly is disposed between piston I and the output port of the liquid output assembly, and the through part III, the through part II, the through hole, and the one-way valve assembly are sequentially connected.

[0020] Preferably, in one embodiment of this application, the drug delivery pressurization device is provided with an outer cavity that is slidably sealed to the outer periphery of piston II and an inner cavity that is slidably sealed to the inner periphery of piston III. A fluid exchange chamber communicating with the inner cavity of the container is provided in the inner cavity. A pressure chamber is formed between the outer cavity, the inner cavity, piston II and piston III. The pressure chamber is connected to the lower side of the conductive part III. The drug delivery pressurization device is provided with a sealing release part at the bottom of the pressure chamber and a conductive part I is provided on the sealing release part.

[0021] When the liquid output component is not pressed down, piston III separates from the inner cavity;

[0022] When the liquid output component is pressed down but not fully, piston III slides and seals with the inner cavity. Piston III is located on the upper side of the unsealed part, and the pressure chamber is not connected to the fluid exchange chamber.

[0023] When the liquid output component is pressed down to the bottom, piston III contacts and engages with the sealing release part, and the pressure chamber is connected to the fluid exchange chamber through the conduction part I.

[0024] Preferably, in one embodiment of this application, the conductive part II is at least one groove formed on the outer peripheral surface of the cavity column I, and the conductive part III is at least one groove formed on the outer peripheral surface of the cavity column III.

[0025] Preferably, in one embodiment of this application, the lower end of piston II is provided with sealing part II, which slides and seals with the inner circumferential surface of the outer cavity; piston III is provided with sealing part III at the lower end of cavity column III, which slides and seals with the outer circumferential surface of the inner cavity.

[0026] Preferably, in one embodiment of this application, the sealing part II is inclined outward and downward, the sealing part III is inclined inward and downward, and the drug delivery pressurization device is provided with a stroke limit adjustment part at the bottom of the pressure chamber, the stroke limit adjustment part being distributed on the outer periphery of the sealing release part;

[0027] When the liquid output component is pressed down to the bottom, the stroke limit adjustment part is inserted between sealing part II and sealing part III.

[0028] Preferably, in one embodiment of this application, the lower end of the inner peripheral surface of the sealing part Ⅲ is provided with a guide part Ⅲ extending outward and downward at an angle, and the upper end of the inner cavity is provided with a guide part Ⅱ extending outward and downward at an angle, and the guide part Ⅲ can contact the guide part Ⅱ.

[0029] Preferably, in one embodiment of this application, the one-way valve assembly includes a main column fixed in the top of the liquid output assembly, a secondary column movably mounted between the main column and piston I, and a reset assembly II. The main column has a valve outlet hole and a valve outlet groove. A valve outlet channel is formed between the outer peripheral surface of the secondary column and the inner peripheral surface of the liquid output assembly. The through hole, the valve outlet channel, the valve outlet hole and the valve outlet groove are connected in sequence. The secondary column has a sealing column that is slidably inserted into the main column. The upper and lower ends of the reset assembly II abut against the secondary column and piston I, respectively.

[0030] When the liquid pressure in the valve outlet channel is less than the spring force of the reset assembly II, the auxiliary column is in an upward state, and the sealing column of the auxiliary column blocks the output port.

[0031] When the liquid pressure in the valve outlet channel is greater than the spring force of the reset assembly II, the secondary column moves downward, the sealing column of the secondary column moves away from the output port, and the valve outlet groove connects with the output port.

[0032] Preferably, in one embodiment of this application, the spray pump assembly further includes a press cover fixed to the outer periphery of the liquid output assembly, a return air gap formed between the press cover and the sealing cover, a gas passage opened on the outer periphery of the lower end of the liquid output assembly, a gas exchange channel opened in the drug delivery pressurization device, a gas-liquid filtration channel formed in the drug delivery pressurization device, and a filter assembly, wherein the return air gap, the gas passage, the gas exchange channel, the gas-liquid filtration channel and the inner cavity of the container are sequentially connected.

[0033] The filter assembly includes a filter sleeve core that is tightly fitted in the gas-liquid filtration channel, a filter membrane core that is tightly fitted in the filter sleeve core, and a filter membrane. The inner circumferential surface of the filter sleeve core is provided with an inwardly protruding fixing step, and the outer edge of the filter membrane is clamped between the fixing step and the filter membrane core.

[0034] Preferably, in one embodiment of this application, the spray pump assembly further includes a reset component I, which is sleeved on the outer periphery of the outer cavity and the piston II, and the upper and lower ends of the reset component I abut against the inner peripheral surface of the liquid output component and the drug delivery pressurization device, respectively.

[0035] The beneficial effects of this application are as follows:

[0036] 1. This application provides a spray nozzle protection structure with a normally closed nozzle, which can effectively block air pollution from the inside of the spray nozzle of the liquid output component when not in use; and is equipped with a protective cover to protect the liquid output component and prevent dust, and the inside of the protective cover is provided with a protrusion to fit and seal the spray nozzle, so as to fit and seal from the outside of the spray nozzle of the liquid output component.

[0037] 2. This application provides a protective cover that facilitates insertion and removal, and is equipped with anti-slip measures to make insertion and removal easier and more convenient; in addition, a notch is provided at the lower edge of the protective cover to facilitate the flow of gas inside and outside the protective cover, reducing resistance during insertion and removal; the protective cover is equipped with reinforcing ribs inside to improve the strength of the head, and the reinforcing ribs are used to improve the strength of the lower part of the protective cover when forming a locking structure; during use, it avoids the problem of excessive force during insertion and removal, which can cause excessive deformation and structural damage.

[0038] 3. This application uses reset component I and reset component II, which are flexible and adaptable to different application scenarios. They can be combined with drug dosage, piston stroke and compression force to meet the application scenarios of spray pumps in multiple scenarios.

[0039] 4. This application provides a gas compensation channel to eliminate the negative pressure formed in the cavity after continuous drug output, avoiding the problem that the remaining drug cannot be pumped out due to the negative pressure in the bottle after a large amount of drug consumption. At the same time, a filter component is set to block liquid and filter air to ensure that the drug is not contaminated and can be fully utilized.

[0040] 5. The combined structure of the three pistons in this application simplifies the structure of the injection mold and reduces product deformation. At the same time, when piston II is assembled with piston I, piston II has a larger force-bearing surface and more balanced force distribution. Attached Figure Description

[0041] Figure 1 This is a perspective view of a nasal drug delivery nebulizer according to the present invention;

[0042] Figure 2 This is a front view of a nasal drug delivery nebulizer according to the present invention;

[0043] Figure 3 for Figure 2 DD sectional view;

[0044] Figure 4 This is a top view of a nasal drug delivery nebulizer according to the present invention;

[0045] Figure 5 This is a front view of the protective cover of a nasal drug delivery nebulizer according to the present invention;

[0046] Figure 6This is a left view of the protective cover of a nasal drug delivery nebulizer according to the present invention;

[0047] Figure 7 This is a bottom view of the protective cover of a nasal drug delivery nebulizer according to the present invention;

[0048] Figure 8 This is an EE cross-sectional view of the protective cover of a nasal drug delivery nebulizer according to the present invention;

[0049] Figure 9 This is a perspective view of the reset component I of a nasal drug delivery nebulizer according to the present invention;

[0050] Figure 10 This is a perspective view of the reset component II of a nasal drug delivery nebulizer according to the present invention;

[0051] Figure 11 for Figure 3 A magnified view of a portion of the image, F;

[0052] Figure 12 An explosion occurred in a nasal atomizing device according to this utility model. Figure 1 ;

[0053] Figure 13 An explosion occurred in a nasal atomizing device according to this utility model. Figure 2 ;

[0054] Figure 14 This is a schematic cross-sectional view of the liquid output component of a nasal drug delivery nebulizer according to the present invention.

[0055] Figure 15 This is a perspective view of the liquid output component of a nasal drug delivery nebulizer according to the present invention;

[0056] Figure 16 The three-dimensional representation of piston I of the nasal drug delivery nebulizer of this utility model. Figure 1 ;

[0057] Figure 17 The three-dimensional representation of piston I of the nasal drug delivery nebulizer of this utility model. Figure 2 ;

[0058] Figure 18 This is a perspective view of piston III of a nasal drug delivery nebulizer according to the present invention;

[0059] Figure 19 This is a top view of the drug delivery pressurization device of a nasal drug delivery nebulizer according to the present invention;

[0060] Figure 20 for Figure 19 CC-direction sectional view.

[0061] Figure 21 This is a perspective view of the main column of a nasal drug delivery nebulizer according to the present invention;

[0062] Figure 22 This is a perspective view of a nasal drug delivery nebulizer according to an embodiment of the present invention;

[0063] Figure 23 This is a top view of a nasal drug delivery nebulizer according to an embodiment of the present invention;

[0064] Figure 24 for Figure 23 AA section view;

[0065] Figure 25 for Figure 23 BB section view;

[0066] Figure 26 This is a diagram showing the state of a nasal atomizing device of this utility model when the nozzle is pressed down but not fully.

[0067] Figure 27 This is a diagram showing the state of a nasal atomizing device of this utility model when the nozzle is pressed down to the bottom.

[0068] Figure 28 This is a schematic diagram illustrating the principle of forming a sealed chamber before the nasal atomizing device of this utility model is used.

[0069] Figure 29 This is a schematic diagram illustrating the principle of gas depressurization in the sealed chamber before the nasal atomizing device of this utility model is activated. Figure 1 ;

[0070] Figure 30 This is a schematic diagram illustrating the principle of gas depressurization in the sealed chamber before the nasal atomizing device of this utility model is activated. Figure 2 ;

[0071] Figure 31 This is a schematic diagram illustrating the principle of the air compensation channel during the use of a nasal drug delivery nebulizer according to this utility model;

[0072] Figure 32 This is a schematic diagram of the air inlet groove of the liquid output component of a nasal drug delivery nebulizer according to the present invention;

[0073] Figure 33 This is a schematic diagram of the air inlet groove of the drug delivery pressurization device of the nasal drug delivery atomizing device according to the present invention;

[0074] Figure 34 This is a schematic diagram of the normally closed nozzle of a nasal drug delivery nebulizer according to the present invention in the open state.

[0075] Figure 35 This is a schematic diagram of the normally closed nozzle of a nasal drug delivery atomizing device according to the present invention in its closed state.

[0076] Figure 36 This is a schematic diagram of the combined piston of a nasal drug delivery nebulizer according to the present invention. Figure 1 ;

[0077] Figure 37 This is a schematic diagram of the combined piston of a nasal drug delivery nebulizer according to the present invention. Figure 2 ;

[0078] Figure 38 This is a schematic diagram of the combined piston of a nasal drug delivery nebulizer according to the present invention. Figure 3 ;

[0079] Figure 39 This is a schematic diagram illustrating the opening principle of the liquid outlet during the spraying process of a nasal drug delivery atomizing device according to this utility model.

[0080] Figure 40 This is a schematic diagram illustrating the principle of sealing the liquid outlet after the nasal atomizing device of this utility model has started spraying;

[0081] Figure 41 This is a schematic diagram showing the resetting of a nasal drug delivery nebulizer after it has been activated;

[0082] Components in the diagram:

[0083] 10. Container

[0084] 20. Sealing cap

[0085] 30. Drug delivery pressurization device

[0086] 31. External cavity

[0087] 32. Internal cavity

[0088] 33. Fluid exchange chamber

[0089] 34. Pressure chamber

[0090] 35. Sealed opening section

[0091] 36. Conductor I

[0092] 37. Travel limit adjustment unit

[0093] 38. Guiding Section II

[0094] 39. Gas exchange channel; 40. Liquid output assembly; 41. Output port; 42. Gas passage; 43. Positioning part; 50. Piston I

[0095] 51. Pressure-bearing sealing part; 52. Cavity column I

[0096] 53. Liquid storage tank; 54. Through hole; 60. Piston II

[0097] 61. Sealing Part II

[0098] 70. Piston III

[0099] 71. End sealing column; 72. Cavity column III

[0100] 73. Sealing Part III

[0101] 74. Guiding Section III

[0102] 81. Conductor II

[0103] 82. Conductor Section III

[0104] 90. Main column; 91. Valve outlet hole; 92. Valve outlet groove; 110. Sub-column; 111. Sealing column; 120. Reset assembly II; 130. Valve outlet channel; 140. Press cover; 151. Filter sleeve; 152. Filter membrane inner core; 153. Filter membrane.

[0105] 160. Reset Component I

[0106] 170, Liquid extraction assembly; 180, Protective cover; 190, Sealing gasket; 310, Gas-liquid filtration channel; 1201, Second helical spring I

[0107] 1202, Second Helical Spring II

[0108] 1203, Second Support Ring I

[0109] 1204, Second Support Ring II

[0110] 1601, First Main Helical Spring I

[0111] 1602, First Main Helical Spring II

[0112] 1603, First pair of spiral springs I

[0113] 1604, First pair of helical springs II

[0114] 1605, First Support Ring I

[0115] 1606, First Support Ring II

[0116] 1801, Reinforcing Rib I

[0117] 1802, Sealing contact part

[0118] 1803, notch; 1804, anti-slip part; 1805, reinforcing rib II

[0119] 1901, sealing groove 101, sealing protrusion I

[0120] 102. Sealing Protrusion II

[0121] 103. Sealing protrusion III. Detailed Implementation

[0122] The specific embodiments of this application will be further described in detail below with reference to the accompanying drawings. These embodiments are only for illustrating this application and are not intended to limit the scope of this utility model.

[0123] In the description of this utility model, it should be noted that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on this utility model. In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0124] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0125] Furthermore, in the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0126] like Figures 1 to 27 A nasal atomizing device for drug delivery, which atomizes liquid medicine and delivers it to the nasal cavity, allowing the medicine to reach the respiratory tract and lungs;

[0127] Normally closed nozzle: The liquid can be sprayed out of the nozzle, but air cannot enter the pump from the nozzle.

[0128] After being filtered, air is supplied to the pressure bottle to keep the gas inside the pressure bottle in a dust-free and sterile state, preventing the medicine from being contaminated.

[0129] The piston assembly includes piston I 50, piston II 60, and piston III 70; the spray pump assembly includes main column 90, secondary column 110, reset assembly II 120, press cover 140, reset assembly I 160, drug delivery pressurization device 30, sealing cover 20, sealing gasket 190, and container 10.

[0130] Protective cover 180: protects the liquid output component 40 and prevents dust; the part of the protective cover 180 that comes into contact with the liquid output component 40 is provided with an antibacterial coating; the antibacterial coating is a metal film, which is a silver plating layer, such as nano silver.

[0131] Main column 90: The main column 90 is fixed on the liquid output component 40. The liquid passes through the cyclone channel of the main column 90 and is mechanically stirred under pressure.

[0132] Sub-post 110: Fixed to piston I 50, forming a passage with main post 90. Through the elastic force of reset assembly II 120, the head, main post 90, and liquid output assembly 40 are in contact, forming a closed passage, preventing gas from entering. When the liquid pressure in the chamber of liquid output assembly 40 exceeds the force of reset assembly II 120, reset assembly II 120 retracts, opening sub-post 110, and liquid is ejected from liquid output assembly 40. After the liquid is ejected and pressure is released, reset assembly II 120 springs back, sealing the liquid outlet of the head.

[0133] Piston I 50: Fixed inside the liquid output assembly 40, with reset assembly II 120 placed at the head, and the lower end cooperates with piston II 60 to form a liquid outlet channel.

[0134] Piston II 60: Fixed on piston I 50, and cooperates with piston I 50, piston III 70 and drug delivery pressurization device 30 to form a sealed liquid outlet channel.

[0135] Piston III 70: Fixed on piston I 50 and piston II 60. When the press cap 140 and liquid output assembly 40 are pressed down, the lower end of piston III 70 and the drug delivery pressurization device 30 begin to seal, forming a closed chamber.

[0136] Reset component I160: A functional component that can reset the part after it is pressed all the way down and then released.

[0137] The dosing pressurization device 30 serves both as a base to fix the various components and as a key component for controlling the dosage.

[0138] Sealing gasket 190: A sealing component that works with container 10 and dosing pressurization device 30 to prevent leakage of the drug solution.

[0139] Sealing cap 20: Anti-opening component, which works with container 10 and sealing gasket 190 to prevent the medicine from being exposed.

[0140] Container 10: Contains the medicinal liquid.

[0141] Reset assembly II 120: Fixed inside the sub-pillar 110 and piston I 50, it abuts against the sub-pillar 110 so that it can close the liquid output assembly 40 port, and resets the sub-pillar 110 to create a seal after the liquid is ejected.

[0142] Liquid output assembly 40: Head base component, externally in contact with the user, internally fixing piston I 50 and main column 90 and forming a liquid outlet channel.

[0143] Press-down cover 140: Fixed to the liquid output assembly 40, it is an extension of the liquid output assembly 40. The hand presses on this part.

[0144] Filter sleeve 151: Fixed inside the drug delivery pressurization device 30, used to hold filter membrane 153.

[0145] Filter membrane 153: Used to filter bacteria in gas, allowing only air to pass through and not liquids to pass through.

[0146] Filter membrane inner core 152: Prevents filter membrane 153 from falling out, and is interference-fitted with filter membrane sleeve core 151.

[0147] Liquid extraction component 170: draws liquid from container 10, connects the inside and outside of container 10, and serves as a channel for gas and liquid transport.

[0148] The working principle and spraying mist process are as follows:

[0149] Before spraying:

[0150] a. Pressing the press cap 140 causes the piston Ⅲ70 to contact the inner column of the drug delivery pressurization device 30, initiating a seal. Figure 28 ;

[0151] b. Forming pressure chamber 34, such as Figure 28 The red-lined area;

[0152] c. Continue pressing; the gas will be gradually compressed. When piston III70 reaches position I36 of the dosing pressurization device 30, as... Figure 29 As shown, when the gas in the pressure chamber 34 is depressurized by the conductive part I 36, the gas pressure is released, such as... Figure 30 Following the path indicated by the arrow, the liquid is drained back into container 10 from the liquid collection component 170; bubbles are generated in container 10.

[0153] d. When the pressing cap 140 is released, the product as a whole begins to reset under the action of the reset component I 160. After the piston III 70 leaves the conduction part I 36 of the drug delivery pressurization device 30 and re-forms the pressure chamber 34, as the piston III 70 moves upward, the liquid in the container 10 will be drawn into the chamber due to the negative pressure.

[0154] After repeating steps a, b, c, and d several times, the chamber will be filled with liquid, and the next press will trigger the spray.

[0155] Initiation of spray:

[0156] like Figure 39 When the press cap 140 is pressed again, after the lower end of piston Ⅲ70 forms a seal with the inner column of the drug delivery pressurization device 30, the liquid in the cavity will flow upward to the sub-column 110 because the liquid is incompressible. When the liquid pressure is greater than the elastic force of the reset component Ⅱ120, the sub-column 110 moves down, the liquid outlet opens, and the liquid is sprayed out in a mist through the action of the cyclone groove of the main column 90.

[0157] It is important to note that:

[0158] Piston I 50, piston II 60, piston III 70 and the upper part are equipped with connecting parts II 81 and III 82, and the connecting parts III 82, connecting parts II 81 and piston I 50 are connected to the liquid outlet hole;

[0159] After spraying:

[0160] like Figure 40 Press the cap 140 all the way down, and after one spray, the secondary column 110 is reset and resealed under the force of the reset component II 120 to ensure a sterile environment inside the container 10.

[0161] Release and reset:

[0162] like Figure 41 Release the pressing cover 140, and the product is reset under the action of the reset component I 160. The liquid in the container 10 is drawn up along the liquid taking component 170 as the piston III 70 moves upward to replenish the volume of the sprayed spray, and waits for the next press.

[0163] Air compensation channel:

[0164] As the medicine is sprayed out, the amount of medicine in container 10 decreases. If air cannot compensate for this, a negative pressure will form inside container 10, making it difficult for the medicine to continue to be pumped out. To prevent this adverse phenomenon, a channel for air to compensate for the decrease in the amount of medicine in container 10 is designed, such as... Figure 31 As indicated by the red arrow;

[0165] like Figure 3 , Figure 32 , Figure 33 As shown, the liquid output component 40 and the drug delivery pressurization device 30 each have an air inlet slot. External gas can compensate for the air in the container 10 through the red arrow route. The filter membrane 153 can filter bacteria and impurities in the air to ensure that the air entering the container 10 is pure gas and will not contaminate the drug liquid in the container 10.

[0166] The nozzle is normally closed; the auxiliary column 110 and the reset assembly II 120 function similarly to a one-way valve; when the spray pump is not in use, under the elastic force of the reset assembly II 120, the auxiliary column 110 is tightly sealed to the liquid output assembly 40, preventing the liquid from flowing out and preventing external air from entering the dosing pressurization device 30; when the spray pump is pressed, the liquid pressure acts on the auxiliary column 110, causing the spring to compress and the auxiliary column 110 to move downward, opening the liquid outlet channel; after one spray is completed, the auxiliary column 110 quickly closes the nozzle under the action of the spring; Figure 34 When it is in the on state, such as Figure 35 It is in a closed state;

[0167] like Figure 3 , Figure 36 , Figure 37 , Figure 38 The present application features a combined three-piston structure; the piston assembly of other similar patented products consists of two parts: a main piston and a secondary piston; the piston assembly of this patent consists of three parts: piston I50, piston II60 and piston III70. The addition of piston III70 simplifies the injection mold structure and reduces product deformation; at the same time, when piston II60 is assembled with piston I50, piston II60 has a larger force-bearing surface and more balanced force distribution.

[0168] Specifically, in one embodiment of this application, the piston assembly includes piston I 50, piston II 60, and piston III 70; the spray pump assembly includes a main column 90, a secondary column 110, a reset assembly II 120, a pressing cover 140, a reset assembly I 160, a drug delivery pressurization device 30, a sealing cover 20, a sealing gasket 190, and a container 10; piston I 50, piston II 60, and piston III 70 are all injection molded parts;

[0169] In the initial stage of the piston assembly, a compression or expansion stroke causes gas from chamber I to enter chamber II. In another corresponding stroke, chamber II is under negative pressure, causing liquid or gas-liquid mixture in chamber II to enter and fill chamber I. The continuous compression or expansion strokes after the initial stage of the piston assembly cause the liquid or gas-liquid mixture in chamber I to be atomized by the nozzle.

[0170] The continuous compression or expansion stroke after the initial stage of the piston assembly unlocks the one-way valve assembly for the liquid or gas-liquid mixture in chamber I. A one-way valve assembly is provided before the nozzle. During the continuous compression or expansion stroke after the initial stage of the piston assembly, the liquid or gas-liquid mixture in chamber I opens the one-way valve assembly.

[0171] Specifically, in one embodiment of this application, the present invention provides a nasal drug delivery atomizing device, including a container 10 and a spray pump assembly. The spray pump assembly includes a sealing cap 20, a drug delivery pressurizing device 30, a liquid output assembly 40, a piston assembly, and a one-way valve assembly. The piston assembly includes piston I 50, piston II 60, and piston III 70. Piston I 50 is fixed inside the liquid output assembly 40 and has a cavity column I 52 and a through hole 54. Piston II 60 has a cylindrical structure and is sealed and fixed to the outer periphery of the cavity column I 52. Piston III 70 is sealed and fixed to the lower end of the cavity column I 52 and / or piston II 60. The drug delivery pressurizing device 30 has an outer cavity 31 and an inner cavity 32. The outer cavity 31, the inner cavity 32, piston II 60, and piston III 70 form a pressure chamber 34. The drug delivery pressurizing device 30 has a sealing release part 35 at the bottom of the pressure chamber 34, and a through part I 36 is provided on the sealing release part 35. This application sets the piston assembly in the spray pump assembly to three pistons, making the structure of each piston more streamlined, making the structure of the injection mold simpler, reducing deformation during product production, and ensuring the product quality of each piston.

[0172] Specifically, in one embodiment of this application, the piston assembly in the spray pump assembly is configured as three pistons: piston I 50, piston II 60, and piston III 70. Piston I 50 does not need to slide and seal with the drug delivery pressurization device 30. Instead, the liquid output component 40 is pressed and the liquid is drawn in through the mutual cooperation of pistons II 60 and III 70 with the drug delivery pressurization device 30. This shortens the pressure-bearing sealing part 51 of piston I 50. At the same time, piston III 70 is assembled at the lower end of piston I 50 and / or piston II 60, which simplifies piston III 70. Combined with the cylindrical structure of piston II 60, the structures of pistons I 50, II 60, and III 70 are all relatively simplified. Ultimately, the structure of each injection mold for producing pistons I 50, II 60, and III 70 is simpler, the deformation during product production is smaller, and the product quality of each piston is effectively guaranteed.

[0173] Specifically, in one embodiment of this application, it should be noted that: Figures 22-25 As shown, the protective cover 180, reset component I 160, and reset component II 120 have been removed, making it easier to observe the cross-sectional view;

[0174] The nasal atomizing device involved in this application includes a container 10 and a spray pump assembly. The container 10 contains liquid medication, and the spray pump assembly is installed at the opening at the upper end of the container 10.

[0175] like Figure 24 and Figure 25As shown, the spray pump assembly includes a sealing cap 20, a drug delivery pressurization device 30, a liquid output assembly 40, a piston assembly, and a one-way valve assembly. The container 10 is a snap-fit ​​bottle, with the sealing cap 20 fastened to the upper end of the container 10, thereby mounting the entire spray pump assembly to the upper end of the container 10. The drug delivery pressurization device 30 is fixed inside the sealing cap 20. The liquid output assembly 40 is movably mounted on the drug delivery pressurization device 30, and its top has an output port 41 for atomizing and spraying the drug solution. The plug assembly is fixed inside the liquid output assembly 40 and can move up or down with the liquid output assembly 40. The one-way valve assembly is assembled between the top of the liquid output assembly 40 and the upper end of the piston assembly. The one-way valve assembly acts on the output port 41, making the output port 41 a normally closed structure. When administering medication, the liquid is allowed to spray out from the output port 41. When not administering medication, the output port 41 is closed, and external air cannot enter the spray pump assembly from the output port 41, which plays a role in inhibiting bacteria and preventing the liquid in the container 10 from deteriorating.

[0176] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 and Figure 25 As shown, the piston assembly includes piston I 50, piston II 60 and piston III 70;

[0177] like Figure 3 , Figure 24 , Figure 25 , Figure 16 and Figure 17 As shown, piston I 50 includes a pressure-bearing sealing part 51 sealed and fixed in the liquid output assembly 40, a cavity column I 52 fixed in the inner periphery of the pressure-bearing sealing part 51, a liquid storage tank 53 connected between the upper end of the pressure-bearing sealing part 51 and the cavity column I 52, and at least one through hole 54 opened on the liquid storage tank 53. A one-way valve assembly is disposed between the top of piston I 50 and the output port 41 of liquid output assembly 40.

[0178] like Figure 24 , Figure 25 As shown, piston II60 is a cylindrical structure and is sealed and fixed on the outer periphery of cavity column I52. A conductive part II81 is provided between piston II60 and cavity column I52.

[0179] like Figure 3 , Figure 24 , Figure 25 and Figure 18 As shown, piston Ⅲ70 is sealed and fixed at the lower end of cavity column Ⅰ52 and / or piston Ⅱ60, and a connecting part Ⅲ82 is provided between piston Ⅱ60 and piston Ⅲ70; the connecting part Ⅲ82, the connecting part Ⅱ81, the connecting hole 54 and the one-way valve assembly are connected in sequence.

[0180] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 , Figure 25 , Figure 19 and Figure 20 As shown, the drug delivery pressurization device 30 has an upper and lower extending outer cavity 31 and an inner cavity 32. The inner cavity 32 has a fluid exchange chamber 33 that communicates with the inner cavity of the container 10. The outer cavity 31 is slidably sealed to the outer periphery of the piston II 60, forming a seal between them. At the same time, during the pressing of the liquid output component 40, the inner cavity 32 can be slidably sealed to the inner periphery of the piston III 70. The outer cavity 31, the inner cavity 32, the piston II 60, and the piston III 70 form a pressure chamber 34, which is an annular chamber. The pressure chamber 34 is directly connected to the lower side of the conductive part III 82. The drug delivery pressurization device 30 has a sealing release part 35 at the bottom of the pressure chamber 34 and a conductive part I 36 on the sealing release part 35.

[0181] Specifically, in one embodiment of this application, the nasal nebulizer is in its initial state when not in use, such as... Figure 3 , Figure 24 , Figure 28 , Figure 34 As shown, when the liquid output assembly 40 is not pressed down, the liquid output assembly 40, piston I 50, piston II 60, and piston III 70 are all at their respective upper limit positions of their strokes. The lower end of piston III 70 is separated from the inner cavity 32, forming a gap between them. At the same time, there is no liquid in the internal channel of the spray pump assembly, and the one-way valve assembly closes the output port 41.

[0182] When using the nasal nebulizer, the user presses down on the liquid output component 40. During this process, the liquid output component 40 moves downward, causing pistons I 50, II 60, and III 70 to move downward as well. As the liquid output component 40, pistons I 50, II 60, and III 70 move downward, firstly, as... Figure 26 , Figure 28 , Figure 29As shown in the process, piston III 70 initially contacts the outer peripheral surface of the inner cavity 32, and the two slide in a sealing engagement. However, piston III 70 is located above the sealing release part 35 and has not reached it. Therefore, through the sliding sealing engagement between piston III 70 and the inner cavity 32, and the sliding sealing engagement between piston II 60 and the outer cavity 31, a seal is formed, creating a closed pressure chamber 34. The pressure chamber 34 is not connected to the fluid exchange chamber 33; the two are separated by the seal between piston III 70 and the inner cavity 32. Subsequently, as the liquid output assembly 40 continues to be pressed, it drives pistons I 50, II 60, and III 70 to continue moving downwards, gradually reducing the volume of the pressure chamber 34 and compressing the gas within it. Then, when the liquid output assembly 40 is pressed down to the bottom, at least one of the liquid output assembly 40, piston II 60, or piston III 70 is limited by the drug delivery pressurization device 30. At this point, if... Figure 27 , Figure 29 , Figure 30 As shown, piston Ⅲ70 is in contact with the sealing release part 35, and the sealing release part 35 is provided with a conduction part Ⅰ36. The conduction part Ⅰ36 breaks the seal, and the pressure chamber 34 is connected to the fluid exchange chamber 33 through the conduction part Ⅰ36. The gas in the pressure chamber 34 is depressurized and discharged into the container 10 through the conduction part Ⅰ36, the gap between piston Ⅲ70 and the outer periphery of inner cavity 32, and the fluid exchange chamber 33. Bubbles are generated in the container 10. Finally, the user releases the pressure on the liquid output component 40, causing it to move upwards. This moves pistons I 50, II 60, and III 70 downwards. Once piston III 70 leaves the sealing release part 35, it re-seales with the inner cavity 32, thus re-forming a sealed pressure chamber 34. As the liquid output component 40, pistons I 50, II 60, and III 70 move upwards, the volume of the pressure chamber 34 gradually increases, generating negative pressure. Under this negative pressure, the liquid medicine in container 10 is drawn out. Finally, with piston III 70 separated from the inner cavity 32, the drawn-out liquid medicine flows into the pressure chamber 34. Repeatedly pressing and releasing the liquid output component 40 fills the pressure chamber 34 with liquid medicine. When the liquid output component 40 is pressed again, the liquid in the pressure chamber 34 cannot be compressed. As the volume of the pressure chamber 34 decreases, the liquid in the pressure chamber 34 flows into the conduction part Ⅲ 82, the conduction part Ⅱ 81, the conduction hole 54 and the one-way valve assembly in sequence. The one-way valve assembly is opened under the liquid pressure of the liquid, and the liquid is sprayed out in a mist through the output port 41 for drug administration.

[0183] After a single dose is administered, the liquid pressure in the spray pump assembly of the nasal nebulizer disappears, and the one-way valve assembly re-closes the output port 41, once again isolating the inside and outside of the output port 41. This prevents the internal medication from deteriorating due to contact with external air or contamination by the external environment, thus ensuring the efficacy of the internal medication.

[0184] This application sets the piston assembly in the spray pump assembly as three pistons: piston I50, piston II60 and piston III70. Piston I50, piston II60 and piston III70 are all injection molded parts and are all produced by injection molding.

[0185] In this application, pistons I 50, II 60, and III 70 are combined to function as the main piston in a prior art antibacterial nasal spray applicator. The drug delivery pressurization device 30 in this application functions as both the auxiliary piston and the pump body in a prior art antibacterial nasal spray applicator. With this configuration, in the spray pump assembly involved in this application, piston I 50 does not need to slide and seal with the drug delivery pressurization device 30. Instead, the liquid output component 40 is drawn after being pressed through the cooperation of pistons II 60 and III 70 with the drug delivery pressurization device 30, thus shortening the pressure-bearing sealing part 51 of piston I 50. Simultaneously, piston III 70 is assembled at the lower end of piston I 50 and / or piston II 60, simplifying piston III 70. Combined with the cylindrical structure of piston II 60, the structures of pistons I 50, II 60, and III 70 are all relatively streamlined. Ultimately, this simplifies the structure of the injection molds used to produce pistons I 50, II 60, and III 70, reduces deformation during production, and effectively ensures the product quality of each piston.

[0186] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 , Figure 25 and Figure 18 As shown, piston Ⅲ70 includes an end sealing post 71 and a cavity post Ⅲ72 fixed at the lower end of the end sealing post 71. The end sealing post 71 is sealed and fixed in the lower end of the cavity post Ⅰ52, and the cavity post Ⅲ72 is sealed and fixed in the lower end of piston Ⅲ70. A connecting part Ⅲ82 is formed between the cavity post Ⅲ72 and piston Ⅲ70.

[0187] Specifically, in one embodiment of this application, in the above-mentioned spray pump assembly, the pressure-bearing sealing part 51 of piston I 50 is tightly fitted and fixed inside the liquid output assembly 40; piston II 60 is tightly fitted and fixed to piston I 50, specifically, piston II 60 is tightly fitted and fixed to the inner circumferential surface of the pressure-bearing sealing part 51 and the outer circumferential surface of the cavity column I 52, so that when piston II 60 and piston I 50 are assembled, piston II 60 has a larger force-bearing surface and more balanced force distribution; the end sealing column 71 of piston III 70 is tightly fitted and fixed to the inner circumferential surface of the cavity column I 52, and the cavity column III 72 of piston III 70 is tightly fitted and fixed to the inner circumferential surface of piston II 60. While achieving fixation through tight fitting, good sealing performance can also be formed between the liquid output assembly 40 and piston I 50, and between piston I 50 and piston III 70.

[0188] Specifically, in one embodiment of this application, the conductive portion II 81 and the conductive portion III 82 can be formed by: forming the conductive portion II 81 by forming a groove on the outer peripheral surface of the cavity pillar I 52 and / or the inner peripheral surface of the piston II 60, and forming the conductive portion III 82 by forming a groove on the outer peripheral surface of the cavity pillar III 72 and / or the inner peripheral surface of the piston II 60; in this embodiment, as... Figure 3 , Figure 24 and Figure 16 As shown, the conductive part II81 has two grooves formed on the outer circumferential surface of the cavity pillar I52. The two grooves constituting the conductive part II81 are distributed at 180-degree intervals along the circumference of the cavity pillar I52, forming a protective shield. Figure 3 , Figure 24 and Figure 27 As shown, the two grooves forming the conductive part III82 are located on the outer circumferential surface of the cavity pillar III72. These two grooves are distributed at 180-degree intervals along the circumference of the cavity pillar III72, forming a protective shield. With this arrangement, it is unnecessary to machine grooves on the inner circumferential surface of the piston II60; instead, grooves are machined only on the outer circumferential surfaces of the cavity pillars III72 of the piston I50 and the piston III70, making machining more convenient.

[0189] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 , Figure 25 , Figure 26 , Figure 27As shown, piston II 60 has a sealing part II 61 at its lower end, which slides and seals with the inner circumferential surface of the outer cavity 31 to achieve a seal between piston II 60 and the outer cavity 31; piston III 70 has a sealing part III 73 at its lower end of the cavity column III 72, which slides and seals with the outer circumferential surface of the inner cavity 32 to achieve a seal between piston III 70 and the inner cavity 32. Furthermore, sealing part II 61 is inclined outward and downward, and sealing part III 73 is inclined inward and downward. The drug delivery pressurization device 30 has a stroke limit adjustment part 37 at the bottom of the pressure chamber 34, which is distributed on the outer circumferential side of the sealing release part 35. When the liquid output assembly 40 is pressed down to the bottom, the stroke limit adjustment part 37 is inserted between the sealing part II 61 and the sealing part III 73; at the same time, the lower end of the sealing part II 61 abuts against the pressure chamber 34, thereby limiting the downward movement of the liquid output assembly 40, piston I 50, piston II 60 and piston III 70, that is, limiting the downward movement distance of piston II 60 and piston III 70 when the liquid output assembly 40 is pressed in sequence, so as to achieve the purpose of controlling the dosage.

[0190] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 , Figure 25 , Figure 26 , Figure 27 As shown, the lower end of the inner circumferential surface of the sealing part Ⅲ73 is provided with a guide part Ⅲ74 extending obliquely outward and downward, and the upper end of the inner cavity 32 is provided with a guide part Ⅱ38 extending obliquely outward and downward. When the liquid output assembly 40 is pressed downward, causing the lower end of the piston Ⅲ70 to begin contacting the inner cavity 32, the guide part Ⅲ74 can contact the guide part Ⅱ38. Through the oblique arrangement of the guide parts Ⅲ74 and Ⅱ38, the sealing part Ⅲ73 can be better guided to expand towards the outer circumference of the inner cavity 32, so that the sealing part Ⅲ73 is tightly attached to the outer circumferential surface of the inner cavity 32, reliably forming a seal. Furthermore, when the sealing part Ⅲ73 is tightly attached to the outer circumferential surface of the inner cavity 32, as... Figure 26 As shown, there is a gap between the cavity column III72 of piston III70 and the inner cavity 32. That is, piston III70 only contacts and cooperates with the inner cavity 32 at its lower sealing part III73, while piston II60 only contacts and cooperates with the outer cavity 31 at its lower sealing part II61. While effectively forming a seal, it can also reduce the contact surface, making it easier for the user to press down the liquid output component 40.

[0191] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 , Figure 25 , Figure 26 , Figure 27As shown, the one-way valve assembly includes a main column 90 fixed in the top of the liquid output assembly 40, a secondary column 110 movably mounted between the main column 90 and the piston I 50, and a reset assembly II 120. The main column 90 has a valve outlet hole 91 and a valve outlet groove 92 at its top. A valve outlet channel 130 is formed between the outer peripheral surface of the secondary column 110 and the inner peripheral surface of the liquid output assembly 40. The through hole 54, the valve outlet channel 130, the valve outlet hole 91, and the valve outlet groove 92 are connected in sequence. The secondary column 110 has a sealing column 111 slidably inserted into the main column 90. The upper and lower ends of the reset assembly II 120 abut against the secondary column 110 and the piston I 50, respectively, and the reset assembly II 120 is preferably housed in a groove at the top of the piston I 50. When the liquid pressure in the valve outlet channel 130 is less than the spring force of the reset assembly II 120, the secondary column 110 is in an upward position, and the sealing column 111 of the secondary column 110 blocks the output port 41; when the liquid pressure in the valve outlet channel 130 is greater than the spring force of the reset assembly II 120, the secondary column 110 moves downward, the sealing column 111 of the secondary column 110 moves away from the output port 41, and the valve outlet groove 92 communicates with the output port 41. Thus, a normally closed output port 41 structure is formed. When the liquid output assembly 40 is pressed several times to allow the liquid to enter the outer periphery of the secondary column 110, the secondary column 110 moves downward under the pressure of the liquid, thereby opening the output port 41; after one spray is completed, the secondary column 110 moves upward under the action of the reset assembly II 120, quickly closing the output port 41. Additionally, as... Figure 21 As shown, the valve outlet 92 at the top of the main column 90 is a cyclone trough. When discharging liquid, the liquid flows through the cyclone trough and is mechanically stirred under pressure. Then, it is sprayed out in a mist form through the output port 41, which improves the liquid discharge effect.

[0192] Specifically, in one embodiment of this application, such as Figure 3 , Figure 24 , Figure 25 , Figure 26 , Figure 27 As shown, the spray pump assembly also includes a reset assembly I 160, which is sleeved on the outer periphery of the outer cavity 31 and the piston II 60. The upper and lower ends of the reset assembly I 160 abut against the inner circumferential surface of the liquid output assembly 40 and the drug delivery pressurization device 30, respectively. When the liquid output assembly 40 is released, the liquid output assembly 40 moves upward and resets under the action of the reset assembly I 160, driving the pistons I 50, II 60, and III 70 to move upward and reset together.

[0193] Specifically, in one embodiment of this application, such as Figure 3 , Figure 12 , Figure 13 , Figure 14 , Figure 15 , Figure 24 , Figure 25 , Figure 26 , Figure 27 As shown, the spray pump assembly also includes a press cover 140 fixed to the outer periphery of the liquid output assembly 40. The press cover 140 has a horizontal plate portion for the user to press, so that the user can press the liquid output assembly 40 downward through the press cover 140. In addition, the spray pump assembly also includes a return air gap formed between the press cap 140 and the sealing cap 20, a gas passage 42 opened on the outer periphery of the lower end of the liquid output assembly 40, a gas exchange channel 39 opened in the drug delivery pressurization device 30, a gas-liquid filtration channel 310 formed in the drug delivery pressurization device 30, and a filter assembly. The return air gap, the gas passage 42, the gas exchange channel 39, the gas-liquid filtration channel 310 and the inner cavity of the container 10 are sequentially connected. The filter assembly includes a filter sleeve core 151 tightly fixed in the gas-liquid filtration channel 310, a filter membrane inner core 152 tightly fixed in the filter sleeve core 151, and a filter membrane 153. The inner peripheral surface of the filter sleeve core 151 is provided with an inwardly protruding fixing step, and the outer edge of the filter membrane 153 is clamped between the fixing step and the filter membrane inner core 152. After each spray dispensing cycle, the amount of liquid in container 10 decreases. At this point, external air enters container 10 sequentially through the return air gap, gas passage 42, gas exchange channel 39, gas-liquid filtration channel 310, and filter membrane 153. This prevents negative pressure from forming inside container 10 and ensures normal dispensing the next time. Filter membrane 153 filters out bacteria and impurities from the air, ensuring that the air entering container 10 is pure gas. This keeps the gas inside container 10 dust-free and sterile, preventing contamination of the liquid in container 10.

[0194] Specifically, in one embodiment of this application, such as Figure 3 , Figure 12 , Figure 13 , Figure 14 , Figure 15 , Figure 24 , Figure 25 , Figure 26 , Figure 27 As shown, the spray pump assembly also includes a liquid collection component 170. The upper end of the liquid collection component 170 is fixed in the drug delivery pressurization device 30 and extends to the lower end of the fluid exchange chamber 33. The lower end of the liquid collection component 170 is placed at the bottom of the container 10, and the fluid exchange chamber 33 is connected to the inner cavity of the container 10 through the liquid collection component 170.

[0195] Specifically, in one embodiment of this application, such as Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 , Figure 12 , Figure 13 , Figure 14 , Figure 15 , Figure 24 , Figure 25 , Figure 26 , Figure 27 As shown, the spray pump assembly also includes a protective cover 180, which can be detachably covered on the outer periphery of the liquid output assembly 40, serving to protect the liquid output assembly 40 and prevent dust. A sealing gasket 190 is provided between the upper end of the container 10 and the drug delivery pressurization device 30 and the sealing cap 20, which serves to seal and prevent the drug solution from leaking out from there.

[0196] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and substitutions can be made without departing from the technical principles of the present utility model, and these improvements and substitutions should also be considered within the protection scope of the present utility model.

Claims

1. A nasal atomizing device for drug delivery, comprising a piston assembly and a spray pump assembly, the piston assembly and the spray pump assembly being used to draw in and atomize a drug, characterized in that: The piston assembly includes piston I (50), piston II (60), and piston III (70); the spray pump assembly includes main column (90), auxiliary column (110), reset assembly II (120), press cap (140), reset assembly I (160), drug delivery pressurization device (30), sealing cap (20), sealing gasket (190), and container (10); In the initial stage of the piston assembly, a compression or expansion stroke allows gas from chamber I to enter chamber II. In the next corresponding stroke, chamber II is under negative pressure, allowing liquid or gas-liquid mixture in chamber II to enter and fill chamber I. The continuous compression or expansion stroke following the initial stage of the piston assembly atomizes the liquid or gas-liquid mixture in chamber I through the nozzle. The continuous compression or expansion stroke following the initial stage of the piston assembly unlocks the one-way valve assembly. A one-way valve assembly is installed before the nozzle. During the continuous compression or expansion stroke following the initial stage of the piston assembly, the liquid or gas-liquid mixture in chamber I opens the one-way valve assembly. The liquid output assembly (40) is provided with a positioning part (43) inside, which is used to abut against the reset assembly I (160), and the reset assembly I (160) is used to cooperate with the piston assembly to reset; the liquid output assembly (40) is provided with a reset assembly II (120) on the outlet side, which is used to cooperate with the check valve assembly to reset. The reset assembly I (160) includes a first support ring I (1605) and a first support ring II (1606). A first main helical spring I (1601) and a first main helical spring II (1602) are disposed between the first support ring I (1605) and the first support ring II (1606), and the first main helical spring I (1601) and the first main helical spring II (1602) are arranged in a staggered rotational configuration. A first auxiliary helical spring I (1603) and a first auxiliary helical spring II (1604) are disposed between the first main helical spring I (1601) and the first main helical spring II (1602), and the first auxiliary helical spring I (1603) and the first auxiliary helical spring II (1604) are arranged in a staggered rotational configuration.

2. The nasal atomizing device for drug delivery as described in claim 1, characterized in that, A gas compensation channel is provided between the cavity containing the drug and the outside to eliminate the negative pressure formed in the cavity after continuous drug output; the gas compensation channel includes a gap between the sealing cap (20) and the pressing cap (140), a gap between the sealing cap (20) and the liquid output component (40), and a gap between the drug delivery pressurizing device (30) and the liquid output component (40); the liquid output component (40) is provided with an air inlet groove, and the drug delivery pressurizing device (30) is provided with an air inlet groove; the gas compensation channel is provided with a filter assembly, which includes a filter sleeve core (151), a filter membrane (153), and a filter membrane inner core (152).

3. The nasal atomizing device for drug delivery as described in claim 1, characterized in that, The liquid output assembly (40) is equipped with a protective cover (180); the outer surface of the middle part of the protective cover (180) is provided with an anti-slip part (1804).

4. The nasal atomizing device for drug delivery as described in claim 3, characterized in that, The lower end of the protective cover (180) has a notch (1803) on the snap-fit ​​edge. The notch (1803) is used for venting air from the inside of the protective cover (180) when it is snapped on and for drawing air from the inside of the protective cover (180) when it is pulled out. There are two notches (1803) symmetrically arranged. The inside of the protective cover (180) is provided with a sealing contact part (1802). The sealing contact part (1802) is used to contact the nozzle of the liquid output component (40) to isolate air pollution.

5. A nasal atomizing device for drug delivery as described in claim 4, characterized in that, A reinforcing rib I (1801) is provided around the sealing contact part (1802) to enhance the structural strength of the protective cover (180); A reinforcing rib II (1805) is provided on the side of the protective cover (180) near the notch (1803) to enhance the structural strength of the protective cover (180); the protective cover (180) locks the liquid output component (40) through the reinforcing rib II (1805) and forms a locking mechanism by limiting the movement through friction and elasticity.

6. The nasal atomizing device for drug delivery as described in claim 1, characterized in that, The side surface of the container (10) is provided with sealing protrusion I (101) and sealing protrusion II (102), and the inner surface of the sealing cap (20) is provided with at least two annular grooves. The container (10) is sealed by the sealing protrusion I (101) and sealing protrusion II (102) being embedded in the annular grooves of the sealing cap (20). The upper end face of the container (10) is provided with a sealing protrusion I (101), and a sealing gasket (190) is provided between the upper end face of the container (10) and the sealing cover (20). The lower end face of the sealing gasket (190) is provided with a sealing groove (1901), and the sealing groove (1901) is embedded in the sealing protrusion I (101) to form a mating seal.

7. A nasal atomizing device for drug delivery as described in claim 1, characterized in that, The spray pump assembly includes a sealing cap (20) mounted on the upper end of the container (10), a drug delivery booster (30) fixed inside the sealing cap (20), a liquid output assembly (40) movable up and down in the drug delivery booster (30), a piston assembly fixed inside the liquid output assembly (40), and a one-way valve assembly. The top of the liquid output assembly (40) is provided with an output port (41).

8. A nasal atomizing device for drug delivery as described in claim 1, characterized in that, Piston I (50) includes a pressure-bearing sealing part (51) sealed and fixed in the liquid output assembly (40), a cavity column I (52) fixed on the inner periphery of the pressure-bearing sealing part (51), a liquid storage tank (53) connected between the pressure-bearing sealing part (51) and the cavity column I (52), and a through hole (54) opened on the liquid storage tank (53); Piston II (60) is a cylindrical structure and is sealed and fixed on the outer periphery of the cavity column I (52), and the piston II (60) and the cavity column I (52) are connected. A connecting part II (81) is provided between the columns I (52); the piston III (70) is sealed and fixed at the lower end of the cavity column I (52) and / or the piston II (60), a connecting part III (82) is provided between the piston II (60) and the piston III (70), and a one-way valve assembly is provided between the piston I (50) and the output port (41) of the liquid output assembly (40). The connecting part III (82), the connecting part II (81), the connecting hole (54) and the one-way valve assembly are connected in sequence. The drug delivery pressurization device (30) is provided with an outer cavity (31) that is slidably sealed to the outer periphery of piston II (60) and an inner cavity (32) that is slidably sealed to the inner periphery of piston III (70). A fluid exchange chamber (33) communicating with the inner cavity of container (10) is provided in the inner cavity (32). A pressure chamber (34) is formed between the outer cavity (31), the inner cavity (32), piston II (60) and piston III (70). The pressure chamber (34) is connected to the lower side of the connecting part III (82). The drug delivery pressurization device (30) is provided with a sealing release part (35) at the bottom of the pressure chamber (34) and a connecting part I (36) is provided on the sealing release part (35). When the liquid output assembly (40) is not pressed down, piston III (70) separates from the inner cavity (32); When the liquid output component (40) is pressed down but not fully, the piston III (70) and the inner cavity (32) slide and seal together. The piston III (70) is located on the upper side of the sealing release part (35), and the pressure chamber (34) is not connected to the fluid exchange chamber (33). When the liquid output assembly (40) is pressed down to the bottom, the piston III (70) contacts and engages with the sealing release part (35), and the pressure chamber (34) is connected to the fluid exchange chamber (33) through the conduction part I (36).

9. A nasal atomizing device for drug delivery as described in claim 8, characterized in that, The conductive part II (81) is at least one groove formed on the outer peripheral surface of the cavity column I (52), and the conductive part III (82) is at least one groove formed on the outer peripheral surface of the cavity column III (72); The piston II (60) is provided with a sealing part II (61) at its lower end, and the sealing part II (61) slides and seals with the inner circumferential surface of the outer cavity (31); the piston III (70) is provided with a sealing part III (73) at the lower end of the cavity column III (72), and the sealing part III (73) can slide and seal with the outer circumferential surface of the inner cavity (32). The sealing part II (61) is inclined outward and downward, and the sealing part III (73) is inclined inward and downward. The drug delivery pressurization device (30) has a stroke limit adjustment part (37) at the bottom of the pressure chamber (34). The stroke limit adjustment part (37) is distributed on the outer periphery of the sealing release part (35). When the liquid output component (40) is pressed down to the bottom, the stroke limit adjustment part (37) is inserted between the sealing part II (61) and the sealing part III (73).

10. A nasal atomizing device for drug delivery as described in claim 9, characterized in that, The lower end of the inner circumferential surface of the sealing part Ⅲ (73) is provided with a guide part Ⅲ (74) that extends outward and downward, and the upper end of the inner cavity (32) is provided with a guide part Ⅱ (38) that extends outward and downward. The guide part Ⅲ (74) can contact the guide part Ⅱ (38). The one-way valve assembly includes a main column (90) fixed in the top of the liquid output assembly (40), a secondary column (110) movably mounted between the main column (90) and piston I (50), and a reset assembly II (120). The main column (90) has a valve outlet hole (91) and a valve outlet groove (92). A valve outlet channel (130) is formed between the outer peripheral surface of the secondary column (110) and the inner peripheral surface of the liquid output assembly (40). The through hole (54), the valve outlet channel (130), the valve outlet hole (91) and the valve outlet groove (92) are connected in sequence. The secondary column (110) has a sealing column (111) slidably inserted in the main column (90). The upper and lower ends of the reset assembly II (120) abut against the secondary column (110) and piston I (50) respectively. When the liquid pressure in the valve outlet channel (130) is less than the spring force of the reset assembly II (120), the auxiliary column (110) is in an upward state, and the sealing column (111) of the auxiliary column (110) blocks the output port (41); When the liquid pressure in the valve outlet channel (130) is greater than the spring force of the reset assembly II (120), the secondary column (110) moves down, the sealing column (111) of the secondary column (110) moves away from the output port (41), and the valve outlet groove (92) is connected to the output port (41); The spray pump assembly includes a press cap (140) fixed to the outer periphery of the liquid output assembly (40), a return air gap formed between the press cap (140) and the sealing cap (20), a gas passage (42) opened on the outer periphery of the lower end of the liquid output assembly (40), a gas exchange channel (39) opened in the drug delivery pressurization device (30), a gas-liquid filtration channel (310) formed in the drug delivery pressurization device (30), and a filter assembly. The return air gap, the gas passage (42), the gas exchange channel (39), the gas-liquid filtration channel (310) and the inner cavity of the container (10) are connected in sequence. The filter assembly includes a filter sleeve (151) that is tightly fixed in the gas-liquid filtration channel (310), a filter membrane core (152) that is tightly fixed inside the filter sleeve (151), and a filter membrane (153). The inner circumferential surface of the filter sleeve (151) is provided with an inwardly protruding fixing step, and the outer edge of the filter membrane (153) is clamped between the fixing step and the filter membrane core (152).

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