Reagent adding mechanism of biological tissue sample section dyeing equipment

Abstract

The utility model provides a reagent adding mechanism of a biological tissue sample section dyeing device, which comprises an automatic dyeing reagent adding assembly, a dyeing reagent adding base and a dyeing reagent temporary storage assembly, and a main console of the biological tissue sample section dyeing device is in control connection with the automatic dyeing reagent adding assembly. The automatic dyeing reagent adding assembly comprises a dyeing reagent adding driving device, a dyeing reagent drawing and releasing mechanical arm, a dyeing reagent adding rotating shaft and a dyeing reagent adding rotating disc, the dyeing reagent adding rotating disc is movably arranged on the dyeing reagent adding base, and the bottom of the dyeing reagent adding rotating shaft is fixedly connected with the dyeing reagent adding rotating disc; the top of the dyeing reagent adding rotating shaft is fixedly connected with one end of the dyeing reagent drainage mechanical arm, and the dyeing reagent adding driving device is in rotary driving connection with the dyeing reagent adding rotating disc. The utility model has the beneficial effect that the dyeing reagent can be automatically added and supplemented into the dyeing tank.

Description

Technical Field

[0001] This utility model relates to the field of biological tissue sample staining technology, specifically to a reagent addition mechanism for a biological tissue sample staining device. Background Technology

[0002] In existing biological sample analysis techniques, commonly used analytical methods include microscopy, microarray analysis (e.g., protein and nucleic acid microarray analysis), and mass spectrometry. Preparing samples for these and other types of analysis typically involves contacting the biological sample with a series of processing liquids. Some of these processing liquids (e.g., staining reagents and counterstaining reagents) can add color and, conversely, alter the visual properties of invisible or difficult-to-see sample components (e.g., at least some types of cells and intracellular structures). Other processing liquids (e.g., deparaffin liquids) can be used to achieve other processing purposes. If multiple processing liquids are used to treat the sample, the application and subsequent removal of each liquid can be crucial for producing a sample suitable for analysis. In some cases, treating samples with multiple processing liquids involves manually applying the liquids to the microscope slides holding the samples. However, this manual sample preparation method tends to be labor-intensive and inaccurate, leading to the development of biological tissue section staining equipment.

[0003] Automated staining technology for biological tissue samples is a crucial and indispensable step in the entire automated staining, drying, and mounting process for biological tissue samples. To ensure that the processed biological tissue samples have an easily observable appearance and maintain consistency and efficiency in the processing, the staining step is an essential aspect that must be strictly controlled during biological tissue sample processing. The purpose of staining is to make different structures within the cellular tissue appear in different colors for easier observation. The classic hematoxylin and eosin staining method is the routine staining method for histological and pathological specimens, abbreviated as HE staining. After staining, the cell nuclei are stained purple-blue by hematoxylin, while most cytoplasm and non-cellular components are stained pink by eosin.

[0004] Existing biological tissue sample staining equipment can replace manual staining. These machines automatically process samples by immersing a rack holding a batch of microscope slides in an open bath containing processing liquid. However, during the immersion staining operation, existing biological tissue sample staining equipment requires frequent replenishment of various staining reagents as they are consumed over time. This manual replenishment is cumbersome, time-consuming, labor-intensive, and prone to errors, resulting in inconsistent production efficiency and product quality that fails to meet user needs. Utility Model Content

[0005] To address the problems in existing technologies, this utility model provides a reagent adding mechanism for a biological tissue sample section staining device. By incorporating a matching automatic staining reagent adding component, a staining reagent adding base, and a staining reagent temporary storage component within the reagent adding mechanism, it is possible to automatically add supplementary staining reagent to the staining tank without manual operation. This saves time and effort, reduces errors, significantly improves the production efficiency and product quality of biological tissue sample section microscope slides, enhances the user experience, and solves the problems of time-consuming, labor-intensive, and error-prone manual addition of supplementary staining reagent during staining operations in existing biological tissue sample section staining devices.

[0006] This utility model provides a reagent adding mechanism for a biological tissue sample section staining device, which cooperates with the automatic staining mechanism of the biological tissue sample section staining device. The automatic staining mechanism has multiple staining tanks for staining individual microscope slides, including an automatic reagent adding component, a reagent adding base, and a reagent temporary storage component. The bottom of the reagent adding base and the bottom of the reagent temporary storage component are fixedly mounted on the worktable. The reagent temporary storage component is located next to the reagent adding base and cooperates with the automatic reagent adding component. The main control console of the biological tissue sample section staining device is controlled and connected to the automatic reagent adding component. The automatic reagent adding component includes... The system includes a staining reagent adding drive, a staining reagent dispensing robotic arm, a staining reagent adding shaft, and a staining reagent adding turntable. The staining reagent adding turntable is movably mounted on the staining reagent adding base. The bottom of the staining reagent adding shaft is fixedly connected to the staining reagent adding turntable, and the top of the shaft is fixedly connected to one end of the staining reagent dispensing robotic arm. The staining reagent adding drive is connected to the staining reagent adding turntable for rotational drive. The staining reagent dispensing robotic arm can extract staining reagent from the staining reagent temporary storage component and, under the control command of the main control console and the drive of the staining reagent adding drive, move to the staining tank to add supplementary staining reagent to the staining tank.

[0007] The present invention is further improved in that the staining reagent addition driving device includes a staining reagent addition driving motor and a staining reagent addition transmission belt, wherein the staining reagent addition driving motor is connected to the staining reagent addition turntable for rotational drive via the staining reagent addition transmission belt.

[0008] The present invention is further improved in that the staining reagent temporary storage component includes a plurality of staining reagent temporary storage tanks arranged in an array, the top opening of the staining reagent temporary storage tanks and cooperating with the staining reagent extraction and dispensing robotic arm.

[0009] This invention is further improved in that the capacity of the staining reagent storage container is >50ml.

[0010] In a further improvement to this invention, the number of temporary storage containers for the staining reagent is eight.

[0011] In a further improvement to this invention, the number of automatic dyeing reagent adding components is two.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: This utility model provides a reagent adding mechanism for a biological tissue sample section staining device. By setting up a matching automatic staining reagent adding component, a staining reagent adding base, and a staining reagent temporary storage component within the reagent adding mechanism, the staining reagent extraction and dispensing robotic arm can extract the staining reagent from the staining reagent temporary storage component and move it to the staining tank under the control command of the main control console and the drive of the staining reagent adding drive device to add supplementary staining reagent to the staining tank. This can realize the automatic addition of supplementary staining reagent to the staining tank without manual operation, saving time and effort and reducing errors. It significantly improves the production efficiency and product quality of biological tissue sample section microscope slides, improves the user experience, and solves the problem that manual addition of supplementary staining reagent during staining operations in existing biological tissue sample section staining devices is time-consuming, labor-intensive, and prone to errors. Attached Figure Description

[0013] Figure 1 This is a structural diagram of the reagent addition mechanism of the biological tissue sample section staining device of this utility model.

[0014] In the figure, 3-automatic staining mechanism, 321-staining tank, 4-reagent adding mechanism, 41-automatic staining reagent adding component, 411-staining reagent adding drive device, 412-staining reagent extraction and dispensing robotic arm, 413-staining reagent adding rotating shaft, 414-staining reagent adding turntable, 42-staining reagent adding base, 43-staining reagent temporary storage component, and 431-staining reagent temporary storage tank. Detailed Implementation

[0015] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments.

[0016] like Figure 1As shown, the present invention provides a reagent adding mechanism 4 for a biological tissue sample section staining device, which cooperates with the automatic staining mechanism 3 of the same device. The automatic staining mechanism 3 has multiple staining tanks 321 for staining individual microscope slides, including an automatic reagent adding component 41, a reagent adding base 42, and a reagent temporary storage component 43. The bottoms of the reagent adding base 42 and the reagent temporary storage component 43 are fixedly mounted on the worktable. The reagent temporary storage component 43 is located next to the reagent adding base 42 and cooperates with the automatic reagent adding component 41. The main control console of the biological tissue sample section staining device is connected to the automatic reagent adding component 41. The device includes a dyeing reagent adding drive device 411, a dyeing reagent dispensing robotic arm 412, a dyeing reagent adding rotating shaft 413, and a dyeing reagent adding turntable 414. The dyeing reagent adding turntable 414 is movably mounted on the dyeing reagent adding base 42. The bottom of the dyeing reagent adding rotating shaft 413 is fixedly connected to the dyeing reagent adding turntable 414, and the top of the dyeing reagent adding rotating shaft 413 is fixedly connected to one end of the dyeing reagent dispensing robotic arm 412. The dyeing reagent adding drive device 411 is rotatably driven connected to the dyeing reagent adding turntable 414. The dyeing reagent adding drive device 411 includes a dyeing reagent adding drive motor and a dyeing reagent adding transmission belt. The dyeing reagent adding drive motor is rotatably driven connected to the dyeing reagent adding turntable 414 through the dyeing reagent adding transmission belt. In this embodiment, the staining reagent extraction and dispensing robotic arm can extract staining reagent from the staining reagent storage component and move it to the staining tank under the control command of the main console and the drive of the staining reagent adding drive device to add supplementary staining reagent to the staining tank. It can automatically add supplementary staining reagent to the staining tank without manual operation, saving time and effort and reducing errors. It greatly improves the production efficiency and product quality of biological tissue sample section microscope slides and enhances the user experience.

[0017] like Figure 1 As shown, the staining reagent temporary storage component 43 includes multiple staining reagent temporary storage tanks 431 arranged in an array. The top of each staining reagent temporary storage tank 431 is open and cooperates with the staining reagent extraction and dispensing robotic arm 412. The capacity of each staining reagent temporary storage tank 431 is greater than 50 ml, and there are 8 staining reagent temporary storage tanks. There are 2 sets of automatic staining reagent adding components 41. In this embodiment, each staining reagent temporary storage tank can temporarily store 50 ml of staining reagent for extraction and dispensing by the staining reagent extraction and dispensing robotic arm. Up to 8 types of staining reagents can be temporarily stored, facilitating automatic replenishment to the staining tank.

[0018] As can be seen from the above, the reagent adding mechanism of the biological tissue sample section staining equipment provided by this utility model, by setting up a staining reagent automatic adding component, a staining reagent adding base and a staining reagent temporary storage component in the reagent adding mechanism of the biological tissue sample section staining equipment, can automatically add staining reagent to the staining tank under the control command of the main control console and the drive of the staining reagent adding drive device, so as to add supplementary staining reagent to the staining tank. It can realize the automatic addition of supplementary staining reagent to the staining tank without manual operation, saving time and effort and reducing errors. It significantly improves the production efficiency and product quality of biological tissue sample section microscope slides, improves the user experience, and solves the problem that manual addition of supplementary staining reagent in the existing biological tissue sample section staining equipment is time-consuming, labor-intensive and prone to errors.

[0019] The specific embodiments described above are preferred embodiments of this utility model, and are not intended to limit the specific scope of this utility model. The scope of this utility model includes but is not limited to the specific embodiments described above. All equivalent changes made in accordance with this utility model are within the protection scope of this utility model.

Claims

1. A reagent adding mechanism for a biological tissue sample section staining device, which cooperates with the automatic staining mechanism of the biological tissue sample section staining device, wherein the automatic staining mechanism is provided with multiple staining tanks for staining individual microscope slides, characterized in that: The device includes an automatic staining reagent dispensing component, a staining reagent dispensing base, and a staining reagent temporary storage component. The bottoms of the staining reagent dispensing base and the staining reagent temporary storage component are fixedly mounted on the worktable. The staining reagent temporary storage component is located next to the staining reagent dispensing base and cooperates with the automatic staining reagent dispensing component. The main control console of the biological tissue sample slide staining equipment is controlled and connected to the automatic staining reagent dispensing component. The automatic staining reagent dispensing component includes a staining reagent dispensing drive device, a staining reagent extraction and dispensing robotic arm, a staining reagent dispensing rotating shaft, and a staining reagent dispensing turntable. The staining reagent dispensing rotating shaft is movably mounted on the staining reagent dispensing base. The bottom of the staining reagent dispensing rotating shaft is fixedly connected to the staining reagent dispensing turntable. The top of the staining reagent dispensing rotating shaft is fixedly connected to one end of the staining reagent extraction and dispensing robotic arm. The staining reagent dispensing drive device is connected to the rotation drive of the staining reagent dispensing turntable. The staining reagent extraction and dispensing robotic arm can extract staining reagent from the staining reagent temporary storage component and move to the staining tank under the control command of the main control console and the drive of the staining reagent dispensing drive device to add supplemental staining reagent to the staining tank.

2. The reagent addition mechanism of the biological tissue sample section staining device according to claim 1, characterized in that: The staining reagent addition driving device includes a staining reagent addition driving motor and a staining reagent addition transmission belt. The staining reagent addition driving motor is connected to the staining reagent addition turntable for rotational drive via the staining reagent addition transmission belt.

3. The reagent addition mechanism of the biological tissue sample section staining device according to claim 2, characterized in that: The staining reagent storage assembly includes multiple staining reagent storage tanks arranged in an array, with the top of each tank open and cooperating with the staining reagent extraction and dispensing robotic arm.

4. The reagent addition mechanism of the biological tissue sample section staining device according to claim 3, characterized in that: The capacity of the temporary storage container for the staining reagent is >50ml.

5. The reagent addition mechanism of the biological tissue sample section staining device according to claim 4, characterized in that: The number of temporary storage containers for the staining reagents is 8.

6. The reagent addition mechanism of the biological tissue sample section staining device according to claim 5, characterized in that: The number of automatic staining reagent addition components is 2 sets.

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