Corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis

Abstract

The utility model discloses a corrosion-resistant and radiation-proof integrated pipeline for radiopharmaceutical synthesis, which relates to the technical field of radiopharmaceutical synthesis and comprises a pipeline and joint bodies positioned at two ends of the pipeline, the pipeline and the joint bodies are subjected to injection molding and shaping by a mould and then are demoulded to form an integrated structure, and the pipeline and the joint bodies are made of COC (Chip on Chip) materials; the connector body comprises a connecting part and a reinforcing part, the connecting part comprises a hollow column body and a connecting piece wrapping the outer side of the hollow column body, one end of the hollow column body is connected with a pipeline, and the other end of the hollow column body is a free end; the connecting piece is located at the end, away from the pipeline, of the hollow column. The reinforcing part is arranged on the hollow column body and located at the end, close to the pipeline, of the hollow column body, one end of the reinforcing part is connected with the connecting piece, and the other end of the reinforcing part is a free end. Therefore, the technical problem is solved.

Description

Technical Field

[0001] This utility model belongs to the field of radiopharmaceutical synthesis technology, specifically relating to an integrated corrosion-resistant and radiation-resistant pipeline for radiopharmaceutical synthesis. Background Technology

[0002] With the development of nuclear medicine, drug synthesis technology has been widely applied in drug preparation processes. To ensure the standardization of drug production processes, the reliability of product quality, the sterility of drugs, and high purity, standardized automated operating procedures and the sealing of connecting pipelines play a crucial role.

[0003] Pipeline connectors are mainly used to connect instruments and ferrules during the production of radiopharmaceuticals and to transport liquids during the production process, acting as a bridge. Therefore, in order to ensure the reliability of radiopharmaceutical production quality, the sealing of pipeline connectors and the connection between pipeline connectors and instruments / ferrules play a crucial role.

[0004] In existing technologies, pipelines and joints are usually bonded or spliced ​​together. High temperatures or long-term storage can pose quality risks, leading to air or liquid leaks during application.

[0005] With the development of science and technology, drug synthesis is no longer limited to manual labeling and simple chemical synthesis. Drug production has certain unique characteristics, requiring high precision in reagent dosages. Furthermore, the reagents include corrosive substances such as acids, alkalis, and organic solvents, and the labeling process involves radioactivity, thus placing extremely stringent requirements on the pipeline. Traditional pipeline materials are not resistant to acid and alkali corrosion, are not resistant to organic solvent corrosion, easily retain radioactivity due to fluoride ion adsorption, and cannot meet the radiation resistance requirements for labeling high-dose radiopharmaceuticals. This product selects materials more suitable for radiopharmaceutical production and is applicable to the automated labeling of various radionuclides (18F, 68Ga, 11C, 64Cu, etc.).

[0006] This product uses cyclic olefin copolymer (COC) material, which, compared to polypropylene (PP) (disadvantages: low dimensional accuracy, insufficient rigidity, poor weather resistance, easy aging and brittle deformation), polyethylene (PE) (disadvantages: relatively poor resistance to sudden cooling and heating, and relatively low heat distortion temperature), polyvinyl chloride (PVC) (disadvantages: poor thermal stability, easy to produce hydrogen chloride gas, which has a certain impact on the environment), and polycarbonate (PC) (disadvantages: easy to soften and deform at high temperatures, prone to stress cracking in certain chemical environments, high melt viscosity, and relatively high molding difficulty), has better high temperature resistance, radiation resistance, acid and alkali resistance, and organic solvent resistance, making it more suitable for high-requirement medical fields. Utility Model Content

[0007] The purpose of this invention is to provide an integrated pipeline for the synthesis of radiopharmaceuticals that is corrosion-resistant and radiation-resistant. The pipeline and the connector body are injection molded to form an integrated structure. This improves the pipeline's pressure resistance and avoids the possibility of gas or liquid leakage. Both the pipeline and the connector body are made of COC material, which has high temperature resistance, radiation resistance, and resistance to acids, alkalis, and organic solvents, making it more suitable for demanding medical applications.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] A corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis includes a pipeline and connector bodies located at both ends of the pipeline. The pipeline and connector bodies are molded and then demolded to form an integrated structure. Both the pipeline and connector bodies are made of COC material. The connector body includes a connecting part and a reinforcing part. The connecting part includes a hollow cylinder and a connector wrapped around the outside of the hollow cylinder. One end of the hollow cylinder is connected to the pipeline, and the other end is a free end. The connector is located at the end of the hollow cylinder away from the pipeline. The reinforcing part is disposed on the hollow cylinder and is located at the end of the hollow cylinder closer to the pipeline. One end of the reinforcing part is connected to the connector, and the other end is a free end.

[0010] Optionally, the length of the hollow column is greater than the length of the connector.

[0011] Optionally, the end of the connector near the pipeline is closed, and the end of the connector away from the pipeline is open; the inner wall of the connector is provided with internal threads.

[0012] Optionally, the outer wall of the connector is provided with anti-slip texture.

[0013] Optionally, the reinforcing part has a wing-shaped structure.

[0014] Optionally, the reinforcing part includes a long side, a short side, and an arc-shaped side; the long side is connected to the hollow column, the short side is connected to the connector, and the arc-shaped side connects the short side and the long side. Along the direction from the free end of the hollow column to the end where the hollow column is connected to the pipeline, the distance from the arc-shaped side to the long side first increases and then decreases.

[0015] Beneficial effects: This utility model provides a corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis. The pipeline and connector body are molded and then demolded to form an integrated structure, which improves the pipeline's pressure resistance and avoids the possibility of air or liquid leakage. Both the pipeline and connector body are made of COC material, which has high temperature resistance, radiation resistance, and resistance to acids, alkalis and organic solvents, making it more suitable for high-requirement medical fields. Attached Figure Description

[0016] Figure 1This is a schematic diagram of the overall structure of an integrated corrosion-resistant and radiation-resistant pipeline for radiopharmaceutical synthesis according to the present invention.

[0017] Figure 2 This is a schematic diagram of the overall structure of the reinforcing part of this utility model.

[0018] In the diagram: 1. Pipeline; 2. Connector body; 21. Connection part; 22. Reinforcement part; 211. Hollow column; 212. Connector; 221. Long side; 222. Short side; 223. Arc edge; 3. Anti-slip texture. Detailed Implementation

[0019] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the present utility model will be briefly introduced below in conjunction with the accompanying drawings and descriptions of the embodiments or the prior art. Obviously, the following description of the structure of the accompanying drawings is only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. It should be noted that the description of these embodiments is used to help understand this utility model, but does not constitute a limitation on this utility model.

[0020] In the description of this utility model, it should be understood that the orientation or positional relationship indicated by directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" is usually based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing this utility model and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this utility model; the directional terms "inner" and "outer" refer to the inner and outer contours relative to the outline of each component itself.

[0021] In the description of this utility model, it should be understood that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore should not be construed as limiting the scope of protection of this utility model.

[0022] Example

[0023] like Figures 1-2As shown, this embodiment provides a corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis, including a pipeline 1 and connector bodies 2 located at both ends of the pipeline 1. The pipeline 1 and connector bodies 2 are molded and then demolded to form an integrated structure. Both the pipeline 1 and connector bodies 2 are made of COC material. The connector body 2 includes a connecting part 21 and a reinforcing part 22. The connecting part 21 includes a hollow column 211 and a connector 212 wrapped around the outside of the hollow column 211. One end of the hollow column 211 is connected to the pipeline 1, and the other end is a free end. The connector 212 is located at the end of the hollow column 211 away from the pipeline 1. The reinforcing part 22 is disposed on the hollow column 211 and is located at the end of the hollow column 211 closer to the pipeline 1. One end of the reinforcing part 22 is connected to the connector 212, and the other end is a free end.

[0024] Specifically, pipeline 1 is a long, cylindrical tube, with connector bodies 2 connected to both ends. One connector body 2 connects to the instrument, and the other connects to the ferrule, acting as a bridge for transporting liquids during the production process. Pipeline 1 and connector bodies 2 are molded and then demolded to form an integrated structure. Both pipeline 1 and connector bodies 2 are made of COC material, which has high temperature resistance, radiation resistance, and resistance to acids, alkalis, and organic solvents, making it more suitable for demanding medical applications. Connector body 2 includes a hollow cylinder 211, a connector 212, and a reinforcing part 22. One end of 211 is connected to pipeline 1, and the other end is a free end. To ensure a tighter connection between the hollow cylinder 211 and pipeline 1, a secondary plastic seal can be applied. The connector 212 is wrapped around the outside of the hollow cylinder 211 and is located at the end of the hollow cylinder 211 away from pipeline 1. The connector 212 is used to connect with instruments or ferrules. The reinforcing part 22 is located at the end of the hollow cylinder 211 close to pipeline 1. The reinforcing part 22 is sheet-shaped, with one end connected to the connector 212 and the other end a free end. The main function of the reinforcing part 22 is to improve mechanical strength, optimize injection molding reliability, and adapt to process requirements.

[0025] In use, simply connect the connector body 2 to the instrument and the ferrule respectively.

[0026] This embodiment describes a corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis. Through pressure testing, the maximum tensile force can reach 20N, and the overall structure is stable. Through gas testing, the maximum pressure can reach 21kg, and the interface has good sealing performance.

[0027] In addition, the corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis in this embodiment is sterilized by cobalt source irradiation. The product is sterilized by irradiation using gamma rays generated by the cobalt-60 radioactive isotope. The product is sterile and has no pyrogen source. This product does not fall under the category of medical devices and is an experimental product.

[0028] In one embodiment, the length of the hollow column 211 is greater than the length of the connector 212. The hollow column 211 passes through the connector 212, with one end of the hollow column 211 being a free end and the other end connected to the pipeline 1.

[0029] In one embodiment, the end of the connector 212 near the pipeline 1 is closed, and the end of the connector 212 away from the pipeline 1 is open; the inner wall of the connector 212 is provided with internal threads; specifically, the connector 212 is cylindrical in shape and has a hollow structure inside. The inner diameter of the connector 212 is larger than the outer diameter of the hollow cylinder 211, so that there is a certain gap between the inner wall of the connector 212 and the hollow cylinder 211. The inner wall is provided with internal threads for connecting with instruments or ferrules.

[0030] In one embodiment, the outer wall of the connector 212 is provided with anti-slip texture 3; the anti-slip texture 3 facilitates the rotation of the connector 212, thereby enabling the connection and installation between the connector 212 and the instrument or ferrule.

[0031] In one embodiment, the reinforcing part 22 has a wing-like structure; specifically, in this embodiment, each connector body 2 includes two reinforcing parts 22, which are symmetrically arranged on the hollow column 211, like two wings; of course, multiple reinforcing parts 22 can also be provided on each connector body 2, and the specific number can be determined according to the actual situation; the wing-like structure increases the contact area, making it easier to operate manually and tighten, especially suitable for scenarios with limited space, and further preventing liquid leakage.

[0032] For details, see Figure 2 The reinforcing part 22 includes a long side 221, a short side 222, and an arc-shaped side 223. The long side 221 is connected to the hollow column 211, the short side 222 is connected to the connector 212, and the arc-shaped side 223 connects the short side 222 and the long side 221. Along the direction from the free end of the hollow column 211 to the end where the hollow column 211 is connected to the pipeline 1, the distance from the arc-shaped side 223 to the long side 221 first increases and then decreases.

[0033] This invention discloses a corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis. The pipeline 1 and connector body 2 are integrally encapsulated, eliminating the possibility of leakage, simplifying operation, facilitating connection with instruments and equipment, and ensuring the reliability of drug production quality. The overall appearance of the connector 212 has been improved for easier connection with instruments and clamps. A reinforcing part 22 is added to enhance overall mechanical strength, optimize the reliability of the encapsulation, and adapt to process requirements. Both the pipeline 1 and connector body 2 are made of COC material, which possesses high temperature resistance, radiation resistance, and resistance to acids, alkalis, and organic solvents, making it more suitable for demanding medical applications.

[0034] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the scope of protection of this utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the scope of protection of this utility model.

Claims

1. A corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis, characterized in that, The system includes a pipeline (1) and connector bodies (2) located at both ends of the pipeline (1). The pipeline (1) and connector bodies (2) are molded and then demolded to form an integrated structure. Both the pipeline (1) and connector bodies (2) are made of COC material. The connector body (2) includes a connecting part (21) and a reinforcing part (22). The connecting part (21) includes a hollow column (211) and a connector wrapped around the outside of the hollow column (211). 212), one end of the hollow column (211) is connected to the pipeline (1), and the other end is a free end; the connector (212) is located at the end of the hollow column (211) away from the pipeline (1); the reinforcing part (22) is provided on the hollow column (211), the reinforcing part (22) is located at the end of the hollow column (211) close to the pipeline (1), one end of the reinforcing part (22) is connected to the connector (212), and the other end is a free end.

2. The corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis according to claim 1, characterized in that, The length of the hollow column (211) is greater than the length of the connector (212).

3. The corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis according to claim 1, characterized in that, The connector (212) is closed at one end near the pipeline (1) and open at the other end away from the pipeline (1); the connector (212) has an internal thread on its inner wall.

4. The corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis according to claim 1, characterized in that, The outer wall of the connector (212) is provided with anti-slip texture (3).

5. The corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis according to claim 1, characterized in that, The reinforcing part (22) has a wing-shaped structure.

6. The corrosion-resistant and radiation-resistant integrated pipeline for radiopharmaceutical synthesis according to claim 1, characterized in that, The reinforcing part (22) includes a long side (221), a short side (222), and an arc-shaped side (223); the long side (221) is connected to the hollow column (211), the short side (222) is connected to the connector (212), and the arc-shaped side (223) connects the short side (222) and the long side (221). Along the direction from the free end of the hollow column (211) to the end where the hollow column (211) is connected to the pipeline (1), the distance from the arc-shaped side (223) to the long side (221) first increases and then decreases.

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