Cell culture bioreactor

Abstract

The utility model relates to a cell culture bioreactor, which belongs to the technical field of bioreactors, and comprises a base and a culture tube, the top of the base is provided with a rotary vibration structure, the rotary vibration structure comprises a motor frame and a rectangular plate, the motor frame is fixedly connected with the top of the outer surface of the base, and the rectangular plate is fixedly connected with the base. A rectangular through groove is formed in the top of the rectangular plate, and a sliding block is slidably connected to the inner wall of the rectangular through groove. By arranging a rotary vibration structure, a rectangular plate can rotate under the action of a transmission rod, so that an eccentric wheel and a transmission wheel are matched for extrusion, a sliding block can slide on the inner wall of a rectangular through groove, a limiting plate can be driven to move, and the limiting plate can move left and right; the limiting plate can be reset under the action of the reset spring, so that the culture tube can be driven to do reciprocating motion, vibration mixing is further performed, precipitation or layering is avoided, and the mixing effect is more uniform.

Description

Technical Field

[0001] This utility model relates to the field of bioreactor technology, and specifically to a cell culture bioreactor. Background Technology

[0002] In the process of biological detection, it is necessary to culture biological cells so that the cells can be isolated and cultured, which facilitates the detection of biological cells. At this time, cell culture bioreactors are needed for auxiliary culture.

[0003] During the use of a bioreactor, cells are cultured in culture tubes. During the culture process, the cells and culture medium inside the culture tube need to be shaken and mixed. However, the common mixing method is to rotate the culture tube to mix the contents. But this method can easily cause the cells to separate into layers under the action of centrifugal force. It is necessary to constantly change the direction of rotation so that the internal solution can be mixed under the action of opposite rotational forces, which is very inconvenient.

[0004] To address the aforementioned issues, this application proposes a cell culture bioreactor. Utility Model Content

[0005] This invention addresses the technical problems existing in the prior art by providing a cell culture bioreactor.

[0006] The technical solution of this utility model to solve the above-mentioned technical problems is as follows: A cell culture bioreactor includes a base and a culture tube. A rotational vibration structure is provided on the top of the base. The rotational vibration structure includes a motor frame and a rectangular plate. The motor frame is fixedly connected to the top of the outer surface of the base. A rectangular through groove is opened on the top of the rectangular plate. A sliding block is slidably connected to the inner wall of the rectangular through groove. An auxiliary fixing structure is provided on the top of the sliding block. The auxiliary fixing structure includes a limiting plate. The bottom of the limiting plate is fixedly connected to the top of the sliding block. A placement groove is opened on the top of the limiting plate. A rubber protrusion is fixedly connected to the inner wall of the placement groove. The culture tube is engaged with the inner wall of the placement groove.

[0007] Preferably, the arc-shaped surface of the motor frame is provided with heat dissipation holes, a drive motor is fixedly installed on the top of the inner wall of the motor frame, a transmission rod is fixedly connected to the output end of the drive motor, and the top end of the transmission rod is fixedly connected to the bottom of the rectangular plate.

[0008] By setting up a drive motor and a transmission rod, the drive motor can provide power to the transmission rod, thereby driving the transmission rod to rotate.

[0009] Preferably, a fixing rod is fixedly connected to both sides of the rectangular through groove, the outer surface of the fixing rod is slidably connected to the inner wall of the sliding block, and a return spring is sleeved on the outer surface of the fixing rod. The two ends of the return spring are fixedly connected to the outer surface of the sliding block and the inner wall of the rectangular through groove, respectively.

[0010] By setting a fixed rod, the sliding block can be guided, and then it can be reset after sliding in conjunction with the return spring.

[0011] Preferably, a connecting rod is fixedly connected to the bottom of the outer surface of the sliding block, an eccentric wheel is fixedly connected to the bottom end of the connecting rod, a support rod is fixedly connected to the top of the base, and a transmission wheel is rotatably connected to the top end of the support rod.

[0012] By setting up an eccentric wheel and a transmission wheel, after the eccentric wheel comes into contact with the transmission wheel, the sliding block can slide on the inner wall of the rectangular through groove under the pressure of the transmission wheel.

[0013] Preferably, the top of the limiting plate is provided with a rectangular slot, the inner wall of the rectangular slot is fitted with a rectangular block, the top of the rectangular block is fixedly connected with an auxiliary connecting rod, the top of the auxiliary connecting rod is fixedly connected with a pressure plate, a second locking hole is provided on one side of the rectangular block, and a first locking hole is provided on one side of the limiting plate.

[0014] By setting rectangular blocks and rectangular slots, the auxiliary connecting rods can be disassembled and assembled, thereby allowing the pressure plate to fix the culture tube.

[0015] Preferably, a threaded rod is rotatably connected to one side of the limiting plate, a threaded hole plate is threadedly connected to the outer surface of the threaded rod, a limiting rod is fixedly connected to one side of the limiting plate, the limiting rod is slidably disposed on the inner wall of the threaded hole plate, and a locking rod is fixedly connected to one side of the threaded hole plate.

[0016] By setting a threaded rod, the threaded rod can drive the threaded hole plate to move, which in turn can drive the locking rod to lock into the inner wall of the first locking hole and the second locking hole, thereby fixing the rectangular locking block and the rectangular locking groove.

[0017] The beneficial effects of this utility model are:

[0018] By setting up a rotary vibration structure, the rectangular plate can rotate under the action of the transmission rod, which in turn causes the eccentric wheel and the transmission wheel to cooperate and squeeze, allowing the sliding block to slide on the inner wall of the rectangular through groove. This, in turn, drives the limiting plate to move, allowing the limiting plate to move left and right. The limiting plate can then be reset under the action of the return spring, which in turn drives the culture tube to reciprocate, thus vibrating and mixing, preventing sedimentation or stratification, and making the mixing effect more uniform.

[0019] By setting up an auxiliary fixing structure, the culture tube can be clamped and fixed under the action of the placement groove. At this time, the culture tube can be further fixed under the action of the pressure plate. At the same time, under the action of the clamping rod, it can cooperate with the first and second clamping holes to further clamp and fix the rectangular clamping block and the rectangular clamping groove. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0021] Figure 2 This is a schematic diagram of the base and related parts of this utility model;

[0022] Figure 3 This is a schematic diagram of the limiting plate and related parts of this utility model;

[0023] Figure 4 This is a schematic diagram of the pressure plate and related parts of this utility model.

[0024] The attached diagram lists the components represented by each number as follows:

[0025] 1. Base;

[0026] 2. Rotary vibration structure; 21. Motor frame; 22. Heat dissipation hole; 23. Drive motor; 24. Transmission rod; 25. Rectangular plate; 26. Rectangular through slot; 27. Fixed rod; 28. Sliding block; 29. ​​Return spring; 210. Connecting rod; 211. Eccentric wheel; 212. Support rod; 213. Transmission wheel;

[0027] 3. Auxiliary fixing structure; 31. Limiting plate; 32. Placement groove; 33. Rubber protrusion; 34. Rectangular slot; 35. Rectangular block; 36. Auxiliary connecting rod; 37. Pressure plate; 38. First locking hole; 39. Second locking hole; 310. Threaded rod; 311. Threaded hole plate; 312. Limiting rod; 313. Locking rod;

[0028] 4. Culture tubes. Detailed Implementation

[0029] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0030] In the description of this application, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the stated features. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0031] In the description of this application, the term "for example" is used to mean "used as an example, illustration, or description." Any embodiment described as "for example" in this application is not necessarily to be construed as being more preferred or advantageous than other embodiments. The following description is provided to enable any person skilled in the art to implement and use the present invention. Details are set forth in the following description for purposes of explanation. It should be understood that those skilled in the art will recognize that the present invention can be implemented without using these specific details. In other instances, well-known structures and processes will not be described in detail to avoid obscuring the description of the present invention with unnecessary detail. Therefore, the present invention is not intended to be limited to the embodiments shown, but is consistent with the broadest scope of the principles and features disclosed in this application.

[0032] Reference Figure 1-4 A cell culture bioreactor includes a base 1 and culture tubes 4. A rotational vibration structure 2 is disposed on the top of the base 1. The rotational vibration structure 2 includes a motor frame 21 and a rectangular plate 25. The motor frame 21 is used to mount a drive motor 23, and the rectangular plate 25 is used to assist rotation and vibration. The motor frame 21 is fixedly connected to the top of the outer surface of the base 1. A rectangular through-slot 26 is formed on the top of the rectangular plate 25. A sliding block 28 is slidably connected to the inner wall of the rectangular through-slot 26. The sliding block 28 can slide on the inner wall of the rectangular through-slot 26, thereby... To cooperate with other components for transmission, the top of the sliding block 28 is provided with an auxiliary fixing structure 3; the auxiliary fixing structure 3 includes a limiting plate 31, the bottom of the limiting plate 31 is fixedly connected to the top of the sliding block 28, the limiting plate 31 can limit the culture tube 4, the top of the limiting plate 31 is provided with a placement groove 32, the inner wall of the placement groove 32 is fixedly connected with a rubber protrusion 33, the culture tube 4 is engaged with the inner wall of the placement groove 32, the culture tube 4 can be engaged into the inner wall of the placement groove 32, and the rubber protrusion 33 can increase the friction with the inner wall of the placement groove 32.

[0033] Reference Figure 2 The arc-shaped surface of the motor frame 21 is provided with heat dissipation holes 22. The top of the inner wall of the motor frame 21 is fixedly installed with a drive motor 23. The output end of the drive motor 23 is fixedly connected to a transmission rod 24. The drive motor 23 can drive the transmission rod 24 to rotate, and thus can cooperate with the movement of other components. The top end of the transmission rod 24 is fixedly connected to the bottom of the rectangular plate 25.

[0034] Reference Figure 2 Fixed rods 27 are fixedly connected to both sides of the rectangular through groove 26. The outer surface of the fixed rods 27 is slidably connected to the inner wall of the sliding block 28. The sliding block 28 can slide on the outer surface of the fixed rods 27, and thus can move in conjunction with other components. A return spring 29 is sleeved on the outer surface of the fixed rods 27. The two ends of the return spring 29 are fixedly connected to the outer surface of the sliding block 28 and the inner wall of the rectangular through groove 26, respectively. The return spring 29 can reset the sliding block 28 after it slides.

[0035] Reference Figure 2 A connecting rod 210 is fixedly connected to the bottom of the outer surface of the sliding block 28. An eccentric wheel 211 is fixedly connected to the bottom end of the connecting rod 210. The eccentric wheel 211 can work in conjunction with the transmission wheel 213 to squeeze the eccentric wheel 211, so that the sliding block 28 can slide on the outer surface of the fixed rod 27. A support rod 212 is fixedly connected to the top of the base 1. The transmission wheel 213 is rotatably connected to the top end of the support rod 212.

[0036] Reference Figure 3 and Figure 4 The top of the limiting plate 31 is provided with a rectangular slot 34, and a rectangular block 35 is engaged with the inner wall of the rectangular slot 34. The rectangular block 35 can be engaged and fixed with the rectangular slot 34. An auxiliary connecting rod 36 is fixedly connected to the top of the rectangular block 35, and a pressure plate 37 is fixedly connected to the top of the auxiliary connecting rod 36. The pressure plate 37 can assist in limiting the culture tube 4. A second locking hole 39 is provided on one side of the rectangular block 35, and a first locking hole 38 is provided on one side of the limiting plate 31.

[0037] Reference Figure 3 and Figure 4 A threaded rod 310 is rotatably connected to one side of the limiting plate 31. A threaded hole plate 311 is threadedly connected to the outer surface of the threaded rod 310. A limiting rod 312 is fixedly connected to one side of the limiting plate 31. The threaded rod 310 can drive the threaded hole plate 311 to move, which in turn can drive the locking rod 313 to move, so that the locking rod 313 can be locked into the inner wall of the first locking hole 38 and the second locking hole 39, thereby fixing the rectangular locking block 35 and the rectangular locking groove 34. The limiting rod 312 is slidably set on the inner wall of the threaded hole plate 311. The locking rod 313 is fixedly connected to one side of the threaded hole plate 311.

[0038] Working principle:

[0039] In use, the culture tube 4 is placed on the inner wall of the placement groove 32, and the rectangular locking block 35 is inserted into the inner wall of the rectangular locking groove 34. The threaded rod 310 is rotated so that the threaded plate 311 can drive the locking rod 313 to move, so that the locking rod 313 can be inserted into the inner wall of the first locking hole 38 and the second locking hole 39, thereby fixing the rectangular locking block 35 and the rectangular locking groove 34. The drive motor 23 is started so that the transmission rod 24 can drive the rectangular plate 25 to rotate, so that the eccentric wheel 211 contacts the transmission wheel 213 and drives the transmission wheel 213 to rotate. At the same time, under the compression of the transmission wheel 213, the sliding block 28 can slide on the outer surface of the fixed rod 27, thereby driving the limiting plate 31 to move. When the eccentric wheel 211 separates from the transmission wheel 213, it can be reset under the action of the return spring 29.

[0040] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of the present invention.

[0041] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A cell culture bioreactor, comprising a base (1) and culture tubes (4), characterized in that, The base (1) is provided with a rotational vibration structure (2) at its top. The rotational vibration structure (2) includes a motor frame (21) and a rectangular plate (25). The motor frame (21) is fixedly connected to the top of the outer surface of the base (1). A rectangular through groove (26) is provided at the top of the rectangular plate (25). A sliding block (28) is slidably connected to the inner wall of the rectangular through groove (26). An auxiliary fixing structure (3) is provided at the top of the sliding block (28). The auxiliary fixing structure (3) includes a limiting plate (31), the bottom of the limiting plate (31) is fixedly connected to the top of the sliding block (28), the top of the limiting plate (31) is provided with a placement groove (32), the inner wall of the placement groove (32) is fixedly connected with a rubber protrusion (33), and the culture tube (4) is engaged with the inner wall of the placement groove (32).

2. The cell culture bioreactor according to claim 1, characterized in that, The arc-shaped surface of the motor frame (21) is provided with heat dissipation holes (22). A drive motor (23) is fixedly installed on the top of the inner wall of the motor frame (21). A transmission rod (24) is fixedly connected to the output end of the drive motor (23). The top end of the transmission rod (24) is fixedly connected to the bottom of the rectangular plate (25).

3. The cell culture bioreactor according to claim 1, characterized in that, Fixed rods (27) are fixedly connected to both sides of the rectangular through groove (26). The outer surface of the fixed rod (27) is slidably connected to the inner wall of the sliding block (28). A reset spring (29) is sleeved on the outer surface of the fixed rod (27). The two ends of the reset spring (29) are fixedly connected to the outer surface of the sliding block (28) and the inner wall of the rectangular through groove (26), respectively.

4. A cell culture bioreactor according to claim 1, characterized in that, A connecting rod (210) is fixedly connected to the bottom of the outer surface of the sliding block (28), an eccentric wheel (211) is fixedly connected to the bottom end of the connecting rod (210), a support rod (212) is fixedly connected to the top of the base (1), and a transmission wheel (213) is rotatably connected to the top end of the support rod (212).

5. A cell culture bioreactor according to claim 1, characterized in that, The top of the limiting plate (31) is provided with a rectangular slot (34), and a rectangular block (35) is attached to the inner wall of the rectangular slot (34). An auxiliary connecting rod (36) is fixedly connected to the top of the rectangular block (35), and a pressure plate (37) is fixedly connected to the top of the auxiliary connecting rod (36). A second locking hole (39) is provided on one side of the rectangular block (35), and a first locking hole (38) is provided on one side of the limiting plate (31).

6. A cell culture bioreactor according to claim 1, characterized in that, A threaded rod (310) is rotatably connected to one side of the limiting plate (31), and a threaded hole plate (311) is threadedly connected to the outer surface of the threaded rod (310). A limiting rod (312) is fixedly connected to one side of the limiting plate (31), and the limiting rod (312) is slidably disposed on the inner wall of the threaded hole plate (311). A locking rod (313) is fixedly connected to one side of the threaded hole plate (311).

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